한의학 기반 반려동물용 치료기술 개발 관련 특허 분석

이지혜,김성호,이수은,남현화,박준홍,천진미,서윤수,김보혜,이정민,문창종,김중선,문병철,Lee, Ji Hye,Kim, Sung Ho,Lee, Sueun,Nam, Hyeon-Hwa,Park, Jun Hong,Chun, Jin Mi,Seo, Yun-Soo,Kim, Bohye,Lee, Jeongmin,Moon, Changjong,Kim, Joong Sun,Moon 대한본초학회 2022 大韓本草學會誌 Vol.37 No.6

Objective : In this study, we conducted to analysis the patents about Korean medicine based treatment technology for pet. Methods : We collected the Korean, Japan, USA, China, EU and PCT patent for the Korean medicine-based treatment technology for pet using WIPSON data base registered by October 4, 2020 were selected. Results : Patents for the development of pet Korean medicine-based treatment technology have been constantly applied since the mid-2000s, starting in 1990, with a total of 84 applications. The number of patent applications filed in Korea was the largest, after Japan and China. The detailed composition of the applications reported until now is pharmaceutical compositions for the treatment of pet were the most applied with 39%(33 cases), followed by feed used as stocks for pet at 36%(30 cases). According to the patent application rate by disease, most of applications rate composed to be associated with immunity in 2009 to 2013 with 40% of applications. In 2014 to 2018 43% of patent applications are associated with gastrointestinal/digestive system. In this regard, multiple applications were filed in the order of immunity, digestive system, obesity and urinary system. Conclusion : This study analyzed the trend of 84 patents about Korean medicine-based treatment technology for pet to date to establish the basis for future research and development. There were many applications related to immunity from 2009 to 2013, and since then, related to digestive disease from 2014 to 2018.

황련해독탕(黃連解毒湯) 열수 추출물의 급성독성 연구

이지혜,음현애,정태호,이윤희,엄영란,임남희,김동선,마진열,Lee, Ji-Hye,Eum, Hyun-Ae,Chung, Tae-Ho,Lee, Yoon-Hee,Um, Young-Ran,Yim, Nam-Hui,Kim, Dong-Seon,Ma, Jin-Yeul 대한한의학방제학회 2010 大韓韓醫學方劑學會誌 Vol.18 No.2

Objective : The objective of this study was to evaluate the single dose oral toxicity of Hwangryundaedok-tang extract in ICR mice. Methods : 0(control group), 1250, 2500 and 5000 mg/kg of Hwangryundaedok-tang extracts were orally administered to 20 male and 20 female ICR mice. After single oral administration of Hwangryundaedok-tang extract to ICR mice, we observed number of the death, clinical signs, changes of body weights for 14 days. After 14 day of Hwangryundaedok-tang extract administration, all mice were sacrificed and major organs were observed. Results : Compared with the control group, we could not find any toxic signs in the mortalities, clinical signs, body weight changes, necropsy findings and hematological values in all treated groups(1250, 2500 and 5000 mg/kg). Conclusions : $LD_{50}$ value of Hwangryundaedok-tang extracts may be over 5000 mg/kg and it may have no side toxic effect to ICR mice.

마우스를 이용한 십전대보탕(十全大補湯) 발효물의 단회투여 독성 연구

이지혜,김태수,곽동훈,마진열,Lee, Ji-Hye,Kim, Tae-Soo,Kwak, Dong-Hoon,Ma, Jin-Yeul 대한한방내과학회 2011 大韓韓方內科學會誌 Vol.32 No.3

Objectives : Sipjeondaebo-tang is a medicine traditionally prescribed as a restorative. The aim of this study was to investigate the single oral dose toxicity and safety of extract of fermented Sipjeondaebo-tang in ICR mice. Methods : In single oral dose toxicity study, non-fermented or fermented Sipjeondaebo-tang were administered by oral gavage to ICR mice (5 males, 5 females) at single doses of varying concentrations: 1250, 2500 and 5000 mg/kg. Changes of body weight, general behavior, adverse effects and mortality were determined throughout the experimental period. Hematological parameters, organ weights and necropsy findings were evaluated at the end of the experiment. Results : There were no mortality or signs of toxicity in single oral dose toxicity studies. There were also no significant differences in body weight, organ weight, or hematological parameters between the treatment and control groups. Conclusions : Fermented Sipjeondaebo-tang did not cause remarkable adverse effects in ICR mice. The oral lethal dose of fermented Sipjeondaebo-tang is more than 5000 mg/kg and no-observed-adverse-effect level (NOAEL) of the extract for both male and female mice is 5000 mg/kg.

보중익기탕 및 발효보중익기탕의 단회투여 독성에 대한 연구

이지혜,황윤환,곽동훈,김태수,마진열,Lee, Ji-Hye,Hwang, Yoon-Hwan,Kwak, Dong-Hoon,Kim, Tae-Soo,Ma, Jin-Yeul 대한한방내과학회 2011 大韓韓方內科學會誌 Vol.32 No.4

Objectives : The aim of this study was to evaluate the single oral dose toxicity and safety of Bojungikgi-tang (Buzhongyiqi-tang) and fermented Bojungikgi-tang (Buzhongyiqi-tang) extracts in male and female ICR mice. Methods : In the single oral dose toxicity study, non-fermented and fermented Bojungikgi-tang (Buzhongyiqi-tang) were administered to male and female ICR mice as an oral dose of 1250, 2500 and 5000 mg/kg. Changes of body weights, general behaviors, adverse effects and mortality were determined throughout the experimental period. Hematological parameters, serum chemistry, organ weights and necropsy findings were evaluated at the end of the experiment. Results : There was no mortality or sign of toxicity in the single oral dose toxicity study. There were also no significant differences in body weights, organ weights, and hematological parameters, serum chemistry values between treatment and control groups. Conclusions : The results obtained in this study suggest that the 50% lethal dose of fermented Bojungikgi-tang (Buzhongyiqi -tang) in both female and male mice can be considered as well over 5,000 mg/kg, so these medicines can be safe in clinics.

실리카가 코팅된 양자점의 코팅두께에 따른 광 특성 변화

이지혜,신현호,이종흔,현상일,구은회,Lee, Ji-Hye,Shin, Hyun Ho,Lee, Jong-Heun,Hyun, Sang Il,Koo, Eunhae 한국전기전자재료학회 2013 전기전자재료학회논문지 Vol.26 No.3

The water soluble quantum dots (QDs) are synthesized by the phase transfer and silica coating reaction. The photoluminescence intensity of silica-coated QDs are mainly affected by the amount of phase transfer agent, SDS (sodium dodecyl sulfate), and the maximum value is obtained at the cmc (critical micell concentration) concentration of SDS in the phase transfer reaction. Based on fluorescence spectra and field emission transmission electron microscope (FETEM), the energy transfer rate by forster resonance energy transfer (FRET) is increasing with the thickness of the silica shell coated on CdSe/ZnS QDs.

탄뎀 가스메탈아크 용접의 토치 극간거리에 관한 실험적 연구

이지혜,김일수,정성명,이종표,김영수,박민호,Lee, Ji-Hye,Kim, Ill-Soo,Jung, Seong-Myeong,Lee, Jong-Pyo,Kim, Young-Su,Park, Min-Ho 대한용접접합학회 2012 대한용접·접합학회지 Vol.30 No.6

The tandem welding process is one of the most efficient welding processes widely used in material joining technique such as manufacturing of strong and durable structures. It facilitates high rate of joint filling with little increase in the overall rate of heat input due to the simultaneous deposition from two electrode wires. The two electrodes in tandem welding process helps in high-efficiency and high productive of welding process. In this study a automated tandem welding system is developed to determine the correlation between cathode and anode and compared with current ratio of the two electrode torch. Three different inter-electrode distances were chosen, 25mm, 35mm and 45mm to perform the experiment with three different current ratio. From the experiment results, the current ratio between two torch has a large impact on width, height and depth of penetration. In addition, a stable bead geometry is obtained when inter-electrode distance is 35mm.

액션러닝 기반 온라인 실습이 간호대학생의 자기주도적 학습능력, 학업적 자기효능감과 협업능력에 미치는효과

이지혜,한미라,Lee, Jihye,Han, Mira 국제문화기술진흥원 2022 The Journal of the Convergence on Culture Technolo Vol.8 No.6

The purpose of this study was to identify the effects of online practicum based on action learning on self-directed learning ability, academic self-efficacy, and cooperation ability of nursing students. Similar experimental study of single group pre-post test design was used to investigate the effects of this online class. A total of 47 nursing students who were junior grade from one college participated in this study and self-administered questionnaire was used for data collection. Data were analyzed by frequencies, paired t test using the SPSS/Window 21.0 program. The result of this study showed that the improvement after online practicum based on action learning was significant in self-directed learning ability(t=3.832, p<.001), academic self-efficacy(t=4.258, p<.001), and cooperation ability(t=3.853, p<.001). These findings imply the value of online practicum based on action learning to enhance competency of nursing students. In the future, more studies should be conducted in the same group including control group and blended learning method using action learning to validate the effectiveness.

무전해 Ni-P 두께와 Assembly Process가 Solder Ball Joint의 신뢰성에 미치는 영향

이지혜,허석환,정기호,함석진,Lee, Ji-Hye,Huh, Seok-Hwan,Jung, Gi-Ho,Ham, Suk-Jin 대한용접접합학회 2014 대한용접·접합학회지 Vol.32 No.3

The ability of electronic packages and assemblies to resist solder joint failure is becoming a growing concern. This paper reports on a study of high speed shear energy of Sn-4.0wt%Ag-0.5wt%Cu (SAC405) solder with different electroless Ni-P thickness, with $HNO_3$ vapor's status, and with various pre-conditions. A high speed shear testing of solder joints was conducted to find a relationship between the thickness of Ni-P deposit and the brittle fracture in electroless Ni-P deposit/SAC405 solder interconnection. A focused ion beam (FIB) was used to polish the cross sections to reveal details of the microstructure of the fractured pad surface with and without $HNO_3$ vapor treatment. A scanning electron microscopy (SEM) and an energy dispersive x-ray analysis (EDS) confirmed that there were three intermetallic compound (IMC) layers at the SAC405 solder joint interface: $(Ni,Cu)_3Sn_4$ layer, $(Ni,Cu)_2SnP$ layer, and $(Ni,Sn)_3P$ layer. The high speed shear energy of SAC405 solder joint with $3{\mu}m$ Ni-P deposit was found to be lower in pre-condition level#2, compared to that of $6{\mu}m$ Ni-P deposit. Results of focused ion beam and energy dispersive x-ray analysis of the fractured pad surfaces support the suggestion that the brittle fracture of $3{\mu}m$ Ni-P deposit is the result of Ni corrosion in the pre-condition level#2 and the $HNO_3$ vapor treatment.

나의 당뇨 체험기

이지혜,Lee, Ji-Hye 사단법인 한국당뇨협회 2007 당뇨 Vol.208 No.-

소아 청소년에서 하악공 및 하악소설의 위치에 대한 CBCT 분석

이지혜,최남기,김병기,김선미,Lee, Jihye,Choi, Namki,Kim, Byunggee,Kim, Seonmi 대한소아치과학회 2021 大韓小兒齒科學會誌 Vol.48 No.1

이 연구의 목적은 CBCT를 이용해 소아에서 연령에 따른 하악공과 하악소설의 위치 및 하악소설의 형태를 평가하고, 하치조신경 전달마취 시 고려할 수 있는 자입점을 제시하는 것이다. 과잉치 발거 또는 매복치 평가를 위해 CBCT를 촬영한 만 6 - 16세의 영상을 수집하였다. 연령에 따라 만 6 - 7세, 10 - 11세, 15 - 16세의 3군으로 분류하였으며 군당 남녀 각 30명씩을 포함하여 총 180명의 하악지 좌우가 분석되었다. 좌우 측의 하악소설로부터 하악지의 전연, 후연, 상연, 하연까지의 최단거리를 계측하고 하악소설과 하악공 사이의 최단거리, 교합평면에 대한 하악소설과 하악공 사이의 수직거리를 각각 측정하였다. 하악소설의 형태를 기준에 따라 4가지 형태로 분류하여 평가하였다. 하악지의 전후방 및 수직적 기준점으로부터 하악소설의 위치는 연령에 따라 모든 방향으로 증가하는 양상을 보였으며 하악소설과 하악공 사이의 거리 역시 연령에 따라 증가하는 양상을 보였다. 교합평면에 대한 하악소설 및 하악공의 거리는 연령에 따라 상방으로 이동하는 양상을 보였다. 하악소설의 형태는 삼각형 형태가 가장 많았고 결절형, 절두형, 동화형 순이었으며 연령에 따른 차이는 보이지 않았다. 연구를 통해 수평적인 마취의 자입점은 하악지의 전연으로부터 연령에 따라 각각 17 mm, 18 mm, 19 mm로 증가된 지점이 권장되며, 수직적인 마취의 자입점은 연령에 따라 교합평면 상방 2 - 3 mm, 5 - 6 mm, 9 - 10 mm로 자입점을 높이는 것이 권장된다. The purpose of this study is to evaluate the position of the mandibular foramen and location and morphological characteristics of the mandibular lingula using Cone-Beam Computed Tomography (CBCT). Mandibular CBCT images of children aged 6 - 16 years were collected. A total of 180 patients were divided into 3 groups, 6 - 7, 10 - 11 and 15 - 16 years, with 30 male and female patients per group. Either side of the ramus was analyzed. The shortest distances from the anterior, posterior, superior and inferior border of the ramus to the mandibular lingula were measured. The shortest distance between the mandibular lingula and the mandibular foramen was also measured. The vertical distance from the mandibular lingula and the mandibular foramen to the occlusal plane was measured. The shapes of the mandibular lingula was classified into 4 types according to the criteria. The distances of the mandibular lingula from the anteroposterior and vertical reference points of the ramus increased in all directions with age. The distance between the mandibular lingula and the mandibular foramen also increased with age. The location of the mandibular lingula and the mandibular foramen in relation to the occlusal plane moved upwards with age. The most common shape of the mandibular lingula was triangular, followed by nodular, truncated and assimilated, and there was no difference in the shape according to age. It is recommended that the horizontal insertion point of the anesthesia from the anterior border of the ramus increased to 17 mm, 18 mm, and 19 mm according to the age groups. It is also suggested that the vertical insertion point increased by 2 - 3 mm, 5 - 6 mm and 9 - 10 mm above the occlusal plane according to the age groups.