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열공형과 비열공형 피질하 혈관성 치매에서 위험인자의 차이에 관한 비교 연구
배희준,정지향,유경호,나덕렬,김상윤,최경규,양동원,손의주,이상도,김재우,박경원,김응규,이재홍,박미영,한일우,함동석,최문성,하충건,최성혜,이애영,이병철,한설희 대한치매학회 2003 Dementia and Neurocognitive Disorders Vol.2 No.2
Backgrounds and Objectives: Vascular dementia is a group of dementing disoders arising from various stroke syndrome. Among these. subcortical ischemic vascular dementia (SIVD) is regarded as a relatively distinct clinical entity. However, MRI patterns of SIVD are not homogenous. In some patients, lacunes are dominant, and in others, subcortical white matter changes are. This study was designed to compare risk factor profiles between SIVD with and without multiple lacunes. Methods: We divided 47 subjects (22 males, mean age. 68 years) recruited from VADAPET (Multicenter Trial For Evaluation Of The Changes In the PET Images Of Subcortical Vascular Dementia Patient) study into two groups one with more than 5 lacunes in deep gray matter (lacune group) and the other with 5 or less(non-lacune group) Clinical characteristics and laboratory findings of two groups were compared. Results: Nineteen of 47 patients (40%) belonged to the lacune group. The lacune and non-lacune groups d d not differ in the following variables: age, hypertension, diabetes mellitus, hyperlipidemia heart disease, history of stroke or TIA, history of trauma or major surgery, family history of hypertension stroke, or dementia, age at diagnosis of dementia, body mass index, white blood cell count, ESR, CRP, fibrinogen, hemoglobin A1C, total cholesterol. LDL cholesterol creatinine, proteinuria, glucosuria, and microhematuria. However, male sex, smoking alcohol. hemoglobin, and HDL cholesterol were possibly associated more with lacune group SIVD than with non-lacune group (p<0 1) Multivariate analyses revealed that smoking, hemoglobin, and HDL cholesterol were independent predictors of SIVD with multiple lacunes Conclusion: Our study suggests that SIVD with multiple lacunes may be significantly different in smoking habits hemoglobin, and HDL cholesterol from SIVD without multiple lacunes.
김희연,홍진환,박혜경,한상배,박종석,이은주,이정성,송경희,최은희,최영준,소경아,성영제,이주엽 식품의약품안전청 2000 식품의약품안전청 연보 Vol.4 No.-
본 연구는 분말상 원료(전분, 대두분)의 저장유통시 품질변화를 건전성과 안전성 측면에서 검토하여 식품의 기준 ·규격 설정f.」 합지적으로 반영하고자 하였다. 전분과 패두분의 이물을 검사하고, 2종 대두분(중국산, 미국산)을 ?0일간 IS'c와 30t에 저장하면서 성상, 수분, 산가, 과산화물가, 지방산 조성,아플라톡신 BB의 생성여부를 분석하였다. 중국산 대두분 30'』 저장군에서 50일 이후 곰팡이가 발생한 것 이외에 모든 시료에서 양호한 성상을 나타내었고, 전분과 대두닥 모든 시료에서 이물은 검출되지 않았다. 산가는 중국산과 미국산 시료간에 편차를 보여 증국산 30"C, 50일 저장시료에서 약 10배끙도 증가하였고, 과산화물가는 저장 90일후 15'E 저장군은 약 2.3배, 30'c 저장군은 3배정도 증가하였다. 대두분의 주요 지방산은 linoleic acidf18. 2), oleic acid(18 : 1), palmitic acid(16 : 0)이었으며, 3개월 저장에 따른 지방산 함량의 변화는 미미하였다. 아플라톡신 B₁은 모든 시료에서 검출되지 않았다. The objective of this study was to investigate auality changes of type raw materials(starch, soy flour) during various storage conditions. Starchflour(source of China, U.S.A) were slfred under two temperature(15'C, 30'c) forSensory evaluation, (o.reign material test, moisture content, acid value, peroxide ualue,composition, aflatorin Bi were analyzed. China soy flour(stor·ed 30'f) was contaminated by fungj on 50 days. Except for soy flour contardnated by fungi, sensory characteristics were not changed and foreign mater;als were notdetected. Acid value of China soy flour(stored at 30'C, 90 days) was about 10 times higherlevel before storage and acid value was more influenced by source(China, USA). Peroxide valuewas in proportion with the storage period slightly. The major fatty acid of soy flour waslinoleic acid(18 . 2), an(3 the change of fatty acid composition was not observed. Aflatoxlrl Blwas not detected.
손윤희,임종국,최혜경,남경수,배만종 경산대학교 생명자원개발연구소 1999 생명자원과 산업 Vol.3 No.-
한방에서 염증, 종양 억제 등에 사용되는 금은화로 약침액을 조제하여 쥐와 사람의 암세포 성장억제효과를 살펴 보았을 때 금은화 약침액 10×, 5×농도는 mouse EATC에 대해 90% 및 86% 세포 성장 억제율이 있었으며, 열수추출액 10×, 5× 농도는 89% 및 87% 세포 성장억제효과가 있었다. 같은 농도의 약침액을 Hepalclc7에 처리했을 때는 89.5%, 69.7%의 억제효과가 있었고 열수추출액은 85.7%, 67.3%의 hepalclc7 세포 성장억제율을 보였다. 사람의 암세포주 A549, HeLa 세포에 대한 금은화 약침액 및 열수추출액의 세포독성 실험에서도 A549 세포에 약침액 10×, 5×를 처리했을 때 82.0%, 46.1% 세포 성장억제효과가 나타났으며 금은화 역수추출액은 75%, 50%의 세포 성장 억제율이 나타났다. HeLa 세포에서는 약침액이 열수추출액보다 세포 성장 억제효과가 더 높았다. 금은화 약침액을 처리한 세포(EATC,Hepalclc7과 human A549, HeLa)의 현미경 관찰에서는 세포수의 감소와 형태의 변화를 관찰할 수 있었다. Lonicerae flos Aqua-acupuncture Solution(LFAS) and Lonicerae flos Water-extracted Solution(LFWS) were prepared and tested for their potential antitumor activities. It was shown to possess considerable toxicity toward various tumor cell lines. Concentration of LFAS at 10× and 5× resulted in more than 50% inhibition of growth in Ehrich ascites tumor cells(EATC), Hepalclc7, and HeLa cells after 72 hours. Toxicity of LFWS to A549 revealed that more than 50% inhibition of growth at LFAS conentration of 10× after 72 hours. Concentration of LFWS at 10× and 5× showed more than 50% inhibition of growth with EATC, Hepalclc7, HeLa and A549. In morphological study, the number of cells were decreased, and the shape of cells was round form in EATC, Hepalclc7, HeLa, and A549.
조명숙,송근배,윤희숙 대구보건대학 1992 대구보건대학 論文集 Vol.13 No.-
The purpose of the present study was to determine the mercury in human scalp hair and urine from amalgam fillings, sixty-five subjects were examined their oral status, alginate impression were taken to make dental arch stone models and calculated their surface area of amalgam fillings. The 28 control subjects had no amalgam filling and 37 compare subjects had an average of 12 surfaces of amalgam. The morning urine and scalp hair were collected from all subjects and samples were digested in acid digestion bomb(Parr Instrument Company, U.S.A.) The mercury contents were determined with atomic absorption spectrophotometer(Model 551, IL Co., U.S.A.) and atomic vapor accessory (Model 440, IL Co., U.S.A.) . The results obtained were as follows ; 1. The urinary mercury contents of control group(no amalgam in oral cavity) were 2±10.0㎍/g. creatinine/L and compare group(amalgam filling) were 16.7±16.0㎍/g. creatinine/L(p<0.05). 2. The scalp hair mercury contents of amalgam filling group(3.29±1.03㎎/L) were slightly higher than those of the amalgam free group(3.04±1.11㎎/L) but not significant difference(p>0.05). 3. The linear correlation coefficient was 0.3490 and significantly different between mercury content of scalp hair and amalgam surface area(p<0.05), but had no significant difference between urinary mercury contents and amalgam surface area(r=0.0934, p>0.05).
불소의 국소도포에 의한 백서 치아 무기이온 용출 억제효과
김동응,송근배,윤희숙 慶北大學校 齒科大學 1990 慶北齒大論文集 Vol.7 No.2
In order to determine the inhibitory effects by topical fluorides on dissolution of inorganic ions, 2% NaF, 10% SnF_2 and 1.23% APF gel were topically applied to the incisors of rat for two to four times. The collected incisors were decalcified with 5ml of acetic acid buffer solutions(pH 4.5)for 30min. and dissolved inorganic ions(Ca & P) were measured with atomic absorption spectrophotometer and U-V spectrophotometer. The results obtained were as follows; Two times and four times application groups of APF, SnF_2 and NaF were superior to control group(F=9.0325, p<0.01) in inhibitory effect of dissolving calcium ions, but four times application groups had no statistically significant difference(F=1.8700, p>0.05). The inhibitory effect of dissolving phosphrus appeared more effective in APF, SnF_2 and NaF groups than control group, but had no statistically significant difference both two and four times topical fluoride application group(p>0.05). In comparing of calcium dissolution, fluoride application groups were more effective than nonfluoride group. It was significantly different in two times application groups (p<0.01), but had no significantly difference in four times application groups (p>0.05). The same result was obtained in the inhibitory effect of the phosphrus dissolution.