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Gastric Syphilis Mimicking Adenocarcinoma: A Case Report
최윤라,한재준,이다근,조민호,권기영,고영혜,박철근,안긍환 대한의학회 2006 Journal of Korean medical science Vol.21 No.3
Syphilis is an unexpected diagnosis in the stomach, and the reduced incidence of syphilis has made its clinical presentation less widely appreciated. We report a 43- yr-old man suffering from epigastric tenderness with an initial diagnosis of gastric carcinoma; gastric syphilis was confirmed by demonstrating spirochetes in a gas-tric biopsy specimen by silver impregnation. Excessive lymphoplasmacytic infiltra-tion with diffuse thickening of gastric rugae should raise suspicion of gastric syphilis, which should be considered in the differential diagnosis of diffuse erosive gastritis and infiltrative lesions of the stomach.
대장-직장암에서의 CD24 발현 증가와 예후 인자들과의 관련성
최윤라,현연화,이상전,박선미,김원재,김희진,김석형 대한병리학회 2006 Journal of Pathology and Translational Medicine Vol.40 No.2
Background : CD24 was originally described as a B cell-specific marker, however its aberrant expression in various solid tumors has recently been reported. Our objective was to determine the pattern and extent of the CD24 expression in colorectal cancer and its related lesions, and to clarify its correlation with clinico-pathological parameters and especially those associated with patients’ prognoses. Methods : A total of 307 colorectal cancers and the related lesions (150 carcinomas, 30 high-grade adenomas, 49 low-grade adenomas, 41 hyperplastic polyps, and 37 normal colorectal epithelia) were immunohistochemically analyzed by treating CD24 monoclonal antibody onto tissue embedded paraffin blocks. Results : CD24 expression was very rarely observed in the normal epithelia, hyperplastic polyps, and low-grade adenomas; however, in high-grade adenomas, the CD24 expression was shown to be mildly increased in the cytoplasm (13.3%). In carcinomas, the CD24 expression was increased substantially in both the membrane (38.0%) and the cytoplasm (44.7%). The expression of CD24 in the membrane was positively correlated with tumor size (p<0.01). The CD24 expression in the cytoplasm was positively correlated with several unfavorable parameters, including a larger tumor size (p<0.01), a higher tumor grade (p<0.01), a higher rate of tumor invasion (p<0.05), and a higher pTNM stage (p<0.05). Conclusion : High levels of CD24 expression in the membrane and cytoplasm were characteristic in colorectal cancer, and the cytoplasmic CD24 expression was correlated with several unfavorable clinical parameters.
최윤라,김태은,노지현,박희정,권지은,강소영,오영륜 대한병리학회 2010 Journal of Pathology and Translational Medicine Vol.44 No.3
Background : Papillary thyroid carcinoma (PTC) is the most common malignant tumor of the thyroid and BRAF (V600E) is the most frequent genetic alteration in PTCs. The aim of this study was to investigate the frequency of BRAF mutation, especially in very small PTCs. Methods : We analyzed the presence of the BRAF mutation in PTCs in subgroups defined by tumor size (0.5 cm intervals). Results : Of 140 patients, 85 (60.7%) showed a BRAF mutation. The frequency of BRAF mutation in the subgroup was: 45/70 (64.3%) in tumors less than 0.5 cm in size, 18/ 28 (64.3%) in 0.6-1 cm tumors, 10/22 (45.5%) in 1.1-1.5 cm tumors, and 12/20 (60.0%) in 1.6-2 cm tumors. There was no statistically significant association between BRAF mutation and tumor size (p = 0.44). Similarly, BRAF mutation was not statistically related to age, sex, stage, perithyroidal extension or lymph node metastasis. On multivariate logistic regression analysis, tumor sizes larger than 0.5 cm were associated with lymph node metastasis (odds ratio, 3.79; 95% confidence interval, 1.81 to 7.91; p < 0.01). Conclusions : The BRAF mutation is not related to tumor size even in very small PTCs. The similar frequency of BRAF mutation in very small PTCs suggests that the BRAF mutation is a very early event in the tumorigenesis of PTCs.
흉막에 발생한 고립 섬유성 종양의 세침흡인 세포학적 소견 - 폐의 선암종으로 오진한 1예 보고 -
최윤라,오영륜,이미숙,한정호,안긍환,Choi, Yoon-La,Oh, Young-Lyun,Lee, Mee-Sook,Han, Jung-Ho,Ahn, Geung-Hwan 대한세포병리학회 2001 대한세포병리학회지 Vol.12 No.2
Solitary fibrous tumor on the pleura is rare but should be included in the differential diagnosis on a peripheral pulmonary nodule. Cytologic features of solitary fibrous tumor of the pleura is not familar to the pathologist and may be misdiagnosed as malignancy. We report fine needle aspiration cytologic(FNAC) findings of a case of solitary fibrous tumor misdiagnosed as adenocarcinoma in a 48-year-old woman. The FNAC displayed a mixture of bland-looking spindle cells and clusters of epithelioid cells, which have hyperchromatic nuclei with prominent nucleoli. The helpful finding to distinguish It from other circumscribed benign and malignant lesions is the presence of fibromyxoid matrix admixed with blood vessels and thin collagen fibers. Familiarity with these features is essential to avoid misdiagnosis and overtreatment.
최윤라,이재연 淑明女子大學校 生活科學硏究所 1989 生活科學硏究誌 Vol.3 No.-
The purpose of this study was to compair a group of abused children with a selected control group in the aggression and empathy. The research question of this study are as follows: (1) Are abused children more aggressive than nonabused children? (2) Are abused children less empathic than nonabused children? The subjects in this study were 68 abused children and 59 nonabused children. The age range of this children was 14-16 years. To select abused children, primarily, on the basis of child Abuse Measure, 68 were selected among runaway children who were at the caring institutions. Nonabused children were selected almost at the same condition as the abused children in terms of age, sex, socioeconomic status. Nonabused children were selected at the jun ior high school in seoul(Low class). CTS(Conflict Tactics Scale) developed by straus(1979) was modified to measure children's physical abuse. To measure neglect, on the basis of NCCAN (National Center of Child Abuse and Neglect) (1986)'s definition, the questionnaire was devised by author. To measure empathy, the questionnaire which is based on the index of Empathy for children and Adolescents by Bryant (1982) was modified and used. The Need Diagonostic Test by Hwang Joung Gyu(1965) was used as the questionnaire for children's aggression. The obtained data were analyzed by Frequency, percentage, Mean, t-test, Chi-square test. The results of this study were as follows: (1) Abused children were more aggressive than nonabused children. That is, it was found that the abused children had higher level of potential aggression drive to harm others physically and verbally. (2) Abused children were less empathic than nonabused children. That is, abused children were lack in helping and understanding others who were in distress compared to the nonabused children.