안전상비의약품 판매 이후 중독환자 특성 변화

김창영,이의중,이성우,김수진,한갑수,Kim, Chang Yeong,Lee, Eui Jung,Lee, Sung Woo,Kim, Su Jin,Han, Kap Su 대한임상독성학회 2018 대한임상독성학회지 Vol.16 No.1

Purpose: On November 15, 2012, sales of OTC (Over-The-Counter) drugs began at convenience stores, which changed the accessibility of some drugs. As a result, the exposure and access patterns of these drugs could have changed. In this study, we reviewed the changes in the characteristics of drug poisoning patients because of the reposition of nonprescription drugs according to the revised Pharmaceutical Affairs Act. Methods: A retrospective study was conducted to evaluate changes in characteristics of drug poisoning patients between 2008 and 2016. A registry was developed by an emergency medical center in a local tertiary teaching hospital, and patients who visited the center were enrolled in this registry. We compared two periods, from 2008 to 2012 (Pre OTC) and from 2013 to 2016 (Post OTC), for type of intoxicant, time from poisoning to visiting the emergency center, intention, psychiatric history, previous suicidal attempt, alcohol status, and emergency room outcomes. The primary outcome was the number of patients who took acetaminophen and NSAIDs (nonsteroidal anti-inflammatory drugs). Secondary outcomes were ICU admission rate, mortality rate, and number of patients who visited the ER when the pharmacy was closed after taking acetaminophen and NSAIDs (nonsteroidal anti-inflammatory drugs). Results: Among 1,564 patients, 945 and 619 patients visited the emergency room during pre and post OTC periods. The number of patients with acetaminophen and NSAIDs poisoning decreased from 9.2% to 6.1% (p=0.016). The ICU admission rate and mortality rate in the emergency room did not show significant results in the relevant patient groups, and so was the number of patients visiting ER when the pharmacy was closed taking acetaminophen and NSAIDs. Conclusion: Despite the sales of nonprescription drugs at convenience stores, the number of acetaminophen and NSAIDs poisoning patients decreased.

Newly emerging geminiviruses in Korea

Eui-Joon Kil,Chairina Fadhila,Vo Thi Bich Thuy,Aamir Lal,Samira Zarghami D.,Hee-Seong Byun,Chung-Kyoon Auh,Ji-Kwang Kim,Joong-Hwan Lee,Gwan-Seok Lee,Chang-Seok Kim,Hong-Soo Choi,Kyeong-Yeoll Lee,Sukch 한국응용곤충학회 2018 한국응용곤충학회 학술대회논문집 Vol.2018 No.10

Geminiviruses are plant-infecting viruses with monopartite or bipartite single-stranded circular DNA genomes. They are known to be mediated by insects such as whiteflies, treehoppers, leafhoppers or aphids and can cause devastating plant diseases in a wide range of economically significant crops worldwide. In Korea, occurrence of geminiviruses were reported officially after the 2000s. Although Honeysuckle yellow vein virus (HYVV) and Sweet potato leaf curl virus (SPLCV) were identified from honeysuckle and sweet potato in 2004 and 2006 respectively, these viruses did not spread and cause much concern for geminiviruses. In 2008, Tomato yellow leaf curl virus (TYLCV) that has caused severe tomato production loss in many subtropical and tropical countries was first reported in tomato plants cultivated in Tongyeong. TYLCV rapidly spread through the country and has been continuously reported from tomato cultivating areas in Korea. In addition to TYLCV, Tobacco leaf curl virus and Sweet potato golden vein associated virus have occurred. In recent years, new geminiviruses including Papaya leaf curl Guangdong virus (PaLCGdV) and Euphorbia leaf curl virus (EuLCV) have been introduced. Newly emerging geminiviruses from tropical and subtropical countries are due to increased demand for various fruits and vegetables, and climate change. In addition, there are reports that some geminiviruses including TYLCV can be transmitted by infected seeds. Therefore it is important to study on epidemiology of virus introduction and spread among the countries and within country.

텅스텐 실리사이드막의 물리적 전기적 특성

김태형,김창일,장의구 중앙대학교 생산공학연구소 1992 생산공학연구소 논문집 Vol.1 No.1

W-polycide(??/n+poly-Si)구조로 poly-Si막과 ?? 막 두께를 변화시켜 LPCVD를 이용하여 증착하고 온도를 달리하여 열처리하였으며 이러한 텅스텐 폴리사이드특성에 poly-Si막과 ??막 두께, 열처리 온도가 미치는 영향을 조사하였다. ??막 두께가 증가함에 따라 면저항은 감소하고 스트레스는 증가하였으며 reflectance는 거의 일정하였다. poly-Si막 두께증가에 따라 스트레스는 다소 증가하였으나 면저항과 reflectance는 일정하였고 열처리 온도 증가에 따라서는 면저항과 reflectance는 감소하였고 스트레스는 증가하였다. 또한 조성(Si/W)비의 변화를 관찰하였다. Poly-Si and ?? films in polycide(??/n+poly-Si) structure were deposited by LPCVD to changed thickness, and then were annealed at various temperatures. The effect of poly-Si and ?? film thickness and annealing temperature on the W-polycide properties was investigated. With increasing ?? film thickness, it has been observed that sheet resistance decreases, stress increases, and reflectance in constant. It has also been observed that as poly-Si film thickness increases, stress increases a little bit, while sheet resistance and reflectance are constant. As the annealing temperature gets higher, the decrease in sheet resistance and reflectance, and the increase in stress have been observed. Also, the variation of composition(Si/W) ratio is examined.

Clinicopathological study on metastatic skin cancer

( Chang Il Kwon ),( Seo Mi Gon Jeong ),( Young Bin Shin ),( Yun Sun Moon ),( Eui Chang Jung ),( Chi Yeon Kim ),( Tae Jin Yoon ) 대한피부과학회 2020 대한피부과학회 학술발표대회집 Vol.72 No.1

Background: Various primary tumors can cause metastatic skin cancer. Metastatic skin lesion should be distinguished from other skin lesion. Objectives: We studied patients with metastatic skin cancer to find out average age, gender distribution, frequency of primary tumor, time interval between manifestation and primary cancer, and their clinical appearance, location and other metastatic sites. Methods: We reviewed the medical records, clinical photographs and histopathologic records of patients who had been diagnosed with metastatic skin cancer. Results: In the comparison according to clinical records, the mean age at the time of diagnosis was 60.6 years. The ratio of men to women was 1.05:1. The most frequent primary tumors were breast cancer (22.0%), lung cancer (17.0%), head and neck cancer (17%), melanoma (17.0%), gastrointestinal cancer (11%), urologic cancer (11%), and gynecologic cancer (6%). Metastatic skin cancers usually presented as discrete, painless, hard nodules, with sudden onset (88%). Conclusion: Based on the results of this study, it is believed that it is important to recognize the metastatic lesion between various skin lesion such as infections and granulomatous changes of other cause due to drugs and reactive changes.

리네졸리드와 반코마이신을 교대로 투여하여 치료한 지속성 메티실린 내성 황색포도알균 균혈증 1예

김낙현,김문석,장은선,강유민,김가연,장희창,박완범,김의종,김남중,오명돈 대한감염학회 2009 감염과 화학요법 Vol.41 No.6

Persistent Staphylococcus aureus bacteremia is frequently defined as bacteremia persisting for ≥7 days despite proper antibiotic therapy. Its treatment includes removal of all infection foci and proper antibiotic therapy. Vancomycin remains the antibiotic of choice in MRSA bacteremia. Alternative agents, linezolid or daptomycin, are available, but a consensus regarding management of persistent MRSA bacteremia on vancomycin failure is still lacking. We report a case of a 60-year-old male who received thoracoabdominal aorta replacement operation due to dissecting aneurysm of the ascending and descending aorta. Surgical site infection and bacteremia caused by MRSA occured, and wound debridement operations were performed. The patient was treated with vancomycin in therapeutic doses but MRSA bacteremia persisted for 168 days in a row. Although the inserted aortic graft was the most probable source of persistent bacteremia, surgical removal was impossible. Linezolid was administered as an alternative antibiotic but had to be discontinued from time to time due to thrombocytopenia induced by this agent. In the end, MRSA bacteremia was successfully managed by alternating vancomycin-linezolid therapy.

建設工事 入札制度의 實態와 改善方向에 關한 硏究

김의식,김창범 朝鮮大學校 建設技術硏究所 1999 建設技術硏究 Vol.19 No.3

The bid and contract system of public sector with such a great scale prepared the various bid systems to prevent the waste of budget according to the highest bid price, but it has not achieved the actual effects in the rapidly changing domestic and overseas environment according to the globalization and openness. Therefore, this study examines the major bid and contract systems of domestic construction works and their changes, compares and analyzes the them to foreign conditions and aims at minimizing the operational problems in the current bid and contract system and presenting the improvement methods for the settlement of fair order. This research is not focused on settling the current problems, but seeks the developmental directions for the standardization of bid and contract system. The suggestions of this research are made as follows; First, the specialization of ordering agency is improved through the cultivation of private professionals and the operation of professional education system and the extended right of discretion is given to the ordering agency with the introduction of dispersed ordering system and the legalization of the various ordering methods. Second, the survey price of actual transaction is reflected as the estimated price through the improvement of government cost calculation system to achieve the rationalization of the estimated price calculation. Third, the incentive system, a kind of value engineering of a new technology, should be legalized for the improvement of competitiveness through the encouragement of the will to develop a new technology and construction and technical ability, escaping from the price centered current system. Fourth, the number of selecting the proper companies is reduced to under 10 companies as the PQ system related improvement method, the computerized system of ordering agencies is prepared, the regular qualification screening is conducted, the work efficiency by the screening system of each case is maximized and the simplification of administrative procedures is pursued.

서울의 Penicillinase Producing Neisseria gonorrhoeae 발생빈도(1998)

김재홍,김준호,반재용,이정우,황성주,정준규,정성태,강진문,조흔정,홍창의,정혜신,이한승,김이선,이봉길,이종호,선영우,한기덕,윤성필,이성훈,안종성,박석범,문승현,조항래,김형섭,류지호,황재영,박준홍,손상욱 한양대학교 의과대학 2001 한양의대 학술지 Vol.21 No.1

In recent years, gonorrhea has been pandemic and remains one of the most common STDs in the world, especially in developing countries. For the detection of a more effective therapeutic regimen and assessing the prevalence of Penicillinase Producing Neisseria gonorrhoeae(PPNG), we have been trying to study the patients who have visited the Venereal Disease Clinic of Choong-Ku Public Health Center in Seoul since 1980 by menas of the chromogenic cephalosporin method. In 1998, 93 strians of N. genorrhoeae were isolated, among which 60(64.5%) were PPNG. The prevalence of PPNG in Seoul, which had been decreased to 39% in 1996 after a peak of 74.3% in 1993, is increased to 64.5% in 1998.

방사선조사가 Porphyromonas gingivalis에 미치는 영향

이창환,김규태,최용석,황의환 대한구강악안면방사선학회 2008 Imaging Science in Dentistry Vol.38 No.1

Purpose : The aim of this study was to observe a direct effect of irradiation on the periodontopathic Porphyromonas gingivalis (P. gingivalis). Materials and Methods : P. gingivalis 2561 was exposed to irradiation with a single absorbed dose of 10, 20, 30, and 40 Gy. Changes in viability and antibiotic sensitivity, morphology, transcription, and protein profile of the bacterium after irradiation were examined by pour plating method, disc diffusion method, transmission electron microscopy, RT-PCR, and immunoblot, respectively. Results : Viability of irradiated P. gingivalis drastically reduced as irradiation dose was increased. Irradiated P. gingivalis was found to have become more sensitive to antibiotics as radiation dose was increased. With observation under the transmission electron microscope, the number of morphologically abnormal cells was increased with increasing of irradiation dose. In RT-PCR, decrease in the expression of fimA and sod was observed in irradiated P. gingivalis. In immunoblot, change of profile in irradiated P. gingivalis was found in a number of proteins including 43-kDa fimbrillin. Conclusion : These results suggest that irradiation may affect the cell integrity of P. gingivalis, which is manifested by the change in cell morphology and antibiotic sensitivity, affecting viability of the bacterium.

A survey of counseling and behavior regarding skin cancer

( Young Bin Shin ),( Chang Il Kwon ),( Jeong Won Jo ),( Yun Sun Moon ),( Eui Chang Jung ),( Chi Yeon Kim ),( Tae Jin Yoon ) 대한피부과학회 2019 대한피부과학회 학술발표대회집 Vol.71 No.2

Background: As the incidence of skin cancer increases, more information and education on skin cancer are needed. Although skin cancer is not rare, most patients are little known about general awareness of skin cancer. Objectives: The purpose of this study is to investigate the post-education effects on skin cancer in our hospital outpaitents and carers. Methods: We reviewed a written questionnaire and patients’ self-checked records including patients’ basic medical information and knowledge of skin cancer protective modalities. Results: In total 340 cases, 215 (63.2%) patients were female and 125 (36.8%) patients were male. 6 people in their teens, 56 people in their 20s and 30s, 156 people in their 40s and 50s, 122 people in their 60s or older. Before education, 142 people said sunlight can cause a skin cancer and 178 did not. After education, 246 people said Yes and 94 people did not. When asked how you wanted to get more information on skin cancer, 104 (30.6%) people said that they were printed handout, 142 (41.8%) were visit to dermatologists, 52 (15.3%) were photos of skin symptoms, and 42 (12.3%) were phone calls. Conclusion: This result showed that people are little known about risk factor of skin cancer such as sunlight and artificial tanning. However, we found that through education, people's perceptions could change. The education on behavior for skin cancer prevention should be continued so that the awareness of the risk of skin cancer can be changed.

온라인 협동학습을 통한 프로그래밍 교육이 학업성취도와 창의적 사고 역량에 미치는 영향

김다은(Da-Eun, Kim),정종인(Chong-In, Jeong),김창석(Chang-Seok, Kim),강신천(Shin-Chun, Kang),김의정(Eui-Jeong, Kim) 한국정보통신학회 2020 한국정보통신학회 종합학술대회 논문집 Vol.24 No.2

4차 산업혁명, 2015 개정 교육과정 도입으로 인하여 학교 현장에서 학생들에게 바라는 인간상과 지녀야 할 핵심역량이 변화되고 있다. 특히 몇 년 전부터 4차 산업혁명을 대비하기 위해 소프트웨어 교육이 쟁점이 되어 대두되고 있고 학교 교육으로 학생들이 신장하여야 할 창의적 사고 역량과 공동체 역량 등 핵심 역량이 강조되고 있다. 소프트웨어 교육에서 중점으로 보고 있는 문제해결을 위한 프로그래밍 교육을 통해 핵심역량을 증진하고 학생들의 학업 성취도를 높이기 위해서는 기존에 진행하고 있는 전통적인 수업 방식으로는 어려움이 있다. 그러므로 4차 산업혁명 속에서 자라고 있으며, 디지털 네이티브라고도 불리는 학생들에게 적합한 새로운 학습 방법이 필요하게 되었고 그 방법을 온라인 협동학습으로 정해서 프로그래밍 교육을 진행하고자 한다. 이 연구를 통하여 실험집단 학생들은 온라인 협동학습을 통한 프로그래밍 교육을 진행하고 비교집단 학생들은 전통적인 수업을 통해 프로그래밍 교육을 진행하여 온라인 협동학습을 통한 프로그래밍 교육이 창의적 사고 역량과 학업 성취도에 긍정적인 영향을 주는지 확인하고자 한다. With the introduction of the 4th Industrial Revolution and the 2015 revised curriculum, the human image and core competencies that schools want from students are changing. In particular, software education has been an issue since a few years ago to prepare for the 4th Industrial Revolution, and core competencies such as creative thinking and community skills that students need to grow through school education are being emphasized. Traditional teaching methods has difficulties in enhancing the core competencies and improving students’ academic achievement, which is a main focus in software education. As a result, we need new learning methods for the new generation of students called “Digital natives” growing up on the 4th Industrial Revolution and now, we are trying to proceed with programming education through the new methods “Online cooperative learning.” With this study, we can see if online cooperative learning has a positive impact on creative thinking competencies and academic achievement by comparing two different student groups: The group who get programming education through online cooperative learning and the other group who get programming education through traditional classes.