실비우스 수도를 경유한 뇌낭미충 낭종의 이주 -증례 보고-

김정훈,송준혁,김명현,박향권,김성학,신규만,박동빈 대한신경외과학회 1999 Journal of Korean neurosurgical society Vol.28 No.4

前腕部 經穴 取穴에서 骨度分寸法과 一夫法의 比較 硏究

박히준,채윤병,차웅석,박종배,이혜정,이향숙,인창식,고형균,김수영,최일환,김강식,문정배,배기태,유경환,육근영,정병주,손인철,임사비나 WHO COLLABORATING CENTRE FOR TRADITIONAL MEDICINE 2004 東西醫學硏究所 論文集 Vol.2004 No.-

Background : The cun measurement System, an essential and convenient method in locating acupoints, has been widely used in the practice of acupuncture. However, traditional cun measurement has been criticized for its lack of reliability. Objectives : The purposes of this study are to determine if one cun measured by the directional methods have a consistency with that of proportional methods and to investigate which factors are related with these differences, especially in forearm. Methods : The distance between the elbow crease and the wrist crease of forearm was compared to a reference value of one cun obtained by the directional method. In this method, one cun is one third of the distance between index finger and Small finger of a subject, measured at proximal interphalangeal joint. In addition, to investigate the factors influencing the differences between these two methods, we measured the height and body weight and calculated body mass index (BMI). Finally we analyzed the factors correlated with these lengths by linear regression test. Results : The results showed that one cun obtained by the directional methods were significantly different from one cun by the proportional methods in forearm. It was demonstrated that the length acquired with the directional method was more correlated with body weight and body mass index, while the length obtained by the proportional method was more correlated with the height.

형질전환 제초제저항성 벼 밀양 204호의 농업적 특성

정응기,이기환,원용재,박향미,전남수,최준호,구연충,한창덕,은무영,김태산,남민희 Plant molecular biology and biotechnology research 2005 Plant molecular biology and biotechnology research Vol.2005 No.

This study was conducted to investigated the major characteristics of genetically modified rice of "Milyang 204" originated from Dongjinbyeo compared to a non-transgenic rice varieties Dongjinbyeo and Junambyeo. Basta resistant transgenic rice lines carrying bar gene produced by the Yeongnam Agricultural Research Institute were evaluated for their agronomic characters. The transgenic Japonica rice of "Milyang 204" showed inferior phenotypic traits compared to a non-transgenic rice variety Dongjinbyeo and Junambyeo. On the basis of UPOV (Union Internationale Pour la Protaection des Obtentions Vegetables) and NSMO(National Seed Management Office) the transgenic "Milyang 204" showed difference in some traits out of some agronomic traits, such as leaf color, angle of flag leaf, number of spikelets, culm length, white core and white belly compared to the nontransgenic varieties rice.

지방척수수막류 14례의 임상 분석 : Clinical Analysis of 14 Cases

이정호,신규만,김명현,송준혁,박향권,김성학,박동빈 대한신경외과학회 1996 Journal of Korean neurosurgical society Vol.25 No.6

Lipomyelomeningocele is the most common malformation leading to spinal cord tethering. Nonetheless, these lesion continues to pose a challenge in patient management. The purpose of this study was to identify the clinical feature, candidate for surgical repair, and outcome of lipomyelomeningocele in young children and adults. We studied the magnetic resonance images and/or lumbar myelo-CT of lipomyelomeningocele performed between January 1987 and September 1995 at our institutions and reviewed the pertinent medical records and radiologic studies to determine clinical feature, surgical candidate, and outcomes of these patients. Of the 14 cases(11 female and 3 males) studied, the most common factor that caused these patients to seek help was the cosmetic effect of the mass on their back, followed by urinary incontinence, and weakness of lower extremities. The patients' age ranged from 2 months to 21 years(mean, 5.0 years). All the patients underwent immediate surgical management that consisted of removal of lipoma, untethering of the cord, and complete dural sac repair. Follow up for these patients ranged from 6 to 82 months(median, 54 mo). None of the patients that underwent surgical correction before the emergence of neurological deficit had ever developed neurological deficits at the end of the follow up. However a few of the patients, despite presented with neurological deficits or urinary incontinence at the time of surgery, improved significantly. In conclusion, early detection and prophylactic surgery is imperative to prevent permanent neurological deficits and urinary dysfunction.

백혈병환자의 요추천자 후 침상안정시간에 따를 두통과 요통의 차이

정영남 ( Young Nam Jeong ),이향련 ( Hyang Yeon Lee ),박영미 ( Young Mi Park ) 경희대학교 동서의학연구소 2008 동서간호학연구지 Vol.14 No.1

요추천자 후 침상안정을 취한 군(침상안정군)과 취하 지 않은 군(활동군)간의 두통의 발생 빈도를 비교하는 여러 연구가 있었으나, 어느 연구에서도 두 군간의 유 의한 차이를 발견하지 못하였다 (Carbaat & Crevel, 1981;Dieterich& Brandt 1985). 하지만 아직 대부 분의 병원에서는 요추천자 후 침상안정을 권하고 있는 실정이다 만약 요추천자 후 침상안정이 반드시 필요하지 않다면 피검자는 검사 후 일상생활에 바로 임할 수 있으므로 간호측면이나 시간적, 경제적 측면에서 많은 효과를 기대할 수 있을 것이다(KWon et al., 1997) . 실 제 서울시내 몇몇 종합병원의 경우를 보면, 성인 백혈병 환자의 요추천자가 시행된 후 대부분이 최소 6시간 이상 침상안정을 시키고 있었으며. 요추천자 후 6시간 이상 침상안정을 하는 환자들은 요통, 식사문제, 각종 검사의 지연, 생리적 현상 등을 참아 하는 고통을 갖게 된다. 특히 외래에서 요추천자를 시행한 경우에는 침상부족이라는 현실적 여건들이 6시간 침상안정을 철저히 준수하기 어렵게 한다고 사료된다. 본 연구에서 시도한 백혈병 환자의 요추천자 후 l시 간 침상안정과 6시간 침상안정에 따른 두통과 요통의 차이는 없었다. 이는 침상안정 시간이 척추마취 후 두 통 및 요통 발생에 영향을 주지 않았음을 확인한 Lee 와 mm (1996) 의 연구결과와, 소아종양환아를 대상으로 요추천자 후 1시간 및 6시간 침상안정 시간에 따라 두 통, 동반증상 및 두통의 강도는 유의한 차이가 없었다 는 Park과 Lee (1997) 의 연구결과와 유사하였다. 또한 18, 60세의 성인 신경계 환자 300명을 대상으로 전혀 침상 안정을 시키지 않은 군과 6시간 침상 안정 (3시간 은 앙와위, 3시간은 복위) 을 시킨 군의 천자 후 두통은 차이가 없음을 입증하여 침상안정을 하지 않는 것이 더 나을 것이라고 주장한 Vil血媤 등 (1988) 의 연구와 유사 하며 이는 6시간 이상 침상안정이 필요하지 않음을 시 사하고 있다. 다만 관찰할 수 있는 시간을 갖는다는 의 미에서 수평자세로 잠시 뉘어 놓는다 (Hong, 1993) 의 ‘잠지를 1시간 정도로 생각하면 무리가 없을 것으로 판단하게 된다는 근거 하에 본 연구에서 요추천자 후 l시 간 침상안정군과 6시간 침상안정군으로 구분하여 두통 정도를 비교하였을 때 두 군간에 통증 차이는 없었으며 통계적으로도 유의한 차이가 없었다 (U= 234. 0, P=. 498). 요추천자 후 요통 정도는 1시간 침상안정군과 6시간 침상안정군간에 통계적으로 유의하지 않아서 (u= 238. q p=. 532), 1시간 침상안정과 6시간 침상안정에 따른 요 통의 차이는 없는 것으로 나타났다. 이는 척추마취 환 자를 대상으로 침상안정 시간에 따른 요통의 발생률에 서 가능한 한 빨리 움직일 수 있도록 한 군이 요통 발생빈도가 적었다는 Lee와 mm (1996) 의 연구결과와 유 사하였다. 그러나 요통 점수에서 l시간 침상안정군의 평균점수보다 6시간 침상안정군의 평균점수가 높게 나 온 것은 대상자를 일찍 움직이게 하여 침상안정 시 히 리에 가해질 스트레스를 줄여 주었기 때문이 아닌가라는 견해를 피력한 Brattebo 등 (1993) 의 연구와도 관련성이 있었다. 통계적으로 유의하지 않았지만 6시간 동 안 침상안정을 시킨 군에시 요통 점수가 높은 것은 요 추천자라는 시술로 인한 스트레스 혹은 한국인에게 익숙하지 않은 침대 생활과 침대 매트리스로 얻어진 gj리 의 불펀감이 포함되었으리라 생각 되어진다. 이상으로 종합해 보면 연구대상이 백혈병으로 입원한 환자로 국한함으로써 전채 백혈병 대상자에게 연구결과를 일반화 하기는 어려우나 대상자 대부분이 움직일 수 있고 정상적인 일상생활을 할 수 있다는 점을 감안할 때 본 연구결과에서 나타난 것처럼 침상안정시간에 다른 두통과 요통정도에 차이가 없다면, l시간 이상 침상 안정을 지속하는 것이 꼭 필요한 것은 아니라고 생각된 다. 추후 연구로는 침상안정 기간 중 지속적으로 두통을 호소하는 환자에게 침상안정을 시키되 침상안정기간 동안 두통의 완화 정도 상대도 계속적으로 연구할 필요 가 있다고 사료된다. Purpose: This study was conducted for an evidence-based nursing intervention on bed rest period after puncture, by confirming whether there was a difference in scores of headache and back pain between the 1-hour bed rest group and the 6-hour bed rest group following lumbar puncture in patients with leukemia. Method: The subjects were 45 inpatients of the department of hematology at a general hospital in Seoul, from January 1 to March 31, 2005. There were 21 patients in the 1-hour bed rest group and 24 patients in the 6-hour bed rest group. A graphic rating scale was used to measure headaches and back pains. Collected data were analyzed With SPSS 12.0. Non-parametric statistics were used to analyze the data. Results: There was no significant difference between the 1-hour bed rest group and the 6-hour bed rest group in the headache level and back pain level. Conclusion: Therefore, it is considered that a long period of bed rest over 6 hours after lumbar puncture is not a necessary nursing intervention, and repeated studies are required to confirm the result.

비강 및 비인두에 발생한 도립유두종과 편평상피암종의 p53단백 및 세포증식능에 관한 연구

한주호,윤기중,이재규,신대균,박근호,조향정,문형배 圓光大學校 醫科學硏究所 1996 圓光醫科學 Vol.12 No.2

The inverted papilloma and squamous cell carcinoma are common neoplasia in the sinonasal cavity and nasopharynx, but the incidence of these tumors are very low and the study on the oncogenesis or biological activity of the tumor cells are not well known. This study was designed to evaluate the oncogenic roles of the p53 gene and the proliferative activity of the tumor cells in the inflammatory polyp, inverted papilloma and squamous cell carcinoma. The experiment was carried by the immunohistochemical stains about the p53 protein, PCNA and Ki-67, histochemical stain about the AgNORs. and flow cytometric analysis about the DNA ploidy using the formalin fixed paraffin embedded tissues. The frequency of the expression of p53 protein was 0%(0/16 cases) in the inflammatory polyps, 18.8% (3/16 cases) in the inverted papillomas, and 87.5%(14/16 cases) in the squamous cell carcinomas. The labelling index(%) of the PCNA and Ki-67 was 5.3% and 3.3% in the inflammatoy polyps, 29.6% and 25.2% in the inverted papillomas, and 51.9% and 36.8% in the squamous cell carcinoma. The expression of the PCNA and Ki-67 was distributed in the periphery of the tumor islands of the inverted papilloma and was distributed in the both of center and periphery of the tumor islands of the squamous cell carcinoma. The number of nuclear AgNORs was increased in the order of inflammatory polyps (0.96), inverted papillomas(1.34) and squamous cell carcinoma(2.09). The frequency of the DNA aneuploidy was 0%(0/16 cases) in the inflammatory polyps, 18.8%(3/16 cases) in the inverted papillomas. and 12.5%(2/16 cases) in the squamous cell carcinomas. Above results indicates that the changes of the p53 gene and proliferative activity of the tumor cells are involved on the oncogenesis and the biological activity of the inverted papilloma or squamous cell carcinoma in the nasopharynx and sinonasa cavity.

Poly(ε-caprolactone) (PCL) fibers incorporated with phase-changeable fatty acid and indocyanine green for NIR light-triggered, localized anti-cancer drug release

Park, Ju Hyang,Choi, Ji Hyun,Son, Jin Ho,Hwang, Se Jeong,Seo, Hojun,Kang, Inn-Kyu,Park, Minwoo,Kim, Jongbok,Hyun, Dong Choon Butterworth Scientific Ltd. etc. 2018 Polymer Vol. No.

<P><B>Abstract</B></P> <P>This paper describes a new system for NIR light-triggered, localized release of drugs. The system consists of biocompatible/degradable poly(ε-caprolactone) (PCL)-based fibers having a core loaded with doxorubicin (DOX) and a sheath incorporated with indocyanine green (ICG) as a NIR-absorbing agent together with a biocompatible/degradable, phase-changeable fatty acid. Upon NIR irradiation, the photothermal agent will generate heat to raise the local temperature of the fibers. When the temperature is above the melting point of the fatty acid, nano-pores will be generated in the fibers. This response to NIR irradiation allows the instant release of DOX from the fibers through the pores, leading to the significant enhancement of anticancer activity in combination with the hyperthermia effect arising from the photothermal agent.</P> <P><B>Highlights</B></P> <P> <UL> <LI> Poly(ε-caprolactone) fibers incorporated with phase-changeable fatty acid and indocyanine green (ICG) have been fabricated. </LI> <LI> The prepared fibers release pre-loaded anticancer drug in response to NIR light irradiation. </LI> <LI> The NIR triggered release leads to the enhancement of anticancer activity in combination with the hyperthermia effect by ICG. </LI> </UL> </P> <P><B>Graphical abstract</B></P> <P>[DISPLAY OMISSION]</P>

Preclinical Evaluation of an Everolimus-Eluting Bioresorbable Vascular Scaffold Via a Long-Term Rabbit Iliac Artery Model

Park Dae Sung,Jeong Myung Ho,진유정,Na Mi Hyang,Sim Doo Sun,Kim Munki,Cho Kyung Hoon,Hyun Dae Young,Oh Seok,Kim Jeong Ha,Lim Kyung Seob,Park Jun-Kyu,김한기,Hong Young Joon,Kim Ju Han,Ahn Youngkeun,Kim Jeong 한국조직공학과 재생의학회 2023 조직공학과 재생의학 Vol.20 No.2

BACKGROUND: Biodegradable poly (l-lactic acid) (PLLA), a bio safe polymer with a large elastic modulus, is widely used in biodegradable medical devices. However, because of its poor mechanical properties, a PLLA strut must be made twice as thick as a metal strut for adequate blood vessel support. Therefore, the mechanical properties of a drug-eluting metal-based stents (MBS) and a bioresorbable vascular scaffolds (BVS) were evaluated and their safety and efficacy were examined via a long-term rabbit iliac artery model. METHODS: The surface morphologies of the MBSs and BVSs were investigated via optical and scanning electron microscopy. An everolimus-eluting (EE) BVS or an EE-MBS was implanted into rabbit iliac arteries at a 1.1:1 stent-toartery ratio. Twelve months afterward, stented iliac arteries from each group were analyzed via X-ray angiography, optical coherence tomography (OCT), and histopathologic evaluation. RESULTS: Surface morphology analysis of the EE coating on the MBS confirmed that it was uniform and very thin (4.7 lm). Comparison of the mechanical properties of the EE-MBS and EE-BVS showed that the latter outperformed the former in all aspects (radial force (2.75 vs. 0.162 N/mm), foreshortening (0.24% vs. 1.9%), flexibility (0.52 vs. 0.19 N), and recoil (3.2% vs. 6.3%). At all time points, the percent area restenosis was increased in the EE-BVS group compared to the EE-MBS group. The OCT and histopathological analyses indicate no significant changes in strut thickness. CONCLUSION: BVSs with thinner struts and shorter resorption times should be developed. A comparable long-term safety/efficacy evaluation after complete absorption of BVSs should be conducted.

Occurrence tendency of the natural enemies of Ceroplastes rubens in citrus on Jeju island

Jeong Hoon Park,Young Min Kim,Moon Hyang Ko,Jeong Heub Song,Tae Hyeon Heo 한국응용곤충학회 2019 한국응용곤충학회 학술대회논문집 Vol.2019 No.04

루비깍지벌레 Ceroplastes rubens는 감귤에 피해를 주는 주요 깍지벌레 중 하나로 연 1회 발생하며 수액을 흡즙하는 직접적인 피해와 분비된 감로로 인한 그을음병 유발의 간접적인 피해가 발생하고 있다. 제주지역에서 루비깍지벌레 천적으로는 루비붉은깡충좀벌 Anicetus beneficus와 애홍점박이무당벌레 Chilocorus kuwanae 2종이 확인되었다. 1975년 일본에서 도입 방사한 천적인 루비붉은깡충좀벌이 현재까지 지속적으로 발생하고 있었으며, 루비깍지벌레 발생 억제에 영향을 미치고 있었다. 2018년 4월부터 12월까지 도내 유기재배 감귤원 (2개소)에서 황색끈끈이트랩을 이용 루비붉은깡충좀벌 성충의 시기별 발생양상을 조사한 결과 월동세대 성충은 5월 중순, 제1세대와 제2세대 성충은 각각 7월 중순과 8월 하순에 발생 정점을 나타내었다. 조사 포장에서 루비깍지벌레의 기생률은 9월 중순에 9.6%와 19.6%이었다.

[P8-04] Studies on Biological Blood Analysis of Feeding Mice of Gelatine Nano-encapsulated Angelica gigas Nakai Extract

Hyang Suk Jeong,Sung-Jin Park,Jae Gun Han,Ji Hye Ha,Young Kim,Sung Ho Oh,Seoung Seop Kim,Myoung Hoon Jeong,Hyeon Yong Lee 한국식품영양과학회 2009 한국식품영양과학회 학술대회발표집 Vol.2009 No.11