히드로클로로치아지드와 감초의 병용에 의한 랫트의 혈청중 칼륨농도 변화

고건일 한국약제학회 1988 Journal of Pharmaceutical Investigation Vol.18 No.1

Effect of hydrochlorothiazide on serum potassium level was studied in the hypokalemia-induced rats by the oral administration of glycyrrhiza extract (GE) for 4 weeks. According to the concentration of GE, serum potassium levels were found to be 5.8±0.2, 5.4±0.2 and 5.5±0.2 mM/l after oral administration of 0.1, 0.2 and 0.5% GE solutions for 4 weeks, respectively, comparing 6.4±0.2 mM/l in normal rats. The i.p. administration of hydrochlorothiazide (100㎎/㎏) showed no significant difference (5.1±0.3-5.2±0.3 mM/l) in the decrease of serum potassium levels between these hypokalemia-induced rats and normal rats, regardless of the concentration of pretreated GE solutions. Therefore it was considered that the administration of hydrochlorothiazide did not worsen the hypokalemia induced by the long term administration of GE in rats.

약국의 기능강화와 약사의 역할

고건일 약사공론 1994 대한약사회지 Vol.1994 No.4

人蔘 butanol 分劃이 中樞作用 藥物에 의한 mouse의 自發 運動의 變化에 미치는 영향에 대한 硏究

高健一 圓光大學校大學院 1980 學位論叢 Vol.4 No.-

Panax Ginseng C. A. Meyer which has been known for more than 2000 years, occupies a particular place in folk medicine as so called Tonic remedy. The brief pharmacological action of Ginseng complied from the numerous reports can be summarized as adaptogenic effect to be increased nonspecific resistance. Among the various components of Ginseng, the effective components has been known Ginseng butanol fraction as so called Gineseng saponin. In order to study on the effects of the Ginseng butanol fraction which influences spontaneous activity by CNS drugs in mice. experiment of response was measured the change of spontaneous activity by CNS drugs in which mice were treated Ginseng butanol fraction. A methods of measuring spontaneous activity in mice used by counting the number of times which were interrupted a beam of light. Results of experiment can be summarized as follows; 1. In case of administrating Ginseng butanol fraction for 1 day, stimulating effect of Ginseng was observed in spontaneous activity by Caffeine in comparison with the control at the first, but after 45 minutes no significant change was observed. 2. In case of administrating Ginseng butanol fraction for 5 days, decreasing tendency was observed in spontaneous activity by Caffeine. 3. In case of administrating Ginseng butanol fraction for 10 days, marked decrease was observed in spontaneous activity by Caffeine in comparisone with the control. From the experiment on the increased dose of Caffeine, no significant change was observed in comparison with Caffeine and sodium benzoate 25mg/kg group. 4. A state of increased resistance was lasted until 5 day, and after 10 days it was disappeared. 5. Otherwise, no significant change was observed for Chlorpromazin·Hcl in comparison with the control. 6. From this result, 10 days administrating of Ginseng butanol fraction appeared to have increased resistance in mice against Caffeine.

수종생약이 Rabbit 의 혈청 Total Cholesterol 치에 미치는 영향

고건일 한국약제학회 1983 Journal of Pharmaceutical Investigation Vol.13 No.4

Banggi, Banggi Whanggi Tang and Gami Jodeung San have been used to prevent and treat arteriosclerosis in oriental medicine. In order to investigate preventive and therapeutic effects of its crude drugs, this research was studied in cholesterol induced hypercholesterolemia rabbits. The results were as follows. 1) By concurrent administration of Banggi or Banggi Whanggi Tang with cholesterol, serum total cholesterol contents were increased more slowly than control group. But in the case of Gami Jodeung San, serum total cholesterol contents were increased as well as control group. 2) By administration of Banggi Whanggi Tang or Gami Jodeung San on induced hydercholesterol rabbits, serum total cholesterol contents were decreased faster than control group. According to this result, it is suggested that Banggi and Banggi Whanggi Tang have preventive and therapeutic effects on hypercholesterolemia rabbits and that Gami Jodeun San has not preventive effect but therapeutic effect.

Rat에서 고지방식이가 Ethanol 유발성 간경화에 미치는 영향

고건일 圓光大學校 藥品硏究所 1994 藥品硏究所報 Vol.9 No.1

We have studied the effects of a high fat diet in the ethanol induced liver cirrhosis. The results are as follows ; 1) proper ethanol administered method is the use of a sonde for rat p.o. 2) Coadministration of high fat diet elevated the ethanol induced liver damage. The ethanol inducible P450 2E1 (P450 2E1) activity was significantly increased in rats fed high fat diet and ethanol These results suggest that P450 2E1 induction in rats fed high fat diet and ethanol can be due to increased liver damage.

녹용수침액이 Mouse 의 Stress 방어작용에 미치는 영향

고건일 한국약제학회 1981 Journal of Pharmaceutical Investigation Vol.11 No.2

Antler, deer horn, occupies a particular place in oriental folk medicine as so called tonic remedy. In order to study on the effects of Antler water extract on stress resistance in mice, quantitative response was measured for the change of spontaneous activity by chemical stress drugs in the control group or the Antler water extract pretreated group. Spontaneous activity in mice was measured by counting the number of interruptions of light. The results of experiment were summerized as follows; I) In case of administrating Antler water extract 10㎎/㎏, 20㎎/㎏, 50㎎/㎏, and 100㎎/㎏, no significant change was observed in spontaneous activity in comparison with the control group. II) In case of administrating Antler water extract for 5 days or 10 days, no significant change was observed in spontaneous activity by chemical stress drugs, caffein and chloropromazine, in comparison with the control group.

비스트카인의 위염 및 위궤양에 대한 약리작용 연구

고건일 圓光大學校 藥品硏究所 1986 藥品硏究所報 Vol.1 No.1

Effects of Bistcain are investigated in acute gastritis and gastric ulcer of mouse, rat and rabbit. In this result, Bistcain showed the decrease of mucouse inflammation and fatality in mice, rats and rabbits.

Multivariate Analysis of Covariance on Characteristics Influencing Technological and Managerial Barriers of Technology Startups

고건일,조남재 한국데이터전략학회 2024 Journal of information technology applications & m Vol.31 No.1

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소셜 데이터 퓨전 메커니즘을 이용한 유사 질병 구분 시스템

고건호(Ko Keun Ho),최환석(Choi Hoan Suk),이우섭(Rhee Woo Seop) 한국통신학회 2017 한국통신학회 학술대회논문집 Vol.2017 No.6

천도교 대교당 건축의 상징성: 자유로운 종교의 중심 만들기

고건호 종교문화비평학회 2020 종교문화비평 Vol.38 No.38

This study explores the symbolic significance of the Chondogyo Central Temple. Chondogyo constructed its Central Temple in the heart of Seoul to create a new “center” for Chondogyo as well as a “symbol of free religion.” Through an advertisement on Chondogyo released in December 1905, Chondogyo proclaimed that it was a free religion and that it will be constructing a new temple. Chondogyo decided to announce its plans to build a new temple in its declaration of the establishment because its leaders considered the temple to be the symbol of “free religion.” After the construction of the Central Temple and the Central Temple Headquarters, the Daesinsa Centennial Hall was also built at the same spot, thus creating a Chondogyo town that expanded and reinforced the symbol of the free Chondogyo. With traumas of the Donghak years fresh in their mind, the Chondogyo leaders chose to proclaim and persuade themselves that Chondogyo was a free religion, rather than obtaining religious freedom from the government. The establishment of a temple was a part of this strategy. While the Chondogyo advertisement, which marked the beginning of the Central Temple's construction, and the articles from the newspapers associated with the enlightenment movement, all displayed the modern discourse on religion, they differed in their emphasis. The Chondogyo article emphasized religious freedom, whereas the press emphasized the boundaries and scope of religion, that is, the limits to religion. As such, the positions of Chondogyo, which intended to expand the scope of religion, and the press, which tried to limit Chondogyo’s scope as a religion, were not easily compromised. Moreover, after Chondogyo was classified as a “quasi-religion” by the Japanese empire’s sanctioning of religions, its symbol as a “free religion” remained a problematic issue. 이 논문은 천도교 대교당 건축의 상징적 의미를 탐구하고 있다. 천도교가 서울 도성 한가운데에 대교당을 건축한 것은 천도교의 새로운 ‘중심’ 만들기이자 ‘자유로운 종교의 상징’ 만들기였다. 이 논문은 천도교 대교당 건축의 시작점인 1905년 12월의 광고 기사를 당시 잡지, 신문 기사와 비교 검토하였다. 2장과 3장에서는 천도교 대교당과 천도교타운의 형성 과정을, 4장에서는 천도교 탄생과 교당 건축의 상관성을, 5장에서는 천도교 대교당 건축의 상징적 의미를 살펴보았다. 종교의 자유가 보장되지 않았던 근대 당대 한국 사회에서 교당은 자신의 종교적 정체성의 상징일 뿐만 아니라 종교의 자유를 선취하기 위한 효과적이면서 현실적인 방편이기도 했다. 천도교 변증론의 정수라 할 수 있는 1905년 12월의 천도교 광고 기사는 천도교는 자유로운 종교라는 선언과 함께 교당 건축의 의지를 천명했다. 천도교가 출범 선언문에서 교당을 건축하겠다는 의지를 밝힌 것은 교당 건물을 ‘자유로운 종교’의 상징으로 여겼기 때문이었다. 그리고 대교당과 중앙총부를 완성한 후 같은 자리에 대신사출세백년기념관까지 아우르는 천도교 타운을 조성하면서 자유로운 천도교의 상징은 보다 확장, 강화되었다. 동학 시절의 트라우마를 기억하는 천도교는 종교의 자유를 정부로부터승인받는 대신 천도교가 자유로운 종교라는 것을 스스로 주장하고 설득하는 방식을 택했다. 교당 건축은 이러한 전략의 일환이었다. 대교당 건축의 시작점이었던 천도교 광고와 당시 계몽언론의 기사는 근대의 종교담론을 공유하고 있었지만 강조점에 차이가 있었다. 천도교 광고는 종교의 자유를 강조했고 계몽언론은 종교에 허용된 영역과 범위, 곧 종교의 한계를 강조했다. 이처럼 종교의 범위를 확장하고자 했던 천도교와, 종교의 영역에 한정하고자 했던 언론의 입장은 쉽게 타협되지 않았다. 더욱이 일제의 공인교정책에 따라 ‘유사종교’로 분류되면서 ‘자유로운 종교’의 상징은 여전히 문제적 영역으로 남아있게 되었다