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컴포넌트 가변성 유형 및 Scope에 대한 정형적 모델
소동섭,신규석,김수동 한국정보과학회 2003 정보과학회논문지 : 소프트웨어 및 응용 Vol.30 No.5
시스템 개발 시 복잡성을 감소시키고 개발 비용과 기간을 단축하기 위하여 컴포넌트 기반 개발(CBD)이 산업계에서 보편화 되고 있다. 그러나, 현재 대표적인 CBD는 한 회사나 하나의 어플리케이tus에 의존적인 컴포넌트를 개발하고 있다[1,2]. 따라서 어떤 도메인의 여러 패밀리에서 컴포넌트를 재사용하기 위한 컴포넌트 가변성이 강조 되고 있다. 하지만, 컴포넌트 가변성의 정의나 유형에 대해 구체적으로 제시된 연구가 미흡하여, 컴포넌트의 주 목적인 재사용 측면보다. 유지보수 목적의 컴포넌트가 개발되고 있다[3]. 본 논문에서는 컴포넌트의 재사용성을 높이기 위하여, 컴포넌트 특징을 반영한 컴포넌트 가변성을 정형적으로 정의한다. 또한, 기존의 컴포넌트 가변성으로 인식된 논리 가변성을 명확하게 정의하고, 추가로 3가지 가변성 유형을 제시함으로써, 컴포넌트에서 존재하는 모든 가변성 유형을 제시한다. 컴포넌트 커스터마이제이션시에 가변성의 경우의 수를 예측, 확인 할 수 있는 컴포넌트 가변성 Scope를 제시한다. 컴포넌트 개발에 있어서 이러한 기법을 적용함으로써, 여러 패밀리 멤버에서 재사용 할 수 있는 고품질의 컴포넌트 개발을 지원 할 수 있다. Component-based development(CBD) has been generalized in industry to master the complexity and reduce the development cost and time. However, current CBD practice is developing the component which is dependent on single application[l][2]. Therefore component variability is emphasized to reuse the component in many family members in a domain[8]. However, components are developed for the reason of replaceability rather than the reusability which is the main purpose of the component due to the insufficiency of the study of component variability definition and type[3]. In this paper, we formally specify the component variability reflecting the characteristics of the component to increase the component reusability. We define the logic variability which was recognized as the existing component variability and we propose all types of variability existing in the component by suggesting three more variability types. And we propose the component variability scope which makes us estimate and verify the number of cases of the variability when we customize the component. We propose these component variability types and scope through formal specification. By applying these techniques in developing components, we can develop high quality components reusable in many family members.
Mitomycin이 Mouse 간장의 인산염분해 효소에 미치는 영향
정호삼,신규석,이군자,이규식 한양대학교 의과대학 1986 한양의대 학술지 Vol.6 No.1
Mitomycin (MC), a wide spectrum antibiotic and anticancer drug, is isolated from streptomyces caespitosus. MC decomposes DNA in cancer cell by forming a complex with DNA and inhibits division of cancer cells by interfering with the biosynthesis of DNA. In the normal cell, MC cross linkes with DNA and inhibits synthesis of RNA and protein. Therefore MC causes many complication in the MC treated patient. The authers have investigated the effect of MC on the mouse liver histochemically observing the change in the activities of alkaline phosphatase and ATPaes. Male mouse, DDY strain, weighing about 20 grams was used as experimental animals. The experimental animals were divided into the control and MC treated group and given food and water unlimited. The animals treated with 4mg of MC per kilogram of body weight were sacrificed at 6, 12, 24, 36 and 48 hour after administration. The animals of control groups were administered only water for injection. The liver specimens were fixed in 10% formalin solution at 4℃ and sliced at 14㎛ thickness in a frozen cryostat. The activities of alkaline phosphatase were observed by the Gormori's method and those of ATPase were observed by the Wachstein-Meisel's method for histochemical study. The result are as follows. 1. As the time passed, the activity of alkaline phosphatase activity was decreased in the hepatic lobule. Negative reactions were showed in the central and intermediate zone of the lobule of 36 hours of MC treated group. Trace activities of the enzyme were observed in the whole hepatic lobule of 48 hours of MC treated group. 2. As the time goes by, the activity of adenosine triphosphatase was decreased in the hepatic lobule. Negative reactions were observed in the entire hepatic lobule of 36 hours of MC treated group. Weak activity of the enzyme were observed in the whole hepatic lobule of 48 hours of MC treated group. Consequently, it is suggested that MC causes decrease in activities of hepatic alkaline phosphatase and ATPase due to live damage by cross linking of DNA with the drug in the hepatocyte and destructive change of organelles of the cell.
김명환,신규석,변종훈,두창준,소군호,고정석,진교현,김서종 대한소화기내시경학회 2000 Clinical Endoscopy Vol.20 No.2
A choledochal cyst is relatively rare lesion in the biliary system, and a carcinoma arising from such a cyst is rarely reported. Until now, a case of a hepatocellular carcinoma combined with a choledochal cyst had not been reported. A 45-year-old woman was recently admitted due to abdominal pain. An abdominal computed tomography revealed a 5 cm-sized low attenuative mass involving the right anterior and left medial segment of the liver and gallbladder fossa. An endoscopic retrograde cholangiopancreatogram showed fusiform dilatation of the common bile duct, but anomalous union of pancreaticobiliary duct was not observed. Fine-needle aspiration of the liver was conducted and yielded a hepatocellular carcinoma. On celiac arteriography, a hypervascular hepatic mass was also found. Transarterial chemoembolization was performed. It is believed this may be the first case of a choledochal cyst combined with a hepatocellular carcinoma in the literature. Hence, this case is herein reported with a review of related literatures.