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담낭암종에서 Urokinase-Type Plasminogen Activator와 Plasminogen Activator Inhibitor-1의 발현
이기형,강행지,이승연,박문향 대한병리학회 2003 Journal of Pathology and Translational Medicine Vol.37 No.6
Background : There are evidences that uPA and its inhibitor play a key role in tumor spread. We studied whether uPA and PAI-1 expressions could serve as prognostic parameters along with clinical, gross and microscopic findings in gallbladder carcinomas. Methods : We analyzed 42 cases of gallbladder carcinomas by immunohistochemical staining and clinicopathologic parameters. Results : uPA and PAI-1 were more frequently expressed in the adenocarcinoma than in the normal or benign gallbladder tissue. The uPA expression in the glands of low grade adenocarcinoma was significantly correlated with both distant and lymph node metastases. The uPA expression in the stroma around the low grade adenocarcinoma was significantly correlated with either distant or lymph node metastasis. The PAI-1 expression was significantly correlated with lymph node metastasis only for both distant and lymph node metastases. In multivariate analysis, the lymphatic invasion was significantly related to poor survival (p=0.0115). In univariate analysis, the cases without lymphatic invasion had prolonged survival. Positive expression of uPA in the glands of low-grade adenocarcinoma was significantly correlated with poor survival (p=0.0391). Conclusion : In conjunction with clinicopathologic findings, expressions of uPA and PAI-1 may be useful prognostic markers in gallbladder carcinomas.
김민회,임덕호,김봉수,구진회,강행지,황용희,최건필 대한대장항문학회 2004 Annals of Coloproctolgy Vol.20 No.4
An appendicocolic fistula is a rare disease. It seems likely that the appendix becomes adherent to the viscus either before or after its perforation due to appendicitis, so surgeons may become confused when an emergency appendectomy in done. We report one case of an appendicocolic fistula to draw attention to the importance of this fistula and to describe the clinical, the diagnostic, and the therapeutic aspects of the disease.
급성 췌장염으로 발현한 부갑상선 선종과 동반된 부신 선종에 의한 무증상 쿠싱증후군 1예
이상훈,조동식,김시우,조유진,차성철,김정권,박순희,강행지 대한내분비학회 2007 Endocrinology and metabolism Vol.22 No.5
The manifestation of primary hyperparathyroidism by acute pancreatitis is a rare event. Furthermore, an asymptomatic adrenal mass may incidentally be detected by abdominal computed tomography. A mass that autonomously secretes glucocorticoid without any symptom is called subclinical Cushing’s syndrome. In this study, we report a rare case of a parathyroid adenoma manifested as acute pancreatitis accompanied with subclinical Cushing’s syndrome due to an incidental adrenal mass. A 47-year-old female patient presented with acute pancreatitis and hypercalcemia had a parathyroid mass detected by neck ultrasonography and a Tc99m-sestamibi scan. An abdominal computed tomography revealed a 3.1 × 4.3 cm mass which was detected in the left adrenal gland. The hormonal levels showed a high serum cortisol level, low ACTH level, and a high 24 h urine free cortisol level. The low and high dose dexamethasone suppression test showed no suppression. The parathyroid and adrenal masses were resected and the laboratory findings were normalized. (J Kor Endocrine Soc 22:353~358, 2007) 고칼슐혈증으로 인한 급성 췌장염은 매우 드문 경우이지만 우리나라에서도 보고된 바 있으나 부갑상선종과 무증상 부신 선종이 동반된 경우는 국내에는 없으며 세계적으로도 Makino 등[19], Sawano 등[20]이 보고한 사례만 있을 정도로 매우 드문 질환이다.
단백상실성 위장증으로 발현된 속발성 위장관 유전분증 1예
구자란,김억,허윤,서동원,박기호,김은주,황일순,강행지,홍성란,김영조 대한내과학회 1997 대한내과학회지 Vol.53 No.3S
저자들은 15년간 류마티스 관절명으로 치료받던 환자에서 단백상실성 위장증을 유발한 속발성 위장관 유전분증 1예를 경험하였기에 문헌고찰과 함께 보가하는 바이다. We report a case of protein-losing gastroenteropathy due to secondary gastrointestinal amyloidosis in a patient with rheumatoid arthritis(RA). A 66-year-old woman with RA for 15 years was admitted to our hospital with complaints of abdominal pain and diarrhea. She had taken bilateral total knee replacement 4 years ago and right shoulder synovectomy 1 year ago. She han been treated with nonsteroidal anti-inflammatory drugs, gold derivatives, or methotrexate. On laboratory examintion, serum total protein was 3.9g/dl and albumin was 1.6g/dl. Stool occult blood was detected but no evidence of infection was present. No urinary peotein including Bence-Jones protein, was detected. Serum and urinary protein electrophoresis were within normal limits. Alpha-l-antitrypsin clearance rate was increased upto 60ml/24hr. Small bowel series revealed thickened mucisal folds and multiple nodular filling defects on the entire small bowel. Histopathologically amyloid deposied, which were proved on immunofluorescence and immunohistochemistry, were present on the biopsied tissuse from gastric antrum, terminal ileum and rectum. Accordingly we established the diagnosis of proteinlosing gastroenteropathy due to secondary amyloidosis, which is the first case so far descripted in Korea to the best of our knowledge.