임부의 연령에 따른 보완대체요법에 관한 인식 태도 경험 비교 연구

김연진,김지연,노경민,신혜리,유예지,이지민,장희조,정아인,최소정,강숙정,이향연,민혜영 이화여자대학교 간호과학대학 2016 이화간호학회지 Vol.- No.50

Purpose: This study aims to test if the age of pregnant women affects the perception, experience, and attitude towards complementary alternative therapy (CAT), by investigating the perception, experience, and attitude of pregnant women under the age of 35, and above 35 (Advanced Maternal Age). The study will 1) find the general characteristics of pregnant women under and over the age of 35 2) compare the perception, behavior, and experience of pregnant women under and over the age of 35, and 3) find the comparison of the perception, behavior, and experience according to the general characteristics of pregnant women under and over the age of 35. Method: The subjects of this study are composed of 44 women under the age of 35 and 44 women above the age of 35, totaling 88 pregnant women visiting midwiferies, obstetrics and gynecology, and baby fairs in Seoul and Gyeong-Gi area. Data for this study was collected from November 28, 2015 to January 6, 2016 for 40 days. The collected data analyzed mean, standard deviation, t test, ANOVA, and chi-square by using SPSS 23.0. Result Results show that there is a significant difference in the perception, attitude, and experience of the two-sample groups in the use of CAT. The question of “what is most necessary when applying CAT in a hospital clinical environment” for the perception criteria came out with the results of t=9.980, p<.05. For the attitude, results showed that the answers of pregnant women under the age of 35 displayed a more positive attitude towards CAT. (t=2.421, p<.05) Lastly, in the experience section, pregnant women under the age of 35 showed more CAT use than the other sample group. Conclusion Results have shown that there is a difference in the perception, behavior, and experience between the two sample groups. Therefore further research on the efficacy and the adverse effects of CAT needs to be done.

SCAMP5 links endoplasmic reticulum stress to the accumulation of expanded polyglutamine protein aggregates via endocytosis inhibition.

Noh, Jee-Yeon,Lee, Huikyong,Song, Sungmin,Kim, Nam Soon,Im, Wooseok,Kim, Manho,Seo, Hyemyung,Chung, Chul-Woong,Chang, Jae-Woong,Ferrante, Robert J,Yoo, Young-Jun,Ryu, Hoon,Jung, Yong-Keun American Society for Biochemistry and Molecular Bi 2009 The Journal of biological chemistry Vol.284 No.17

<P>Accumulation of expanded polyglutamine proteins is considered to be a major pathogenic biomarker of Huntington disease. We isolated SCAMP5 as a novel regulator of cellular accumulation of expanded polyglutamine track protein using cell-based aggregation assays. Ectopic expression of SCAMP5 augments the formation of ubiquitin-positive and detergent-resistant aggregates of mutant huntingtin (mtHTT). Expression of SCAMP5 is markedly increased in the striatum of Huntington disease patients and is induced in cultured striatal neurons by endoplasmic reticulum (ER) stress or by mtHTT. The increase of SCAMP5 impairs endocytosis, which in turn enhances mtHTT aggregation. On the contrary, down-regulation of SCAMP5 alleviates ER stress-induced mtHTT aggregation and endocytosis inhibition. Moreover, stereotactic injection into the striatum and intraperitoneal injection of tunicamycin significantly increase mtHTT aggregation in the striatum of R6/2 mice and in the cortex of N171-82Q mice, respectively. Taken together, these results suggest that exposure to ER stress increases SCAMP5 in the striatum, which positively regulates mtHTT aggregation via the endocytosis pathway.</P>

Cellular regulators of polyQ-track protein aggregation and Huntington's disease

Noh, Jee-Yeon,Jung, Yong-Keun 이화여자대학교 세포신호전달연구센터 2008 고사리 세포신호전달 심포지움 Vol. No.10

Many of human disease are not well understood at molecular level yet, remaining an area for active research to identify and characterize genes critical in disease. We have developed cell-based assay systems to screen and isolate new genes playing a important role in the signaling pathways associated human disease, such as Alzheimer's disease, Huntington's disease, ischemia/hypoxia, and protein aggregation. With gain-of-function assay using full-length cDNAs in mammalian expression vector, we have screened regulatory genes modulating the reporter activity of cell-based assay. Especially in Huntington's disease, the aggregation of polyQ-track protein was assessed. From cell-based functional screening following ectopic expression of individual cDNA, we have isolated new genes modulating the aggregation of Huntingting^(exon1) proteins, including Huntington disease regulatory gene1(HRG1) and HRG2. Ectopic expression of HDRG1 induces ubiquitine-positive and detergent resistant aggregation of polyQ-track protein. Inversely, reduced expression of HDRG1 attenuates the aggregation of polyQ-track protein. From further analysis, we found that these genes playa role in ER stress-induced aggregation of polyQ-track protein. In addition, this protein was highly increased in the striatums of human HD patients. These results indicate that our cell-based assay using cDNA in expression vector will provide new insight into the efficient discovery of new drug target of human diseases and DHRG1 plays a critical role in the aggregation of polyQ-track protein.

The expression of VEGF receptor genes is concurrently influenced by epigenetic gene silencing of the genes and VEGF activation.

Kim, Jee Yeon,Hwang, Jun Ha,Zhou, Wei,Shin, Jieun,Noh, Seung Moo,Song, In Sang,Kim, Ji Yeon,Lee, Suk Hoon,Kim, Jei Landes Bioscience 2009 Epigenetics Vol.4 No.5

<P>Vascular endothelial growth factor (VEGF) activates the VEGF-VEGF receptor (VEGFR) signaling pathway in angiogenesis. Some cancer cell lines show decreased expression of the two VEGFRs, Flt-1 and KDR, even though VEGF is uniformly expressed in cancer cell lines. Promoter methylation is a well-known cause of epigenetic gene silencing in cancer cells. Although VEGF, Flt-1 and KDR have typical CpG islands in their promoter regions, the epigenetic transcriptional alterations of these genes have not yet been described. The present study evaluated the epigenetic gene silencing of VEGF and VEGFR genes in cancer tissues. We also analyzed whether the epigenetic alterations of VEGFR genes influence VEGFR expression concurrently with VEGF activation in cancer tissues. All cancer tissues we tested showed no methylation of VEGF, and variable promoter hypermethylation of Flt-1 and KDR. The promoter hypermethylation of Flt-1 and KDR was correlated with decreasing expression of the respective genes. In contrast, an increase in VEGF expression was positively correlated with Flt-1 and KDR expression in primary cancer tissues. The opposing influences of promoter methylation of VEGFR and increased VEGF expression concurrently influence Flt-1 and KDR expression in stomach cancer, colon cancer and hepatocellular carcinoma. The findings we observed showed that the epigenetic alteration developing in VEGFR genes might be an important factor to concurrently modulate expressions of the genes in addition to VEGF stimulation in cancer tissues. The epigenetic silencing of VEGFR genes should be considered in the activation of VEGF-VEGFR signaling pathway in the cancer cells.</P>

대장 협착을 유발한 Shigella flexneri 감염 1예

지중배,박종현,조용익,노창석,이수하,송정훈,이은빈,박남선,김은순,강석우,조삼권,한상택,김은나,서상렬,변형근,김수연,김영채,최현경,김용성 圓光大學校 醫科學硏究所 2005 圓光醫科學 Vol.20 No.1

Systematic Variation of Wintertime Precipitation in East Asia by MJO-induced Extratropical Vertical Motion

Yeon-Hee Noh,Jee-Hoon Jeong,Baek-Min Kim,Chang-Hoi Ho 한국기상학회 2006 한국기상학회 학술대회 논문집 Vol.2006 No.-

Treatment of rituximab in patients with idiopathic membranous nephropathy: a case series and literature review

( Soo-jee Jeon ),( Ji-hye Kim ),( Hee-won Noh ),( Ga-young Lee ),( Jeong-hoon Lim ),( Hee-yeon Jung ),( Jang-hee Cho ),( Ji-young Choi ),( Chan-duck Kim ),( Yong-lim Kim ),( Sun-hee Park ) 대한내과학회 2022 The Korean Journal of Internal Medicine Vol.37 No.4

Background/Aims: Membranous nephropathy (MN) is a major cause of nephrotic syndrome in adults. This study aimed to evaluate the effect of rituximab (RTX) in patients with idiopathic MN (iMN) who have a high risk of progression. Methods: We retrospectively analyzed data of 13 patients with iMN, who received RTX treatments from January 2014 to July 2020. RTX was indicated in patients with iMN with severe proteinuria and decreasing estimated glomerular filtration rate (eGFR) in the previous 6 months despite other immunosuppressive therapies. Results: The patients were predominantly males (n = 11) and with a mean age of 55.3 years; median eGFR, 37.0 mL/ min/1.73 m² (interquartile range [IQR], 26.3 to 66.5); serum albumin level, 2.6 g/dL (IQR, 1.9 to 3.1); and spot urine protein-to-creatinine ratio at baseline, 6.6 g/g (IQR, 5.7 to 12.9). In a median follow-up of 22 months, eight patients (61.5%) achieved complete or partial remission. In responder group (n = 8), median eGFR increased from 31.5 to 61.5 mL/min/1.73 m² (p = 0.049) and serum albumin level increased from 2.3 to 4.2 g/dL (p = 0.017) from RTX initiation to last follow-up. Antiphospholipase A2 receptor antibody (anti-PLA2R-Ab) was positive in six among seven tested patients, which markedly decreased in the responder group. There were no adverse events after RTX. Conclusions: This study suggests that RTX is a safe and effective treatment option for patients with iMN who have a high risk of progression. Individualized therapy based on anti-PLA2R-Ab titer would be needed for better outcomes.

긴장성 요실금 환자에서 Tension-Free Vaginal Tape 수술의 1년 추적 결과

한지혜 ( Jee Hye Han ),구연희 ( Yeon Hee Ku ),이경희 ( Kyung Hee Lee ),이유경 ( Yoo Kyung Lee ),박노현 ( Noh Hyun Park ),송용상 ( Yong Sang Song ),강순범 ( Soon Beom Kang ),이효표 ( Hyo Pyo Lee ) 대한산부인과학회 2007 Obstetrics & Gynecology Science Vol.50 No.5

목적: 긴장성 요실금 환자에 대해 실시한 TVT 수술의 결과와 초기 합병증에 대해 알아보고자 하였다. 연구방법: 2002년부터 2005년까지 서울대병원 산부인과에서 긴장성 요실금으로 진단 받고 TVT 수술을 받은 환자를 대상으로 하였다. 환자들의 의무기록을 바탕으로 필요한 정보를 조사하였으며, 수술 이후 추적 관찰을 통해 수술 성적과 합병증을 평가하였다. 결과: 총 164명의 환자를 대상으로 하였으며, 평균 연령은 52.0±9.6세, 평균 출산력은 2.5±1.2회, 평균 체질량 지수는 24.6±3.0 kg/m2이었다. TVT 수술만을 실시한 경우, 평균수술 시간은 37.0±16.4분, 평균 재원일수는 2.9±1.3일이었다. 수술 이후 도뇨관 유치기간은 평균 1.9±1.0일이었다. 수술 성공률은 수술 2개월 이후, 1년 이후가 각각 94.5%, 87.9%로 조사되었으며, 합병증은 경미한 합병증이 대부분이었다. 결론: 1년간의 단기 추적 결과 TVT 수술은 긴장성 요실금에 대한 안전하고 간편한 수술 방법임을 알 수 있었다. Objective: To evaluate one-year outcomes of tension-free vaginal tape (TVT) procedure in women with stress urinary incontinence (SUI). Methods: From 2002 to 2005, all patients with stress urinary incontinence undergoing the TVT procedure were enrolled in this retrospective study. All cases were diagnosed as SUI by the evidences in history, physical examination, and urodynamic study. Outcomes and post-operative complications were investigated from review of medical records and interview during post-operative follow-up. Results: Totally 164 cases were enrolled in this study. The success rates (cure or improved) of two-month and one-year after the TVT procedure were 94.5% and 87.9%, and the failure rates were 5.5% and 3.0%, respectively. The follow-up loss rate in one-year was 9.1%. There was no serious complication related to the procedure in one-year follow-up. Conclusion: This preliminary report indicates that the TVT procedure is a safe treatment modality for female SUI. Further investigation with long term follow-up is required to estimate cumulative success rate and late complications.

Polyploidization of Hepatocytes: Insights into the Pathogenesis of Liver Diseases

Kim Ju-Yeon,Choi Haena,Kim Hyeon-Ji,Jee Yelin,Noh Minsoo,Lee Mi-Ock 한국응용약물학회 2022 Biomolecules & Therapeutics(구 응용약물학회지) Vol.30 No.5

Polyploidization is a process by which cells are induced to possess more than two sets of chromosomes. Although polyploidization is not frequent in mammals, it is closely associated with development and differentiation of specific tissues and organs. The liver is one of the mammalian organs that displays ploidy dynamics in physiological homeostasis during its development. The ratio of polyploid hepatocytes increases significantly in response to hepatic injury from aging, viral infection, iron overload, surgical resection, or metabolic overload, such as that from non-alcoholic fatty liver diseases (NAFLDs). One of the unique features of NAFLD is the marked heterogeneity of hepatocyte nuclear size, which is strongly associated with an adverse liver-related outcome, such as hepatocellular carcinoma, liver transplantation, and liver-related death. Thus, hepatic polyploidization has been suggested as a potential driver in the progression of NAFLDs that are involved in the control of the multiple pathogenicity of the diseases. However, the importance of polyploidy in diverse pathophysiological contexts remains elusive. Recently, several studies reported successful improvement of symptoms of NAFLDs by reducing pathological polyploidy or by controlling cell cycle progression in animal models, suggesting that better understanding the mechanisms of pathological hepatic polyploidy may provide insights into the treatment of hepatic disorders.

부인암 여성의 증상 클러스터(Symptom Cluster)

전나미,권지연,노기옥,김상희 병원간호사회 2008 임상간호연구 Vol.14 No.1

Purpose: Women with gynecologic cancer often experience various physical and psychological symptoms relating to the cancer and its treatment. The purpose of this study was to identify symptom clusters. Method: A survey was conducted on 184 women with diagnoses of cervical, ovarian or endometrial cancer. Fifty symptoms were assessed for prevalence, severity and interference, and symptom clusters were identified. Cluster analysis was done using SPSS version 12.0. Results: Fatigue was identified as the most prevalent symptom (81.52%), lack of vaginal lubrication (2.26) as the most severe symptom, and lack of vaginal lubrication as the most interfering one (2.15). Identified six clusters were: Anorexia-pain cluster (loss of appetite, taste change, weight loss, appearance change, alopecia, weakness, pain), Fatigue cluster (lack of concentration, lack of memory, fatigue, dry mouth), Urinary-bowel distress cluster (urinary difficulty, constipation), Abdominal discomfort cluster (lower abdominal pain, abdominal pain, bloating), Emotional distress (sadness, anxiety-worry, nervousness, restlessness), and Menopausal cluster (sweating, hot flush, fever). Conclusion: The result of this study provides fundamental data to health care professionals in developing interventions for effective symptom management for women with gynecologic cancer by understanding identified 6 symptom clusters.