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      • KCI등재후보

        약국서비스 만족에 영향을 미치는 요인 분석 : 환자체감시간과 실 조제시간 비교를 중심으로

        박성희,서준규,윤혜설,홍진영,박군제 한국의료QA학회 1998 한국의료질향상학회지 Vol.5 No.2

        Purpose : To shorten processing time for variety of medical affairs of the patient at the outpatient clinic of a big hospital is very important to qualify medical care of the patient. Therefore, patient's waiting time for drug delivery after doctor's prescription is often utilized as a strong tool to evaluate patient satisfaction with a medical care provided. We performed this study to investigate factors influencing patient satisfaction related with waiting time for drug delivery. Methods : The data were collected from July 21 to August 12, 1998. A total 535 patients or their families who visited outpatient clinics of Inha University Hospital were subjected to evaluate the drug delivery time and the level of their satisfaction related, which were compared with those objectively evaluated by Quality Improvement Team. The reliability of the scale was tested with Cronbach's alpha, and the data were analyzed using frequency, t-test, ANOVA, correlation analysis and multiple regression. Results : The mean drug delivery time subjectively evaluated by the patient (16.1 13.0 min) was longer than that objectively evaluated (10.9 7.6 min) by 5.2 min. Drug delivery time objectively evaluated was influenced by the prescription contents, total amount or type of drug dispensed, etc, as expected. The time discrepancy between two evaluations was influenced by several causative factors. One of those proved to be a patient's late response to the information from the pharmacy which the drug is ready to deliver. Interestingly, this discrepancy was found to be more prominent especially when waiting place for drug delivery was not less crowded. Other factors, pharmaceutical counseling at the pharmacy, emotional status or behavior of a patient while he waits for the medicine, were also found to influence the time subjectively evaluated. Regarding the degree of patient satisfaction with the drug delivery, majority of patients accepted drug delivery time with less than 10 min. It was also found to be influenced by emotional status of the patient as well as kindness or activity of pharmaceutical counselor. Conclusion : The results show that, besides prescription contents, behavior pattern or emotional status of a patient, environment of the waiting place, and quality of pharmaceutical counseling at the pharmacy, may influence the patient's subjective evaluation of waiting time for drug delivery and his satisfaction related with the service in the big hospital. In order to improve patient satisfaction related with waiting time for drug delivery, it will be cost effective to qualify pharmaceutical counseling and information system at the drug delivery site or waiting place rather than to shorten the real processing time within the pharmacy.

      • 시멘트 및 고성능AE감수제가 고유동콘크리트의 유동특성에 미치는 효과에 관한 실험적 연구

        박선규,반성수,우영제,김규용,김무한 忠南大學校 産業技術硏究所 1998 산업기술연구논문집 Vol.13 No.1

        The fluidity of high flowing concrete can be affected by numerous parameters which characterize either the cement or the admixture. The reactivity of a cement as determined by its chemical compositions (especially its C₃A content), its fineness and its content in sulfates and alkalies obviously plays a key role in rheology of high flowing concrete in fresh state. Specific properties of high range water reducing AE agent used to enhance the workability of high flowing concrete also exert important influence. The purpose of this experimental study is to investigate and analyze the effect of cement and high range water reducing AE agent in fluidity, setting, compressive strength of high flowing concrete. As a result, we found that fluidity of high flowing concrete is affected greatly by kind of cement and high range water reducing AE agent, also, there is harmonic character between high belite cement and polycarbonic acid high range water reducing AE agent.

      • KCI등재

        타리비드 정(오플록사신 100㎎)에 대한 파비드 정의 생물학적동등성

        박완수,조성희,이헌우,임호택,홍성제,서성훈,류재환,이경태 한국약제학회 2005 Journal of Pharmaceutical Investigation Vol.35 No.1

        The purpose of the present study was designed to evaluate the bioequivalence of two ofloxacin tablets, Tarivid (Jell Pharm. Co., Ltd.) and Favid (ILHWA Co., Ltd.), according to the guidelines of Korea Food and Drug Administration (KFDA). Twenty-four normal male volunteers, 23.67±3.12 year in age and 68.50±7.23 kg in body weight, were divided into two groups and a randomized 2x2 cross-over study was employed. After four tablets containing 100 mg of ofloxacin were orally administered, blood was taken at predetermined time intervals and concentrations of ofloxacin in plasma were deter mined using HPLC. Pharmacokinetic parameters such as AUC_(t) and T_(max) were calculated and ANOVA test was utilized for the statistical analysis of the parameters using logarithmically transformed AUC_(t), and C_(max) and untransformed T_(max). There were no sequence effects between two formulations in these parameters. The 90% confidence intervals for the log transformed data were acceptance range of log 0.8 to log 1.25 (e.g., log 0.94-log 1.04 and log 0.90-log 1.07 for AUC_(t) and C_(max) respectively). The major parameters. AUC_(t) and C_(max) met the criteria of KDFA for bioequivalence indicating that Favid tablet is bioequivalent to Tarivid tablet.

      • KCI등재후보

        Research Articles : Physiological characteristics of the Large Copper butterfly, Lycaena dispar (Lepidoptera: Lycaenidae)

        ( Seong Hyun Kim ),( Seong Jin Hong ),( Young Bo Lee ),( Hae Chul Park ),( Yeon Ho Je1 ),( Nam Jung Kim ) 한국잠사학회 2011 International Journal of Industrial Entomology Vol.23 No.2

        To establish an indoor-rearing system for the Large Copper butterfly, Lycaena dispar and the Small Copper butterfly, Lycaena phlaeas, the effect of temperature, photoperiod and host plants on larval development was investigated. The larvae of Lycaena dispar fed on Rumex crispus, whereas the larvae of Lycaena phlaeas ate both Rumex crispus and Rumex acetosa. The duration of the larval period of Lycaena dispar was 13.8 days on R. crispus and that, of Lycaena phlaeas was 15.9 days and 15.2 days on R. acetosa and R. crispus respectively. Laboratory experiments show that the Large Copper larvae are able to feed on other Rumex species without harming their overall survival and can utilize these alternative host plants at least as efficiently as their natural host plant. This result suggests that plant chemistry is not responsible for their lack of utilization of the alternative host plants in the wild. Host plant choice by ovipositing females was measured with the two alternative hosts. Lycaena dispar preferred R. crispus to R. acetosa, wheareas Lycaena phlaeas preferred R. acetosa to R. crispus. Temperature has been proposed as an important determinant of developmental rate, lifespan and mortality in invertebrates. As temperature increased, length of the developmental period gradually decreased. The developmental period of the Large Copper larvae was 11.0 days and 28.5 days at 30oC and 17.5oC, respectively.

      • 중증 재생불량성 빈혈 환자의 동종골수이식 후에 병발한 간정맥폐색질환(Hepatic Veno-Occlusive Disease)의 임상 경과 및 혈액응고 인자들의 변화

        이제환,이규형,최성준,민영주,김신,이정신,김상희,박찬정,지현숙,김우건 대한조혈모세포이식학회 1999 대한조혈모세포이식학회지 Vol.4 No.2

        연구배경: 재생불량성 빈혈 경우에는 조혈모세포 이식 후 VOD의 발생에 관한 보고가 거의 없는 실정이다. 저자 등은 cyclophosphamide와 antithymocyte globulin으로 전처치 후에 동종골수이식을 시행한 재생불량성 빈혈 환자들을 대상으로 하여 VOD의 발생과 임상 양상, 혈액응고 인자들의 변화에 관하여 분석하여 보았다. 방법: 재생불량성 빈혈로 동종골수이식을 시행 받은 13예 환자를 대상으로 하였다. 임상적 기준에 따라 VOD를 진단하였으며 임상 경과에 따라서 경중을 분류하였다. Protein C, protein S, antithrombin Ⅲ, tPA, PAI-1 등의 혈액응고 인자들을 전처치 투여전, 골수 주입당일, 이식 후 제7, 14, 21일에 측정하였다. 결과: 7예(53.8%)에서 VOD가 발생하였으며, 경증 5예, 중등도 2예였다. VOD군에서 혈소판치가 20.000/㎕ 이상을 유지하는 데까지 걸리는 시간이 더 길었다(p=0.026). 또한 VOD군에서 적혈구 및 혈소판의 수혈 요구량이 각각 유의하게 많았다(p=0.025, 0.015). 혈액응고 인자들의 변화를 보면, 제 0일에 VOD군에서 PAI-1의 혈중 농도가 유의하게 더 높았다.(p=0.034). 결론: 재생불량성 빈혈환자에서도 조혈모세포 이식 후에 VOD의 높은 발생률을 관찰하였으며, 대부분이 경증이었다. VOD 환자에서의 혈액응고 인자들의 변화는 PAL-1이 VOD의 감별 진단을 위하여 이용될 수 있음을 시사하고 있다. Background: There are few reports about the occurrence of hepatic veno-occlusive disease(VOD) after bone marrow transplantation (BMT) for severe aplastic anemia (SAA). We analyzed the incidence and clinical outcomes of VOD and changes of coagulation factors in patients with SAA who were conditioned with cyclophosphamide plus ATG and underwent allogeneic BMT. Methods: Thirteen patients with SAA who underwent allogeneic BMT were included. A diagnosis of VOD was made according to clinical criteria, and severity of VOD was classified according to clinical course. Plasma levels of protein C, protein S, antithrombin Ⅲ, t-PA, and PAI-1 were determined before preparative chemotherapy, in the day of marrow infusion, and days 7, 14, and 21. Results: VOD occurred in 7/13(53.8%). Five were mild VOD and two were moderate VOD. Time to platelet ≥20,000/L was slower (p=0.026) and red cell and platelet transfusion requirements were higher (p=0.025,0.015) in patients with VOD . The mean plasma level of PAI-1 at 0 were higher in patients with VOD (p=0.034). Conclusion: We observed the high incidence of VOD after allogeneic BMT in patients with SAA. A majority of cases of VOD were mild. The changes of PAI-1 after BMT may be useful marker of hepatic VOD

      • KCI등재

        정신보건관련시설 입원(소)자의 주요 정신장애 유병률 : 전국 20개 시설의 입원(소)자를 대상으로

        조성진,조맹제,서동우,함봉진,홍진표,배재남,이준영,이동우,박종익,전홍진,김성주,김용익 大韓神經精神醫學會 2004 신경정신의학 Vol.43 No.6

        Objectives : One of the objectives of this study is to estimate the prevalence rates of psychiatric diagnoses in the combined populations of psychiatric hospitals, psychiatric nursing facilities and homeless asylums using the Korean version of the Composite International Diagnostic Interview (K-CIDI), which is a comprehensive and fully standardized interview schedule to assess psychiatric disorders for diagnosis. The Other objective is to compare with previously studied prevalence rates of Psy-chiatric diagnoses using the results of this study. Methods : The study subjects, aged from 181o 64 years, were randomly selected from 64,582 institutionalized population of psychiatric hospitals, Psychiatric nursing facilities and homeless asylums as of 30, June, 2001. Twelve trained interviewers administered the K-CIDI to the selected respondents. A total of 1,875 respondents (male 1,194, female 681) completed the interview. Results : The lifetime and one year prevalences of any diagnosis excluding nicotine dependence · withdrawal, anxiety disorder, eating disorder, somatoform disorder were 88.2% (male 88.1%, female 88.3%), and 65.8% (male 62.7%, female 73.7%), respectively. The lifetime and one year prevalences of schizophrenia and other psychotic disorders were 78.5% (male 75.3%, female 83.7%), and 56.8% (male 51.9%, female 64.8%), respectively. The lifetime and one year prevalences of alcohol use disorder (dependence/abuse) were 26.7% (male 37.9%, female 8.3%), and 8.7% (male 12.8%, female 2.1%), respectively. The lifetime and one year prevalences of mood disorder were 18.1% (male 13.5%, female 25.8%), and 10.4% (male 7.2%,female 16.9%), respectively. The lifetime and one year prevalences of schizophrenia and other psychotic disorders were comparable with the 2001 community survey by 1.19% to 1.32%, and 0.51% to 0.61%, respectively. The lifetime and one year prevalences of schizophrenia were also comparable by 0.16% to 0.28%, and 0.16% to 0.25%, respectively. There were no significant changes of prevalence rates when correction were applied to other psychiatric diagnosis. Conclusion : The results of this study could be used for evaluating the distribution of psychiatric diagnoses in mental health related facilities and for planning mental health policies.

      • 한국사람 손바닥문의 생김새

        이제만,정민석,정호근,이경종,신동훈,안미선,김도윤,이민석,정구영,정연무,조한범,유상준,박성식 아주대학교 1997 아주의학 Vol.2 No.2

        Palm prints have been used for personal identification because they are unique to each individual. Palm prints have also been used for diagnosing genetic disorders and for revealing physical anthropological characteristics, due to their specific appearance characteristic of genetic factors and nationality. Therefore, several analytical methods of palm prints have been developed and applied for the purpose described. However, in the previous reports, the analytical methods of palm prints and the numbers of subjects were insufficient to find Standard values for Korean palm prints. In this study, in order to determine the Standard value for Korean palm prints, we examined palm prints of 3216 Korean adults (2095 males and 1121 females), analyzed the data according to sex and side of hand, and compared with those of foreigners. The results are s follows: 1) The incidence of 7, 9, and 11 of D was 41.8%, 33.5%, and 20.4%, respectively. Comparing the incidences 017, 9, and 11 of D in Koreans with those of foreigners, the Korean belong to the Asians including the Japanese, the Chinese, and the Philippine, however, the Korean was doser to the Blacks and distant from the Whites than the other Asians. 2) The palm prints were classified into the open type in which B terminates at the ulnar border of hand, and the dosed type in which B does not. Open type, 7-5-5 (male 37.6%, female 39.5%) and 9-7-5 (male 23.9%, female 25.5%), was more frequent in female than in male, while dosed type, 11-9-7 (male 9.8%, female 9.1%), was more frequent in male than in female. Also, open type, 7-5-5 (right 28.9%, left 47.6%), was more frequent in left hand than in right hand, while dosed type, 11-9-7 (right 17.1%, left 2.1%), was more frequent in right hand than in left hand. Consequently, open type was more frequent in the weak hand, whereas dosed type was more frequent in strong hand. 3) Because a-b (39.2) and c-d (35.0) were more numerous than b-c (27.8), distance between a and b and between c and d were longer than that between c and d. The long distance of a, b and c, d could be resulted by wide moving range of second finger and fifth finger, respectively. Also, there was a tendency that the palmar ridge counts of right hand was more numerous than those of left hand, which could be resulted by wide moving range of right fingers in the right-handed persons who were more frequent than the left-handed persons. 4) O, in which there was no triradius, and X, in which dermal ridge from a triradius was blocked and terminated at the other dermal ridge, were frequent in C (O 7.8%, × 7.2%) than in D (O 0.1%, × 0.1%) or in B (O 0.4%, X 1.2%). The frequency of 0 and X in C was thought to be related with the location of ein the narrow space between d and b. The narrow space between d and b was known because c-d and b-c was less numerous than a-b. 5) The distances between adjacent triradii were longer in male than in female, however, the palmar ridge counts for a-b, b-c, and c-d were less numerous in male than in female. Consequently, dermal ridges were thought to be thicker in male than in female. The Standard values of Korean palm prints obtained from this study are expected to be used for both diagnosing genetic disorders and for revealing physical anthropological characteristics in Korea. Further studies to clarify the relationship between the palm prints and the power of hand as well as the moving range of fingers are in need.

      • KCI등재

        노인정신장애 평가척도(Psychogeriatric Assessment Scale)의 한국판 표준화 연구

        조맹제,박임순,신영민,김무진,정희연,정은기,최용성,조성진,서국희,함봉진 大韓神經精神醫學會 2000 신경정신의학 Vol.39 No.1

        연구목적 : 본 연구는 치매와 우울증을 다차원적으로 평가할 수 있는 도구인 Psychogeriatric Assessment Scale(PAS)의 한국판(PAS-K)을 개발하기 위한 것이다. 방 법 : 번역, 역번역, 그리고 세차례의 예비조사를 통하여 PAS-K를 제작하였다. 60세 이상의 노인 291명(임상환자군 : 58명, 지역사회노인군 : 168명, 수용시설 거주자 : 67명)과 그들의 정보제공자들을 대상으로 PAS-K, Geriatric Depression Scale(GDS), Korean version of Mini-Mental State Examination(MMSE-K), Hamilton Rating Scale for Depression(HRSD), 그리고 Hachinski Ischemic Score 를 적용하고, Diagnostic Interview chedule(DIS-Ⅲ-R)을 사용하여 치매와 우울증을 진단하였다. PAS-K의 신뢰도와 타당도를 평가하고, 예민도와 특이도, Kappa값, 그리고 ROC커브 분석법을 이용하여 PAS-K의 6개의 소척도들(피검자면접 : 인지기능 장애척도, 우울척도, 뇌졸중척도, 정보제공자면접 : 인지기능 저하척도, 행동변화척도, 뇌졸중척도)의 최적 절단점을 구하였다. 결 과 : PAS-K는 높은 내적 일관성을 보였고, 검사자간 신뢰도도 만족할 만한 수준이었다. PAS-K의 소척도들을 다른 표준화된 검사도구들과 비교하였을 때 인지기능 장애척도와 인지기능 저하척도는 MMSE-K와, 우울척도는 GDS 및 HRSD와 유의한 상관관계를 보였으며, 뇌졸중척도는 Hachinski Ischemic Score와 통계적으로 의미있는 상관관계를 보였다. 최적절단점은 인지기능 장애척도 10점, 인지기능 저하척도 3점, 우울척도 5점, 피검자면접과 정보제공자 뇌졸중척도 모두 1점, 그리고 행동변화척도 2점으로 추정하였다. 결 론 : 본 연구를 통해 PAS-K의 신뢰도와 타당도가 검증되었고, 노인정신의학 역학연구나 보건분야에서 치매와 우울증의 임상경과관찰 및 일차 선별도구로서 유용하게 사용될 수 있게 되었다. Objectives : This study was designed to develop the Korean version of the Psychogeriatric Assessment Scale(PAS-K), a multidimensional screening tool for the dementia and depression. Methods : Through three times preliminary trials, the authors translated PAS into Korean. The PAS-K, Geriatric Depression Scale, Hamilton Depression Rating Scale, Hachinski Ischemic Scale and Mini-Mental State Examination-Korean version were administered to 291 subjects over the age of 60 and the same number of their informants(67 subjects were institutionalized, 168 subjects were in community, 58 subjects were psychiatric hospital patients). And the Diagnostic Interview Schedule(DSM-Ⅲ-R) was independently administered to exactly diagnose dementia and depression. The reliability and validity test, optimal cut-off point estimation for six each scale and ROC curve analyses were done to investigate the diagnostic validity of PAS-K. Results : Internal consistency and interrater reliability of the PAS-K were high. Concurrent validity of each scales of PAS-K was good in being measured with other standardized scales. The optimal cut-off points of each scale of the PAS-K were estimated as follows : 1) Stroke Scale of subject interview : 1, 2) Cognitive Impairment Scale of subject interview: 10, 3) Depression Scale of subject interview : 5, 4) Stroke Scale of informant interview : 1, 5) Cognitive Decline Scale of informant interview : 3, and 6) Behavioral Change Scale of informant : 2. conclusions : The PAS-K was valid and reliable screening tools for detecting dementia and depression. Therefore the PAS-K could be widely and extensively used in psychogeriatric epidemiological research or clinical setting of primary screening for dementia and depression.

      • SCOPUSSCIEKCI등재

        골격성 Ⅲ급 부정교합자의 두개안면형태에 대한 하악이부의 형태 및 하악절치의 위치에 대한 연구

        김성식,박재억,손우성 대한치과교정학회 1998 대한치과교정학회지 Vol.28 No.5

        골격성 Ⅲ급 부정교합자의 두개안면골격형태가 하악이부형태와 하악전치의 위치에 미치는 영향을 알아보고자 연구를 시행하였다. 전후방적인 악골부조화가 나타나지 않고 교정치료의 경험이 없는 만 20세 이상의 성인남녀(정상군)와, 하악전돌의 악골부조화를 보이며 교정치료의 경험이 없는 만 20세 이상의 성인남녀(하악전돌군)를 비교하여, 두개안면골격형태에 따른 하악이부형태와 하악전치의 위치에 관하여 다음과 같은 결론을 얻었다. 1. 두개안면골격형태의 비교에서 하악에 관련된 ∠SN-Mn, ∠FMA, ∠Pal-Mn, ∠LFH은 하악전돌군이 정상군에 비하여 크게 나타났지만, (p<0.05) 상악에 관련된 항목은 차이를 나타내지 아니하였다(p>0.05). 2. 하악전치를 둘러 싸고 있는 치조돌기는 하악전돌군이 정상군에 비해서 수평적으로 좁고, 수직적으로 긴 형태를 나타내었다(p<0.05). 하악이부의 형태에서도 수평적으로는 하악전돌군이 정상군에 비해서 좁게 나타났으나, 수직적으로는 차이를 나타내지 아니하였다(p>0.05). 3. 하악전돌군의 두개안면골격형태와 이부계측항목과의 상관관계에서 두개저와 하악하연에 기인하는 수직적인 악골부조화가 증가할수록 LaABH, LiACBW, LaACBW, LiABBW, SW, ∠LISA가 감소하는 역상관계를 나타냈지만(p<0.05), 전후반적인 악골부조화와는 별다른 상관관계가 나타나지 않았다(p>0.05). 4. 하악전돌군에서 수직적인 두개안면골격형태를 나타내는 ∠SN-Mn, ∠FMA, ∠Pal_Mn, ∠LFH와 하악이부의 계측항목인 ∠LiACBW. LiaBBW, SW, ∠LISA사이에 높은 상관관계가 존재하여, 수직적인 악골부조화로 하악이부의 형태와 하악전치의 경사도를 예측할 수 있었다(p<0.001). The purpose of this study was to evaluate the morphology of mandibular symphysis and location of lower incisor under the influence of the craniofacial skeleton in skeletal Class III malocclusion. The sample consisted of 132 adults who have severe Class III malocclusion (prognathism group, 33 males and 33 females), and who have normal occlusion (normal group, 33 males and 33 females). They had not received any orthodontic treatment or orthognathic surgery. The lateral cephalograms were evaluated. The results were as follows: 1. Prognathism group were larger than normal group in comparison of facial skeleton (p<0.05) with the exception of ∠FH-Pal, ∠SNA. 2. In the morphology of symphysis, measurements of anteroposterior width(LaABBW, LiABBW, SW) of prognathism group were significantly less than that of normal group(p<0.001). 3. In the correlative analysis between the craniofacial skeleton and symphysis measurements of prognathism group, vertical measurements in relation with cranial base and mandibular plane showed reverse correlationship with anteroposterior with of symphysis(LiACBW, LaACBW, LiABBW, SW)(p<0.05). But, there was not distinct difference between horizontal skeletal measurements and symphysis measurements(p>0.05). 4. The probability by regression test between vertical measurements(∠SN-Mn, ∠FMA, ∠Pal-Mn, ∠LFH) and symphysis measurements(LiACBW, LiABBW, SW, ∠LISA)were very high(p<0.001).

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