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서울의 Penicillinase Producing Neisseria Gonorrhoeae 발생빈도(1996)
김재홍,황동규,전재홍,김윤석,김중환,김용준,이창균,임동진,김현수,조창근,김경문,박상훈,전우형,김희성,이호정,차명수,김갑형,김형석,김석우,황지환,박병순,권오상,이민수,송기훈,성소영,이인섭,부태성 대한화학요법학회 1999 대한화학요법학회지 Vol.17 No.2
Background : In recent years, gonorrhea has been panedemic and remains one of the most commom STDs in the world, especially in developing countries. Objective & Methods: For the detection of a more effective therapeutic regimen and assessing the prevalence of PPNG, we have been trying to study the patients who have visited the VD Clinic of Choong-Ku Public Health Center in Seoul since 1980 by means of the chromogenic cephalosporin method. Results: In 1996, 139 strains of N. gonorrhoeae were isolated, among which 53(39.0%) were PPNG. Conclusion: Our results suggests that after a peak of 74.3% in 1993, the prevalence of PPNG in Seoul is gradually declining.
정진우,염석란,조석주 대한응급의학회 2003 대한응급의학회지 Vol.14 No.1
Fenfluramine is an amphetamine-derived substance first developed in the late 1960s for appetite control. Because of its known side effects at therapeutic doses, it is now controlled by the government and has been withdrawn from the market, but the underground market is still big. When overdosed, it can produce a wide range of neurologic and car diovascular symptoms, and even death, when a large amount is ingested. We report two cases of acute fenfluramine overdose: a fatal case with generalized seizure and pulseless electrical activity, and a case of relatively mild intoxication.
Xanthelasma successfully treated with the novel 1,927-nm diode laser
( Hyun Seok Choi ),( Won Seon Koh ),( Hyoung Il Kwon ),( Eun Jin Kim ),( Jeong Eun Kim ),( Jooyeon Ko ),( Young Suck Ro ) 대한피부과학회 2016 대한피부과학회 학술발표대회집 Vol.68 No.1
Xanthelasma is a cutaneous xanthoma characterized by slightly raised, yellow, soft plaque on the eyelids. There are several therapeutic approaches including surgical resection, chemical peeling, carbon dioxide laser, Erbium:YAG laser, or electrodessication but, treatment outcomes vary. The novel 1,927-nm diode laser may provide a more localized heating and a higher affinity in fat because the 1,927-nm wavelengths promote greater water and fat absorption than previous wavelengths. A 53-year old woman presented with 6-year history of 1 cm-sized asymptomatic yellowish plaque at the medial canthus of both upper eyelid. She had a history of unknown laser treatment at local clinic, but it recurred after 3 months. She was diagnosed with xanthelasma and received three sessions of treatment with the novel 1,927-nm diode laser (XLENDER^{®}, Won Tech., Daejeon, Korea). After treatment, skin lesion almost resolved and no relapse has been noted for 9 months. Another 41-year old woman presented with asymptomatic 6~7 mm-sized yellowish papule at the both upper eyelid. She was diagnosed with xanthelasma and received treatment with the novel 1,927-nm diode laser. After one session of laser treatment, she also remarkably improved without any adverse effect. Herein, we report two cases of xanthelasma which showed clinical improvement with the novel 1,927-nm diode laser and suggest that it could be considered as an alternative option in treating xanthelasma.
Vitiligo developed in a patient with cutaneous lupus erythematosus
( Hyun Seok Choi ),( Won Seon Koh ),( Hyoung Il Kwon ),( Eun Jin Kim ),( Jeong Eun Kim ),( Joo Yeon Ko ),( Young Suck Ro ) 대한피부과학회 2016 대한피부과학회 학술발표대회집 Vol.68 No.1
Vitiligo is a common dermatological disorder characterized by depigmented macules and patches due to progressive loss of melanocytes. It has been associated with various autoimmune disorders such as autoimmune thyroid disease, rheumatoid arthritis, psoriasis, type 1 diabetes, and Addison’s disease. However, few cases of vitiligo coexisting with systemic lupus erythematosus (SLE) have been reported. A 35-year-old man presented with 15-year history of erythematous patches and plaques on the face, neck, trunk, and extremities. Also, peripheral hypopigmentation around erythema subsequently developed during recent 3 years. He was diagnosed with SLE 15 years ago and has been treated with systemic steroid and anti-malarials. Serological tests showed antinuclear antibodies at a titer of 1:2560 and positive anti-nRNP. Histopathologic findings from erythematous lesion were compatible with cutaneous lupus erythematosus (CLE). With intralesional steroid injection and topical tacrolimus, CLE lesions showed improvement while peripheral depigmented patches gradually enlarged. Biopsy specimen from depigmented patch with melan-A and fontana silver staining showed absence of melanocyte in the basal layer of epidermis. These were consistent with vitiligo, and the diagonosis of vitiligo developed in CLE was made. Herein, we report a rare case of vitiligo that developed in a patient with CLE, which has rarely been reported in the dermatologic literatures.
( Dong Seok Shin ),( Young Wook Ko ),( Dong Uk Cheon ),( Byeong Jin Park ),( Jeong Eun Kim ),( Joo Yeon Ko ),( Young Suck Ro ) 대한피부과학회 2018 대한피부과학회 학술발표대회집 Vol.70 No.2
Background: Alitretinoin is a first generation retinoid indicated for moderate to severe chronic hand eczema (CHE) resistant to topical steroid therapy. The efficacy and safety of oral alitretinoin in Asian patients with CHE has rarely been studied. Objectives: The aim of this study was to evaluate the efficacy and safety of oral alitretinoin in the treatment of CHE in Korean patients under daily real life, which admitted concomitant use of topical corticosteroids. Methods: We performed a retrospective study of 110 Korean patients diagnosed as CHE. Participants were treated with oral alitretinoin for at least 4 weeks and were divided into 4 groups according to the treatment periods (4-8, 8-16, 16-24, ≥24 weeks). We compared the treatment success rate and recurrence rate among the groups. Results: Treatment success rate was 73.63% (n=81) and recurrence rate was 43.21% (n=35). Treatment success rate appeared to be significantly higher in groups treated for more than 16 weeks than that of group treated for 4-8 weeks. In the aspect of recurrence rate, there was no statistically significant difference among the 4 groups but recurrence rate tended to decrease as treatment duration got longer. Conclusion: We confirmed that oral alitretinoin therapy showed higher treatment success rate for Korean patients with CHE under daily real life compared with previous reports but frequent relapse of the disease was observed with treatment cessations.
A case of subungual extraskeletal chondroma
( Hyun Seok Choi ),( Won Seon Koh ),( Jae Min Shin ),( Eun Jin Kim ),( Jeong Eun Kim ),( Joo Yeon Ko ),( Young Suck Ro ) 대한피부과학회 2016 대한피부과학회 학술발표대회집 Vol.68 No.1
Extraskeletal chondroma is a relatively uncommon, benign tumor that occurs in soft tissue, without adhesion to the underlying bone. It is usually solitary and may attach to tendon, tendon sheaths, or joint capsule. Although the most common site is hand, consisting of more than 60% of all extraskeletal chondromas, a few case of testis, liver and subungual area have been documented. A 59-year-old woman presented with solitary hyperkeratotic nodule on right first toe. Skin lesion had gradually developed over a period of 15 years. She complained of mild pain and tenderness on palpation. On physical examination, a 0.8 x 0.4 cm sized nodule was on the medial side of toenail with nail deformity. We planned to perform an incisional biopsy, but well-circumscribed mass was observed after partial nail extraction and we removed the mass completely. Histopathologically, epidermis showed hyperkeratosis, parakeratosis, and irregular acanthosis and there was a fibrous and hyalinized stroma composed of plump chondrocytes with distinctive reniform and elonaged nuclei and partially concomitant calcification. From these findings, she was diagnosed with subungual extraskeletal chondroma. The nail regenerated without deformity and there was no recurrence over 10 months. Herein, we report a case of subungual extraskeletal chondroma and clinicians should consider it as a differential diagnosis when a subungual nodular lesion occurs.
공복이 정상 성인의 십이지장 점막 유당분해효소 활성도에 미치는 영향
김진호,송인성,이명석,이창홍,박영태,최인석 대한내과학회 1986 대한내과학회지 Vol.31 No.3
In order to investigate the fasting effect on duodenal lactase activity in normal adult, 41 cases after NPO for 12hra (basal study) and 11 cases after NPO for 60 hrs were evaluated. The following results were obtained in this study; 1) The lactase activity and sucrase activity in duodenal 2nd portion were 2.01±1.47, and 34.00±22.63mu/mg protein(mean±SD). 2) The lactase activity and sucrase activity in NPO for 48 hrs after basal study were 2.15±40.25, and 14.18±14.68mu/mg protein. The sucrase activity was reduced significantly compare to that of basal activity but the lactase activity was not changed significantly. 3) Marked increase of lactase activity in 2 cases and. decrease in 1 case were noted in 48 hrs after basal study, but its interpretation needs further investigation by more cases evaluated.