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導入 機器의 效率的 活用을 위한 敎授-學習 敎材의 開發 : 8 個 學科 共同 硏究
李昌甲,孟琦錫,李載元,朴萬植,廷吉煥,金鍾悟,朴景采,李英浩,李東周,邕章祐,柳盛淵,趙澤東,姜理錫,李殷雄,李興浩,金健中,韓相玉,金良模,張錫明,朴俊灝,洪鳳植,金太均,金再韓,宋海永,盧載星 충남대학교 공업교육연구소 1982 論文集 Vol.5 No.1
In this study, through the combined effort and collaboration of 8 engineering education departments, teaching-learning processes and models were reviewed, and printed and bound student manuals developed on 120 different tasks and subjects. Audio-visual supportive material, already in use in laboratories, was added to form a complete teaching-learning package. In addition to promoting the maximum use of the newly acquired equipment, this study will also contribute to the development of laboratory practice, the in-service training of technical high schools teachers and help in the development of their own instructional program.
한국형 자궁경부 촬영진 ( New Cervicography ) , 세포검사 그리고 HPV-DNA 검사를 이용한 새로운 자궁경부암 검진 모델 ( Model ) 개발
김승조(SJ Kim),박찬규(CK Park),이효표(HP Lee),남궁성은(SE Namkoong),강순범(SB Kang),서호석(HS Saw),이재관(JK Lee),김수녕(SN Kim),김재원(JW Kim),배석년(SN Bae),김찬주(CJ Kim),이근호(KH Lee),이선영(SY Lee),김인호(IH Kim),이찬(C Lee),이정노(JN Lee) 대한산부인과학회 2001 Obstetrics & Gynecology Science Vol.44 No.5
N/A Objective : The false negative rate of conventional cytology is reported to range from 18 to 45%. It is necessary to develop more effective screening strategies that would ideally be more accurate than conventional cytology. This study is designed to investigate the potential of conventional cytology, cervicography, HPV-DNA testing and their combinations as primary screening techniques for cervical neoplasia. The purpose of this project is to develop the models and guidelines for screening tools of cervical cancer of the uterus by evaluating sensitivity, specificity and cost-effectiveness of all the screening methods. Study design : We conducted a screening of random sample of women who visited the department of OB-Gyn. of five different major university hospitals such as Catholic University Hospital, Korea University Hospital, Seoul National University Hospital, Yeonsei University Hospital and Pochon CHA University Bundang CHA Hospital, from May 1, 1996 to April 30, 1999. In a cohort women with an age range of 20 to 70 who underwent routine cytologic screening at Catholic University, Hospital Bundang CHA General Hospital and local clinics from April 1, 1996 to Decomber 31, 2000. cervicography (n=417,125) and testing for HPV-DNA (n=1,347) by the hybrid capture assay were studied for the ability of the cervical cancer screeuing. A new cervicography system with Kim's classification which was developed by Prof. Kim Seung Jo as an adjunctive method for the cervical cancer screening was applied in this cohort study. And then, accuracy, effectivencess, cost-effectiveness of the single or combined screening method were analysed. Result : Sensitivity and specificity of Pap smear were ranged from 55.6% to 83.1% and 72.8% to 88.3% respectively. The combination of Pap smear and cervicography had sensitivity from 89.7% to 98.6%, specificity from 68.2% to 93.2%. With combination of Pap smear, HPV DNA test and cervicography, sensitivity became also highest accuracy among all screening methods from 92.8% to 98.8%. Considering medical charges for diagnosis and social cost occurred by false positive and false negative results, the most cost-effective diagnostic modality was thought to be the combination of Pap smear and cervicography(91,433 won). In patients who were diagnosed as LSIL, colposcopic examination confirmed progression to high grade intraepithelial lesion(HSIL) in 10.7% patients, persistence of LSIL in 55% patients during the 3 year follow-up period. Accuracy of the screening for cervical cancer and CIN can significantly be improved by cytology with new cervicography rather than cytology alone. We concluded that cervicography can be important adjunctive tests for cervical cytology, improving the effectiveness of cervical screening by allowing a more sensitive detection of cervical neoplasia.
이선경,김승보,이재현,홍진기,이주희,정재돈 대한산부인과학회 1995 Obstetrics & Gynecology Science Vol.38 No.10
p53의 발현이 상피성 난소종양의 성장과 예후에 미치는 영향을 알아보기 위해 본 경희대학 교 산부인과학교실에서 38예의 상피성 난소암환자와 12예의 경계성 난소종양 10예의 정상난 소를 대상으로 p53 과 PCNA 면역조직화학염색을 시행하여 다음과 같은 결론을 얻었다. 정상난소에서는 p53 의 발현이 일어나지 않으며(0%), 경계성 난소종양에서도 아주 낮은 빈도(8.3%)로 발현이 되었으나 상피성 난소암에서는 39.5%(15/38)의 발현율을 보여 p53 이상 피성 난소암의 발생에 관련된다는 것을 알수 있었다. 병기, 나이, 종양의 크기 , 종양의 세포종류에 따른 p53 의 발현은 의미있는 차이를 보이지 않았으며 각각의 예후인자별로 분류한후 p53 발현여부에 따른 생존율의 차이도 보이지 않았다. 상피성 난소암의 조직학적 분화도에 따른 p53 발현율은 고분화도군보다 증등도이하의 분화 도군에서 높은 것으로 나타났다. p53 발현에 따른 재발율에 비교해 본바 p53 발현군에서 높은 재발율(41.7% p=0.03726)을 보였다. PCNA 면역염색정도와 p53의 발현을 비교해본바 p53 발현군에서 더높은 PCNA면역염색 도를 보여 간접적으로 세포의 성장이 왕성하게 일어남을 알 수 있었다. It has been recongnized that abnormalities of tumor suppressor gene play a significant role in development of human cancer. One of the most common genetic alterations seen in human malignancies is inactivation of p53 tumor suppressor gene. In recent studies many authors has reported that intranuclear accumulation of p53 suppressor gene is common finding of various types of human cancer and is closely correlated with poor prognosis. We adapted p53 and PCNA immunohistochemical staining to evaluate the prognostic significance of p53 expression in epithelial ovarian cancer and to compare the relationship between p53 expression and cellular proliferation. We used paraffine embeded block of epithelial ovarian cancer from 38 patients treated at Kyunghee University between 1982-1992. p53 expression was seen in 39.5%(15/38) of epithelial ovarian cancer , 8.3 %(1/12) in borderline malignancy but not in normal ovary. Although p53 expression was lower in early stage ovarian cancer(stage I, II)than advanced stage and lower in mucinous cancer(26.7%) than other types of epithelial ovarian cancer, the relationship were not statistically significant. There were no relationship between p53 expression and size of tumor or disease free survival but significantly higher recurrence rate was seen in p53 expression group . The present study suggested that p53 expression could be utilized as a predictor of recurrence and showed that p53 expression was associated with inappropriate cellular growth but not with adverse outcome of epithelial ovarian cancer.
Lee, SW,Elfadl, AK,Chung, MJ,Arif Ullah, HM,Yuh, DK,Lee, SH,Jeong, KS,Park, JK Czech Academy of Agricultural Sciences 2018 Veterinární medicína Vol.63 No.10
<P>The present case report describes a case of chronic renal failure characterised by renal medullary fibrosis and renal papillary necrosis in a male Siberian tiger (Panthera tigris altaica). A 12-year-old male Siberian tiger presented with depression, anorexia and weight loss. Blood urea nitrogen (> 50.4 mmol/l) and ammonia (71.7 µmol/l) were increased, suggesting chronic renal failure and uraemia. The tiger died secondary to gastric haemorrhage. At necropsy, the kidneys had yellow lesions in the medulla and renal papillae and petechiae in the cortex. The stomach had multiple mucosal ulcers and haemorrhage. Microscopically, marked renal medullary fibrosis and renal papillary necrosis were observed with tubular atrophy, degeneration, coagulative necrosis, calcification and chronic inflammatory cell infiltration. The renal cortex showed moderate interstitial inflammation. The urinary bladder exhibited epithelial desquamation and submucosal fibrosis. The tiger was diagnosed with chronic renal failure secondary to renal papillary necrosis and medullary fibrosis.</P>
이현,신희철,윤보현,전종관,이재학,이용찬 대한산부인과학회 1996 Obstetrics & Gynecology Science Vol.39 No.11
Holoprosencephaly is a complex developmental abnormality of the brain arising from failure of cleavage of the prosencephalon during the fifth week of development. The prognosis of holoprosencephaly is generlaly grave. With recent development of high resolution ultrasonography, it is possible to detect fetus with holoprosencephaly antenatally. To ascertain clinical manifestations, we reviewed the records of 7 fetuses antenatally diagnosed as holoprosencephaly at Department of Obstetrics and Gynecology of Seoul National University Hospital from Nov. 1993 to Apr. 1996. The incidence of holoprosencephaly is 7/4,857(0.14%). Mean gestational age at diagnosis and delivery was 29 weeks of pregnancy(range from 17 to 37 weeks) and 30 weeks of pregnancy (range from 17 to 40 weeks), respectively. Modes of delivery were 1 cases of normal fullterm spontaneous delivery, 2 cases of preterm delivery, 2 cases of stillbirth, and 1 case of abortion. One case was lost after work-up for diagnosis and associated anomalies including targeted ultrasonography, fetal echocardiography, and karyotyping. Perinatal mortality was 83%(5/ 6) and only 1 case survived. Of 7 cases, 5 cases were alobar type and 2 cases were semilobar type. The frequency of associated anomaly was as follows: 5 cases of facial anomaly which were cyclopia, proboscis, single nostril, arhinia, and midline cleft lip and palate; 3 cases of cardiovascular anomaly; 2 cases of lung anomaly; 2 cases of limb anomaly; 1 case of gastrointestinal anomaly; 1 case of abdominal wall defect. Abnormal karyotypes were identified in 4 cases(57.1%) which include 2 cases of trisomy 13, 1 case of 46,XY, -13, M(+), and 1 case of 46, XX, 18p-. Fetus with holoprosencephaly shows a high incidence of associated anomaly and abnormal karyotyping. To predict prognosis accurately, it is desirable to confirm the diagnosis and type of holoprosencephaly and to find associated anoamly with high-resolution ultrasonography and to undergo fetal karyotyping.
초음파검사에 의한 한국인 태아의 임신주수별 태아성장지표의 정상치에 관한 연구
이재훈,김승욱,이진용,신희철,윤보현,전종관,이성구 대한산부인과학회 1994 Obstetrics & Gynecology Science Vol.37 No.10
본 연구는 1993년 서울대학교 의과대학 교육연구재단 산부인과학교실 지정연구기금의 보조로 이루어진 것임. Fetal weight and other fetal growth parameter gestational age tables have been calculated for 442 singleton fetuses by ultrasonic measurement. Twin pregnancies, stillborn and malformed infants were excluded as were those born to mothers with diabetes mellitus, preeclampsia, eclampsia and any medical and surgical illness during pregnancy that have any possibilities of altering fetal growth. The 5th, 10th, 25th, 50th, 75th, 90th and 95th percentiles were determined for 25-42th nearest weeks of gestation and compared with preexisting reportes by postnatal study. The results were as follows. 1. Fetal weight calculated by ultrasonic measurement in our prenatal study showed significant difference compared with that in previous postnatal studies before 37th nearest week of gestational age. 2. There were no significant growth velocity deceleration after 40th nearest week of gestational age. It is concluded that any growth standards based on prenatal study by ultrasonic measurement of fetal grwth parameters can be used as our standard without significant problems.
충수돌기 점액류 및 난소점액성 낭종을 동반한 복막 위점액종 1 례
이선경,김승보,이재현,허주엽,홍진기,이영기,최은림 대한산부인과학회 1993 Obstetrics & Gynecology Science Vol.36 No.10
저자들은 난소의 점액성 낭선종 및 충수돌기의 점액규와 동반된 복막위 점액종 1 례를 경험하였기에 문헌고찰과 함께 보고하는 바이다. Pseudomyxoma peritonei refers to peritoneal implants of mucin , columnal epithelium and variable amounts of free mucin associated with benigh , borderline and malignant mucinous neoplasm most often originating in the ovary or appendix. A case of pseudomyxoma peritonei originated from ovarian mucinous cystadenoma and mucocele of appendix was reported with the brief review of literature.