복합운동이 비만청소년의 식용조절호르몬과 비만 스트레스에 미치는 영향

김재호(Kim, Jae-Ho),권창기(Kwon, Chang-Ki),이상호(Lee, Sang-Ho) 한국체육과학회 2013 한국체육과학회지 Vol.22 No.2

The purpose of this study proposed an effective method improving obesity of adolescents who attend a combined exercise program during 12 weeks, by obesity stress, changes in blood levels of Appetite control hormone(ghrelin, leptin). The subjects of study were a total of 18 persons each 9 people, allocating combined exercise group (CG), control group(C) that divided by using the simple method conducted obese boys who had more than 25 percent body fat from pre-test. Combined exercise took four days a week, 45 minutes per a day and continued total 12 weeks. Measurement and analysis of all participants were measured after 12 weeks of pre-and post-test. For comparison of each group repeated measurements were performed among groups (repeated measure analysis of variance). The level of statistical significance in all analysis was set at α =. .05. Then that produced through the research process and how conclusions are as follows:1)changes of Ghrelin :CG group showed significant difference(p<.05) in group that ghrelin was decreased from 772.19pg/㎖ at 0 day to 429.77pg/㎖ at 12th week. 2)changes of Leptin : In CG group, the amount of leptin was increased from 12.38ng/㎖ at 0 day to 17.83ng/㎖ at 12th week(p<0.05). 3) Change of obesity stress: In CG group obesity stress was reduced from 109.33 at 0 day to 52.17 at 12th week, respectively. In CG group, obesity stress were significant difference (p<.05). In summary of above results, it showed that ghrelin and leptin hormone concentrations in blood were significantly changed. Therefore, we confirmed that continuous combined combination of exercise were positively effects for obese adolescents as a tool associated with a interventions of obesity.

최근 30년간 스포로트리쿰증 임상 병형의 추세에 대한 관찰

임채성,권경술,장호선,정태안,오창근 대한의진균학회 1997 대한의진균학회지 Vol.2 No.1

Background: The clinical types of sporotrichosis are generally classified into four group: lymphocutaneous, fixed cutaneous, and cutaneous disseminated, and hematogenous. Of these, the lymphocutaneous variety is the most frequently encountered pattern, constituting 80% of sporotrichosis patients and the fixed cutaneous sporotrichosis is the next. Potassium iodide (KI) was the most commonly used drug for the treatment of sporotrichosis. Many studies about these clinical findings of sporotrichosis have been reported, but comparative study on the changes in clinical findings has not been reported. Objective: The purpose of this study is to clarify the changes of the clinical findings in sporotrichosis in Korea. Methods: A total of 58 patients with sporotrichosis who had visited the Department of Dermatology, Pusan National University were divided into 2 groups according to the period and then the clinical findings of sporotrichosis were compared. Results: The results of study are summarized as follows: 1. During this period, there were 58 cases of sporotrichosis. In the past period (1967~1979) there were 35 cases of sporotrichosis, and there were 23 cases in the recent period (1980~1997) 2. In the past period, most cases (71.4%) were lymphocutaneous type, however in the recent period, most cases (69.2%) were fixed cutaneous type. 3. The most commonly affected site was right upper extremity in the past period, but face fright upper extremity were the most commonly affected sites in the recent period. 4. In the past period, 2nd and 3rd decades were prevalent age group, but 5th to 7th decades were prevalent age group in the recent period. 5. In the treatment of sporotrichosis, potassium iodide (KI) was the choice of treatment in the past period, however itraconazole is gradually used in the recent period. Conclusion: According to this study, many changes in clinical findings of sporotrichosis were noted, especially in the clinical type. We found that clnical type of sporotrichosis changed from lymphocutaneous type to the fixed cutaneous type with time. And we suggest that further observation would be necessary to define the meaning of these changes.

중부지역 옥수수 파종기에 따른 생육단계 및 수량성 변화

서종호, 문중경, 정건호, 서민정, 구자환, 박장환, 배환희, 신성휴, 권영업 忠北大學校 農業科學硏究所 2014 農業科學硏究 Vol.30 No.2

Maize hybrids were planted on April 1, April 25, May 20 and June 15 in 2012, 2013 at the experimental paddy and upland fields in Suwon city , respectively to know changes of growth stage and yield according to different planting time. Maize planting on April 1 was not recommended because total growing days at planting on April 1 was not different with that at planting on April 25 due to many days from planting to emergence over 20 days at planting on April 1. Total growing days were not much different among three planting time after April 25 because days from silking to maturity was lengthened though days from planting to silking was shortened at later planting time. Stalk weight was decreased as planting time was delayed, particularly at planting times after May 20 at paddy field by excess water injury during early growth stage. But, grain yield was not low as in May and June. It is needed to introduce early maturity maize variety as Yanganok at late planting for higher grain yield and enough time for soil preparation for next winter crops

급성 췌장염으로 발현된 낭성 변화를 일으킨 종격동 부갑상선 선종 1예

권태현,박진흥,윤설영,이창렬,이준호,최소진,손성표,허갑도,최영식,박영효 성분도병원 1998 성분도병원논문집 Vol.4 No.-

출산에 따른 그레이브스병의 재발 및 관련이자

임창훈,최현아,한승석,김해성,이창욱,정호연,한기옥,장학철,박원근,윤현구,한인권 대한내분비학회 2002 Endocrinology and metabolism Vol.17 No.2

Background: Pregnancy affects the course of Graves' Disease (GD), and patients who initially maintain euthyroid function into their middle trimester with minimum doses of antithyroid drugs become exacerbated after delivery. Even patients who are completely cured, requiring no treatment during pregnancy, can relapse after delivery. In this study, we examined the postpartum changes in the thyroid functions of patients with GD, and attempted to determine the factors contributing to these changes. Methods: The study subjects were recruited from pregnant women visiting our outpatient clinic for routine prenatal evaluations. 45 women previously diagnosed with GD, who had been treated and cured with hyperthyroidism, and were no longer taking any thyroid medications, were evaluated for 1 year post delivery. Results: Among 45 patients, 20 (44.4%) developed thyroid disorders following delivery. Postpartum thyroiditis (PPT) developed in 8 patients (17.8%), and GD developed in 12 (26.0%). The onset of the PPT disease 3.1 ± 1.4 months following delivery, which was significantly earlier than the 6.7 ± 2.7 months required for the post delivery onset of GD (p=0.003). The TBII values, measured during the thyrotoxic state in each womaen, were negative in women with PPT and positive in 71.4% of women with GD (p=0.030). The duration of treatment for hyperthyroidism prior or pregnancy, the number of recurrences, and the time interval without treatment, were not associated with the development of postpartum thyroid disorders. Whereas, the mean number of past pregnancies for women who developed PPT was 3.9 ± 2.1, and was significantly higher than the 2.2 ± 1.7 for women developing no thyroid dysfunctions (p=0.044). In 13 women their initial onset of GD occurred within one year postpartum, 7 (53.8%) having had a recurrence, which was significantly higher than in women whose disease onset occurred unrelated to delivery (5 of 32 women: 15.6%). Conclusion: Women with GD developed postpartum thyroid dysfunctions in 44.4% of cases. Women whose initial disease onset occurred within one year postpartum had higher recurrences of GD, and women who developed PPT had a history of higher gravidity compared to the euthyroid women postpartum. Therefore, if women with GD develop postpartum thyroid dysfunctions, the diagnosis should be made, and a treatment modality planned, following careful considerations of the patients' past obstetric history, changes in clinical manifestations and the TBII values

급성 췌장염으로 발현된 낭성 변화를 이릉킨 종격동 부갑상선 선종 1예

이준호,최영식,박진홍,허갑도,윤설영,최소진,권태헌,이창렬,손성표,박영효 대한내분비학회 1998 Endocrinology and metabolism Vol.13 No.3

Hypercalcemia due to hyperparathyroidism is rarely associated with acute pancreatitis. But, the relationship between hypercalcemia and pancreatitis still remains controvesial. Ectopic parathyroid adenoma with cystic change is one of the rare causes of hyperparathyroidism, and is usually located in neck and mediastinum. We report a case of mediastinal parathyroid adenoma with cystic change associated with acute pancreatitis. A 54-year-old male presented with epigastric pain for 3 days. The serum calcium, phosphate, elastase were 16.8mg/dL, 1.1 mg/dL, 2772.0 ng/mL respectively and his parathyroid hormone level in serum was 651.84 pg/mL. Chest CT showed a mediastinal mass with well defined inhomogenously enhanced density located between SVC and aorta. The patient was diagnosed to hyperparathyroidism with acute pancreatitis due to mediastinal parathyroid adenoma with cystic change, and was surgically removed. The surgical biopsy showed parathyroid adenoma with cystic change. After operation his general condition was improved and serum calcium, phosphate, amylase, lipase level were normalized (J Kor Soc Endocrinol 13:473-479, 1998).

정신분열병 및 정신분열형 장애에 대한 올란자핀의 효과와 안전성

안용민,강대엽,권준수,김창윤,김철응,반건호,신영민,이기철,이동우,이중서,조현상,채정호,김용식 大韓神經精神醫學會 2001 신경정신의학 Vol.40 No.4

연구목적 : 본 다기관 공동임상연구는 국내 환자를 대상으로 새로운 항정신병약물인 올라자핀의 치료 효과와 안전성을 확인하고자 시행되었다. 방 법 : 1999년 7월부터 2000년 3월까지 국내 10개 병원에 방문한 정신분열병 및 정신분열형 장애 105명을 대상으로 비대조 개방 임상연구를 시행하였다. 중등도 이상의 정신병 증상을 지니거나, 부작용으로 약물교체가 필요한 경우 또는 기분장애 증상의 치료가 필요한 환자를 대상으로 하였다. 2∼7일간의 약물 배설기간 후에 1일 10mg의 올란자핀을 투여하였고, 이후로 3∼7일 간격으로 용량을 조절하여 총 8주간 투여하였다. 치료 효과는 PANSS(Positive and Negative Syndrome Scale), BPRS(Brief Psychiatric Rating Scale), CGI(Clinical Global Impression-Severity), MADRS(Montgomery-Asberg Depression Rating Scale), HAM-A(Hamilton Rating Scale for Anxiety)로 판정하였다. 안전성 평가는 자발적인 이상반응 보고, 활력징후와 혈액 검사 및 SAS(Simpson-Angus Scale), BARS(Barnes Akathisia Rating Scale), AIMS(Abnormal Involuntary Movement Scale)척도를 이용하였다. 결 과 : 105명중에서 85.7%인 90명이 8주간의 치료를 완료하였다. 평균 최빈 용량은 일일 16.1(±4.7)mg이었고, 종료시점에서의 BPRS전체 점수가 기저 상태에 비해 40%이상 감소된 반응군은 69.5%이었다. PANSS의 양성 증후군과 일반정신병리 뿐만 아니라 음성 증후군 소척도에서도 유의한 감소를 보였으며, 이 감소들은 치료 초기부터 나타나서 8주간 지속되었다. 43.8%의 피험자가 중등도 이상의 우울증상을 같이 지니고 있었으며, 올란자핀에 의해 MADRS와 HAM-A가 유의하게 감소하였다. 치료 기간 동안에 활력징후에는 뚜렷한 변화가 없었으나 체중은 8주간 지속적으로 증가하였다. SAS와 AIMS는 감소하였으며, 정좌불능증을 제외한 나머지 추체외로 증상의 발생비율도 낮았다. 임상적인 증상이나 징후를 동반하지 않는 ALT/SGPT의 상승을 보였지만 프로락틴을 포함하는 대부분의 혈액 검사상 뚜렷한 이상 변화는 없었다. 결 론 ; 비록 본 임상연구가 비대조 개방 임상연구로서 많은 제한점을 가지고 있지만, 올란자핀이 기존 약물에 내약성을 보이거나 기분증상을 동반하는 정신병에 치료 효과가 있었다. 그리고 기존 항정신병약물 치료시에 문제가 되었던 추체외로 증상과 고프르로락틴 혈증을 포함하는 대부분의 부작용면에서 안전성을 보여 주었다. Objective : This multicenter clinical trial was carried out to investigate the efficacy and the safety of olanzpine for the treatment of Korean patients. Mothod : 105 patients with schizophrenia and schizophreniform disorder, visited at 10 mental or university hospitals, had received an open and non-comparative treatment with olanzapine for 8 weeks. Patients had psychotic or depressive symptoms with the severity above moderate degree or intolerable side effects to previous antipsychotics. After a wash-out period of 2-7 days, 10mg olanzapine was prescribed initially to all the patients, and then the dosage could be adjusted within the range of 5-20mg/day of olanzapine by 3-7 days. Results : 90(85.7%) of 105 patients completed the 8-weeks trial and the mean modal dose of olanzapine was 16.1(±4.7%)mg/day. At the end of the trial, 73 patients(69.5%) were classified as responder, which was defined as 40% or more improvement in BPRS(Brief Psychiatric Rating Scale) score comparing to baseline. There was a significant reduction in the scores of PANSS(Positive and Negative Syndrome Scale)and subscales including negative symptom scores and CGI. Also weekly analysis showed that the reductions in scores were kept on for the whole period of the trial. 43.8% of all the patients had depressive symptoms at the baseline and total scores of MADRS(Montgomery-Asberg Depression Rating Scale) and HAM-A(Hamilton Rating Scale for Anxiety) were also reduced after the trials. Vital signs revealed no clinically significant changes but continuous weight gain was observed during the treatment with olanzapine. The scores of SAS(Simpson-Angus Scale) and AIMS(Abnormal Involuntary Movement Scale) for assessing the EPS(extrapyramidal symptoms)and tardive dyskinesia respectively were significantly decreased and only a few patients reported EPS as adverse events. Although mild and clinically non-significant of ALT/SGPT was observed, most laboratory parameters including plasma prolactin level showed to significant changes during the trial. Conclusions : Although this trial had many limitations because it was a non-comparative and open study, olanzapine showed high efficacy on the positive, negative and depressive symptoms in schizophrenia and schizophreniform disorder.In addition to that, olanzapine showed a substantially favorable safety profile, such as low incidence of EPS and hyperprolactinemia.

中風病辨證診斷標準에 의한 臨床的 硏究

任長信,文祥官,高昌男,權正男,曺基湖,金永錫,裵亨燮,李京燮 경희대학교 1997 慶熙醫學 Vol.13 No.3

Japonica 및 Indica ×Japonica 品種의 細胞核 DNA의 特性 硏究

權容雄,蘇昌鎬 서울大學校 農科大學 1985 서울대농학연구지 Vol.10 No.2

벼의 品種群間 染色質 및 核 DNA의 특성을 비교하기 위하여 Japonica 品種인 삼남, 설악과 Indcia×Japonica 品種인 삼강, 풍산을 파종하여 5葉期에 뿌리를 사용하여 실험한 결과를 요약하면 다음과 같다. 1. 核當 DNA 함량은 설악 2.16×10??g, 삼남 2.07×10??g, 삼강 2.21×10??g, 풍산 2.42×10??g으로 Japonica보다 Indica×Japonica가 약간 많은 경향이었다. 2. 핵당 RNA, 核단백질中 염산에 용출된 단백질(大部分 histones) 및 기타 단백질의 DNA에 대한 함량비는 각각 0.14∼0.18, 0.87∼1.02, 2.99∼3.54로 품종간 차이는 있었으나 一樣性을 보이지 않았다. 3. DNA의 denaturation 온도 특성(Tm)은 설악 70.5℃, 삼남 71.0℃, 삼강 71.5℃, 풍산 69.5℃이었고, GC함량은 설악 40.5%, 삼남 41.7%, 삼강 42.9%, 풍산 38.6%으로 일정한 경향은 없었다. 4. DNA의 renaturatron (50℃)은 설악 62.8%, 삼남 66.3%, 삼강 54.0% 및 풍산 54.3%으로 Japonica 품종이 Indica×Japonica 품종보다 renaturation이 잘 되었다. Some biochemical characteristics of chromatin and nuclear DNA isolated from rice roots were compared for Japonica varieties, Samnam and Seolak, and Indica×Japonica varieties, Samgang and Pungsan. Hydroponically grown rice roots were harvested at the 5th leaf stage. The roots were washed three times or more with distilled water and then the nuclei and the chromatins were isolated and purified. The results are summarized as follows: 1. DNA content per nucleus was 2.16×?? in Seolak, 2.07×?? in Samnam, 2.21×?? in Samgang, and 2.42×?? in Pungsan. The DNA content per nucleus was smaller in the Japonicas than in the Indica×Japonicas. 2. Content ratio of RNA to DNA was 0.14 to 0.18, HCl-soluble proteins (mostly histones) to DNAwas, 0.87 to 1.02, and NACl- and Chloroform/MeOH soluble proteins (non-histones)to DNAwas, 2.99 to 3.54. 3. Transition temperature of DNA occurred at 70.5℃ in Seolak, at 71.0℃ in Samnam, at 71.5℃ in Samgang, and at 69.5℃ in Pungsan. GC content ratio was 40.5% in Seolak, 41.7% in Samnam, 42.9% in Samgang, and 38.6% in Pungsan. 4. Renaturation percent was 62.6% in Seolak, and 66.3% in Samnam, and 54.0% in Samgang, and 54.3% in Pungsan when heated DNA at 95℃ for 5 minutes was slowly cooled to 50℃, Japonica varieties being renatured to a greater degree than Indica×Japonicas.

유기성슬러지 처리를 위한 Vermistabilization 기초 연구

권영택,이창호 경남대학교 환경문제연구소 1996 환경연구 Vol.18 No.-

An application of vermicomposting technology was developed for the treatement of sedimentation sludge. Worms were found to be growing well in feed sludges stored during 30 days. The physicochemical properties of feed sludges were measured that the average values of pH, moisture content. Zn. Mn. Fe and Cu were 6.2. 88%. 472.8 ㎍/g. 1.576 ㎍/g. 114.1 ㎍/g and 4.2 ㎍/g respecting. Manure worm(Helodrilus foetidus) was seleted by the comparison studies on the hatching, growth treatment efficiency of the two species.