EGFR 돌연변이와 ROS1 전위를 동시에 가진 폐선암 환자의 Erlotinib 치료 1예

김민환,박예현,박혜정,지아영,송창호,진무년,김영주,김선욱,이중희,김인수,김혜련,김주항,조병철 Ewha Womans University School of Medicine 2014 EMJ (Ewha medical journal) Vol.37 No.1

The rearrangement of c-ros oncogene 1 (ROS1) has been recently identified as an important molecular target in non small cell lung cancer (NSCLC). ROS1 rearrangement and epidermal growth factor receptor (EGFR) mutation were mutually exclusive each other in previous studies, and the clinical implication of co-existence of the two genetic alterations has not been determined. We report a case of 46-year-old female never-smoker NSCLC patient whose tumor harbored ROS1 rearrangement and EGFR mutation concomitantly. She had undergone curative surgery for stage IIIA NSCLC, and the recurrence in left pleura and brain occurred at 2 years after the surgery. She received several lines of chemotherapy including docetaxel plus carboplatin, erlotinib, pemetrexed, and gemcitabine. Erlotinib therapy showed a favorable treatment response with progression-free survival of 9.5 months and partial response of tumor on radiologic evaluations. This case represents a successful erlotinib treatment in a NSCLC patient with concurrent ROS1 rearrangement and EGFR mutation.

Effect of Mori Cortex in the Cardiac Injury Induced by Skin Burn

조현국,--,-- THE KOREAN SOCIETY FOR BIOMEDICAL LABORATORY SCIEN 2004 Journal of biomedical laboratory sciences Vol.10 No.2

This study was conducted to investigate an effect of Mori Cortex in the cardiac injury following dermal scald bum in rats. Sprague-Dawley rats were induced scald burn (15% of total body surface area). Heart was removed at 5 h postburn and examined with biochemical assay, ultrastructural observations and stereological analysis. The activity of serum aspartate aminotransferase and creatinine was increased at 5 h postburn compared with them of control. Administration of heat extracts of Mori Cortex after scald bum inhibited the production of KC (neutrophil chemoattractant cytokine) and increased the activity of protein kinase C (PKC) in heart tissue. The activity of myeloperoxidase (MPO) in heart tissue was decreased both at 5 h postburn and in case of Mori Cortex administration after scald burn. Ultrastructurally, many contraction bands and separation of intercalated disk induced by scald bum were decreased by administration of heat extracts of Mori Cortex. In stereological analysis, administration of Mori Cortex after scald burn resulted the volume densities of myofibril and mitochondria were increased compared with them of burn control. These data suggest that Mori Cortex may be a useful stuff to the range of available treatments for cardiac injury induced by skin burn.

학교행정가의 리더십과 핵심역량에 대한 인식 연구

조경원,한유경,서경혜,조정아,이지은 이화여자대학교 교육과학연구소 2006 교육과학연구 Vol.37 No.1

21세기 지식정보화 사회는 전통적인 학교교육의 변혁을 요구한다. 이에 학교교육 개혁을 성공적으로 이끌어 나아갈 수 있는 교원의 리더십 특히 학교행정가의 리더십이 절실히 요구되고 있다. 그렇다면 지식정보화 사회에서 요구되는 학교행정가의 리더십이란 무엇이며 어떤 역량을 포함하는가? 본 연구는 학교행정가의 리더십과 핵심역량에 대한 선행연구가 학교 현장과는 유리된 채 이론적, 당위적 수준에 그치고 있다는 문제의식에서 출발하여 학교행정가의 리더십을 구성하는 핵심역량이 무엇인가에 대한 교사, 교감, 교장, 행정실장 및 서무부장의 인식을 파악하고 이들 집단의 인식을 비교 분석하는 데 목적을 두었다. 이를 위해 우선 문헌연구를 통해 리더십에 대한 관점과 개념의 변화를 고찰하였고 변혁적 리더십 관점에 기초하여 학교행정가가 갖추어야 할 핵심역량으로 교육적 리더십, 학교 계획 및 조직, 학교교육과정 편성 및 운영, 학교운영, 인적자원 개발, 학교재정 관리, 교육법 이해 및 집행, 학교교육정책 이해, 학교·학부모 및 지역사회 협력, 정보통신기술 활용과 같은 열 가지 역량을 도출하였다. 문헌연구를 통해 도출된 핵심역량에 대한 학교 현장의 관점을 알아보기 위해 초·중·고등학교 교직원을 대상으로 10대 핵심역량의 중요도와 현재 실행정도에 대해 설문조사를 수행하였다. 설문조사에는 144개 학교의 교직원 1,136명이 참여하였다. The purpose of this study is to investigate the perspectives of teachers, vice-principals, and school staff on school administrators' leadership and core abilities. For this purpose, first, we examined the perspectives and concepts of school administrator's leadership and identified 10 core abilities that constitute the school administrator's leadership. Second, we developed a questionnaire to investigate the perspectives of teachers, vice-principals, and school staff on to what extent the 10 core abilities are important and whether their school administrators actually exert these 10 core abilities. Finally, we conducted a survey research, including teachers, vice-principals, and school staff with various years of experiences in elementary and secondary schools in Korea. The findings show that teachers, vice-principals, principals, and school staff consider the 10 core abilities very important for school administrators. However, they perceive that school administrators, in reality, do not exert the 10 core abilities as much as they think these abilities are important. In particular, teachers rated school administrators' leadership relatively low compared to principals, vice-principals, and school staff. The difference between their perception on the importance and exertion of 10 core abilities indicates the need for programs that promote the development of 10 core abilities for school administrators and consequently support the development of school administrator's leadership.

대혈관 전위증의 병리

조수연,오미혜,김정선,이용희,강행지,서정욱 한국소아심장연구회 2003 소아심장 Vol.7 No.2

내부 응력이 .06 taper Profile의 피로 파절에 미치는 영향

정혜림,김진우,조경모,박세희 大韓齒科保存學會 2012 Restorative Dentistry & Endodontics Vol.37 No.2

Objectives: The purpose of this study was to evaluatie the reation between intentionally induced internal stress and cyclic fatigue failure of .06 taper ProFile. Materials and Methods: Length 25 mm, .06 taper ProFile (Dentsply Maillefer), and size 20, 25, 30, 35, and 40 were used in this study. to give the internal stress, the rotary NiTi files were put into the .02 taper, Endo-Training Bloc (Dentsply Maillefer) until auto-stop by torque controlled motor. Rotary NiTi files were grouped by the number of induced internal stress and randomly distributed among one control group and three experimental groups (n = 10, Stress 0 [control], Stress 1, Stress 2 and Stress 3). For cyclic fatigue measurement, time for separation of the rotary NiTi files was recorded. the fractured surfaces were observed by field emission scanning electron microscope (FE-SEM, SU-70, Hitachi). The tiem for separation was statistically analyzed using two-way ANOVA and post-hoc Scheffe test at 95% level. Results: In .06 taper ProFile size 20, 25, 30, 35, and 40, there were statistically significant difference on time for separation between control group and the other groups (p < 0.05). Conclustion: In the limitation of this study, cyclic fatigue failure of .06 taper ProFile is influenced by internal stress accumulated in the files. (Restor Dent Endod 2012;37(2):79-83)

차아염소산나트륨 용액과 고압증기멸균이 근관치료용 니켈-타이타늄 파일의 주기적 피로 파절에 미치는 영향

조혜영,정일영,이찬영,김의성 大韓齒科保存學會 2008 Restorative Dentistry & Endodontics Vol.33 No.1

The purpose of this study was to determine the effect of sodium hypochlorite and steam autoclaving on the cyclic fatigue of nickel-titanium endodontic files. Two types of files with a .06 taper and #30 were used, K3^(ⓡ) (SybronEndo, Glendora, California, USA) and Hero642^(ⓡ)(Micro-Mega, Besancon, France). The files were divided into 6 experimental groups containing 10 files each group depending the soaking time in 6% sodium hypochlorite solution and number of cycles of steam autoclave. After sterilization, a cyclic fatigue test was performed on each file, and the fracture time was recorded in seconds. The control group underwent the cyclic fatigue test only. After the test, the surface characteristics of the files were observed using scanning electron microscopy (SEM). All groups containing the Hero 642^(ⓡ) files showed a similar cyclic fatigue fracture time. However, the cyclic fatigue fracture time with the K3^(ⓡ) files was significantly shorter in groups which were treated with sodium hypochlorite than in the control group (P < 0.05). SEM revealed both Hero642^(ⓡ) and K3^(ⓡ) files to have significant corrosion on the file surface in groups treated with sodium hypochlorite, compared with the sharp and regular blades of the control group. K3^(ⓡ) files showed more corrosion than the Hero642^(ⓡ) files. Bluntness of the blades of the K3^(ⓡ) file was observed in groups treated with steam autoclave. Although there was no obvious destruction on the surface of steam autoclaved Hero642^(ⓡ) files, slight bluntness was observed. Sterilizing with a steam autoclave is much less destructive to K3^(ⓡ) files than sodium hypochlorite. The longer time exposed to sodium hypochlohte, the more destructive pattern was shown on the blades of the files. Therefore, when using sodium hypochlorite solution, the exposure time should be as short as possible in order to prevent corrosion and increase the cyclic fatigue fracture time. 본 연구에서는 차아염소산나트륨 용액 및 고압증기멸균이 근관 치료용 Ni-Ti 파일의 주기적 피로 파절에 미치는 영향을 알아보고자 하였다. 파일 첨단 크기가 #30이고 .06 taper를 가지는 Hero 642^(ⓡ)와 K3^(ⓡ)파일 70개를 10개씩 7개의 군으로 나누었으며, 6% 차아염소산나트륨 용액에 15분 (N15군), 30분 (N30군),고압증기멸균은 121 ℃의 온도, 0.12 ㎫의 압력에서 20 분간 시행하는 것을 일 회로 하여 5회 (H5군), 10회 (H10), 고압증기멸균 5회 후 차아염소산나트륨 용액 15분 (H5N15),고압증기멸균 10회 후 차아염소산나트륨 용액 30분 (H10N30) 처리 후 주기적 피로 파절 실험을 수행하여 파일이 파절될 때까지의 시간을 초 단위로 측정하였다. 대조군은 전처리를 하지 않고 주기적 피로 파절을 시행하였다. 95%의 신뢰도로 one-way analysis of variance를 이용하여 통계 처리하였으며 , 다중 비교는 Tukey방법으로 분석하였다. 파일의 표면을 주사전자현미경으로 관찰하였다. 주기적 피로 파절에 소요된 시간은 Hero 642^(ⓡ)는 각 군별로 유의할 만한 차이가 없었으며, K3^(ⓡ)는 N15, N30, H5N15군에서 대조군에 비해 짧은 시간이 소요된 것으로 나타났다 (p < 0.05). 주사전자 현미경에서 관찰했을 때 Hero 642^(ⓡ)와 K3^(ⓡ) 모두 N15, N30 군에서 파일의 표면과 날이 부식이 되어 대조군에서 관찰된 일정방향으로 배열된 정형화된 예리한 빗살무늬가 부분적으로 파괴된 형태가 관찰되었으며 ,N15군에 비해 N30군에서 파일의 형태가 파괴된 양상이 뚜렷했으며 ,Hero 642^(ⓡ)보다 K3^(ⓡ)가 심하게 부식된 양상이었다. H5군과 H10군에서는 K3^(ⓡ)파일은 날 부분이 무디어진 양상을 보였고, Hero 642^(ⓡ)는 형태 파괴가 뚜렷하지 않았으나 H10군에서 표면의 빗살무늬가 약간 무디어진 양상을 보였다. H5N15군과 H10N30군에서는 그다지 뚜렷한 형태변화는 없었다. 본 연구 결과 K3^(ⓡ)파일을 사용 시에는 가능한 한 차아염소산나트륨에 적은 시간 노출 시키는 것이 파일의 부식으로 인한 형태의 손상을 방지 할 수 있고, 주기적 피로 파절에 걸리는 시간도 감소시킬 수 있을 것이다.

Gα^(h)-단백질에 의해 활성화되는 Phospholipase C 이소효소의 확인

조강호,박권식,채규영,한기정,김형석,김형일,윤혜영,권년수,이희성,백광진 중앙대학교 의과대학 의과학연구소 2000 中央醫大誌 Vol.25 No.4

복강경을 이용한 부인과 수술의 임상적 고찰

조혜진,정효영,정혁 朝鮮大學校 附設 醫學硏究所 2005 The Medical Journal of Chosun University Vol.30 No.2

Background and Objectives : To assess the advantages, disadvantages, appilcability, and complications of laparoscopy in gynecologic disease. Materials and Method: A retrospective study which includes 591 patients who underwent laparoscopic surgery from January, 1994 to February, 2005 for gynecologic diseases was done. Results: The patient's ages ranged from 19 to 65 years and their mean age was 40years. The indications of laparoscopy were myoma in 240 cases (40.6%), ovarian tumor, ectopic pregnancy, pelvic adhesion, primary infertility, secondary infertility, endometriosis, pelvic inflammatory disease, hemorrhagic corpus luteum and tubal obstruction in decreasing order. The operations performed were laparoscopic-assisted vaginal hysterectomy in 247 cases (41.8%), diagnostic laparoscopy, oophorectomy, salpingo-oophorectorny, ovarian cystectomy, pelvic adhesiolysis, salpingectomy, ovarian wedge resection and fulgarization in order. Operation times were from 10 to 240 minutes (mean 64 minutes). Postoperative hospital stays were from 0 day to 15 days (mean 3.9 days). There were 11 surgical complications including 1 trocar site hematoma, 11 incision site infection, 2 postoperative ileus and 1 patient underwent reoperation because of delayed ureteral fistula. Conclusion: We conclude that operative laparoscopy is useful in gynecologic diseases but need development of laparoscopic equipments, research of operative method, extension of operative indications, and skilled laparoscopic surgeons.

색동직물의 배색 선호도에 따른 이미지 연구

정경임,박혜원,조오순 창원대학교 생활과학연구소 2002 생활과학연구 Vol.- No.6

The purpose of this study is for confirming about image research by color scheme of saekdong textile fabrics used modern Korean traditional costume. Method of this study is taste analysis by ten person who is specialized in clothing at changwon national university and ten person of the general about seven samples of saekdong that is selling Korea in domestic. The results are as follows. 1. Image of saekdong arrangement of color are dim, noble (stimulus1,4), unpretending-ness(stimulus5,6), calm, sharp(stimulus7), and activity, splendor(stimulus2,3). 2. Stimulus 1 liked everything is most for taste of saekdong arrangement of color. If apply saekdong in design development according to consumers' changed mark and demand, is expected that can do popularization.

Clostridium difficile 장염에 의한 속발성 유전분증에서 발현된 독성 장염

조형원,정혜경,강현주,이윤표,강혜원,심기남,정성애 Ewha Womans University School of Medicine 2014 EMJ (Ewha medical journal) Vol.37 No.1

Amyloidosis is characterized by extracellular deposition of protein fibrils in one or multiple organs. AA amyloidosis is secondarily occurred to be related with chronic infections or inflammatory diseases. We report a 67-year-old man suffered from secondary AA amyloidosis related with chronic Clostridium difficile colitis after repeated total hip replacement surgery. Infection control is the most important treatment of AA amyloidosis secondary to chronic infection. However, the patient’s C. difficile colitis was not controlled well, eventually toxic megacolon with sepsis was developed. Consequently, he had to take total colectomy, but he expired with multi-organ failures. We suggested that early surgical procedure might be one option for intractable C. difficile colitis complicated with secondary amyloidosis.