허실변증(虛實辨證)과 가미청상보하탕(加味淸上補下湯)의 임상효과

이재성,정승연,이건영,이경기,정희재,이형구,정승기,최준용,Lee, Jae-Sung,Jeong, Seung-Yeon,Lee, Kun-Young,Lee, Kyung-Ki,Jung, Hee-Jae,Rhee, Hyung-Koo,Jung, Sung-Ki,Choi, Jun-Yong 대한한방내과학회 2004 大韓韓方內科學會誌 Vol.25 No.3

Objectives: The aim was to compare and analyse the clinical effects between excess syndrome and deficiency syndrome in asthmatics through treatment with herbal dicoction, Gamichuongsangboha-tang. Materials and Methods: The subjects consisted of 30 patients with asthma and were treated with Gamichuongsangbohatang for four weeks. All patients were divided into three groups as Excess Syndrome Group(ESG), Deficiency Syndrome Group(DSG) and Coexistence Syndrome Group(CSG). PHs were checked before and 4 weeks after treatments, and QLQAKAs were checked three times; before treatments, 2 and 4 weeks after treatments. The results of QLQAKA and PH were compared and analysed between ESG, DSG and CSG. Results: Treatment of Gamichuongsangboha-tang resulted in a significant increase of QLQAKA during the first two weeks in DSG and during the last two weeks in ESG. FEV1% and PEFR% significantly increased in both DSG and ESG. There were no significanctly changes of QLQAKA and PH in CSG. Conclusions: Observations suggest that asthma in DSG was more immediately and effectively managed through treatment with Gamichuongsangboha-tang than in ESG and CSG in ease of breading and pulmonary function.

10 V 이하의 프로그래밍 전압을 갖는 Ta2O5/SiO2 로 구성된 안티휴즈 소자

이재성,오세철,류창명,이용수,이용현 ( Jae Sung Lee,Seh Chul Oh,Chang Myung Ryu,Yong Soo Lee,Yong Hyun Lee ) 한국센서학회 1995 센서학회지 Vol.4 No.3

This paper presents the fabrication of ametal-insulator-metal(MIM) antifuse structure consisting of insulators sandwiched between top electrode, Al, and bottom electrode, TiW and additionally studies on antifuse properties depending on the condition of insulator. The intermetallic insulators, prepared by means of sputter, comprised of silicon oxide and tantalum oxide. In such an antifuse structure, silicon oxide layer is utilized to decrease the leakage current and tantalum oxide layer, of which the dielectric strength is lower than that of silicon oxide, is also utilized to lower the breakdown voltage near 10V. Finally sufficient low leakage current, below InA, and low programming voltage, about 9V; could be obtained in antifuse device comprising Al/Ta₂O₃(10nm)/SiO₂=(10nm)/TiW structure and OFF resistance of 3.65㏁ and ON resistance of 7.26Ω could be also obtained. This Ta₂O₃/ SiO₂= based antifuse structures will be promising for highly reliable programmable device.

활성탄에 의한 CFC - 113 의 흡착특성에 미치는 Presorbed Water 의 영향

이재성,전해수,조성용,이윤용 ( Jae Sung Lee,Hai Soo Chun,Sung Yong Cho,Youn Yong Lee ) 한국화학공학회 1996 화학공학의이론과응용 Vol.2 No.1

H2 15O 양전자단층촬영술을 이용한 뇌기능 지도 작성 ( II ) - 작업 기억의 지도 작성

이재성,이동수,이상건,남현우,김석기,박광석,정재민,정준기,이명철 ( Jae Sung Lee,Dong Soo Lee,Sang Kun Lee,Hyun Woo Nam,Seok Ki Kim,Kwang Suk Park,Jae Min Jeong,June Key Chung,Myung Chul Lee ) 대한핵의학회 1998 핵의학 분자영상 Vol.32 No.3

Purpose: To localize and compare the neural basis of verbal and visual human working memory, we erforrned functional activation study using H2O PET. Materials and MethoDs: Repeated H213O PET scans with one control and three different activation tasks were performed on six right-handed narmal volunteers. Each activation task was composed of 13 matching trials. On each trial, four targets, a fixation dot and a probe were presented sequentially and subjects task was to press a response button to indicate whether or nat the probe was one of the previous targets. Short meaningful Korean words, simple drawings and monochromic pictures of human faces were used as matching objects for verbal or visual memory. All the images were spatially normalized and the differences between control and activation states were statistically analyzed using SPM96. Results: Statistical analysis of verbal memory activation with short words showed activation in the left Broca's area, premotor cortex, cerebellum and right cingulate gyrus. In verbal memory with simple drawings, activation was shown in the larger regions including where activated with short words and left superior temporal cortex, basal ganglia, thalamus, prefrontal cortex, anterior portion of right superior temporal gyrus and right infero-lateral frontal cortex. On the other hand, the visual memory task activated predominantly right-sided structures, especially inferior frontal cortex, supplementary motor cortex and superior parietal cortex. Conclusion: The results are :consistent with the hypothesis of the laterality and dissociation of the verbal and visual workmg memory from the invasive electrophysiological studies and emphasize the pivotal role of frontal cortex and cingulate gyrus in working memory system. (Korean J Nucl Med 1998;32:238-49)

MeSH 시소러스를 이용한 한영 교차언어 키워드 자동 부여

이재성,김미숙,오영순,이영성,Lee Jae-Sung,Kim Mi-Suk,Oh Yong-Soon,Lee Young-Sung 한국정보처리학회 2006 정보처리학회논문지B Vol.13 No.2

의학용 시소러스인 MeSH (Medical Subject Heading)는 영어 의학 논문 색인을 위한 통제어 시소러스로서 오랫동안 사용되고 있다. 본 논문에서는 한국어 MeSH를 이용하여 한국어 의학 논문의 요약문에 자동으로 영문 MeSH 색인어를 부여하는 '교차언어 키워드 부여' 방법을 제안하고 색인 전문가 및 저자의 색인 효율과 비교한다. 이 색인어 부여 과정은 우선 한국어 MeSH 용어를 문장에서 인식하여 추출하고, 이 용어를 다시 영어 MeSH 용어로 바꾼 후, 용어의 중요도를 계산하여 상위의 용어를 색인어로 부여한다. 특히, 한국어 MeSH 용어 추출을 위해 효과적으로 띄어쓰기 변이를 처리할 수 있는 방법을 제안한다 실험 결과, 띄어쓰기 변이를 효과적으로 처리하여 한국어 MeSH의 크기를 약 42% 정도 줄였을 뿐만 아니라, 후보 색인어 추출의 효과도 높였다. 또 이 방법을 이용하여 색인어 자동 부여를 한 후, 색인 전문가 및 저자의 색인 결과를 비교한 결과, 이 자동 색인 방법이 전문가의 색인 능력보다는 부족했지만, 저자의 색인 능력과는 별 차이가 없음을 보였다. The medical thesaurus, MeSH (Medical Subject Heading), has been used as a controlled vocabulary thesaurus for English medical paper indexing for a long time. In this paper, we propose an automatic cross language keyword assignment method, which assigns English MeSH index terms to the abstract of a Korean medical paper. We compare the performance with the indexing performance of human indexers and the authors. The procedure of index term assignment is that first extracting Korean MeSH terms from text, changing these terms into the corresponding English MeSH terms, and calculating the importance of the terms to find the highest rank terms as the keywords. For the process, an effective method to solve spacing variants problem is proposed. Experiment showed that the method solved the spacing variant problem and reduced the thesaurus space by about 42%. And the experiment also showed that the performance of automatic keyword assignment is much less than that of human indexers but is as good as that of authors.

금은화(金銀花)가 Bleomycin에 의한 폐섬유화(肺纖維化)에 미치는 영향(影響)

이재성,정희재,정승기,이형구,Lee Jae-Sung,Jung Hee-Jae,Jung Sung-Ki,Rhee Hyung-Goo 대한한방내과학회 2004 大韓韓方內科學會誌 Vol.25 No.1

Objective : Idiopathic Lung Fibrosis(IPF) is chronic fibrotic interstitial pneumonia. The pathogenesis is unclear. Lonicerae Flos is known to prevent the inflammation and reinforce the immune system. The effects of Lonicerae Flos on bleomycin-induced lung fibrosis is evaluated. Material and Methods: Lonicerae Flos extract was given to the Normal rats, control(bleomycin) rats everyday and treated(bleomycin and lonicerae flos) rats 21.0 mg per body weight 109 for 14 days. 14 days after, we observed the change of leukocyte count and percentage of IFN-gamma and IL-4 in BALF. and that of Semiquantative histological index(SHI). Results : Compared to control rats, Lonicerae Flos decreased leukocyte count(P<0.01) lymphocyte, neutrophil percentage(P<0.05), SHI(P<0.01), IFN-gamma and IL-4(P<0.05) in Treated rats. Otherwise, macrophage percentage was increased(P<0.01) in Treated rats. Conclusion : This study showed that Lonicerae Flos reduced the change of inflammatory cells and cytokines in bleomycin-induced lung fibrosis and reduced the fibrosis of tissue. And, we needed many other distinct researches on lung fibrosis.

${H_2}^{15}O$ PET을 이용한 뇌혈류 파라메트릭 영상 구성을 위한 알고리즘 비교

이재성,이동수,박광석,정준기,이명철,Lee, Jae-Sung,Lee, Dong-Soo,Park, Kwang-Suk,Chung, June-Key,Lee, Myung-Chul 대한핵의학회 2003 핵의학 분자영상 Vol.37 No.5

목적: ${H_2}^{15}O$ PET의 정량화를 위하여 1-조직 구획모델이 쓰이며, 뇌혈류와 조직/혈액 분배계수를 구하기 위하여 nonlinear least squares (NLS) 방법이 사용되나 계산 시간이 긴 등의 문제로 파라미터를 각화소마다 구해야 하는 파라메트릭 영상 구성에는 적합하지 않다. 이 연구에서는 이와 같은 NLS 문제점을 극복하여 파라메트릭 영상을 빠르게 구성하기 위하여 제안된 파라미터 추정 알고리즘들을 구현하고, 이 방법들의 통계적 신뢰도와 계산의 효율성을 비교하였다. 대상 및 방법: 이 연구에서 이용한 방법들은 linear least squares (LLS), linear weighted least squares (LWLS), linear generalized least squares (GLS), linear generalized weighted least squares (GWLS), weighted integration (WI), 그리고 model-based clustering method (CAKS)이다. 노이즈 정도에 따른 각 파라메트릭 영상법의 정확성 및 통계적 신뢰성을 알아보기 위하여 Zubal 뇌모형(brain phantom)으로부터 동적 PET 영상을 모사하고 포아송노이즈를 더한 후 각 파라메트릭 영상 구성 방법을 적용하였다. 또한 정상인 16명에 대하여 얻은 실제 자료에 대하여 이 방법들을 적용하고 결과를 비교하였다. 결과: 뇌혈류와 분배계수에 대한 평균 오차는 방법에 따라 크게 다르지 않았으며 모든 방법이 뇌혈류 및 분배계수 추정에 있어 무시할 만한 바이어스를 보였다. 파라메트릭 영상의 정성적 특성 또한 유사하였으나 CAKS 방법의 계산 속도가 월등하여 NLS 방법의 약 1/500, LLS 방법의 약 1/25의 계산시간을 보였다. 결론: 뇌혈류 파라메트릭 영상 구성을 위한 빠른 파라미터 추정 알고리즘들 중에 보다 개선되어 제안된 LWS, GLS, GLWS, CAKS 방법들이 단순하고 빠른 LLS, WI 방법들에 비하여 통계적 신뢰성을 크게 향상시키지는 못하나 CAKS 방법은 계산 시간을 유의하게 단축시키므로 가장 적합한 파라메트릭 영상 구성방법이라 할 수 있을 것이다. Purpose: To obtain regional blood flow and tissue-blood partition coefficient with time-activity curves from ${H_2}^{15}O$ PET, fitting of some parameters in the Kety model is conventionally accomplished by nonlinear least squares (NLS) analysis. However, NLS requires considerable compuation time then is impractical for pixel-by-pixel analysis to generate parametric images of these parameters. In this study, we investigated several fast parameter estimation methods for the parametric image generation and compared their statistical reliability and computational efficiency. Materials and Methods: These methods included linear least squres (LLS), linear weighted least squares (LWLS), linear generalized least squares (GLS), linear generalized weighted least squares (GWLS), weighted Integration (WI), and model-based clustering method (CAKS). ${H_2}^{15}O$ dynamic brain PET with Poisson noise component was simulated using numerical Zubal brain phantom. Error and bias in the estimation of rCBF and partition coefficient, and computation time in various noise environments was estimated and compared. In audition, parametric images from ${H_2}^{15}O$ dynamic brain PET data peformed on 16 healthy volunteers under various physiological conditions was compared to examine the utility of these methods for real human data. Results: These fast algorithms produced parametric images with similar image qualify and statistical reliability. When CAKS and LLS methods were used combinedly, computation time was significantly reduced and less than 30 seconds for $128{\times}128{\times}46$ images on Pentium III processor. Conclusion: Parametric images of rCBF and partition coefficient with good statistical properties can be generated with short computation time which is acceptable in clinical situation.

느타리 버섯균으로부터 wood meal-wheat bran 배지에서의 리그닌분해효소 생산

이재성,하효철,Lee, Jae-Sung,Ha, Hyo-Cheol 한국응용생명화학회 2002 한국농화학회지 Vol.45 No.2

주파수 영역 등화기가 적용된 위성 DMB 시스템의 성능 분석

이재성,김덕경,Lee Jae-Sung,Kim Duk-Kyung 한국통신학회 2006 韓國通信學會論文誌 Vol.31 No.5a

위성 DMB(Digital Multimedia Broadcasting) 시스템은 중앙의 송신기인 위성과 지상보조 중계기인 Gap-filler로 구성되는 단일 주파수 망이다. NLOS 환경의 음영지역을 커버하기 위해서는 다수의 Gap-filler 설치가 필요한데, 이로 인해 다중경로 성분이 증가하여 Finger의 수가 제한된 현 RAKE 수신기의 성능을 저하시킨다. 이에 본 논문은 RAKE 수신기를 대신하여 주파수 영역 등화기를 사용하되, 현재 시스템의 변경을 최소화하기 위하여 기존 주파수 영역 등화기 기술에서 필요로 한 보호구간을 사용하지 않는 것으로 하고, 시뮬레이션을 통해 그 성능을 분석한다. 시뮬레이션 결과를 통해 주파수 영역 등화기는 현 RAKE 수신기보다 Gap-filer 개수의 증가에 둔감하고, 보다 큰 CDM 채널 용량을 가질 수 있음을 확인할 수 있다. 뿐만 아니라, 다양한 채널 모델에서의 결과는 주파수 영역 등화기가 기존의 시스템에서도 환경에 따라 충분히 사용가능할 수 있음을 말해준다. Satellite-Digital Multimedia Broadcasting(S-DMB) systems are single frequency networks which consist of a satellite and gap fillers. Though gap fillers are required to extend the coverage to NLOS(Non Line-of-Sight) area, the receiver performance can be degraded with a limited number of fingers due to the increased number of multi-paths. The paper proposes to use frequency domain equalizer(FDE) instead of conventional Rake receiver, where the guard interval is not considered in order to minimize the impact on the current S-DMB systems. Through a campaign of simulations, it is found that the proposed FDE is less sensitive to the number of gap fillers compared to the conventional Rake receiver, and can achieve a greater channel capacity in most channel environments.

다결정 실리콘 박막으로 구성된 Metal-Semiconductor-Metal 광검출기의 제조

이재성,최경근,Lee, Jae-Sung,Choi, Kyeong-Keun 한국전기전자재료학회 2017 전기전자재료학회논문지 Vol.30 No.5

A polysilicon-based metal-semiconductor-metal (MSM) photodetector was fabricated by means of our new methods. Its photoresponse characteristics were analyzed to see if it could be applied to a sensor system. The processes on which this study focused were an alloy-annealing process to form metal-polysilicon contacts, a post-annealing process for better light absorption of as-deposited polysilicon, and a passivation process for lowering defect density in polysilicon. When the alloy annealing was achieved at about $400^{\circ}C$, metal-polysilicon Schottky contacts sustained a stable potential barrier, decreasing the dark current. For better surface morphology of polysilicon, rapid thermal annealing (RTA) or furnace annealing at around $900^{\circ}C$ was suitable as a post-annealing process, because it supplied polysilicon layers with a smoother surface and a proper grain size for photon absorption. For the passivation of defects in polysilicon, hydrogen-ion implantation was chosen, because it is easy to implant hydrogen into the polysilicon. MSM photodetectors based on the suggested processes showed a higher sensitivity for photocurrent detection and a stable Schottky contact barrier to lower the dark current and are therefore applicable to sensor systems.