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홍현옥,임은지,박성호 동의공업대학 2000 論文集 Vol.26 No.1
Through the dramatic growth of Internet, it becomes easy for people to access geographically distributed vast amounts of information. But, currently Internet is suffering from problems such as server overload, network congestion and client response time. In addition, currently the number of continuous media data such as audio and video is growing rapidly. In this paper, we propose SCU(Smallest Caching Utility) proxy caching scheme that stores a portion of continuous media stream or entire stream on the Internet. The proposed scheme reduces client latency and maximizes the amount of data served directly from cache without accessing the central server. By caching the initial fraction of stream data, service startup latency can be reduced. And, by varying the size of the fraction of stream to be cached according to variation of stream popularity, we can utilize the cache space efficiently and maximize the amounts of data served directly from cache. We use the caching utility formula of each stream for the measurement of cache replacement. The way to measure popularity of continuous media stream should be different from that of traditional data such as text and image. We propose the method of measuring popularity of stream using the amounts of data played by clients. We have performed simulations to evaluate our caching policy, Simulation results show that our caching policy outperforms other caching algorithms such as LRU, LFU and SIZE in aspects of BHR(byte hit ratio), initial latency and replacement overhead.
만성 정신분열증 환자의 인지기능에 미치는 Clozapine 효과
이홍식,정미정,김지현 大韓神經精神醫學會 1994 신경정신의학 Vol.33 No.5
Objects : Prior reviews have indicated that antipsychotic drugs may impair planning ability and memory but otherwise may even improve attention and reaction time performance. This study was performed to evaluate the effect of clozapine on cognitive functions and psychopathology in chronic schizophrenic patients. Methods : Neuropsychological tests such as Wisconsin Card Sorting test, Digit Span test and Judgment of Line Orientation test were applied to 21 chronic schizophrenic patients and 15 normal controls. The schizophrenic patients were retested with the same instruments after 3 monthes of treatment period with clozapine. Psychopathology was assessed in the same patients before initiation of clozapine and at 12 weeks using BPRS. Results : Cognitive impairment was found in each measure of executive function, attention, short-term memory and visual perception ability as compared with the normal controls. After 12 weeks of clozapine treatment, signigicant improvement occured in attention, short-term memory and visual perception ability as well as psychotic symptoms including both positive and negative symptoms, but had little effect on executive functions. Conclusion : Short-term treatment with clozapine may possibly improve parts of cognitive functions of chronic schizophrenics, and these effects can contribute to increase capacity for work and social function.
백지현,박은영,정윤숙,홍재원,채윤태,진성준,최희경,신소연,한상훈,진범식,김창오,최준용,송영구,조남훈,김준명 대한감염학회 2009 감염과 화학요법 Vol.41 No.4
Coccidioidomycosis is a fungal infection that results from inhaling the airborne arthroconidia of the Coccidioides species. It is an endemic disease in the southwest part of North America and rarely diagnosed in Korea. As tourism to endemic areas and the number of immunocompromised patients have been increasing, the incidence of this infection has increased in non-endemic areas. Treatment is usually successful with antifungal agents; however, recurrence is common. It is difficult to decide when to discontinue the antifungal treatment especially in non-endemic areas where doctors are not familiar with the disease. We report a case of recurrent coccidioidomycosis manifesting as osteomyelitis after the treatment of the patient for disseminated coccidioidal infection. The complement fixation test was a useful tool for the assessment of patient response and to evaluate suspected recurrence.
서울의 Penicillinase Producing Neisseria gonorrhoeae 발생빈도(1997)
김재홍,문득곤,김정수,김용준,임동진,박상훈,김희성,이민수,송기훈,김갑형,김형석,성소영,이인섭,김석우,황지환,조창근,김경문,부태성 대한화학요법학회 2000 대한화학요법학회지 Vol.18 No.3
Background : In recent years, gonorrhea has been pandemic and remains one of the most common STDs in the world, especially in developing countries. Objective & Methods : For the detection of a more effective therapeutic regimen and assessing the prevalence of PPNG, we have been trying to study the patients who have visited the Venereal Disease Clinic of Choong-Ku Public Health Center in Seoul since 1980 by means of the chromogenic cephalosporin method. Results : In 1997. 99 strains of N. gonorrhoeae were isolated, among which 45(45.5%) were PPNG. Conclusion : The prevalence of PPNG in Seoul, which had been decreased to 39% in 1996 after a peak of 74.3% in 1993, is increased to 45.5% in 1997.
이현경,김지용,성낙진,홍성태 동국대학교 경주대학 1996 東國論集 Vol.15 No.-
목적: 간흡충증에서 초음파검사의 진단적 가치를 알아보기 위하여 본 연구를 시행하였다. 대상 및 방법: 1996년 5월 한달 동안 간흡충의 농후유행지인 형산강 유역 포항지역의 436명의 자원자를 대상르로 초음파검사, 피내반응검사, 대변검사를 시행하였다. 이후 대변검사를 기준(gold standard)으로하여 초음파검사의 민감도, 특이도, 양성예측도 및 음성예측도를 알아보았다. 결과: 간내담관의 확장 및 담관주위 에코를 양성 소견으로 하였을 경우 초음파검사의 민감도 65.5%, 특이도는 64.6%, 양성예측도는 38.2%, 음성예측도는 84.3% 이었다. 결론: 초음파검사는 피내반응검사보다 민감하지는 못하나 특이적이었다. 그리고 피내반응검사 양성자에게 초음파 검사를 시행하는 것은 진단기준의 특이도를 높여 주는 효과가 있었다. Objectives: In this study we aimed to evaluate the diagnostic value of sonography on clonorchiasis. Subjectives and Methods: During a month, May 1996 sonographic examination, skin test, and stool examination were performed to 436 volunteers of Pohang which is located along the Hyong-San-Gang river and is one of well known endemic areas. Sensitivity, specificity, positive predictive value(PPV), and negative predictive value(NPV) of sonography were determined while stool examination was assumed as a gold standard. Results: The sensitivity of sonography was 65.5%; specificity, 63.2%; PPV 38.2%; NPV, 84.3% if both intrahepatic duct dilatation and periductal echogenicity were assumed as positive findings. Conclusions: Sonography was less sensitive but more specific than skin test. And sonographic examination perfomed to skin test positive subjects could increase the specificity of diagnostic criteria.
제조합 대장균에서 과발현된 Citrobacter freundii KCTC2006 유래의 β-Tyrosinase를 이용한 3,4-Dihydroxyphenyl-L-alanine의 생산
이승구,노현수,홍승표,이규종,왕지원,태동년,엄기남,방상구,김영준,성문희 한국미생물생명공학회 ( 구 한국산업미생물학회 ) 1996 한국미생물·생명공학회지 Vol.24 No.1
재조합 대장균에서 대량발현 시킨 Citrobacter freundii KCTC 2006 유래이 효소 β-tyrosinase를 이용하여 pyrocatechol, sodium pyruvate, ammonium acetate로부터 3,4-dihydroxy phenyl-L-alanine을 생산하기 위한 연구를 수행하였다. 이 효소반응에 적합한 온도 및 pH 조건은 각각 18℃와 8.5로 결정되었고, 반응액 중의 ammonium acetate와 sodium pyruvate의 농도는 각각 300 mM, 50 mM 이상으로 조절하는 것이 적합하였다. Pyrocatechol의 경우는 20 mM에서 가장 높은 반응성을 나타냈으나, 기질을 반복적으로 첨가하며 장시간 동안 효소반응을 수행하는 경우에는 pyrocatechol의 고갈을 피하기 위하여, 20 mM에서 50 mM 사이로 조절하였다. 한편, 반응액 중에 ethanol을 10% 첨가한 경우에는 반응속도가약 20% 증가하였다. 이상과 같은 효소반응특성에 기초하여 조제한 기질용액에 β-tyrosinase를 1 unit/㎖ 농도로 가하고, pyrocatechol과 pyruvate가 고갈되지 않도록 간헐적으로 첨가하면서 효소반응을 수행한 결과, 24시간 만에 85.2%의 수율로 31.6g/ℓ의 3,4-dihydroxyphenyl-L-alanine를 생산할 수 있었다. By using the β-tyrosinase of Citrobacter freundii KCTC2006, which was cloned and overexpressed in Escherichia coli, 3,4-dihydroxy phenyl-L-alanine (L-DOPA) was synthesized efficiently from pyrocatechol, sodium pyruvate, and ammonium acetate. Optimal temperature and pH for the reaction were determined to be about 18℃ and 8.5, respectively. The effects of substrate concentrations were also examined at different concentrations of ammonium acetate, sodium pyruvate, and pyrocatechol. Ammonium acetate and sodium pyruvate increased the reaction rate until the concentrations reached to 300 mM and 50 mM, respectively. Although pyrocatechol showed the optimal concentration at 20 mM, it was controlled between 20 mM and 50 mM to avoid the depletion of substrate during the enzymatic synthesis. Based on above results, a reaction medium for the production of L-DOPA was prepared and incubated with 1 unit/㎖ of β-tyrosinase. Pyrocatechol and sodium pyruvate was added to the reaction solution intermittently to avoid the substrate depletion during the enzymatic reaction. After 24 hour of reaction, 31.6 g/ℓ L-DOPA was accumulated in the reaction solution as soluble and precipitated ones and the conversion yield was about 85.2%.
[PB-0073] 무(Raphanus sativus L.) 품종의 표현형적 특성과 heterozygosity 간의 상관관계 분석
Hui Yeon Hong(Hui Yeon Hong),Jun Ho Lee(Jun Ho Lee),Yoon Ah Jang(Yoon Ah Jang),Jin Hee Kim(Jin Hee Kim),Ji Won Kim(Ji Won Kim),Ji Hyeon Lim(Ji Hyeon Lim),Hye Won Yu(Hye Won Yu),Won Byoung Chae(Won Byo 한국육종학회 2022 한국육종학회 공동학술발표집 Vol.2022 No.-
[PB-0071] GBS 분석을 통한 국내 무(Raphanus sativus L.) 품종의 유전적 유연관계 분석
Hui Yeon Hong(Hui Yeon Hong),Jun Ho Lee(Jun Ho Lee),Yoon Ah Jang(Yoon Ah Jang),Jin Hee Kim(Jin Hee Kim),Ji Won Kim(Ji Won Kim),Ji Hyeon Lim(Ji Hyeon Lim),Hye Won Yu(Hye Won Yu),Won Byoung Chae(Won Byo 한국육종학회 2022 한국육종학회 공동학술발표집 Vol.2022 No.-
Flowing with Jeju heanyeo - Jeju National University High school club Tewak is floating
Hong Ji Hee,Kang Gyeong Ji,Kim Eun Hee,Kim On Yu,Lee Yu Bin,Ko Jun Hyeok,Kang Min Jae,Yang Hyeon Jeong,Yang Yeon Jae,Sim Yu Rim,Kim Min Ji,Geum Na Hyeon,Kim Geum Byeol,Heo Jeong In 제주학회 2016 제주학회 학술발표논문집 Vol.2016 No.2