사람태아골모세포에 대한 GBM의 골형성 유도에 관한 효과

최호철,최희인,유형근 원광대학교 치의학연구소 2003 圓光齒醫學 Vol.12 No.2

The purpose of the present study was to investigate the effects of GBM on the activity, differentiation and alkaline phosphatase(ALP) synthesis of hFOB1s. To examine the cellular activity, hFOB1s were cultured with DMEM/F-12 1:1 Mixture and 100 ㎍, 2 mg, 5 mg, 10 mg of GBM for 2 days and 4 days. To compare the ALP synthesis, hFOB1s were cultured with DMEM/F-12 1:1 Mixture and 100 ㎍, 2 mg, 5 mg, 10 mg, 20 mg of GBM for 3days. The cellular activity of hFOB1s treated with 100 ㎍ of GBM was increased at 2 and 4-day(p>0.05) to control. The activity of ALP in hFOB1s treated with 100 ㎍ GBM was significantly increased at 3 day(p<0.05). This study indicated that 100 ㎍ of GBM has an inductive effect on bone formation in vitro increasing with cell proliferation, ALP activity.

상악동에 발생한 치성각화낭종

최유성,이희철,주미 대한악안면성형재건외과학회 2002 Maxillofacial Plastic Reconstructive Surgery Vol.24 No.1

Odontogenic keratocyst is one of the jaw cysts which have high recurrence rate and aggressive behavior. The radiographic findings and clinical symptoms of this disease are similar with other jaw cyst. So the final diagnosis requires the histopathologic confirmation and the patiend should be examined periodically due to recurrence rate of this disease. This was the case of odontogenic keratocyst including a tooth which is in the left maxillary sinus. We thought it was a dentigerous cyst including a tooth preoperatively. The lesion was enucleated with yellow cheese-like material and histopathologic findings revealed abundant keratinizing debris, lining epithelium characterized by palisaded basal layer, orthokeratosis, and multifocal parakeratosis.

인천 인현동 호프집 화재 피해자 분석

최정태,안무업,안희철,최영미,정재봉,서정열,유기철,이삼우,박석현,조준휘,김성환,김아진,송근정 대한응급의학회 2001 대한응급의학회지 Vol.12 No.4

Purpose : This study was conducted to develop field triage, transportation, distribution, and prehospital care at a fire disaster by analyzing the victims of the fore that broke out at a bar in Incheon. Method : We analyzed the cases of the victims of a fire in Incheon in Oct. 1999. We determined the primary care hospital, the arrival time, the burn size, the outcome, and the injury type from the medical records, the concerned organ records, and interviews with concerned persons. Result : The total number of victims was 137: 56 prehospital deaths, 1 hospital death, and 80 survivals. The Pearson correlation coefficient between the burn size and the severity was -0.175. There were 121(89.6%) cases of inhalation injury, 59 (43.7%) cases of flame burns, 66 (48.9%) cases of hypoxic brain damage, and 16 (11.9%) cases involving other types of injury. Conclusion : The causes of death of the fire victims were inhalation injury and hypoxic brain damage due to CO poisoning and other toxic inhalants. We propose the use of a simple triage and rapid treatment(START) system and a reassessment the delayed category in fire disasters.

중환자실 환자에서 원내 칸디다혈증 발생의 위험 인자

이유현,최희정,이미애 대한감염학회 2004 감염과 화학요법 Vol.36 No.4

Background : Nosocomial candidemia is one of the most important disease entity in hospital not only because of increasing incidence but also because of its high fatality rate. The purpose of this study is to identify risk factors predicting the development of nosocomial candidemia and to evaluate its clinical outcome of nosocomial candidemia in the intensive care unit (ICU) patients. Materials & Methods : We conducted a retrospective, matched case-control study in adult patients admitted to ICU from January 1998 through December 2002 in Ewha Womans University Mokdong hospital. Sixty cases with candidemia were retrospectively identified from the records of the Department of Clinical Microbiology. The possible risk factors for the development of nosocomial candidemia were compared between 60 patients and 120 control subjects. Results : Candida albicans was the most commonly isolated organism. In the multivariate analysis, number of concomitant bacteremia (OR=17.3), number of candida infection in other site (OR=20.6), number of antibiotics used (OR=4.2), duration of indwelling central venous catheter (OR=16.1), and insertion of arterial line for more than 8 days (OR=6.9) were identified as significant risk factors for development of candidemia. Crude mortality rate was higher in candidemia patients compared with control subjects (P=0.004). Conclusion : The best predictors of development of candidemia in ICU patients were concomitant bacteremia, candida colonization in other site, combined use of antibiotics, and long-indwelling arterial and central venous catheter. For the ICU patients with high risk factors of candidemia, we could consider the intervention to prevent emergence of candidemia. 목적 : 원내 감염 칸디다혈증은 최근 의학 기술의 발전과 함께 면역 기능이 감소된 경우 특히 발생 빈도가 증가할 뿐 아니라 높은 치사율로 그 중요성이 강조되고 있다. 이 연구의 목적은 중환자실에 입원한 환자에서 칸디다혈증 발생의 위험 요인과 이로 인한 사망률을 파악하는데에 있다. 재료 및 방법 : 1998년 1월부터 2002년 12월까지 5년간 이화여대 목동병원 중환자실에 입원하였던 환자를 대상으로 후향적으로 입원 기록을 검토하여 환자-대조군 연구를 시행하였다. 환자군은 진단 검사의학과 미생물실 자료에 의거, 칸디다혈증이 있었던 60명을 대상으로 하였고 대조군은 같은 시기에 중환자실에 입원하였으나 칸디다 혈증은 없었던 120명으로 짝지어 각기 28개의 가능성있는 위험 인자와 치사율에 대해 조사하였다. 결과 : 칸디다혈증을 유발하는 균종은 Candida albicans가 24예(40%)로 가장 흔하였다. 다변량 분석을 통해서 균혈증이 동반된 경우(OR=17.3), 칸디다가 다른 부위에서도 검출된 경우(OR=20.6), 항생제 병용이 많을수록(OR=4.2), 중심정맥관 삽입 기간이 길수록(OR=16.1), 동맥관 삽입이 8일 이상인 경우(OR=6.9)가 중환자실 환자에서 칸디다혈증 발생의 독립적인 위험인자이었다. 보통 사망률(Crude mortality)은 환자군에서 48.3%, 대조군에서 26.7%로 칸디다혈증 환자에서 사망률이 유의하게 높았다(P=0.004). 결론 : 칸디다혈증의 발생은 균혈증이 동반된 경우, 다른 부위에서 칸디다가 검출된 경우에 증가하며, 항생제 병용이 많을수록, 혈관 내에 중심정맥관이나 동맥관이 장기간 유치되어 있을수록 증가하였다. 칸디다혈증의 사망률 역시 높아, 칸디다혈증의 위험이 높은 중환자실 환자를 조기에 색출하고 칸디다혈증 발생을 예방할 수 있는 방법들에 대한 연구가 필요하겠다.

완전 방실차단을 동반한 급성 심근염

이유선,정진옥,박용규,박형서,노상필,정승현,김정희,이재환,최시완,성인환 충남대학교 의학연구소 2003 충남의대잡지 Vol.30 No.2

급성 심근염환자에서 발행한 완전 방실차단을 영구 심장박동 조율기로 치료한 1예를 경험하였기에 문헌고찰과 함께 보고하는 바이다. Myocarditis, an inflammatory process involving the myocardal wall, may be caused by most infectious agents. Irrespective of its etiology, it presents commonly with evidence of heart failure, hypotension, and various electrocardiographic abnormalities. Patient with myocarditis may be asymptomatic or may have a rapidly progressive fatal disease. Medical management of patients with myocarditis includes specific therapy for underlying infection and control of the complication of myocarditis such as congestive heart failure and arrhythmia. Recently we had experienced myocarditis with complete atrioventricular block in 37-year-old man. Although he had shown complete recovery of heart failure, he had shown complete atrioventricular block, so we inserted permanent pacemaker. We report it with review of the literature.

유·초등학생 장애이해 교육

이유훈,권택환,김희규,유장순,최세민 국립특수교육원 2003 연구보고서 Vol.- No.1

특수교육이 장애학생을 포함한 모든 학생의 특성과 요구에 부응하는 통합교육으로 발전하기 위해서는 무엇보다도 장애인에 대한 편견과 차별이 없어야 한다. 장애인에 대한 편견과 부정적인 태도는 결국 장애인의 사회통합에 부정적인 영향을 미치기 때문에 우선적으로 해결해야 할 과제라고 할 수 있다. 본 연구에서는 「유ㆍ초등학생 장애이해 교육」자료를 개발ㆍ보급하여 장애인에 대한 편견과 차별을 해소하는데 그 목적을 두고, 전문가 협의회, 관련 문헌 탐색, 기존 장애이해 교육 자료 분석, 현장교사 설문 및 심층면담 등을 실시하였고, 이를 통해 얻은 연구 결과를 요약 정리하면 다음과 같다 첫째, 우리의 학교현장에서는 장애이해 교육 시간확보가 어려운 실정이다. 이런 현상은 교육경력이 낮은 교사일수록 또는 학교경영자와 일반교사의 이해가 부족할수록 더욱 심각하게 나타나는데, 이러한 문제를 해결하기 위해서는 국립특수교육원이나 시ㆍ도교육청에서 장애 이해 교육에 따른 시간확보 방안을 제공할 필요가 있다. 장애이해 교육의 필요성에 대한 학교경영자 및 일반교사의 인식 부족을 해결하기 위해서는 학교경영자와 일반교사가 특수교육과 장애인에 대한 이해를 넓힐 수 있도록 하는 다양한 연수프로그램이 마련되어야 한다. 둘째, 장애이해 교육에 활용할 수 있는 자료의 양이 부족할 뿐 아니라, 기존에 개발된 자료를 활용할 수 있는 체계적인 방안이 마련되어 있지 많다는 점이다. 따라서 장애이해 교육에 활용할 수 있는 다양한 자료가 개발되어야 하고, 기존에 개발된 자료는 쉽게 활용될 수 있도록 종류별로 정리되어야 하고, 활용할 수 있는 구체적인 방법도 제시할 필요가 있다. 셋째, 장애이해 교육이 학기초나 '장애인의 날'과 같은 특정기간에 편중되어 있다는 점이다. 장애인식 개선을 위한 교육은 년 중 계획을 세워 일정기간 단위로 실시하여야 한다. 넷째, 장애이해 교육에 활용되는 모델이나 이해교육 방법이 주로 감각장애(시각장애ㆍ청각장애) 또는 지체부자유학생을 중심으로 되어 있다는 점이다. 교육현장에서는 발달장애학생도 많기 때문에 발달장애학생을 모델로 하는 장애이해 교육 프로그램이나 교수-학습방법도 지속적으로 개발되어야 한다. 다섯째, 장애이해 교육방법이 다양하지 못하다는 점이다. 장애이해 교육이 효율적으로 이루어지기 위해서는 장애인의 다양한 특성이 고려되어야 한다. 그러기 위해서는 교수활동 방법 또한 이들의 특성을 고려하여 보다 다양하게 이루어져야 할 것이다. 위에서 제시한 장애이해 교육 실태를 토대로 본 연구보고서에서는 현장교사들이 쉽게 활용할 수 있도록 하기 위해서 1부, 2부로 나누어「유ㆍ초등학생 장애이해 교육자료」를 안내하였다. 제 1부 「장애이해 교육의 개관」에서는 장애이해 교육자료 개발의 필요성, 목적, 연구방법 및 절차, 장애이해 관련 제이론, 장애이해 교육의 현황 및 문제점, 개선방안 등을 기술하여 학교현장의 교사들이 장애이해 교육에 대해 보다 폭 법은 이해를 도모하도록 하였다. 제 2부 「장애이해 프로그램 및 교육자료」에서는 장애유형별 즉, 시각장애, 청각장애, 정신지체, 정서장애, 자폐성장애, 학습장애, 지체부자유 등으로 나누어 제시하여 교사들이 장애 이해 지도를 보다 쉽게 접근할 수 있도록 하였고, 아울러 기존에 개발된 장애이해 교육자료를 도서, 방송프로그램, 영화, 인터넷 웹사이트 등으로 분류 제시하여 학교현장에서 학생의 수준과 활동 내용에 따라서 다양하게 활용할 수 있도록 하였다. 본 프로그램은 「유ㆍ초등학생 장애이해 교육자료」의 한 예에 불과하다. 학교 현장의 지도 교사는 프로그램의 수준을 상향 또는 하향 조정하여 지도할 수 있으며, 생활 주변의 다양한 소재로 프로그램의 내용을 수정 또는 대체할 수 있다. 나아가 창의적으로 새로운 상황을 전개할 수 있도록 하는 노력도 필요하겠다. 2004년에는 「중ㆍ고등학생 장애이해 교육자료」가 개발되어 학교현장에 보급될 계획이다. In order for special education to develop into an inclusive education system that meets the characteristics and needs of all children, including those who are disabled, there must be no prejudices and discriminations against children who are physically or mentally challenged. As the biases and negative attitudes toward persons with disabilities could eventually exert negative influences on their integration into society, these tasks must be effectively taken care of above all else. This study, with the aim of dissolving prejudice and discrimination against the persons with disabilities by developing and disseminating materials for the "Education for Non-disabled Preschoolers and Elementary School Children to Understand Disabilities", has had consultations with experts, researched related books and other documents, analyzed the existing educational materials for understanding individuals with disabilities and conducted surveys on and interviews with teachers in the field of education. The results of the study are summarized as follows. First, the fact remains that it is difficult to secure time to educate on how to understand the children with disabilities at the nation's schools. Such a phenomenon occurs more seriously among teachers with less educational experiences as well as school managers and general education teachers without adequate understanding of the children with disabilities. To resolve this problem, either the Korea Institute for Special Education or the municipal and provincial educational agencies need to provide ideas to secure time to educate the understanding of those who are challenged. In order to solve the lack of understanding of the children with disabilities among school managers and general education teachers, various programs must be created and implemented to train the school administrators and regular teachers to expand their understanding of the persons with disabilities. Second, not only is the amount of materials available for the education of the children with disabilities insufficient, but moreover there are no systematic measures to make the most of those materials that are already developed. Therefore, diverse resources must be developed to use for educating the understanding disabilities, and already developed materials must be classified into categories for easy use along with concrete methods for utilizing such resources. Third, education for understanding the children with disabilities is concentrated on specific periods, such as the early semester or the "Day for the Persons with Disabilities". Education to improve the perception of disabilities should be conducted in periods under an annual program. Fourth, the models or methods used to educate for understanding the persons with disabilities are centered mainly on the individuals with sensory injured (with visual or hearing impairments) or the persons with physically disabled. At educational sites, there are many children with developmentally disabled and so educational programs and teaching-learning methods to educate the understanding of the children with disabilities should be modeled after the children with developmentally challenged. Fifth, the methods to educate the understanding of the persons with disabilities are not diverse. For the efficient education of the understanding disabilities, the diverse characteristics of the persons with disabilities should be taken into account. To be successful in this matter, more diverse methods of teaching activities also need to be used by considering the characteristics of the people with disabilities. On the basis of the reality of developing an understanding and proper awareness of those who are disabled as presented above, this study report guides the "Education for non-disabled preschoolers and elementary school children to understand disabilities" in Part 1 and Part 2 for easy use by teachers on active duty. In Part 1, titled as "A General Survey of Educating the Understanding of the Children with Disabilities", I have described the necessity and purpose of educating the understanding of the children with disabilities, its study methods and procedures, various theories on educating the understanding of the children with disabilities, the current situations and problems of educating the understanding of the children with disabilities and their improvement measures to deepen the understanding about educating the understanding disabilities by teachers on active duty. In Part 2, titled the "Programs to Educate the Understanding Disabilities and Educational Materials," I have classified types of disabilities into visual impairment, hearing impairment, mental retardation, emotional disorder, autism, learning disability and the physical impairment for easy approach to educate the understanding disabilities by teachers. At the same time, I re-categorized the already developed materials to educate the understanding disabilities into books, broadcasting programs, movies, Internet web-sites and others for diverse use at schools according to the children' levels and activities. This program is just one example of the "Education for Non-disabled Preschoolers and Elementary School Children to Understand Disabilities". I have arranged it in such a way as to allow teachers to teach the children by upgrading or downgrading the program's level as well as modifying or replacing the contents of this program by using various materials that can be obtained in everyday lives. In 2004, I am planning to develop and distribute the "Education for non-disabled Middle-and High-school Students to Understand Disabilities".

이상 문학의 원전 확정 및 주석 연구

김주현,최유희 우리말글학회 2001 우리말 글 Vol.22 No.-

This paper is about establishment of authentic text and annotation on Lee Sang's literature. Frist, we pointed out the fallacies of the first printing of Lee Sang's Japanese Poems and scrutinized the fallacies of translation and compiling process of collection in many aspects. The fallacies of translation were grouped 10category such as opposite translation, absurd translation, colloquial expression, chinese writing style expression and so on. Some of the results have already been pointed out but many of them are new We believe that this paper ascertained more authentic text version but the establishment of authentic text has not been finished. Still, we can not identify initial name 'R' presented in the prefaces of 〈ChoSeon and Architecture(朝鮮と建築)〉. We reserve this part of work unfinished for another time and another researcher. Secondly, this paper also focused on 〈Raven's eye view(烏瞰圖)〉 which is the most annotated poem of Lee Sang. After we studied former researcher's opinions about the title 〈Raven's eye view〉, We bring up the possibility that the title 〈bird's eye view(烏瞰圖)〉is more original one than 〈Raven's eye view〉. In addition to that, we studied annotation of 〈poem number 1〉the most discussed poem of Lee Sang's and studied 〈poem number 1(詩第1號)〉. Annotation work about poems of Lee Sang first developed by Lee Ur-rhyueng and studied more seriously by Lee Seoung-hun. Based on their studies. This paper presented more particular and detailed annotation work after fully surveying almost all papers, criticisms, and books, which are related to Lee Sang. Specifically we supplemented annotation that Lee Seoung-hun omitted annotation amongst papers published by 1989 and added new research results. We still feel something wanting that we can not bring up everything. It is because of the shortage of research period and different style of this paper from general paper. The remainder of works are annotation of full 〈Raven's eye view〉and the whole works of Lee' Sang. Then, we can avoid duplicated study and will present new results based of authentic text version. If this is completed, we can enhance the level of study about Lee Sang.

우골유도합성골이 세포 증식 및 염기성 인산분해 효소 활성에 미치는 영향

현하나,최희인,유형근 원광대학교 치의학연구소 2003 圓光齒醫學 Vol.12 No.2

The ultimate goal of periodontal therapy is to promote the regeneration of lost periodontal tissue, there have been many attempts to develop a method to achieve this goal, but none of them was completely successful. The purpose of this study was to evaluate the effects of BBP?? on alkaline phosphatase(ALP) activity in human fetal osteoblast (hFOB1). The results of this study were as follows, BBP?? didn't show any significant increased cell proliferation and cell activity in the human fetal osteoblast as compared to non-supplemented controls at 2 and 4 day. In ALP activity, 100 ㎍/㎖ BBP?? treated group showed significantly increased value than negative control group.

탈희동결건조골과 이종골이 사람태아 골모세포의 골형성에 관한 효과

윤호상,최희인,유형근 원광대학교 치의학연구소 2003 圓光齒醫學 Vol.12 No.1

The ultimate goal of periodontal disease therapy is to promote the regeneration of lost periodontal tissue, there have been many attempts to develop a method to achieve this goal. The purpose of this study was to evaluation the effects of BBP, DLB on bone formation in human fetal osteoblasts. We examined the effect of BBP, DLB on collagen synthesis of human fetal osteoblasts. Collagen synthesis level of 5mg of BBP(5.80±0.18㎍/mg/ml), DLB(5.51±0.57㎍/mg/ml) showed significant difference compare with control group(3.58±0.35㎍/mg/ml). We also examined expression of BMP-2 by Western blot analysis. BMP-2 was expressed in both of BBP and DLB. These results suggest that BBP, DLB have an inductive effect on bone formation in vitro increasing with collagen synthesis and expression of BMP-2.

참치 뼈를 이용한 Hydroxyapatite 세라믹 복합체의 합성 및 생체 친화성(제3보) : 인공체액에서의 Hydroxyapatite 세라믹 복합체간의 결합의 전자현미경 관찰 SEM Photographs of Bonding Properties between Hydroxyapatite Ceramics Composites in the Simulated Body Fluid

김세권,최진삼,이창국,변희국,전유진,이응호,박인용 대전산업대학교 반도체기술연구소 1999 半導體技術硏究所報 Vol.1 No.-

참치 뼈에서 추출한 hydroxyapatite를 출발물질로 여러 가지 세라믹 복합체를 제조하여 인공체액에서의 hydroxyapatite 복합체간의 화학결합을 조사하였다. hydroxyapatite 복합체들은 인공체액에서 4주 후부터 화학 결합성질을 나타내었다. 결합강도는 bioglass가 가장 강하게 나타났으며, 조성에 따른 의존성은 관찰할 수 없었다. 인공체액에서 복합체들은 이들의 경계면에서 불균일 핵생성 및 성장에 의해 화학적 결합으로 이루어졌다. Chemical bonding was investigated in the simulated body fluid of several selected hydroxyapatite-containing composites. The hydroxyapatite-containing composites chemically bonded with each other in the simulated body fluid after 4 weeks. Bioglass was strongly bonded in the simulated body fluid, but bonding strength was not depended on composition. Their composite bodies were chemically bonded by heterogeneous nucleation and growth at the interfaces of the specimens in the simulated body fluid.