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Oleoylethanolamide induces eosinophilic airway inflammation in bronchial asthma
Kwon Eun-Kyung,최영우,Yoon Il-Hee,Won Ha-Kyeong,심소윤,Lee Hee-Ra,Kim Hyoung Su,예영민,신유섭,박해심,Ban Ga-Young 생화학분자생물학회 2021 Experimental and molecular medicine Vol.53 No.-
Asthma is a chronic eosinophilic inflammatory disease with an increasing prevalence worldwide. Endocannabinoids are known to have immunomodulatory biological effects. However, the contribution of oleoylethanolamide (OEA) to airway inflammation remains to be elucidated. To investigate the effect of OEA, the expression of proinflammatory cytokines was measured by RT-qPCR and ELISA in airway epithelial (A549) cells. The numbers of airway inflammatory cells and cytokine levels in bronchoalveolar lavage fluid, airway hyperresponsiveness, and type 2 innate lymphoid cells (ILC2s) were examined in BALB/c mice after 4 days of OEA treatment. Furthermore, eosinophil activation after OEA treatment was evaluated by measuring cellular CD69 levels in eosinophils from human peripheral eosinophils using flow cytometry. OEA induced type 2 inflammatory responses in vitro and in vivo. OEA increased the levels of proinflammatory cytokines, such as IL-6, IL-8, and IL-33, in A549 cells. In addition, it also induced eosinophilic inflammation, the production of IL-4, IL-5, IL-13, and IL-33 in bronchoalveolar lavage fluid, and airway hyperresponsiveness. OEA increased the numbers of IL-5- or IL-13-producing ILC2s in a mouse model. Finally, we confirmed that OEA increased CD69 expression (an eosinophil activation marker) on purified eosinophils from patients with asthma compared to those from healthy controls. OEA may play a role in the pathogenesis of asthma by activating ILC2s and eosinophils.
( Hyoung Il Kwon ),( Hyun Seok Choi ),( Sung Soo Han ),( Young Gyun Kim ),( Joung Soo Kim ) 대한피부과학회 2017 大韓皮膚科學會誌 Vol.55 No.1
Granuloma annulare is a relatively common benign dermatosis of unknown etiology. It is typically characterized by skin-colored to violaceous annular or arcuate lesions. The localized form of the disease usually resolves spontaneously, but treatment may be required in cases of intractable symptoms such as pruritus, or for cosmetic purposes. Herein, we report the case of a 65-year-old man diagnosed with a localized form of granuloma annulare that was refractory to various treatments but showed clinical improvement with a combined regimen of excimer laser and topical tacrolimus. (Korean J Dermatol 2017;55(1):65∼67)
Efficacy and Safety of Alitretinoin for Chronic Hand Eczema in Korean Patients
( Hyoung Il Kwon ),( Jeong Eun Kim ),( Joo Yeon Ko ),( Young Suck Ro ) 대한피부과학회 2016 Annals of Dermatology Vol.28 No.3
Background: Chronic hand eczema (CHE) tends to be refractory to conventional therapy. Previous clinical trials have found that a 24-week treatment course of oral alitretinoin is effective and well tolerated for CHE treatment. Objective: The aim of this study was to investigate the efficacy and safety of oral alitretinoin in Korean CHE patients. Methods: A total of 27 patients with moderate to severe CHE took 30 mg of alitretinoin daily for 12 weeks. The primary efficacy parameter was the physician’s global assessment (PGA). The response was defined as a patient being “clear” or “almost clear” of disease. The secondary efficacy parameters were the modified total lesion symptom score (mTLSS) and the patients’ global assessment (PaGA). All adverse events and laboratory abnormalities were recorded during the treatment period. Results: Alitretinoin led to CHE symptom improvement in 44.4% of patients. The PGA, mTLSS, and PaGA scores correlated well with each other. Reported adverse events were typical retinoid class effects and headache was the most common. Conclusion: Taking 30 mg of oral alitretinoin daily for 12 weeks was found to be effective in treating Korean patients with CHE, compared with the 24 week-treatment shown in previous studies. (Ann Dermatol 28(3) 364∼370, 2016)
FCT 8 : Lichen nitidus successfully treated with topical retinoid
( Hyoung Il Kwon ),( Eun Jin Kim ),( Jeong Ho Hong ),( Jeong Eun Kim ),( Joo Yeon Ko ),( Young Suck Ro ) 대한피부과학회 2014 대한피부과학회 학술발표대회집 Vol.66 No.1
Lichen nitidus is a chronic inflammatory skin disease characterized by a large number of asymptomatic skin-colored or erythematous millimetric papules. Topical or systemic steroids, topical tacrolimus, PUVA and NB-UVB may yield various results. Also, retinoids are thought to have anti-inflammatory and antiproliferative effects and there are a few reported cases of lichen nitidus treated with oral retinoids. However, there was no reported case that tried topical retinoid to treat lichen nitidus. A 51-year-old man presented with asymptomatic tiny flat-topped, flesh-colored papules clustered on both sides of abdomen for 20 years. Histopathologic examination showed typical features of lichen nitidus which is well circumscribed lymphocytic infiltrate closely confined to a widened dermal papillae, so called “claw clutching a ball” pattern. From these findings, we diagnosed this case as lichen nitidus. We tried topical retinoid on the right side and topical steroid on the left side of the abdomen to compare the therapeutic effects between two topical agents. After 3-months, the retinoid side had better response than steroid side, although flattening of papules and pigmentation showed on both side. Herein, we present a man with lichen nitidus who was successfully treated with topical retinoid.
증 례 : 선국소피부경화증에서 진행하여 경화 태선을 동반한 전신국소피부경화증
권형일 ( Hyoung Il Kwon ),홍정호 ( Jeong Ho Hong ),김정은 ( Jeong Eun Kim ),고주연 ( Joo Yeon Ko ),노영석 ( Young Suck Ro ) 대한피부과학회 2015 대한피부과학회지 Vol.53 No.9
Morphea is an autoimmune condition characterized by excessive accumulation of collagen in the skin and underlying tissues. Lichen sclerosus (LS) is another connective tissue disease for which an autoimmune cause has been proposed, given the high association with other autoimmune diseases. The coexistence of morphea and lichen sclerosus has been sometimes reported in the literature, and is suggestive of a common pathogenic background between the two diseases. Among various types of morphea, generalized morphea has been associated with an increased rate of autoimmune disease, including LS. We report a case of extragenital LS during the progression of linear morphea into generalized morphea. (Korean J Dermatol 2015;53(9):713∼716)
권형일 ( Hyoung Il Kwon ),오의현 ( Eui Hyun Oh ),정연도 ( Yun Do Jung ),고주연 ( Joo Yeon Ko ) 대한피부과학회 2018 大韓皮膚科學會誌 Vol.56 No.10
Vitiligo is a multifactorial disorder. Neural, biochemical, and autoimmune mechanisms have been hypothetically suggested as etiopathological contributors to this condition. Autoimmunity focuses primarily on genetic factors and the association between vitiligo and other autoimmune disorders including autoimmune thyroid disease, rheumatoid arthritis, psoriasis, type 1 diabetes, pernicious anemia, and Addison’s disease. We describe a 35-year-old man with systemic lupus erythematosus who developed concurrent vitiligo and discoid lupus erythematosus suggesting the possible autoimmune association between these 2 different diseases. (Korean J Dermatol 2018;56(10):620∼623)