The Safety and Efficacy of Daclatasvir and Asunaprevir with Chronic HCV Genotype 1 Infection and Hemodialysis

( Myeong Jun Song ),( Jung Hyun Kwon ),( Soon Woo Nam ),( Tae Hee Lee ),( Young Woo Kang ),( Ji Woong Jang ),( Seok Hyun Kim ),( Byung Seok Lee5 ),( Sea Hwan Lee ),( Hong Soo Kim ),( Ji Hoon Kim ),( S 대한간학회 2017 춘·추계 학술대회 (KASL) Vol.2017 No.1

Aims: We aimed to evaluate the efficacy and safety of Daclatasvir (DAV) and Asunaprevir (ASV) in patients with chronic hepatitis C virus (HCV) and chronic renal failure (CRF). Methods: 22 chronic hemodialysis patients with HCV infection at 12 medical centers have prospectively enrolled from Feb, 2016 to Feb, 2017 (NCT02580474). Of those, 9 patients who were followed 12 weeks after treatment ended were included. We evaluated the virological responses at each week 4, 12, 24 and the 12-week sustained virologic response (SVR12). The tolerability and safety of patients were also evaluated. Results: Of these 20 patients, there had no resistance-associated variant of NS5A (NS5A RAVs) and 2 patients showed indeterminate NS5A RAVs. 12 patients (54.5%) completed the 24 weeks treatment of DAV and ASV. 6 patients (27.2%) have continued, but 4 patients discontinued study prior to 12 weeks. Overall, all patients (n=9) achieved SVR12. Virologic response at week 4, 12 and 24 showed 94.4% (17/18), 93.3% (14/15), and 100% (12/12) respectively. DCV and ASV were well tolerated among the majority of patients and discontinuation of the treatment due to adverse events (hypertension, bradycardia, leukemia) was occurred in 3 patients. In two patients with indeterminate NS5A RAVs, one achieved SVR12 but the other showed viral breakthrough and discontinued treatment. Conclusions: In this study, DAV and ASV combination therapy for chronic hemodialysis patients with HCV infection achieved high sustained virological response with few adverse events. Close monitoring of safety and tolerability may be necessary when treating chronic hepatitis C patients with CRF receiving DCV and ASV.

곰솔(Pinus thunbergii )에서 소나무재선충병 예방을 위한 나무주사용 약제선발

이상명(Sang Myeong Lee),김동수(Dong Soo Kim),이상길(Sang Gil Lee1),박남창(Nam Chang Park),이동운(Dong Woon Lee) 한국농약과학회 2009 농약과학회지 Vol.13 No.4

This study was carried out to select effective preventive pesticides against pine wilt disease caused by pinewood nematode (PWN), Bursaphelenchus xylophilus on trunk injection. 1,000 fold aquatic solution of abamectin 1.8% EC and emamectin benzoate 2.15% EC were lower mortality (7.3% and 8.3% respectively) against PWN on 1 day after treatment. However effects of abamectin 1.8% EC, emamectin benzoate 2.15% EC, fosthiazate 30% SL and fenitrothion 30% SL were inhibited the reproduction of PWN over 99.6% in Botrytis cineria media. Effect of trunk injection of abamectin 1.8% EC and emamectin benzoate 2.15% EC at the rate of 10 ㎖ per 10 ㎝ in diameter of breast height (DBH) on mortality of Japanese black pine, Pinus thungergii by inoculated PWN was 0% and 3.3%, respectively at the applied year however when injection of fosthiazate 30% SL were treated with the rate of 5 ㎖ per 10 cm tree DBH, mortality of tree was 63.3%. Abamectin 1.8% EC and emamectin benzoate 2.15% EC was showed high preventive efficacy representing >90% against PWN at the following year. PWN preventing efficacy of trunk injection was lower in naturally occurred area (mortality of pine tree in control was 11.7% at the first year) of PWN than artificially infected site (mortality of pine tree in control was >76.7% at the first year), PWN preventing efficacy of trunk injection of abamectin 1.8% EC and emamectin benzoate 2.15% EC at the rate of 10 ㎖ per 10 ㎝ in DBH was 91.5% and 82.9%, respectively, at the applied year and 89.5% and 82.6% respectively at the following year in PWN naturally occurred site. Control efficacy by trunk injection of abamectin 1.8% EC and emamectin benzoate 2.15% EC was more higher in 10 fold dilution with 10 fold high amount of aquatic solution than no dilution with 10 fold less amount of aquatic solution. The preventive effect of trunk injection of abamectin 1.8% EC and emamectin benzoate 2.15% EC at the rate of 5 ㎖ per 10 ㎝ in DBH was showed 100% at the applied year in PWN inoculated tree.

체간안정화 훈련이 만성 뇌졸중 환자의 호흡기능에 미치는 효과

이경진(Kyeong-Jin Lee),정주현(Ju-Hyeoun Jeong),조명래(Myeong-Rae Jo),김세윤(Se-Yoon Kim),김난수(Nan-Soo Kim) 대한심장호흡물리치료학회 2019 대한심장호흡물리치료학회지 Vol.7 No.1

Purpose : The purpose of this study is to examine the effects of trunk stability training on improving trunk control, respiratory function, and respiratory muscle activation in stroke patients. Methods : The subjects were assigned to two groups: the intervention group (n=15) and the control group (n=15). Both groups participated in a conventional stroke rehabilitation program, but the intervention group also received trunk stability training for 30 minutes a day, 3 times a week, for 6 weeks. The main trunk stability exercise consisted of the dead bug exercise. Trunk control was assessed using a trunk impairment scale, and respiratory function (pulmonary function and respiratory muscle function) was assessed using spirometry. The data were analyzed using the Pearson correlation, independent t-test, and paired t-test. Results : Trunk control was significantly positively correlated with pulmonary function and respiratory muscle strength. Both groups showed a significant increase in trunk control and respiratory function. Conclusion : This study demonstrated that a conventional stroke rehabilitation program and trunk stability training have positive effects on respiratory function and respiratory muscle activation in stroke patients.

좌전하행지 관동맥 개구부위의 망사형의 관(Slotted Tube)스텐트와 나선형 코일(Coil)스텐트 삽입후 단기 및 장기 암상 경과의 비교

박훈기,박성욱,이일수,이상곤,김진우,이근,정상식,이철환,홍명기,김재중,박승정 대한순환기학회 1998 Korean Circulation Journal Vol.28 No.6

심신의학(心身醫學)

이명수,장혜숙,류훈,문성록 한국정신과학학회 2002 韓國精神科學學會誌 Vol.6 No.2

The oriental idea that health begins in mind is currently being applied in the clinical field by mind-body medicine. In the past decade. we have seen an increase 10 the popularity of mind-body medicine as an alternative or complement to traditional health care interventions. This paper explores the scientific idea of mind-body medicine and how particular mind-body intervention focusing on stress reduction and relaxation can be useful methods to Improving health state. On the basis of the psycho- neuroendocrine-immune triangular circuit, the mind-body pathway has been Investigated. Among many mind-body intervention, Qi-training and Qi-therapy are described, research on their effectiveness is reviewed, conclusions are drawn, and the applicability to clinical practice is discussed. Given existing empirical support for the effectiveness of these interventions, the authors provide Korean scientists With an overview of the psychoneuroimmunological effects of Qi-training and Qi-training, and possibility of their medical benefits.

심장으로 전이된 악성 흑색종의 고식적 절제 1예

이경수,이현희,연태진,남기병,김동운,조명찬 대한순환기학회 2000 Korean Circulation Journal Vol.30 No.9

한국의 기수련이 심장박동간격변화에 미치는 영향

이명수,허화정,김병기,류훈,정현택 한국정신과학학회 1998 韓國精神科學學會誌 Vol.2 No.2

심장박동간격은 최근 교감신경과 부교감신경의 안정을 알아보는 척도로 쓰이고 있다. 본 연구는 4~12개월 천도선법 기수련을 행한 20대의 20명의 기수련자와 동일 연령층의 20명의 일반인을 대상으로 하여 1시간 동안 천도선법을 수행하게 하여 전, 참선, 후의 심장박동을 생리 기록계로 측정을 하여 빠른 퓨리에 변환 (FFT)을 통하여 심장박동간격을 조사하였다. 그 결과 자율신경제의 안정척도인 저주파수 적분 값과 고주파수 적분 값의 비(LF/HF)가 수련전과 수련 중에서 천도선법 기수련생들의 값이 일반인과 비교하여 통계적으로 유의한 차이가 났으며 (p<0. 01) 특히 두 그룹 모두 HF 의 값이 유의하게 변화하는 것을 보았을 때 천도선법 기수련이 부교감신경의 활동을 조절하여 자율신경계를 안정화 시킨다는 것을 보여주었다. The effects of ChunDoSunBup (CDSB) Qi-training on the power spectrum of heart rate variability were studied in 20 healthy subjects and 20 CDSB Qi-trainee (subjects with CDSB Qi-training for 4-12 months) Continuous ECG signals were recorded during 1) 10 min of rest in sitting position, 2) 1 hour of CDSB Qi-training , 3) 10 min of post-training. Fast Fourier transformation was used to determine the power spectrum of heart rate variability While CDSB Qi-training, there were significant decrease in the ratio of low to high frequency power spectrum. And value of pre and mild-training in CDSB Qi-trainees were lower than that of control subjects There was a significant changes in high frequency power of both group, but net in low frequency These results suggest that CDSB Qi-training may stabilize autonomic nervous system by modulate parasympathetic nervous system.

p-n 접합을 이용한 ISFET의 전기적 절연

이강열,강명성,김창수,서화일,권대혁,손병기 경북대학교 센서기술연구소 1992 센서技術學術大會論文集 Vol.3 No.1

4세대 이동 멀티미디어 시스템의 연구동향 분석

최명수,박형준,박남철,김경호,이성로 목포대학교 정보산업연구소 2000 情報産業硏究誌 Vol.8 No.-

In this paper, we first define 4th-generation multimedia systems that play an important role in 21C information society. Nest, we investigate and analyze the international trend of the related research and then predict the evolutionary model for 155Mbps wireless mobile multimedia systems.

노인의 인구통계학적 특성이 여가활동유형에 미치는 영향

정명수,이강욱 한국스포츠리서치 2004 한국 스포츠 리서치 Vol.15 No.4

This study alms to examine the relationship among the types of Leisure activities of the aged, their satisfaction with Leisure, their concentration on leisure and their loneliness. The subject of this study is the aged over 65 years old residing In Jeollanamdo and Gwangju by random sampling and total 520 subjects of 238 men (43.3%) and 282 women (51.3%) are used for the final analysis. The examination method accepts self-test recording and questionnaire to analyze the actual conditions and satisfaction of leisure through direct participation In the leisure program conducted by educational agencies for the aged and the statistical methods used for data analysis Include SPSS 10.0 for Windows, t-test and one-way ANOVA. This study obtains the four conclusions through the above methods and procedure as follows: First, It is found that the types of Leisure activities according to the demographical character Is tics of the aged are sports, health activities, hobby and cultural activities, amusement and social activities, there Is no statistical difference according to the presence of spouse, but there are difference in the types of Leisure activities enjoyed by the aged according to general characteristics. Second, it is known that there are statistically significant differences In the degree of subjective health, their satisfaction with pocket money and preparation for their old age and those who enjoy leisure activity show low loneliness, feel a considerable satisfaction with leisure and concentrate on the leisure activities.