Fine Needle Aspiration Cytology of Kikuchi’s Lymphadenitis: with Emphasis on Differential Diagnosis with Tuberculosis

한강민,고재향,명나혜,이원애 대한병리학회 2011 Journal of Pathology and Translational Medicine Vol.45 No.6

Background: Although Kikuchi’s lymphadenitis (KL) has been known to have characteristic cyto-logical features, pathologists encounter difficulties in making a diagnosis with fine needle aspira-tion cytology (FNAC). The objective of this study was to assess the diagnostic pitfalls of KL with FNAC, particularly with emphasis on differential diagnosis with tuberculosis. Methods: FNAC of 10 patients with a histological diagnosis of KL and tuberculosis was reviewed. Results: Acidophilic cells were observed in all the 10 KL cases, even if the smears were insufficient. Crescentic histiocytes were seen in 8, granular background in 7, and karyorrhectic debris in 3 cases. Epithe-lioid histiocytes or neutrophils were not seen in any of the KL cases. Of the 10 cases of tubercu-losis, acidophilic cells were observed in 6 cases, crescentic histiocytes in none of them, cheese-like background in 9, karyorrhectic debris in 8, epithelioid histiocytes in 4, and neutrophils in 8 cases. Conclusions: The acidophilic cell could be the most sensitive but not the specific marker of KL with FNAC. The crescentic histiocytes might be the sensitive and considerably specific marker of KL. The cytological features distinguishing tuberculosis from KL may be cheese-like necro¬sis admixed with neutrophils and epithelioid histiocytes.

Fine Needle Aspiration Cytology of Pulmonary Epithelioid Hemangioendothelioma with Prominent Hyaline Degeneration - A Case Report -

명나혜,한강민,김동훈 대한병리학회 2010 Journal of Pathology and Translational Medicine Vol.44 No.5

Pulmonary epithelioid hemangioendothelioma (PEH) is a rare vascular tumor of low to intermediate malignant potential, and PEH can mimic other more common tumor entities pathologically as well as clinically. Compared to its well-recognized histological features, its cytological findings have been reported rarely to be plasmacytoid or epithelioid cells with abundant dense or finely granular cytoplasm, cytoplasmic vacuoles, round nuclei and prominent nucleoli. We report here on the fine needle aspiration cytologic findings of a 38-year-old woman with EH of the lung, that showed in addition to its classical cytomorphology, a somewhat peculiar cytologic finding such as big twig-like rosettoid structures with prominent hyalinized stroma. This tumor was histologically and immunohistochemically proven to be PEH by primary antibodies for CD31, CD34 and vimentin. We emphasize that the accuracy of making a cytologic diagnosis of this rare tumor can be increased by recognizing the peculiar cytologic finding that we report on here.

눈꺼풀에 발생한 피부골종

이상혁,한강민,장민욱 대한안과학회 2019 대한안과학회지 Vol.60 No.12

Purpose: To present the first report describing lesions of osteoma cutis on the upper eyelid and medial canthus. Case summary: A 4-year-old female complained of a right upper eyelid mass. The examination showed a well-delineated, mild bluish-colored, hard mass over the upper eyelid and the medial canthus measuring 10 × 10 mm and 2 × 2 mm. During the cutaneous examination, her forearm, left shin, right dorsum of the foot, neck, and abdominal wall also showed well-delineated, mild bluish-colored, immobile hard masses, similar to the upper eyelid mass. A right upper eyelid and medial canthus mass excision was performed and a biopsy specimen was collected. Hematoxyline and eosin staining showed a mature bone in the dermis with spicules of bone and osteoblasts. She was finally diagnosed with osteoma cutis on the upper eyelid and the medial canthus. Conclusions: Osteoma cutis is a rare, benign skin disorder characterized by bone formation in the skin. Albright hereditary osteodystrophy, which causes a metabolic disorder, should also be considered to prevent complications. 목적: 우측 위눈꺼풀과 내안각의 종괴절제술을 시행 후 시행한 조직검사에서 피부골종(osteoma cutis)을 발견한 증례를 경험하여 이를 보고하고자 한다. 증례요약: 4세 여아가 우측 위눈꺼풀과 우측 내안각의 종괴를 주소로 내원하였다. 검진에서 경계가 명확하고 딱딱한 가로 10 mm, 세로 10 mm의 종괴가 우측 위눈꺼풀에서 발견되었고, 가로 2 mm, 세로 2 mm의 종괴가 우측 내안각에서 발견되었다. 종괴 주위는 경도의 푸른 색을 띠었고, 촉진 시 압통은 없었다. 좌측 종아리, 우측 발등, 복부, 목에도 유사한 형태의 종괴가 관찰되었다. 우측 위눈꺼풀과 내안각의 종괴에 대해 절제술을 시행하였고 병리조직 검체를 얻었다. Hematoxyline and eosin 염색을 이용한 병리조직검사에서 진피조직에서 성숙된 침상의 골조직(mature bone with spicules)과 조골세포가 피부골종이 확인되었고, 우측 위눈꺼풀과 내안각의 피부골종으로 진단되었다. 결론: 피부골종은 드문 양성 피부질환으로 피부에 골조직을 형성하는 것을 특징으로 한다. 피부골종이 발견된 환아에서는 저칼슘혈증 및 고인산혈증을 일으킬 수 있는 올브라이트 유전성 골이영양증이 발생할 수 있어 주의 깊게 경과 관찰을 하여 합병증을 예방하는 것이 필요하다.

Aspiration Cytology of the Osteoclastic Variant of Anaplastic Thyroid Carcinoma: with Special Emphasis on the Undifferentiated Mononuclear Cells

이원애,한강민,김동훈 대한병리학회 2010 Journal of Pathology and Translational Medicine Vol.44 No.6

Anaplastic thyroid carcinoma (ATC) is an uncommon aggressive malignant tumor, and the osteoclastic variant of ATC is extremely rare. We report here on the fine needle aspiration cytology of the osteoclastic variant of ATC in an 83-year-old woman. The smear was composed of many oval to slightly elongated undifferentiated mononuclear cells admixed with multinucleated osteoclast-like giant cells. The mononuclear tumor cells revealed inconspicuous nuclear pleomorphism and the nuclei were characterized by vesicular chromatin and an indented or lobulated nuclear membrane with conspicuous nuclear grooves. A few epithelial clusters suggestive of a papillary carcinoma component were also observed. Making the proper cytological diagnosis of the osteoclastic variant of ATC is helpful to determine the proper treatment modality for these patients.

비인두에 발생한 분리종 1예

이상은,오협,한강민,박석원 대한이비인후과학회 부산,울산,경남 지부회 2023 임상이비인후과 Vol.34 No.4

Choristoma is a rare, non-malignant histologically normal tissue in abnormal regions. It should be differentially diagnosed from hamartoma or teratoma. We report a case of nasopharyngeal choristoma of 61-year-old women with snoring and sleep apnea. She previously visited our hospital with incidentally found left nasopharyngeal mass. Mass excision was conducted and microscopic report showed it as a choristoma.

Breast Metastasis from Rhabdomyosarcoma of the Anus in an Adolescent Female

정승필,이윤,한강민,이세경,김상민,배수연,김지영,김민국,김신일,길원호,구홍회,남석진,배정원,이정언 한국유방암학회 2013 Journal of breast cancer Vol.16 No.3

Rhabdomyosarcoma (RMS) of the breast is rare and there is scant information about the clinical behavior and treatment strategies. We report an adolescent female patient with metastatic RMS of the breast from the anus. An 18-year-old female patient was referred to our clinic due to palpable mass in the left breast. At age seven, she was diagnosed with acute lymphoblastic leukemia and treated with chemoradiation therapy. After 10 years of complete remission state, she presented with anal mass which was diagnosed as RMS and she received chemoradiation therapy. After 1 year of complete remission state, she noticed a palpable mass in her left breast. The breast mass was diagnosed as metastatic RMS based on core needle biopsy specimen. The RMS in breast was excised for the decreasing tumor burden despite of another metastatic lesion. Although rarely reported, metastasis of RMS should be considered as a cause of breast mass. Tissue biopsy is recommended when clinically suspected lesion is detected.

Recurrent Submandibular Gland Swelling Relieved by Antihistamine Medication: Is It Eosinophilic Sialodochitis?

김도형,김보해,한강민,이상은 대한이비인후과학회 2022 대한이비인후과학회지 두경부외과학 Vol.65 No.8

Sialodochitis fibrinosa is a disease characterized by salivary duct obstruction. A 21-year-oldmale presented with a painful submandibular gland (SMG) swelling. Serum eosinophilia andWhartons’ duct dilatation with strong enhancement were observed on contrast CT. Core needlebiopsy (CNB) for SMG parenchyma revealed lymphocytic infiltration between dilated intralobularducts. In another case, a 39-year-old male complained of recurrent major salivaryglands swelling for ten years with an itching sensation on the overlying skin of the salivarygland. Enhancement of both SMG parenchyma, dilatation of both Wharton’s ducts and elevatedserum eosinophilia were observed on contrast CT study. CNB for SMG parenchyma revealedlymphocytic infiltration with many eosinophils around a markedly dilated interlobularduct. The recurrent SMG swelling in both cases were relieved by antihistamine medication,warranting suspicion that these cases might organ-specific eosinophilic disease. We dicussthese two cases with a literature review.

체결볼트 단속에 의한 갱폼 추락방지기구

김현소,노승찬,한강민,박상현,신승훈,이웅균 한국생태환경건축학회 2019 한국생태환경건축학회 학술발표대회 논문집 Vol.19 No.1

KRAS Mutation Detection in Non-small Cell Lung Cancer Using a Peptide Nucleic Acid-Mediated Polymerase Chain Reaction Clamping Method and Comparative Validation with Next-Generation Sequencing

이보람,최윤라,이보인,한강민,권미정,한정호 대한병리학회 2014 Journal of Pathology and Translational Medicine Vol.48 No.2

Background: KRAS is one of commonly mutated genetic “drivers” in non-small cell lung cancers (NSCLCs). Recent studies indicate that patients with KRAS-mutated tumors do not benefit from adjuvant chemotherapy, so there is now a focus on targeting KRAS-mutated NSCLCs. A feasible mutation detection method is required in order to accurately test for KRAS status. Methods: We compared direct Sanger sequencing and the peptide nucleic acid (PNA)-mediated polymerase chain reaction (PCR) clamping method in 134 NSCLCs and explored associations with clinicopathological factors. Next-generation sequencing (NGS) was used to validate the results of discordant cases. To increase the resolution of low-level somatic mutant molecules, PNA-mediated PCR clamping was used for mutant enrichment prior to NGS. Results: Twenty-one (15.7%) cases were found to have the KRAS mutations using direct sequencing, with two additional cases by the PNA-mediated PCR clamping method. The frequencies of KRAS mutant alleles were 2% and 4%, respectively, using conventional NGS, increasing up to 90% and 89%, using mutant-enriched NGS. The KRAS mutation occurs more frequently in the tumors of smokers (p=.012) and in stage IV tumors (p=.032). Conclusions: Direct sequencing can accurately detect mutations, but, it is not always possible to obtain a tumor sample with sufficient volume. The PNA-mediated PCR clamping can rapidly provide results with sufficient sensitivity.

Delayed formation of sterile abscess after zygomaticomaxillary complex fracture treatment with bioabsorbable plates

도경현,박수진,홍기용,임수아,한강민,어수락 대한두개안면성형외과학회 2018 Archives of Craniofacial Surgery Vol.19 No.2

We present a patient who showed a sterile abscess after facial bone fixation with bioabsorbable plates and screws. He had zygomaticomaxillary complex and periorbital fracture due to falling down. The displaced bones were treated by open reduction and internal fixation successfully using bioabsorbable plate system. However, at postoperative 11 months, abrupt painless swelling was noted on the previous operation sites, left lateral eyebrow and lower eyelid. By surgical exploration, pus-like discharge and degraded materials were observed and debrided. The pathologic analysis revealed foreign body reaction with sterile abscess. This complication followed by bioabsorbable device implantation on maxillofacial bone surgery has been rarely reported in which we call attention to the maxillofacial plastic surgeons.