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미니돼지에서 Acellular dermal matrix에 배양된 치주인대섬유모세포을 이용한 자가치아이식술: 치주인대로써의 잠재력에 대한 조직학적 평가
유상준,김병욱,박주철,장현선,Yu, Sang-Joun,Kim, Byung-Ock,Park, Joo-Cheol,Jang, Hyun-Seon 대한치주과학회 2007 Journal of Periodontal & Implant Science Vol.37 No.1
The aim of this study was to examine the possibility of periodontal ligament regeneration when autotransplantation was used by the periodontal ligament fibroblasts cultured on the acellular dermal matrix in teeth without a periodontal ligament. One minipig was used in this study. The mandibular and maxillary permanent incisors were ex-tracted for the culture of the periodontal ligament cells. The roots of the unextracted teeth were classified into a positive control group, in which the normal periodontal ligament was preserved. The roots of the extracted teeth were divided into the following two groups: The negative control group, in which the periodontal ligament had been removed and the acellular dermal matrix was not applied; and an experimental group, in which the periodontal ligament had been removed and periodontal ligament fibroblast cultured on an acellular dermal matrix was applied. The prepared teeth were transplanted, and completely submerged using physical barrier membranes. The animal was sacrificed 4 weeks after the autotransplant. The transplanted teeth were examined histologically. In this study, the periodontal ligament was normal in the positive control group, and ankylosis was discovered on the denuded root surface in the negative control group. Periodontal ligament-like connective tissue was found adjacent to the denuded root and the new cementum-like layer of hard tissue was formed in the experimental group. These results suggest that the periodontal ligament fibroblasts cultured on the acellular dermal matrix may play a role in regenerating the periodontal ligament-like tissue with new cememtum-like tissue formation.
Multiparametric magnetic resonance imaging for prostate cancer: A review and update for urologists
유상준,김정곤,정인갑 대한비뇨의학회 2015 Investigative and Clinical Urology Vol.56 No.7
Recently, imaging of prostate cancer has greatly advanced since the introduction of multiparametric magnetic resonance imaging (mpMRI). mpMRI consists of T2-weighted sequences combined with several functional sequences including diffusion-weighted imaging, dynamic contrast-enhanced imaging, and/or magnetic resonance spectroscopy imaging. Interest has been growing in mpMRI because no single MRI sequence adequately detects and characterizes prostate cancer. During the last decade, the role of mpMRI has been expanded in prostate cancer detection, staging, and targeting or guiding prostate biopsy. Recently, mpMRI has been used to assess prostate cancer aggressiveness and to identify anteriorly located tumors before and during active surveillance. Moreover, recent studies have reported that mpMRI is a reliable imaging modality for detecting local recurrence after radical prostatectomy or external beam radiation therapy. In this regard, some urologic clinical practice guidelines recommended the use of mpMRI in the diagnosis and management of prostate cancer. Because mpMRI is the evolving reference standard imaging modality for prostate cancer, urologists should acquire cutting-edge knowledge about mpMRI. In this article, we review the literature on the use of mpMRI in urologic practice and provide a brief description of techniques. More specifically, we state the role of mpMRI in prostate biopsy, active surveillance, high-risk prostate cancer, and detection of recurrence after radical prostatectomy.
유상준,박성한,임재림,서정민,장성호,홍성철,이병인 대한상하수도학회 2014 상하수도학회지 Vol.28 No.4
This study assessed the removal efficiency of NOM which is known as the precursors of DBPs in advanced water treatment using the ceramic membrane filtration, introduced the first in the nation at the Y water treatment plant (WTP). It is generally well-known that the removal of NOM by MF Membrane is very low in water treatment process. But, the result of investigation on removal efficiency of NOM in advanced water treatment using the ceramic membrane was different as follows. The removal rate of organic contaminant by the ceramic membrane advanced water treatment was determined to be 65.5% for the DOC, 85.8% for UV254, and 77 to 86% for DBPFP. The removal rate of pre-ozonation was found to be 6 to 15% more effective compared with the pre-chlorination. The removal rate of DOC and UV254 in biological activated carbon(BAC) process was over 50% and 75%, respectively although the rate was decreased 10 ~ 20% according to analysis items in converting from GAC to BAC.
유상준,한경도,김광택,최우석,하윤석,김정현,곽철 대한비뇨기종양학회 2023 대한비뇨기종양학회지 Vol.21 No.1
Purpose: The purpose of this study was to evaluate the incidence rate and trend of bladder cancer in South Korea using a nationwide database. In addition, we aimed to determine the risk factors and their influence on the incidence of bladder cancer. Materials and Methods: We extracted data from the health insurance database and estimated the incidence rate of newly developed bladder cancer from 2007 to 2019. In addition, we conducted further analysis of 10,210,654 individuals who underwent general health check-ups in 2009 to investigate the risk factors for bladder cancer. Variables associated with bladder cancer were evaluated using Cox regression analysis. Results: Bladder cancer significantly increased especially in the last 10 years. In 2019, 21.07 people per 100,000 were diagnosed with bladder cancer, whereas 13.62 people per 100,000 were diagnosed with bladder cancer in 2007. The compound annual increase rate from 2007 to 2019 was 3.7%. Among 10,210,654 individuals who had general health check-ups in 2009, bladder cancer was diagnosed in 83 people per 100,000 population in the 10-year follow-up. After adjusting for other variables, smoking-related variables were most significantly associated with bladder cancer incidence, followed by metabolic syndrome and its related variables. In the further analysis of the effect of smoking on bladder cancer according to sex, the smoking amount was more significantly associated with bladder cancer incidence in women compared to that in men. Conclusions: The crude incidence of bladder cancer continuously increased in South Korea during the last 10 years. Smoking, in addition to sex, age, and metabolic syndrome-related variables, was significantly associated with bladder cancer, especially in women.