Al-Ti-Cr 합금계 L1_2기지 합금의 800℃에서의 상안정성

오민욱,이재경,오명훈,위당문 대한금속재료학회 2003 대한금속·재료학회지 Vol.41 No.1

Relationship between the phase stability and the composition of L1_2-based Ti-Al-Cr alloys at 800℃ was investigated. It was found that the yield strength of Al-21Ti-23Cr and Al-21Ti-15Cr alloys with Ti-lean composition after exposure at 800℃showed a relatively small increase compared with that of alloys homogenized at 1150℃. However, yield strength of al-30Ti-15Cr alloy with Ti-rich composition after exposure at 800℃ increased very remarkably. The difference in strength increment after exposure at 800℃ was due to the partial decomposition of L1_2 phase in Al-21Ti-23Cr and Al-21Ti-15Cr alloys, and the complete decomposition of L1_2 phase in al-30Ti-15Cr alloy. Therefore, alloys with Ti-lean composition were expected more suitable for light heat resistant and oxidation resistant coating material with respect to stability of L1_2 phase. It was also revealed that the phase decomposition of L1_2 phase resulted from the shift of L1_2 phase region to Al-rich corner in Al-Ti-Cr phase diagram with decreasing temperature.

뇌경색을 동반한 Haemophilus parainfluenzae에 의한 감염성 심내막염 1예

오은영,배상수,정윤재,이창근,이혁,김성민,박승우,백경란,송재훈 대한화학요법학회 1998 대한화학요법학회지 Vol.16 No.3

저자들은 뇌경색을 동반한 H. parainfluenzae에 의한 심내마염을 ampicillin과 gentamicin의 병합요법으로 치료한 1예를 경험하였기에, 이를 문헌고찰과 함께 보고하는 바이다. We experienced a case of infective endocarditis due to Haemophilus parainfluenzae complicated by cerebral infarction. A 40 year-old woman was admitted because of right-sided hemiparesis and dysarthria, which was accompanied by high fever up to 40 C with chills. She had been suffering from low-grade fever and general weakness for one month prior to admission. Blood cultures grew H. parainfluenzae, and the brain CT scan demonstrated cerebral infarction of MCA territory. Transesophageal echocardiogram showed mitral valve prolapse with regurgitation, and no vagetation was found. She was successfully treated with ampicillin and gentamicin for six weeks. To our knowledge, this is the first case of infective endocarditis caused by H. parainfluenzae in Korea.

自然型 接觸酸化法에 의한 都市下水 處理에 關한 硏究

오종민,김무훈,윤동선,박재영 경희대학교 산학협력기술연구원 1997 산학협력기술연구논문집 Vol.3 No.-

This study was performed to estimate the organic matter removal efficiency when apply to natural purification method with variable media. We used gravel, concrete, tire, scrubber as media of contact oxidation reactor. And when scrubber, gravel, the average SS, BOD, COD removal efficiency was very high(when scrubber, 96.3, 78.1, 59.0 % and gravel, 82.1, 73.8, 56.5 %, respectively). If the physical and chemical operations are added to contact oxidation process for the removal of nitrogen, phosphorous, the water quality of urban small stream which is polluted by municipal waste water will be purified.

외음부에 발생한 혈관근육섬유아세포종 1례

오혜근,구자봉,김동출,심재영,박정훈,박영균,임성철 조선대학교 2003 The Medical Journal of Chosun University Vol.28 No.1

We present a case of angiomyofibroblastoma of the vulva in a 32-year-old woman. The asymptomatic lesion measured 4×3cm and appeared as a gray-white myxoid mass on cut sections Histologically, it appeared as a relatively well-circumscribed spindle cell proliferation with alternating hypercellular and hypocellular areas and proliferation of thin-walled blood vessels. Immunohistochemically, the stromal cells expressed vimentin, CD34 and progesterone receptor, but not desmin, α-smooth muscle actin, S-100 protein and estrogen receptor. These features were similar to those of angiomyofibroblastoma as previously reported in the vulva except negativity for desmin A case of pathologically proven very rare tumor of angiomyofibroblastoma of the vulva is presented with a literature review

저유량 마취를 위한 전자제어식 기화기 개발

오영택,박재훈,장인배 江原大學校 産業技術硏究所 2009 産業技術硏究 Vol.29 No.B

For the environmental safety of the operating room and patient healthcare, the closed type rebreathing system is widely adopted. In order to reduce the anesthesia gas during surgery, the mixing ratio of anesthesia gas with breathing air should be precisely controlled. Generally, the breathing air passes through the vaporizer to mix the anesthesia gas, but there is a difficulty in controlling the mixing ratio precisely. In this paper, the stand-alone style vaporizer is designed and the operating characteristics are investigated. The vaporizer measures the temperature and pressure in the vaporizing chamber and chamber temperature is precisely controlled by proportional controlled heater. Exact quantity of anesthesia media is feeded by PID controlled peristaltic pump and vaporized gas is mixed with breathing air flow by PWM controlled solenoid valve. The experimental result shows that the vaporizer has an excellent command following performances that it can be applied to the low flow anesthesia system.

GSIS를 이용한 소하천 경계경보 발령기준 설정 및 관리방안에 관한 연구

오명진,박재훈 경복대학 2004 京福論叢 Vol.8 No.-

최근 홍수피해의 문제점을 분석해 보면 기상 이변으로 집중호우가 발생하고 특히, 국지적인 호우에 의한 돌발홍수(flash flood)로 인한 피해가 빈번하게 발생하고 있다. 대하천의 경우에는 각 홍수 통제소에 의한 홍수 예·경보시스템(flood warning system)을 통하여 인명 혹은 재산피해는 과거에 비하여 상당히 감소하였으나 소하천에서는 반대로 피해가 증가하고 있는 실정이다. 본 연구에서는 하천 지역의 돌발홍수의 특성을 밝혀 보고자 지형공간정보(GSIS, Geo-Spatial Information System)기법을 이용하였으며, 하천 유역의 수문학적 돌발홍수 예측모형을 GIUH(geomorphoclimatic instantaneous unit hydrograph) 기법으로 구축하였다. 본 연구를 통하여 구축된 돌발홍수 예·경보 시스템을 통하여 하천 지역에 있어서의 인명 및 재산피해를 상당부분 감소시킬 수 있을 것이며, 다른 지역의 돌발홍수 예·경보 시스템구축을 위한 기초 자료를 제공할 수 있을 것이다. Recently, local heavy rain for a short term is caused by unusual changing in the weather. This phenomenon has, several times, caused an extensive flash flood, casualties, and material damage. In case of large river, the extent of loss of lives and properties has been decreased through the flood warning system by flood control stations. However, the extent of damages in other small rivers has increased to the contrary. This study is aimed at calculating the characteristics of flash floods in streams. For this purpose, the anslysis of topographical characteristics of water basin through applying GSlS techniques will be conducted. The flash flood prediction model we used is made with GIUH(geomorphoclimatic instantaneous unit hydrograph). As a result, we can suggest a rational warning criteria for the mitigation of flash flood damage and the reduction of the casualties as well as those for the decrease of property damage. Therefore, it will provide basic materials to establish a new flash food warning system, which can replace current system for other places.

폐렴구균의 용혈능 변화와 pneumolysin 유전자의 변이 양상

오원섭,장현하,정숙인,김연숙,이혁,김신우,김성민,백경란,이남용,송재훈 대한화학요법학회 2002 대한화학요법학회지 Vol.20 No.3

목적 : 폐렴구균은 인체에서 폐렴, 수막염 및 패혈증 등을 일으키는 중요한 병원균으로 현재 전 세계적으로 항균제 내성이 큰 문제가 되고 있다. 하지만 폐렴구균의 항균제 내성에 따라 병독성이 어떻게 변화하는지에 대해서는 구체적으로 알려져 있지 않다. 이에 기능적 및 구조적 분석을 통하여 폐렴구균의 주요 병독성 인자인 pneumolysin의 병인론적 역할을 규명하고자 하였다. 방법 : 임상 검체에서 분리된 페니실링 감수성 균주 20주와 내성 균주 20주를 대상으로 하였다. Pneumolysin의 세포 독성의 변화를 관찰하기 위하여 각각의 균주들의 용혈능을 측정하였고, pneumolysin 유전자를 중합효소 연쇄반응으로 증폭한 후 증폭 산물의 유전자 구조를 분석하였다. 결과 : 페니실린 감수성 균주와 내성 균주간의 용혈능은 유의한 차이를 보이지 않았으나, 일부 용혈능이 매우 낮은 균주에서 Lys152→Thr, Thr-172→Ile, Lys-224→Arg와 같은 변이가 관찰되었다. 결론: pneumolysin의 세포 독성의 변화는 항균제 내성 정도와는 무관하였으나, 일부 용혈능이 저하된 균주에서 발견된 pneumolysin 유전자의 변이가 pneumolysin의 세포 독성에 영향을 주는 것으로 보인다. Background : Pnumolysin (Ply) is one of the most important virulence factors of Streptococcus pneumoniae. To investigate the functional and structural variation of Ply, hemolytic activity (HA) and gene sequences of pneumolvsin were determined. Methods : A total of 40 invasive pneumococcal isolated (20 penicillin-susceptible & 20-resistant strains) were analyzed. HA of each isolate was measured in crude extracts (1×10^8 CFU/mL) hourly from the time of inoculation to 9h. Crude extracts (50㎕) and DTT buffer (100㎕) were serially diluted in 96-well plate and mixed with 1% sheep blood (50㎕). HA was represented as the reciprocal of the greatest dilution, which resulted in the complete lysis. Two sets of oligonucleotide primers were used to amplify a 1,474-bp fragment containing the coding region and a 578-bp fragment of upstream region of ply gene, respectively. Amplified products were directly sequenced. Results : HA showed a wide variation from 0 to 87,480 regardiess of penicillin MICs, serotypes or specimen sources. Two bacteremic strains showed completely no hemolytic activity. No significant differences in HA between penicillin-susceptible (Mean± SE : 15,468± 4,693) and penicillin-resistant strains (21,384± 4,087) were found (p > 0.05).Sequencing of the coding region showed unique alterations in amino acids in strains with markedly reduced hemolytic activity (≤ 40): Thr-172-Ile and Lys-224-Arg. However, upstream region of ply gene was highly conserved. Conclusions : Ply activity was not related with antibiotic resistance. Absence of HA in some strains was associated with unique alterations in amino acid sequences in ply gene. Relationnship between genomic alteration and functional changes in pneumolysin should be further investigated.

혈액 및 비장조직에서 일산화탄소 헤모글로빈 농도에 관한 연구 : A Comparison of CO-Hb in Blood and Spleen Specimens

이진훈,오세진,김유나,이진숙,유재훈,장성길 內務部 國立科學搜査硏究所 2001 國立 科學 搜査 硏究所 年報 Vol.33 No.-

고속 승산기 알고리즘에 관한 연구

이훈재,오주환 경운대학교 산업기술연구소 2001 産業技術硏究論文誌 Vol.3 No.2(B)

Public-key cryptosystems carry out the modular exponentiation of large integer for security, and modular exponentiation is presented by the serial of the modular multiplication. This thesis presents the classical multiplication method, Montgomery algorithm, Yang algorithm to implement high-speed multiplication above 512-bit.]

자가 면역성 간염에서 자가항체의 발현 양상과 스테로이드 치료의 효과

박기오,채경훈,허원석,강윤세,정재훈,김연수,문희석,이엄석,김선문,이병석,김남재,이헌영 충남대학교 의과대학 의학연구소 2003 충남의대잡지 Vol.30 No.1

목적 : 최근 8년간 본원에서 경험한 자기면역성 간염의 혈액학적 특징과 스테로이드의 치료효과를 알아보고자 본 연구를 시행하였다. 방법 : 1996년 이후부터 2002년까지 충남대학교 병원에서 1999년 International Autoimmune Hepatitis Group(LAHG)에서 제시한 수정 진단 기준안에 의거하여 총 진단점수가 probable 이상에 해당하는 환자들을 대상으로 임상적 특징, 검사실 및 조직 소견과 스테로이드와 azathioprine의 치료 효과를 후향적으로 조사하였다. 결과 : 9예의 환자들은 여성이 78%, 40대가 많았고, 급성 발병이 33.3%, 피로감, 식욕부진 및 황달 등이 나타났으며, 항핵항체가 55.6%에서 그리고 항평활근 항체가 77.8%에서 양성이었고, 동반 질환은 류마치스 관절염이 2예, 특발성 혈소판 감소증 1예, Henoch-Sch nlein 자반증 및 그레브스병이 각각 1예 씩이었다. 7예에 대해서 스테로이드와 azathioprine으로 치료하여 생화학적 임상적 완해가 이루어져서 유효한 치료 결과를 얻었다. 결론 : 자가면역성 간염은 우리 나라에서 원인을 찾을 수 없는 만성 간질환의 경우, 특히 중년여성에서 다른 자가면역성 질환이 동반되었을 때 자가면역성 간염을 의심하여 자가항체 선별검사를 시행해 보아야 할 것으로 생각된다. 향후 다기관 연구를 통하여 좀 더 많은 증례를 모으고 전향적인 연구를 시행하여야 할 필요가 있다. Although autoimmune hepatitis(AIH) is common in western contries, some studties have been reported in Korea. The aim of the study was to analyze the clinical and histological features and expression pattern of the autoantibody and to examine clinical course of AIH in Korea. For 9 patients diagnosed as having AIH in our hospital since 1996, we reviewed medical records and analyzed clinical and laboratory findings retrospectively. They had a probable or definite AIH according to the revised criteria of International AIH group. The mean age was 42.7(21∼68)years and 7(77.8%) were female. Three of them(33.3%) showed acute hepatitis and five of them showed cirrhosis. Fatigue and anorexia were the most frequently complained symptoms(55.6%). Four patients(44.4%) were accompanied with other autoimmune diseases. Antinuclear antibody was detected in 5(55.6%) and anti-smooth muscle antibody was detected in 7(77.8%). Three patients showed focal picemeal necrosis and four showed periportal fibrosis. Among 7 patients who received immunosuppressive therapy, six patients(85.7%) showed initial response. and biochemical and serologic remission were achived in 5(71.4%) and 3(42.8%) patients, AIH seems to be partly responsible for chronic liver disease of unknown etiology in Korea. AIH should be suspected in female patients with unknown chronic liver disease of unknown etiolgy, especially accompanied with other autoimmune disease. The clinical characteristics of AIH may not be quite different from those of Western countries.