진해지역 도시관급수불화사업효과에 관한 조사연구

이충섭,성진효,김동기 ( Choong Sub Lee,Jin Hyo Seong,Dong Kie Kim ) 대한예방치과·구강보건학회 1996 大韓口腔保健學會誌 Vol.20 No.2

생쥐의 심장발생과정에서 세포증식과 세포고사의 역할

김어진,김효수,서정욱,김어진,김효수,서정욱 대한병리학회 1998 Journal of Pathology and Translational Medicine Vol.32 No.12

Molecular analysis of TMC1 gene in the Korean patients with nonsyndromic hearing loss

Hyo‐Kyeong Kim,Yee Hyuk Kim,사공보름,권태준,오세경,Hye‐Jin Lee,Kyu‐Yup Lee,이상흔,김언경 한국유전학회 2011 Genes & Genomics Vol.33 No.2

Hereditary nonsyndromic hearing loss (NSHL) is a highly heterogeneous disorder in humans. Mutations of the transmembrane channel‐like (TMC1) gene have been identified as the genetic cause for both autosomal recessive (DFNB7/11)and autosomal dominant (DFNA36) nonsyndromic hearing loss. To evaluate the spectrum and frequency of mutation(s)caused by TMC1 gene in the Korean population, we have performed sequencing analysis of the PCR products amplified from genomic DNA of each proband in 193 unrelated families showing 30 autosomal dominant and 163 autosomal recessive inheritance patterns. As a result, we identified eight different novel sequence variations for the first time in this study,respectively. However, none of these showed co‐segregation of phenotype in the families. Therefore, our study suggests that the TMC1 gene is not the cause of nonsyndromic hearing loss in the Korean population.

쇼펜하우어 의지론의 도덕교육적 함의 : 불교 수행론과의 관련에서

장효진(Hyo-Jin Chang) 한국도덕교육학회 2019 道德敎育硏究 Vol.31 No.3

‘칸트의 물자체는 바로 의지’라고 요약되는 쇼펜하우어의 철학은 칸트 철학의 기반 위에서 시작되는 것이지만, 쇼펜하우어는 자신의 ‘의지론’을 통하여 ‘물자체’와 ‘선의지’를 중심으로 하는 칸트 철학의 입장을 수정한다. 칸트의 인식론과 윤리학은 인식과 도덕적 실천의 ‘논리적 조건’을 밝히는 과정을 보여준다는 점에서 메타피직스의 전형에 해당한다. 그러나 인식론과 윤리학이 그것을 읽는 사람의 도덕적 성장을 꾀할 수 있으려면 그것들은 인식과 도덕에 관한 ‘형식적 설명’ 이상으로 양자의 관련과 이상적 상태에 도달하기 위한 노력을 구체적으로 다룰 수 있어야 한다. 쇼펜하우어의 의지론은 칸트가 말한 물자체가 우리 자신의 존재와 삶에 어떻게 관련되는가를 보여준다. 의지는 ‘의지 그 자체’(Wille)와 ‘삶에의 의지’(Wille zum Leben) 사이의 구분을 기반으로 하는 쇼펜하우어의 의지론은 불교 수행론의 진여-육바라밀의 관계에 비추어 볼 때 칸트의 메타피직스를 극복하려는 ‘메타프락시스’로서의 의미를 더욱 뚜렷하게 드러내며, 그의 염세주의 또한 의지론의 논리적 확장이요, 교육받은 인간이 나타낼 수 있는 삶의 자세로 해석될 수 있다. Schopenhauer’s main philosophical theory can be summed up in a single statement ‘Kant’s thing-in-itself is Will’. By this statement he launches his own philosophy in Kantian base, but he modifies Kant’s main theories of epistemology and ethics elaborated in CPR and CPrR. In his view, Kant’s epistemology and ethics only deals with the logical presuppositions of knowing and moral practice, and if they are to be able to bring moral growth for a person who reads it, they should deal with specifically the efforts to reach the ideal state not just the ‘formal explanations’. Schopenhauer’s Will is a concept that shows how Kant’s ‘thing-in-itself’ related to our own existence and life. By this concept of Will, knowledge and morality can be related with each other, while these two have nothing to do with each other in Kant’s philosophy. Schopenhauer s theory of Will can reveal its meaning as ‘metapraxis’ more clearly given the relation between Jin-yeo and Yookbaramil in the theory of Buddhist practice.

알코올의 섭취가 흰쥐의 혈액과 간의 지질대사에 미치는 영향

이명숙,김영연,김효숙,김매하,전진순,서진숙,송선미,양영재,윤원손,이미라,이효영,정승현 誠信女子大學校 生活文化硏究所 2004 生活文化硏究 Vol.18 No.-

To investigate the effects of ethanol on the lipid metabolism in blood and liver, twenty one male Sprague Dawley rats had orally taken the 25% alcohol and 50% alcohol by 5g per Kg of weight during 3 weeks after the adjusting period. For the energy balance, 85% sucrose and 45% sucrose was added in control group and 25% alcohol group each. The weight was reduced by alcohol treatment according to the levels, otherwise the weight of liver and heart was little increased in alcohol groups rather than in control without significance. Moreover, RBC, WBC, hemoglobin and hematocrit were increased by alcohol treatment according to the levels without significance. Otherwise, adjusted bilirubin levels by 100g of weight was significantly increased by alcohol treatment dose dependently. Alcohol induced RBC degradation and increased circulated bilirubin because of liver damage. For blood lipid profiles, blood cholesterol was increased in 50% of alcohol group compared to that of 25% and control groups, otherwise, blood triglycerides (TG) was increased by 30% in 25% alcohol groups rather than in control but not significantly different. The hepatic lipid composition, cholesterol levels in alcohol treatment groups was lower than those in control. The hepatic TG was not influenced by alcohol treatment. The two reasons of decreasing hepatic lipids were suggested by 85% sucrose of control for energy balance more synthesized cholesterol and TG than those in 25 or 50% alcohol groups, and by cholesterol and TG could not be synthesized because of liver damage from alcohol.

Bupivacaine과 ropivacaine이 Xenopus oocyte에 발현된 HERG 전류에 미치는 영향

김국성,이규승,김효신,손숙진,이상도,김광진,전병화,김윤희,박진봉 충남대학교 의과대학 의학연구소 2003 충남의대잡지 Vol.30 No.1

Bupivacaine is an amide-type local anesthetic widely used for regional anesthesia. Ropivacaine is developed as a less cardiotoxic alternatives to bupivacaine. In the present study, we have analyzed the effects of bupivacaine and ropivacaine on HERG currents expressed in Xenopus oocytes. Bupivacaine and ropivacaine(3∼1,000μM) blocked HERG currents in a concentration dependent manner. EC_(50) was 26.1±3.1μM(n_(R) 0.65±0.04) and 43.5±7.9μM(n_(H) 0.99±0.13) in bupivacaine and ropivacaine, respectively. Bupivacaine and ropivacaine did not affect the activation and deactivation kinetics of HERG channels. However, the drugs decreased the slope conductance measured from fully activated current-voltage relationship curves. These results suggest that bupivacaine and ropivacaine have a similarinhibitory effect on HERG channels, which could be a possible cellular mechanism of LQT or ventricular arrythmia by the drugs.

Bacillus licheniformis가 생산하는 Extracellular biopolymer의 생산조건 및 이용특성

진효상 전주대학교 1999 論文集 Vol.24 No.2

고추장에서 점물질을 생산하는 세균을 분리하고 Bacillus licheniformis로 동정하였다. 본 균주는 sucrose 6%, Yeast extract 0.1%, peptone 0.1%의 배지조성에서 pH를 6으로 조정하였을 때 점물질 생산량이 가장 높았고 생산량은 34㎎/250㎖였다. 이 점물질은 1% 농도에서 필름 형성능이 있었고, 0.25-1.00%의 시험범위에서 Kaolin을 침전시키고, 유산균 현탁액을 안정화시키는 능력을 나타내었다. A bacterium that produce biopolymer was isolated from Gochujang, one of Korean traditional fermented foods, and identified as Bacillus licheniformis. The production of biopolymer was highest and 34mg/250ml, when the baterium was cultivated in condition of sucrose 6.0%, Yeast extract 0.1%, peptone 0.1%, Nacl 3.0%, and pH 6.0. The 1% solution of this biopolymer was able to form a translucent and glossy film. And the solution of biopolymer was found to precipitate Kaolin solution and also stabilize the suspension of lactic acid bacteria within the range of 0.25-100%.

다발성 장 천공을 동반한 베체트병 - 1예 보고 -

윤효영,이상전,송영진 대한대장항문학회 1995 Annals of Coloproctolgy Vol.11 No.2

Flavobacterium meningosepticum이 생산하는 Carotenoids의 동정 및 생리활성

진효상,최영순 전주대학교 자연과학종합연구소 2003 전주대학교 자연과학연구소 학술논문집 Vol.15 No.1

Some carotenoids isolated from F. meningosepticum showed 3 different bands on thin layer chromatogram, one of which was the dominant. The dominant band had 455 nm of λmax, showed negative result on epoxide test, 20 nm of basochromic shift on ketone test, and absorption band characteristic of hydroxyl group on IR spectrum, which means that the main component is hydroxyechinenone. Also, the carotenoids had ROS scavenging activity and antioxidant activity. The carotenoids showed no cytotoxic activity. So it was found out that this carotenoids could be used in industry.

순창고추장의 팽창 원인 효모의 분리 및 특성

진효상,이경자 한국식품영양학회 1999 韓國食品營養學會誌 Vol.12 No.4

순창지역에서 전통적인 방법으로 제조되는 고추장으로부터 순수분리된 66주의 균주들 중 가스생성과 고추장의 팽창력을 모두 보이는 1주의 균을 분리하고 Saccharomyces sp.로 동정하였다. 본 고추장 팽창균은 제조원료들 중 엿기름에서만 3.0 logCFU/g 이상으로 분리되어 고추장의 제조중 엿기름 원료를 통해 유입되는 것으로 추정되었다. 그러나 엿기름 당화액을 열처리하여 담근 고추장은 열처리하지 않고 담근 고추장에 비해 저장 초기의 고추장 팽창균 수가 낮았으나 이러한 차이는 6개월 이후에 소실되었다. 고추장 팽창균은 순창지역의 제조업체에서 제조후 1개월에서 3년이 경과한 제품들 사이에서 5.67∼7.75 Log_10CFU/g의 사이로 분포하였다. A strain of gas-producing and volume-expanding yeast was isolated from Gochujang made in Sunchang by the traditional ways and was identified to be a Saccharomyces sp. This yeast was detected only in malt among the several ingrediants of Gochujang, which means that the volume-expanding yeast comes into Gochujang at the time of making products through malt, one of the major ingredients. However, boiling of the malt-saccharified rice could not prevent the occurrence of the volume-expanding yeast in Gochujang. This yeast was contained in the range of 5.67∼7.75 log_10CFU/g in products made and aged between 1 month and 3 year in Sunchang area.