폴리메타크릴레이트를 이용한 케토로락 트로메타민 서방성 정제의 제조와 용출평가

전일순,윤재남,이은미,박용근,김동우,이계원,지웅길 충남대학교 약학대학 의약품개발연구소 2003 藥學論文集 Vol.18 No.-

To improve administration of ketolorac tromethamine, we prepared matrix tablets with Eudragit (RS 100 or 30D), diluents (avicel:lactose=l:l or Ca phosphate) and Mg stearate using wet-granulation method. Sustained release matrix tablets using Eudragit® RS 100 7 and 10% decreased dissolution rate at pH 1.2 and 68 Ca. phosphate as diluents showed more decreased dissolution rate than that of avicel:lactose (1:l). Sustained release matrix tablets using Eudragit® RS 30D also showed very effective sustained release of KT.

두경부 마사지가 중환자실 환자의 수면과 불안에 미치는 효과

김미용,전선영,송윤희,최은진,김재희,김미성,주명순,김남선 병원간호사회 2006 임상간호연구 Vol.11 No.2

Purpose: This study was to apply head and neck massage to patients in intensive care unit and to inventigate the effect of that massage on sleep and state anxiety. Method: The subjects in this study were 27 patients who were admitted in medical intensive care unit. The study was performed from June thru September of 2005 on the One-group pretest-posttest design and the sleep, state anxiety of the subjects were measured before and after head and neck massage. For data analysis, paired t-test and Pearson correlation coefficient were utilized. Result: The first hypothesis that the subjects might have a better sleep after being exposed to head and neck massage was accepted. The second hypothesis that the subjects might feel less state anxiety afrer being exposed to head and neck massage was accepted. The third hypothesis that the sleep of the ICU patients maight be correlated to their anxiety was accepted, as there appeared correlation between their sleep and anxiety. Conclusion: Head and neck massage is identified as one of independent nursing interwentions to improve the sleep of ICU patients and ease their anxiety, and it is necessary to apply it to clinical practices.

피부 적용 겔제제의 첨가제에 의한 수분 보유력 평가

이은미,박종희,경기열,전일순,조혜정,지웅길 충남대학교 약학대학 의약품개발연구소 2004 藥學論文集 Vol.19 No.-

The aim of this study was to improve the moisturizing and water retaining effects of a gel containing poloxamer 407, glycerin, sod hyaluronate, sorbo(sorbitol 70%). Topical preparations were formulated as a gel containing different concentration poloxamer 407, glycerin, sod. hyaluronate, sorbo(sorbito1 70%), lipid(ceramide. sphingosine ratio 1:l). We tested a various combination of different additives for the moisturizing effect The water holding capacity of the mixture was measured using a moisture analyzer. In vivo test was carried out on human skin using Skicon-200 and water retaining effect was increased by addition of lipid. Water evaporation test was performed by various concentration of additives and water evaporation characteristics of the preparations were determined using the moisture analyzer. Moisturizing and water retaining effects was increased by adequate combination of various additives with topical gel formulations.

헤파셀정의 cross-over test에 의한 국내시판 제제와의 생물학적 동등성 시험

박은전,이성희,이미현,김혜주,손동환,고건일,김재백 圓光大學校 藥品硏究所 1995 藥品硏究所報 Vol.10 No.1

무용학습자의 심상훈련이 불안에 미치는 영향

이지은,서영,전미령,심영 圓光大學校 附設 體力科學硏究所 2003 體力科學硏究 Vol.26 No.2

The purpose of the study was to investigate the effect of image ability and factor of anxiety upon the dancing performance. Investigated Surveyed were 60 girls enrolled in the 2nd grade of Y Middle School located in K City taken as population. They were divided into the physical training group, physical video image training group and control group with 20 assigned to each group at random. The sence of anxiety between these treatment groups before and after the dancing repeat motion was compared and analyzed, Which leads to the following conclusion: First, an negatively proportional correlation of r=.34, p<.05 was found between sport image ability and factor of anxiety, a statistically significant relation to justify. Second, regarding the effect of test treatment on the factors governing the factor of anxiety, the physical training group falls from 46.05 before the treatment to 45.75±2.49 after the treatment, a slight decrease with little statistical significance. On the other hand, the physical video image training group showed a drastic fall from 46.25±2.51 before the treatment to 40.20±2.53 after the treatment, with t=7.89, p<.001 being statistically significant.

금연구연 지정에 대한 공공기관 근무자의 태도

최연희,전은영,김현미 慶山大學校 保健福祉硏究所 2003 保健福祉硏究 Vol.8 No.-

The purpose of this study is to investigate the attitude of public works on the nonsmoking areas. The subjects were a volunteer sample of 436 public workers in Daegu city. Data was collected through interviews and questionaires from March 10 to May 9, 2001, and analyzed by frequency, percentage, chi-square test and multiple logistic regression, using a SPSS program. The results of this study were as follows: Smokers of the subject group accounted for 47.9%, and smokers who smoke one pack of cigarettes per day and a cigarette to its two-thirds length was the most. 42.6% of smokers have positive attitude to quit smoking, but 36.6% has no intention to quit. Among the subjects who answer 'yes' to designate the nonsmoking area were 63.3%. In the designated places of nonsmoking area within public workplace, 'elevator' showed the highest(95.0%), 'cafeteria'(73.0%), 'physical-training room'(71.6%), and 'passage'(66.4%). For designation of nonsmoking areas, nonsmokers were more positive than smokers and the difference was statistically significant. To designated the factors influencing attitude of public workers on nonsmoking areas, logistic regression analysis has been done. According to the results of this analysis, the volume of smoking and a job barrier being due to cigarette smoking were selected as significant factors. In conclusion, more smoking and health education for public workers is needed to reduce the rate of national smoking and allow people to have a good smoking attitude. It is required to arrange an institutional system who can strictly public workers' smoking in their offices.

IMT-2000서비스가 國內 經濟에 미치는 影響

李明豪, 金銀美, 全孝悧 서울대학교 경제연구소 2000 經濟論集 Vol.39 No.1

정보통신산업은 우리나라 총수출의 27.6%, 전체 무역흑자의 60.0%를 차지(1999년)하고 있는 등 국민경제에서 큰 비중을 차지하고 있다. 특히 차세대이동통신으로 알려진 IMT-2000서비스는 관련사업자의 직접적인 이해관계 및 경제적 파급효과 측면에서 세간의 큰 주목을 받고 있다. 본 논문에서는 이러한 IMT-2000서비스 도입의 파급효과를 통신서비스산업에 미치는 영향, 관련산업에 미치는 영향, 국민경제에 미치는 영향, 국민생활에 미치는 영향 등으로 나누어 살펴보고 있다. IMT-2000서비스 도입에 따른 긍정적 효과를 극대화하기 위해서는 첫째, 해외의 사업자 허가 추세에 비추어 볼 때 IMT-2000사업자를 조속히 선정하여 경쟁력을 확보하는 것이 중요하며, 둘째, 특히 멀티미디어 컨텐츠 관련산업의 보다 적극적인 지원 육성이 필요하고, 셋째, 기술표준의 결정이 국내 기술력과 시장성에 대한 정확한 분석과 예측을 바탕으로 이루어지는 한편 이에 대한 연구개발의 지원 및 단말기나 시스템부품의 기술력을 보유한 벤처기업 육성 등의 대책이 필요하다.

고콜레스테롤 혈증 환자에서 Cerivastatin(LIPOBAY, 의과학연구소)의 임상효과 및 안전성에 관한 연구

박성훈,김미연,정수진,이영숙,박창한,변은경,전성희 梨花女子大學校 醫科大學 醫科學硏究所 2001 EMJ (Ewha medical journal) Vol.24 No.3

목적 : Cerivastatin(LIPOBAY)은 최근에 개발되어 사용되기 시작한 HMG-CoA 환원효소 억제제로서 저용량으로 탁월한 콜레스테롤 강하효과를 보이는 약물이다. 저자들은 Cerivatatin(LIPOBAY)의 혈중 콜레스테롤 강하효과를 평가하고 약물의 안전성을 평가하기 위하여 본 연구를 시행하였다. 방법 : 고콜레스테롤혈증 환자 37명(남자 13명, 여자 24명)을 대상으로 하였다. 대상환자는 2주간의 저콜레스테롤 식이 후에도 혈청 콜레스테롤이 240㎎/㎗이상이거나, 관상동맥질환이 있는 환자는 혈청콜레스테롤이 220㎎/㎗이상인 경우 cerivastatin 0.4㎎을 8주간 복용하도록 하였다. 임상적 관찰과 검사실 검사(간기능검사, 일반혈액검사, 혈청지질검사)는 투약개시 후 4주 및 8주 후에 시행하였다. 결과 : Cerivastatin 0.4㎎을 4주간 투여한 후 측정한 LDL 콜레스테롤, 총콜레스테롤, triglyceride, 및 HDL 콜레스테롤은 각각 38%, 28.8%, 11.6% 및 7.8% 감소하였다. 총콜레스테롤/HDL 콜레스테롤 비 및 LDL/HDL비는 각각 20.8% 및 31.1% 감소하였다. 투약 8주후에 측정한 검사소견은 4주후에 비해 유의한 변화를 보이지 않았다. 한명의 환자(2.7%)에서 간기능 검사상 AST, 및 ALT의 지속적인 상승으로 투약을 중지하였다. 결론 : Cerivastatin 0.4㎎/day는 혈청콜레스테롤을 효과적으로 감소시켰으며 심각한 부작용은 볼 수 없었다. 따라서 적극적으로 LDL콜레스테롤을 낮출 필요가 있는 고콜레스테롤혈증 환자에서 cerivastatin은 효과적이고 안전한 약물이라고 생각된다. Objectives : Cerivastain(LIPOBAY) is recently developed HMG-CoA reductase inhibitor which is effective in lowering serum cholesterol levels at microgram does. We evaluated the clinical efficacy and safety of cerivastatin(LIPOBAY) in patients with hypercholesterolemia. Method : Thirty-seven patients(male : 13, female : 24) with hypercholesteolemia defined as baseline serum total cholesterol ≥240㎎/㎗, or ≥220㎎/㎗ in patients with known coronary artery disease were included for this study. After 2 weeks of low cholesterol diet, if the serum total choesterol level meet the criteria, cerivastain 0.4㎎/day was prescribed for 8 weeks. Clinical follow-up and laboratory tests were performed 4 weeks and 8 weeks after medication. Results : After 4 weeks of cerivastain 0.4㎎/day treatment, low density lipoprotein(LDL) cholesterol decreased 38% and total cholesterol decreased 28.8% from baseline. Triglyceride decreased 11.6%, and high density lipoprotein(HDL) cholesterol decreased 7.8% from baseline. Total cholesterol/HDL ratio decreased 20.8% and LDL/HDL ratio decreased 31.1% from baseline. After 8 weeks of treatment, no further significant changes were noted compared with the values at 4 weeks. Cervastatin was discontinued in one patient(2.7%) due to continuous liver enzyme elevation. Conclusion : Cerivastatin 0.4㎎/day is effective in lowering serum cholesterol levels without significant adverse reactions. Cerivastatin is effective and safe for patients with hypercholesterolemia who needs aggressive LDL cholesterol lowering.

분무건조법을 이용한 방출 제어형 케토로락 고형지질마이크로스피어의 제제설계

윤재남,이은미,김동우,박용근,전일순,이계원,지웅길 충남대학교 약학대학 의약품개발연구소 2003 藥學論文集 Vol.18 No.-

Ketorolac (KA) and ketorolac tromethamine (KT) is the nonsteroidal anti-inflammatory drugs (NSAIDs) and has been used widely. To improve its frequent administration by control of drug release. we prepared SLM of KA and KT using Mirj 45 and 52 as surfactants and tripalmitin and tristearin as lipids by spry drying method SLM, as a disperse system for injection, were evaluated by measurement of particle sizes. SEM and drug release pattern As a result. spherical SLM were prepared and their particle size were in the range of 25-125 μm, which were dependant on the types and contents of lipid and sururfactants. Their dissolution rate were decreased as increasing lipid contents.

생선묵에 첨가된 전분 함량

김난주,송미선,이기주,전미영,조성희,허은영 효성여자대학교 가정대학 학도호국단 1985 家政大論集 Vol.4 No.-

시판 생선묵 26종을 무작위로 수집해서 전분 함량을 조사한 결과는 아래와 같다. 1. 전분 함량이 5∼10%되는 것이 19.2%, 10∼20%되는 것은 69.2%로서 가장 많았고, 20∼30%나 되는 많은 양의 전분을 첨가한 제품도 11.5%나 되었다. 2. 비교적 값비싼 제품이 전분을 더 많이 첨가하고 있었다. The purpose of this experiment was to investigate the content of starch in the 26kinds of fishcake which were randomly sampled The results of it were as follows ; 1. The highest percentage of those fishcake, the starch containing rate 10~20%, was 69.2% among all of them. The next, the starch containing rate 5~10%, was 19.2% And the last, the starch containing rate 20~30%. was 11.5%. 2. The expensive fishcake, the higher containing rate of starch.