Intracavitary Radiation Therapy for Recurrent Cystic Brain Tumors with Holmium-166-Chico : A Pilot Study

Ha, Eun Jin,Gwak, Ho-Shin,Rhee, Chang Hun,Youn, Sang Min,Choi, Chang-Woon,Cheon, Gi Jeong The Korean Neurosurgical Society 2013 Journal of Korean neurosurgical society Vol.54 No.3

Objective : Intracavitary injection of beta-emitting radiation source for control of cystic tumors has been tried with a benefit of localized internal radiation. The authors treated cystic brain tumor patients with Holmium-166-chitosan complex (Ho-166-chico), composed of a beta-emitting radionuclide Holmium-166 and biodegradable chit polymer, and evaluated the safety and effective measurement for response. Methods : Twenty-two patients with recurrent cystic brain tumor and/or located in a deep or eloquent area were enrolled in this pilot study. The cyst volume and wall thickness were determined on CT or MRI to assess radiological response. The activity of Ho-166-chico injected via Ommaya reservoir was prescribed to be 10-25 Gy to the cyst wall in a depth of 4 mm. Results : There was neither complications related to systemic absorption nor leakage of Ho-166-chico in all 22 patients. But, two cases of oculomotor paresis were observed in patients with recurrent craniopharyngioma. Radiological response was seen in 14 of 20 available follow-up images (70%). Seven patients of 'evident' radiological response experienced more than 25% decrease of both cyst volume and wall thickness. Another 7 patients with 'suggestive' response showed decrease of cyst volume without definitive change of the wall thickness or vice versa. All patients with benign tumors or low grade gliomas experienced symptomatic improvement. Conclusion : Ho-166-chico intracavitary radiation therapy for cystic tumor is a safe method of palliation without serious complications. The determination of both minimal effective dosage and time interval of repeated injection through phase 1 trial could improve the results in the future.

한국인 직무 스트레스 측정도구의 개발 및 표준화

장세진,고상백,강동묵,김성아,강명근,이철갑,정진주,조정진,손미아,채창호,김정원,김정일,김형수,노상철,박재범,우종민,김수영,김정연,하미나,박정선,이경용,김형렬,공정옥,김인아,김정수,박준호,현숙정,손동국 大韓産業醫學會 2005 대한직업환경의학회지 Vol.17 No.4

Background and Purposes: Over the past three decades, numerous studies performed in Korea have reported that job stress is a determinant risk factor for chronic diseases and work disability. Every society has its own culture and occupational climate particular to their organizations, and hence experiences different occupational stress. An occupational stress measurement tool therefore needs to be developed to estimate it objectively. The purpose of this study is to develop and standardize the Korean Occupational Stress Scale (KOSS) which is considered to be unique and specific occupational stressors in Korean employees. Subjects and Methods: Data were obtained from the National Study for Development and Standardization of Occupational Stress (NSDSOS Project: 2002-2004). A total of 12,631 employees from a nationwide sample proportional to the Korean Standard Industrial Classification and the Korean Standard Occupational Classification were administered. The KOSS was developed for 2 years (2002-2004). In the first year, we collected 255 items from the most popular job stress measurement tools such as JCQ, ERI, NIOSH and OSI, and 44 items derived from the a qualitative study (depth interview). Forty-three items of KOSS, in the second year, were retained for use in the final version of the KOSS by using Delphi and factor analysis. Items were scored using conventional 1-2-3-4 Likert scores for the response categories. Results: We developed eight subscales by using factor analysis and validation process: physical environment (3 items), job demand (8 items), insufficient job control (5 items), interpersonal conflict (4 items), job insecurity (6 items), organizational system (7 items), lack of reward (6 items), and occupational climate (4 items). Together they explained 50.0% of total variance. Internal consistency alpha scores were ranged from 0.51 to 0.82. Twenty-four items of the short form of the KOSS (KOSS-SF) were also developed to estimate job stress in the work setting. Because the levels of the subscales of occupational stress were gender dependent, gender-specific standard norms for both the 43-item full version and the 24-item short form using a quartile for the subscales of KOSS were presented. Conclusion: The results of this study suggest that KOSS might be an appropriate measurement scale to estimate occupational stress of Korean employees. Further and more detailed study needs to be conducted to improve the validity of this scale.

수압보증시험시의 음향방출에 의한 복합재 연소관의 파괴거동 예측

이상호,김호철,오치환,송성진,정현조,임수용 韓國非破壞檢査學會 1998 한국비파괴검사학회지 Vol.18 No.2

섬유강화 복합제 연고관은 복합재료의 사용, 필라멘트 와인딩 및 경화공정 등으로 인하여 제작 중 다양한 결함이 발생할 수 있으며, 또한 사용 도중에도 예기치 않은 손상을 받아 기계적 성질이 저하될 수 있다. 따라서 제작 완료된 연소관의 품질 보증을 위해 수압보증시험이 사용되고 있으나 이를 위해 가한 수압이 오히려 연소관에 예기치 않은 손상을 가하여 실제 사용시 그 성능을 저하시키는 요인으로 작용하는 경우도 있다. 이러한 문제를 해결하기 위해 본 연구에서는 수압보증시험시의 음향방축을 감지하여, 그 신호의 특성으로부터 복합제 연소관의 파손 거동을 예측하는 체계적인 기법의 개발을 시도하였다. 음향방출을 이용하여 연소관에 발생한 손상의 개략적 위치를 결정할 수 있었으며, 또한 파괴모드의 식별도 가능하였다. 다만, 시료의 부족으로 최종파열압력의 변화와 충격손상의 영향에 대한 신뢰성있는 분석은 불가능하였다. Prediction of failure behavior in filament-wound composite motor cases is one of the important issues for their reliable application. Acoustic emission during hydroproof testing of the cases is used to solve this problem. Based on the acoustic emission behavior, failure sites can be located successfully. The identification of failure modes is also possible using the distribution of acoustic emission amplitude. Due to the limitation in the number of samples, it is not possible to predict the final burst pressure of motor cases and the effect of impact damage on the final burst pressure.

Incoterms2000의 거래조건에 관한 연구

이정호 조선대학교 지역사회발전연구원 2001 地域發展硏究 Vol.5 No.2

WTO體制下에서의 國際貿易과 環境 連繫에 따른 韓國의 對應方案에 관한 硏究

李延浩,金種得 조선대학교 경영경제연구소 1996 經營經濟硏究 = Management and economics research Vol.19 No.1

歐洲地域의 學問動向 硏究 : 文學, 哲學, 經營學의 動向

李文浩,鄭喆,金洙正,李正道 慶北大學校 人文大學 1982 인문학총 Vol.7 No.-

This modern age is a time of divided learning. In ancient times, at the beginning, there was one philosophical thinking and from that the special sciences separated gradually. Today, all knowledge has tendencies to become more and more detailed. Certain sciences of today have no relation to any philosophy in spite of the past relationship. Because of specialised learning, there is today less research for the ultimate reasons, and more research in minutiae. These days mam does not intend to obey nature but intends to control it. Man can think that this world is composed of material staff only. This is the aspect of this modern age. Unfortunately neither science nor materialism can save our modern age. Love, however can do it. Love is the ultimate thing in the world. Therefore, we haue value Gabriel Marcel's theory of love.

정형회과영역에서의 Cefmetazole(Cefmetazon^(�)) 임상적 효과

이정웅,문형석,안상로,이준규,이광진,윤승호 최신의학사 1988 最新醫學 Vol.31 No.5

동경파 유젠(東京派 友禪)에 관한 연구 : 수묘 유젠(手描友禪) 작가 중심으로

김호연,이정화 홍익대학교 산업디자인연구소 2006 미술디자인 논문집 Vol.- No.11

급성신우신염의 임상적 고찰

신영태,신승훈,이순구,이정호,이강욱 충남대학교 의과대학 지역사회의학연구소 1990 충남의대잡지 Vol.17 No.2

A clinical retrospective study was undertaken in 81 patients with acute pyelonephritis admitted to the Department of Internal Medicine, Chungnam National University Hospital from January 1983 to December 1989. The results were as follows : 1. Total number of patients studied was 81(M/F ratio, 1 : 4.4). The M/F ratio of 22 complicated patients (27.2%) was 1 : 2.7 2. The predisposing factors associated with complicated patients were as follows : 7 cases of urinary tract stone, 7 cases of pregnancy, 4 cases of neurogenic bladder and each one case of prostatic hypertrophy, ureter cancer, bladder diverticulum and polycystic kidney disease. 3. The common subjective symptoms on admission were fever and chills, frank pain, nausea and vomiting. High body temperature and CVA tenderness were noted in 61% and 95% of patients respectively. And 50.6% of patients revealed right CVA tenderness and 28.4% in left, 16% in both respectively. There was no difference in symptoms and signs between complicated and uncomplicated groups 4. In 50 patients(61.7%) microorganisms were isolated on the urine culture specimens. The most common organism was E. coli(80%), and followed by Staphylococcus aureus and Serratia odorifera. E coli was the most frequent pathogen in both female and male patients, and in complicated and uncomplicated groups. (In sensitivity test of complicated and uncomplicated groups). In sensitivity test of causative pathogens to antibiotics, E coli was sensitive to amikacin(93%), tobramycin(83.3%) and gentamycin(79.4%) and 88.9 percent of E coli were ressistant to ampicillin 5. In urinary examination on admission, pyuria was noted in 81% of patients, and proteinuria and microscopic hematuria were noted in 68% and 44% of patients respectively. 6. Within 3 days after antibiotics treatment deference was occured in 73.5% of total patients, and complicated patients revealed delayed defeverence compared to uncomplicated ones.

결핵성 수막염 환자에서 결핵균 30 kDa 및 32 kDa 단백항원에 대한 항체반응의 비교

백태현,김선영,이건수,김화중,김성호,조은경,박정규 충남대학교 의과대학 지역사회의학연구소 1996 충남의대잡지 Vol.23 No.2

The 30 and 32 kDa antigens from Mycobacterium tuberculosis H37Rv culture filtrates, identified as biologically important proteins in the immune responses against mycobacterial infection, were purified and used in enzyme linked ummunosorbent assay (ELISA) for the determination in specific IgG and IgM levels in cerebrospinal fluids of 15 patients with tuberculous meningitis and 17 controls with nontuberculous diseases. High reactivity to both antigens was observed in tuberculous meningitis. Mean IgG and IgM antibody levels differed significantly (P < 0.001) between patients and con trols. Mean IgG antibody levels were also higher than IgM levels in tuberculous meningitis. A comparison of the antibody levels against the 30 and 32 kDa antigen within the tuberculous meningitis patients showed higher IgG reactivity to the 30 kDa than to the 32 kDa antigen, suggesting that the antibody response of these patients is directed predominantly against the 30 kDa protein. However, the patterns of reactivity to 30/32 kDa, 30 kDa and 32 kDa antigen in individual subjects were similar. By the cut-off value adding 2 stsndard deviation to the mean absorbance of controls, the sensitivity and specificity of the IgG antibody to the 30 kDa antigen were 100% and 94.4%, respectively. These values were higher than those obtained by 30/ 32 kDa and 32 kDa antigen. From the above results, it is suggested that the 30 kDa antigen may be dominant antigen and more valuable in the diagnosis of tuberculous meningitis than 32 kDa antigen.