Adult Patients with Congenital Muscular Torticollis Treated with Bipolar Release : Report of 31 Cases

Lee, Gun Sang,Lee, Myung Ki,Kim, Woo Jae,Kim, Ho Sang,Kim, Jeong Ho,Kim, Yun-Suk The Korean Neurosurgical Society 2017 Journal of Korean neurosurgical society Vol.60 No.1

Objective : We assessed the surgical results of bipolar release in 31 adult patients with uncorrected congenital muscular torticollis (CMT) and more than 12 months of follow-up. Methods : Thirty-one patients underwent a bipolar release of the sternocleidomastoid muscle (SCM) and were retrospectively analyzed. The mean follow-up period was 14.9 months (range, 12-30). The mean age at time of surgery was 30.3 years (range, 20-54). Patients were evaluated with a modified Lee's scoring system, cervicomandibular angle (CMA) measurement, and a global satisfaction rating scale using patient self-reporting. Results : The modified Lee's scoring system indicated excellent results in 4 (12.9%) patients, good in 18 (58.1%), and fair in 9 (29.0%) at the last follow-up after surgery. The improvements in neck movement and head tilt were statistically significant (p<0.05). The preoperative mean CMA was $15.4^{\circ}$ (range, 5.4-29.0), which was reduced to a mean of CMA of $6.3^{\circ}$ (range, 0-25) after surgery (p<0.05). The global satisfaction rating scale was 93.7% (range, 90-100). A transient sensory deficit on the ipsilateral lower ear lobe was noted in three cases. No significant permanent complications occurred. Conclusion : Bipolar release of the SCM is a safe and reliable technique for the treatment of CMT in adults.

조혈모세포이식 환자에서 침습성 진균 감염에 대한 Micafungin의 예방 효과 및 안전성

김시현,이동건,최수미,권재철,박선희,최정현,유진홍,이성은,조병식,김유진,이석,김희제,민창기,조석구,김동욱,이종욱,민우성,박종원 대한감염학회 2010 감염과 화학요법 Vol.42 No.3

Background: Micafungin, a potent inhibitor of 1,3-β-D-glucan synthase, is a novel antifungal agent of the echinocandin class. In vitro study showed that micafungin was effective against Aspergillus species as well as Candida species, but clinical data on the prophylactic efficacy against invasive fungal infections (IFIs) other than candidiasis are still lacking. Materials and Methods: We identified 60 consecutive adult hematopoietic stem cell transplantation (HSCT) recipients who received at least 3 doses of micafungin during neutropenic period. Micafungin was started as an alternative in patients who were intolerant or had adverse events (AEs) to primary prophylactic antifungal agents. We retrospectively reviewed the medical records and analyzed the efficacy and safety of micafungin for prophylaxis against IFIs. Results: The patients either had autologous (n=9) or allogeneic (n=51: 1 syngeneic, 24 sibling, 26 unrelated donor) HSCT. Itraconazole oral solution (n=58) was the most frequently used first line antifungal agent for prophylaxis and was administered for median 11 days. The most frequent cause of switch to micafungin was vomiting (n=42). The duration of neutropenia and micafungin administration was median 13 and 12 days, respectively. A successful outcome was achieved in 45 (75%) patients. Empirical antifungal therapy was initiated in 13 (22%) patients. There were 2 cases (3.3%) of breakthrough fungal infections which comprised a probable invasive pulmonary aspergillosis and a possible invasive fungal sinusitis. There was no case of invasive candidiasis. A total of 53 (88%) patients experienced at least one AE regardless of causality during micafungin administration. The most frequent AEs were hypokalemia, vomiting, diarrhea, and elevated serum aspartate aminotransferase or alanine aminotransferase. Among the aforementioned AEs, only 1 case of diarrhea could be classified as a probable relation with micafungin when causality was assessed. There was no AEs that caused discontinuation of micafungin. Conclusions: Micafungin seems to be a safe and effective agent for prophylaxis of IFIs including aspergillosis as well as candidiasis in HSCT recipients. However, further large, prospective, and randomized comparative studies are warranted for aspergillosis.

제대군인 취업지원 프로그램 구안

정철영,서우석,김성호,이예성,최동선,이종범,이성식,이건남,양안나,김성남 한국직업능력개발원 2007 직업능력개발연구 Vol.10 No.1

이 연구의 목적은 중·장기복무를 마치고 제대하여 재취업하고자 하는 제대군인들의 원활한 전직을 돕기 위한 제대군인 취업지원 프로그램의 개발방향과 개발안을 제시하는 데 있다. 이를 위해 국내·외에서 이루어지고 있는 제대군인 취업지원 프로그램의 실태를 분석하였고, 제대군인 취업지원 프로그램에 대한제대예정군인 및 제대군인과 기업체의 요구를 분석하여 시사점을 도출하였다. 그리고 이를 기초로 제대군인 취업지원 프로그램의 기본방향과 전체 흐름도, 세부 프로그램 개발안을 제시하였다. 이를 위해서 활용된 연구의 방법은 문헌연구, 조사연구, 전문가협의회 등이다. 이 연구를 통해서 제시된 제대군인 취업지원 프로그램의 개발방향과 개발안을 토대로, 일관되고 지속적인 수요자 중심의 제대군인 취업지원 프로그램의 개발이 가능할 것이다. The purpose of this study is to suggest plans and directions for developing. job-seeking support program for military veterans. The study is conducted through literature review, survey and interview. The results of this study are as follows: ⒧ basic development directions and flowchart of job-seeking support program for military veterans are suggested; and ⑵ development plans for sub-programs are suggested.

골다공증의 위험인자 : 아산시 지역 주민을 대상으로

김용배,장원기,황보영,김화성,안규동,이병국,이용진,이남수,이상건,이상범,이상우,이선정,이성수 순천향대학교 2006 Journal of Soonchunhyang Medical Science Vol.12 No.1

Objective : As the average lifespan of human increases, osteoporosis and osteoporosis-related fractures have become major health care problems. Despite recent advances in medical treatment, few studies have assessed the recognition of osteoporosis in general adults. This study examined the recognition of osteoporosis and analyzed the relating factors. Method : A population-based sample of 1086 adults in Asan-city, Korea was investigated with questionnaires and height, weight, Information regarding the general characteristics(gender, age, economic state), lifestylef exercise, smoking, alcohol),medical history(progestin, GH, steroid, calcitonin, PTH), demographic parameter, obesity, stress, and family history was collected through an interview using a structural questionnaire. The level of obesity was measured by the body mass index(BMI). BMD(Bone mineral density) at the lumbar spine and femoral neck was measured by dual energy X-ray absorptiometry. Osteoporosis was considered to be T-score below -2.5. Results : The prevalence of osteoporosis increased progressively with age, decreased with BMI and predominant in women by the result of x^(2) -test, T-test. Age, weight, BMI were significantly correlated with osteoporosis by the result of Pearson correlation ana1ysis(P<0.05). And age, gender, BMI, family history of osteoporosis were proved to be significant risk factors of osteoporosis by the result of multiple logistic regression(P<0.05). Conclusion : These results suggest that age, gender, BMI might be the most important risk factors of osteoporosis. And the history taking about family history of osteoporosis is helpful for diagnosing osteoporosis.

P3HT 유기물을 활성층으로 이용한 박막 트랜지스터 제작

이건웅,홍남경,권오성,이형규 충북대학교 컴퓨터정보통신 연구소 2005 컴퓨터정보통신연구 Vol.13 No.1

구동회로가 유기물로 구성된다면 단순하고 저렴한 제작공정의 장점으로 인해 두루마리 디스플레이, RFID 카드에 사용될 수 있다. 본 연구는 이를 위해 고분자 유기물인 P3HT(poly-3-hexylthiophene)를 산화막이 성장된 Si 기판위에 스핀코팅하여 활성층으로 사용한 박막 트랜지스터를 제작하고 소자 구조에 따른 특성을 측정하였다. 트랜지스터는 하부 게이트 전극으로 Si 기판을, 몰리브덴 소스와 드레인이 유기물 활성층 하부 또는 그 상부에 위치하는 구조를 채택하였다. 제작된 박막 트랜지스터는 정상전도 p-채널 MOSFET 동작특성을 보이며 V_(GS) = -60 V, V_(DS) = -100 V에서 측정한 드레인 전류는 하부, 상부 접촉 구조에서 각각 I_(DS) = 8 pA/㎛, 4.7 pA/㎛ 이었으며 점멸비 (I_(on/off))는 10^(2)과 10을 나타내었다. 또한, 계산된 전계 효과 이동도는 두 구조에서 동일한 값으로써 약 1×10^(-6) ㎠/V-s 을 보이고 있었다. 상부구조의 장점은 트랜지스터의 특성은 박막의 품질이 향상되고 낮은 접촉저항을 나타내는 금속을 선택함으로써 들어날 것으로 기대된다. If the driving circuits were formed by organic materials, these can be applicable to flexible displays and RFID cards due to the simple fabrication methods and inexpensive costs of production, In this article, we report on the characteristics of organic thin-film transistors using P3HT(poly-3-hexylthiophene) polymer as an active layer material by spin-coating on a Si wafer. The transistor is composed of a Si back-gate, 150 nm thick thermal oxide, and Mo source/drain contacts formed either below (bottom-contact) or above (top-contact) the active channel. Fabricated devices have exhibited the normally-on p-channel MOSFET characteristics with the drain currents of 8 pA/㎛ and 4.7 pA/㎛, and with I_(on/off) ratios of 10^(2) and 10, from bottom- and top-contact structure, respectively, measured at V_(GS) = -60 V and V_(DS) = -100 V. And, the calculated mobility shows about 1×10^(-6) ㎠/V-s same in both structures. We expect that the advantages of top-contact structure could be revealed by employing low contact resistance metal and improvement of the film quality.

중합방법이 다른 의치상 레진의 적합도 평가

이상건,송윤관,송광엽 대한치과기재학회 1999 대한치과재료학회지 Vol.26 No.3

In addition to continuing the search for more accurate and dimensionally stable materials for denture bases, recently several processing methods for denture base resins which may reduce dimensional change during fabrication has been developed. The purpose of this study was to compare the dimensional accuracy of denture bases cured by four denture base processing methods, using the conventional heat-compression molding method, the continuous-pressure injection method, the microwave curing processing method, and the Sulfone system. A metal die simulating a maxillary edentulous arch and a polyvinylsiloxane impression(Reprosil, L. D. Caulk Co. U.S.A.) were used to construct 40 simulated master casts and denture bases with artificial teeth. Forty simulated denture bases 3 to 4㎜ thick were processed by four denture base processing methods following the manufacturer's instructions. The processed denture bases and casts sectioned through the posterior palatal region to allow measurement of its change by means of an travelling microscope. Observations were made on center of posterior palatal sectioned region. One-way ANOVA and paired samples t-tests were employed to compare the differences in distortion after deflasking and after finishing and polishing. The obtained results were as follows; 1. After deflasking, dimensional changes were diminished in order of conventional heat-compression molding, Sulfone system, continuous-pressure injection method, microwave processing method(p<0.05). 2. After finishing and polishing, dimensional changes were diminished in order of conventional heat-compression molding method, Sulfone system, microwave processing method, continuous-pressure injection method. The significant difference was found between conventional hear-compression method, continuous-pressure injection method(p<0.05). 3. The significant difference was found between after deflasking and after polishing in all methods, except continuous-pressure injection method(p<0.05).

ebXML에 기반한 항만물류 전자상거래 시스템의 개발

이석희,황성진,성명건,박경환 동아대학교 정보기술연구소 2003 情報技術硏究所論文誌 Vol.10 No.2

In 1993, our country has been introduced and used ED1 for business transaction of the Port Logistics. But an ED1 have many problems : expensive cost of development and maintenance, use of specially VAN, and etc. There is an ebXML by a solution of this problems. An ebXML, sponsored by UN/CEFACT and OASIS, is a next generation internet electronic business standard framework. In this paper, we represent to develop an e-business system of the Port Logistics based on an ebXML.

Melittin-Hybrid 합성 폡타이드가 Fusarium oxysporum의 성장에 미치는 저해효과

이동건,신송엽,이성구,이명규,함경수 한국미생물생명공학회 ( 구 한국산업미생물학회 ) 1996 한국미생물·생명공학회지 Vol.24 No.5

꿀벌의 독액으로부터 분리된 ME은 강항 항균활성을 가지나, 진핵세포에 대하여 세포독성 활성을 포함하고 있다. 본 연구에서는 구조와 항진균활성과 상관관계를 검토하며, 세포독성을 가지지 않으며 보다 강한 항진균활성을 가진 펩타이드의 디자인하기 위하여, ME와 CA 또는 MA으로 이루어진 hybid 펩타이드인 MA(10-17)ME(1-12) 및 CA(1-8)ME(1-12)을 고상합성법의 의하여 합성 하였다. CA(1-8)ME(1-12) 및 MA(10-17)ME(1-12)는 인간의 적혈구에 대하여 용혈현상을 나타내지 않으며, Fusarium oxysporum에 대하여 ME 만큼의 강한 항진균활성을 나타내었다. 또한 이들 hybrid 펩타이드는 (1,3)-β-D-glucan synthase의 활성을 강하게 억제하였다. 이 결과는 Fusarium oxysporum에 대한 hybrid 펩타이드의 활성은 균의 세포벽의 합성의 억제에 의한 것과 관련성이 있는 것을 시사한다. 또한 본 연구의 결과는 세포독성을 가지며 강한 항진균활성을 가지는 펩타이드의 설계에 기초를 제공하였다고 생각된다. Melittin (ME) from honeybee venom has a broad range of strong antimicrobial activity, but it has hemolytic activity against eukaryotic cells. In order to design peptides with powerful antifungal activity without cytotoxic property of ME and understand structure-antifungal activity relationships, the hybrid peptides derived from the sequences of ME and cecropin A (CA) or magainin 2 (MA), MA(10-17) ME(1-12) and CA(1-8)ME(1-12), were synthesized by solid phase method. MA(10-17)ME(1-12) showed potent antifungal activity comparable to ME against Fusarium oxysporum with no hemolytic activity against human red blood cells. The hybrid peptides showed strong inhibition of (1,3)-β-D-glucan synthase. This result indicates that the antifungal activity of the hybrid peptides against Fusarium oxysporum is attributed to the inhibition of cell wall synthesis. The results therefore showed a successful design of a peptide having antifungal activity without hemolytic property.

냉기 치료에 따른 둔근에서의 피부 및 근육내 온도 변화

정우성,김미정,박시복,이상건,김영호,양길태,장윤희 大韓再活醫學會 1998 Annals of Rehabilitation Medicine Vol.22 No.2

대전지역 와인소비자의 와인구매행동특성에 관한 연구

이상건 배재대학교 공학연구소 2006 사회과학연구 Vol.28 No.-

This study examines the association between wine consumers' demographic variables and wine purchase characteristics variables. Correspondence analysis was employed to visualize the association between wine purchase characteristics. The results shows that significant associations between monthly income as demographic variable and wine purchase frequency, wine drinking frequency and wine information search, wine purchase frequency and wine information search, preferred price range of wine and wine purchase frequency. The implications of these results for wine marketing are examined, and directions for further research on this topic are also considered.