자궁경부에 발생한 Behcet 증후군 1예

배석년(SN Bae),김열회(YH Kim),유영옥(YO Yoo),김창이(CY Kim) 대한산부인과학회 1982 Obstetrics & Gynecology Science Vol.25 No.8

Behcet disease는 다양한 임상증상과 특이한 검사소견이 없으므로 초기에 정확한 진단을 하는 것이 쉽지 않고, 이번 증례에서 보듯이 환자는 임상증상이 나타나는 부위에 따라 임상각과를 순회하는 경우를 많이 보게 된다. 따라서 이 증후군은 어떤 한 부위만을 중점적으로 볼 것이 아니고, 전신적인 질환으로써 진단하고 치료해야 할 것이다. 본 증례는 자궁경부에 커다란 궤양이 단일적으로 나타난 예로써 여타의 질환과 구별이 어려웠으므로 이를 보고하고 아울러 간단한 문헌을 고찰 보완하였다. Behcets syndrome has been originally recognized by a diagnostic triad of the recurrent ulceration of the mouth and ulceration in the genital region and inflammatory ocular lesion. But now, the spectrum of entity appears to be a systemic disease involving many other organs. We report a case of Behcets disease with aphthous stomatitis, cervical ulceration, polyarthralgia and ocular inflammatory lesions and review the literatures as well.

전자간증 환자의 혈청 Antithrombin-Ⅲ 값의 임상적 의의

배석년(SN Bae),정재근(JK Jung),이헌영(HY Lee) 대한산부인과학회 1985 Obstetrics & Gynecology Science Vol.28 No.9

1983년 6월 1일부터 1983년 12월 31일까지 강남성모병원 및 성바오로병원 산부인과에서 입원, 분만한 정상 산모(18명) 및 전자간증 산모(경증 13명 : 중증 16명)를 대상으로 분만전, 분만후 24시간, 72시간에 모체의 혈소판, 혈청 FDP 및 혈청 AT-Ⅲ 값을 측정분석하여 다음과 같은 결론을 얻었다. 1. 질환의 중증도에 따라 평균 혈소판값은 감소되었으나 대조군에 비해 경증군에서는 현저한 변화가 없었지만 중증군에서는 1 SD이상의 감소를 보였고 분만후에는 통계적으로 유의한 증가를 보였다 (P<0.05). 2. 대조군 및 경증군에서의 분만전후의 FDP 값은 모두 정상범위(10㎍/㎖ 이하)였으며 중증군에서는 분만전에는 75%, 분만후 72시간에는 6%가 비정상(10㎍/㎖)이였다. 3. 대조군에서의 분만전후 평균 AT-Ⅲ값은 모두 정상범위내(23.1∼37.5㎍/㎗)에 있었다. 전자간증군에 서는 질환의 중증도에 따라 통계적으로 유의한 감소가 있었다(P<0.05). 대조군에 비해 경증군과 중증 군에서는 각각 1 SD, 2 SD이상의 감소가 있었고 분만후 증가하였다(P<0.05). In oreder to evaluate the significance of antithrombin-Ⅲ value in preeclampsia we studiedf antepartum and postpartum changes of platelets count, serum fibrin degradation products and serum antithrombin-Ⅲ in 18 normal pregnant women as a control group and 29 preeclamptic patients as a mild and a severe group who were delivered between June 1, 1983 December 31, 1983 at the Kangnam St Mary`s Hospital and St. Paul`s Hospital The results were as follows: 1. Mean platelet counts in the control and the mild and severe group were within normal limits(15-40x104/mm2) Mean platelets count were decreased in proportion to the degree of severity of diseas Compared with the control group there were no significant changes in the mild group But platelet counts were decreased over ISD before delivery and it showed significant increase after delivery (P<0.05) in the severa group 2. Serum fibrin degradation products were negative(below 10g/ml) in the control and mild groups but positive(10-40m/) in 75% of severe group 3.Mean antithrombin-Ⅲ value in the control value in the control group was within normal ranges in proportion to the severity of disease. Compared with the control group there were decrease over 1 SD and 2 SD in the mild and the severe group respectively adn significnat increase agter delivery(P<0.05) We concluded from the above results that serum antithombin-Ⅲ test is important to make diagnosis and to predict the prognosis of preeclampsia.

부인의 자궁경부 및 직장 도찰 피검물에서의 혐기균의 분리빈도

정재근(JK Jung),배석년(SN Bae),박종섭(JS Park),윤순옥(SO Yoon),김은중(EJ Kim),이종훈(CH Lee) 대한산부인과학회 1984 Obstetrics & Gynecology Science Vol.27 No.3

부인 생식기 계통 및 직장내에서의 혐기균의 분리빈도를 알아보기 위하여 산부인과 외래환자 87명, 임신부 68명, 정기 신검자 및 단순 검사의뢰자 60명 합해서 215명을 대상으로 하였다. 일부 검사 대상자에서는 자궁경부 도찰과 직장 도찰을 동시에 하였다. 이들 도찰물을 thioglycollate배 양액에서 증균시킨후 BHIBSA평판 배지에 획선 도말하여 Gas Par Jar내에서 협기균을 분리 배양하였 다. 배양 후 분리균주에 대한 그람염색상의 형태, 생화학적 성상, 연령별 분포를 관찰 조사하고 또한 항생제에 대한 감수성 실험을 실시하여 다음과 같은 결론을 얻었다. 1. 총 검사물 297건중 혐기성 세균이 218주(73.4%)가 분리되었다. 자궁경부 도찰물 190건 중에서 혐 기균주는 142주가 분리되었고 (74.7%), 직장 도찰물에서는 107건중 76주가 분리되었다.(71.0%). 자궁경부 에서는 그람음성 간균이 70.4%, 그람양성 구균이 26.8%였으며, 직장에서는 그람음성 간균이 27.6%였다. 2. 연령별로는 21세에서 40세 사이가 전체의 72.9%였으며, 자궁경부에 78%, 직장에 63.2%를 점유하였 다. 3. 자궁경부에서 분리된 혐기균 주에서는 Bacteroides ovatus, B. fragilis, B. vulgatus, Peptostretococcus products 순으로 많았고, 직장도찰물에서는 Eubacterium aeroficience, b. fragilis, Peptostreptococcus productus순이었다. 4. 자궁경부 및 직장에서 분리된 혐기성균주의 대부분이 항생제에 대하여 내성이 높았으나 Chloramphenicol과 kanamycin에 대하여는 다소 감수성을 나타냈다. To observe the distribution and frequency of anaerobes from the uterine cervix and rectum in women, a total of 297 specimens (cervix; 190, rectum; 107) were obtained from 123 swabs from healthy women (n=60), 106 swabs from out-patient women(n=87) and 68 swabs from pregnant women (n=68). 82 swabs (n=41) of 229 specimens were abtained both from the uterine cervix and rectum in the same persons. Cervical and rectal swabs were put into thioglycollate medium and immediately transferred to the labortory. After 48 hours incubation in thiogly collate medium at 37℃, anaerobes were isolated by culture on the brain heart in fusion blood supplemented agar (BHIBSA). Sugar fermentation on isolated anaerobes was performed by miniteck plate and sensitivity to antiiotics was measured by_Kirby-Bauer method. All procedures were performed under the anaerobic condition. The results were as follows: 1. Total 218 strains of anaerobes were isolated from 297 specimens. 142 strains were isolated from 190 specimens of uterine cervix (74%), 76 strains from 107 specimens of rectal swabs(71%). In uterine cervix, gram negative bacilli (70.4%) were predominantly isolated, and the next was gram positive cocci (26.8%). In rectal swabs, the rate of isolated anaerobes between gram positive (32.9%) and negative (39.5%) bacilli were similar. 2. Most strains of anaerobes isolated from uterine cervix (78.1%) and rectal swabs (63.2%) were distributed in 20∼40 year old age. 3. Of total 142 strains isolated from uterine cervix, the most frequent strains were Bacteroides obatus, B. fragilis, B. vulgatus and Peptostreptococcus productus in the decreasing order of frequency. Of total 76 strains isolated from rectal swabs, the most frequent strains were Eubacterium aeroficience, B. frgilis, P. productus in the decreasing order of frequency. 4. Isolated anaerobic strains were mostly resistant to tested antibiotics. A few strains were susceptible in some degree to chloramphenicol and kanamycin.

화학요법치료에 "최소저항"을 갖는 융모성 질환의 임상연구

이동욱(DW Lee),배석년(SN Bae),김종복(CB Kim),강병철(BC Kang),허필형(PH Hur),김승조(SJ Kim) 대한산부인과학회 1983 Obstetrics & Gynecology Science Vol.26 No.6

1973년 1월부터 1982년 5월까지 카톨릭의과대학부설 융모성질환연구소에 등록 화학요법치료를 받은 융모성 질환 340예중 혈청 β-hCG값이 경쾌수준에 거의 도달 했으나 화학요법치료를 4회 이상 계속해도 20mIU/ml 이하값에서 "plateau"를 보이는 "최소저항군"의 연구조 사 결과 다음과 같은 결론을 얻었다. 1. 화학요법치료를 받은 융모성질환 340예중 "최소 저항군"은 31예(9.1%)였다. 2. "최소저항군" 31예중 화학요법치료를 중지한 6예 의 예후는 재발이 4예(66.7%), 경쾌가 2예(33.3%)로 서 이점주의 2/3가 잔여종양이며 1/3이 경쾌된 것으로 판단되었으며, 융모성질환의 경쾌판정기준의 절대성을 의심케 했다. 3. "최소저항군" 31예중 계속적인 화학요법제 치료 는 25예였으며, 동일한 화학요법제치료가 17예, 다른 화학요법제 치료로 전환한 것이 8예였고, 전예의 경우 경쾌는 15예(88.2%), 후예의 경우 경쾌는 8예(100.0 %)로써 약제내성군의 치료원칙에 따른 화학요법제 전 환이 예후가 좋았다. 4. "최소저항군"의 소인이외는 위험인자를 규명하기 위한 조사결과는 다음과 같다. (1) 환자의 연령은 "최소저항군"의 빈도에 영향을 미 치지 않았다. (2) 기왕분만회수는 "최소저항군"의 빈도에 영향을 미치지 않았다. (3) 혈액형이 AB형인 경우 "최소저항군"의 빈도가 높았다. (4) 선행임신은 "최소저항군"의 빈도에 영향을 미치 지 않았다. (5) 종양위 진행기간이 7개월이상인 경우 "최소저항 군"의 빈도가 높았다. (6) 혈청 β-hCG값이 높을수록 "최소저항군"의 빈도 는 증가했다. (7) 자궁의 크기는 "최소저항군"의 빈도에 영향을 미치지 않았으나 전자궁적출술을 시행한 경우 그 빈도는 현저히 높았다. (8) 골반강전이가 다른 장기전이에 비해 "최소 저항 군"의 빈도가 높았다. (9) 치료목적으로 사용한 기왕화학요법실패시 "최소 저항군"의 빈도가 높았다. (10) 세포면역반응을 위한 DNCB검사가 낮은 반응을 보일수록 "최소저항군"의 빈도가 높았다. (11) Methotrexate 와 Actinomycin-D의 복합치료경 우 다른 화학요법치료에 비해 "최소저항군"의 빈 도가 높았다. (12) Stage II 융모성질환에서 "최소저항군"의 빈도 가 높았으나 위험군별 분류는 그 빈도에 영향을 미치지 않았다. 5. 본 연구는 저자들이 "최소저항군"이라 명명한 융 모성질환의 한 범주를 임상고찰한데 지나지 않고 그정 의의 타당성 및 경쾌판정 기준에 관한 연구는 계속되 어야할 것으로 사료되며 아울러 hCG β-submit와 다 른 호르몬과의 교차반응문제 혹은 다른 세포수준에서 의 hCG분비등의 보고를 주시하여야 할 것이다. ln order to investigate risk factors of minimum resistance cases, 31 cases were selected from 340 patients of trophoblastic disease with chemo therapy registered at Korea lnstitute of Triophoblastic Disease in Catholic Medcal School from January, 1973 to May, 1982. The study group revealed 1.5~2.0mIU/ml of serum β-hCG value for 4 consecu­ tive weeks although they revealed remission level(below 1.5mIU/ml) for 3 consec- utive weeks. ln this study, the group was named minimum resistance to be differ- entiated from persistent.trophoblastic disease or drug resistance and was compared with controlgroup of 252 cases of trophoblastic disease with remission except 31 cases of minimum resistance and expired 51 cases. Among this study group, 17 cases were treated with continuous chemotherapy with same regimen and remission rate was 88.2% (15 cases), and 8 cases were treated with continuous chemotherapy with switching regimen and remission rate was 100% (8 cases). Chemotherapy was discontinued in 6 case and remission was revealed in 2 cases(33.3%) Of them. Residual tumor was revaled in 66.6% of min- imum resistance cases. ln comparison of statistical results between control group and study group, authors obtained the result that risk factors of minimum resistance were affected by long period of tumor age, AB type of ABO blood group, failed preⅵous therapeutic chemotherapy, previous initial hysterectomy, DNCB negative, and combination chemotherapy of Methotrexate and Actinomycin-D.

Cis-platinum 화학요볍 환자의 혈중 전해질 및 신장기능 변화

김승일(SI Kim),나덕진(DJ Rah),최광호(KH Choi),배석년(SN Bae),김대훈(DH Kim),남궁성은(SE Namkoog),김승조(SJ Kim) 대한산부인과학회 1983 Obstetrics & Gynecology Science Vol.26 No.11

본 가톨릭의과대학 산부인과학교실 종양부에서 조사한 Cis-platinum을 주제로한 병합화학요법을 받은 환자의 변화는 다음과 같았다. 1. 신기능 검사상 BUN 및 creatinine 증가해 의해 판단된 신독성을 보인 경우는 환자의 20.7%였다. 2. 혈중 전해질 농도의 변화는 저 calcium 혈증은 37.9% 저 phosphate 혈증은 6.9%, 저 kalium 혈증은 20.6%, 저 natrium 혈증은 13.8%. 저 magnesium 혈증은 48.2%였으며 특히 저 magnesium 혈증이 있으며 저 calcium 혈증을 흔히 동반함을 확인하였다. 3. 14명의 저 magnesium 혈증 환자중 3 명에서 magnesium 의 신배설에 이상이 발견되었고. 또 심한 magnesium 결손 증상을 일으켰다. Since the platinum coordination complex was introduced for cytotoxic agents by Rosenberg (1965), cis-platinum was known to be active against tumors, testicular, ovarian, bladder, head and neck carcinomas. especially testicular, ovarian, bladder, head and neck carcinomas. Recently, these inorganic platinum compounds has been widely used by single or combination with other chemotherapeutic agents for the purpose of ovarian and cervical cancer treatment. The limitation for using these agents is gastrointestinal troubles, myelosuppression, ototoxicity and nephrotoxicity. The nephrotoxicity in the form of azotemia is thought to result from renal tubular damage but renal tubular dysfunction in patients receiving this drug bas not been well described. We proceded to review the admission charts of the 42 patients who treated with combination chemotherary with cis-platinum to examine the changes of renal function and serum electrolytes in the patients during chemotherapy. The results of this study were as follows; 1. Nephrotoxicity was noted in 20.7% of patients as determined by an elevation of BUN and serum creatinine. 2. For the changes of serum electrolytes, hypocalcemia 37.9%, hypophosphatemia 6.9%, hypokalemia 20.6%, hyponatremia 13.8%, hypornagnesemia 48.2% was observed. 3. Three patients among fourteen hypomagnesemic renal magnesium wasting and showed deficiency. serious clinical patients had inappropriate symptoms of magnesium

난소종양 1338 예의 임상병리학적 고찰

김재호(Kim JH),마수영(SY Ma),신왕근(WG Shin),배석년(SN Bae),남궁성은(SE Namkoog),김승조(SJ Kim) 대한산부인과학회 1985 Obstetrics & Gynecology Science Vol.28 No.5

A clinico-pathological survey was carried out on a series of 1338 ovarian tumors who were confimred with postoperative hisopathological study at Department of Obstetrics & Gynecology, in 7 affiliated hospitals of Catholic Medical Center during the period of 12 years from January 1, 1972 to December 31, 1983. The results were obtained as follows: 1. Among 1338 cases, the incidence of nonneoplastic ovarian cyst, benign ovarian tumors and malignant ovarian tumors were 39.7%(531 cases), 50.7%(679 cases) and 9.6%(128 cases) respectively. 2. The incidence of cystic teratoma, corpus luteal cyst, mucinous cystadenoma and simple cyst were 31.3%(419 cases), 13.2%(176 cases), 12.1%(162 cases) and 12.0%(161 cases) respectively. 3. The age distribution of ovarian tumor was 4~74 years old, and that of nonneoplastic ovarian cyste was 16~74 years old, and that of benign ovarian tumors was 4~71 years old, and that of malignant ovarian tumors was 17~70 years old. The mean ages of nonneoplastic ovarian cyst, benign ovarian tumors and malignant ovarian tumors were 33.1, 33.0 and 44.7 years old respectively. 4. In the incidence of ovarian tumors by age, the high incidence of nonneoplastic ovarian cyst and benign ovarian tumors showed in fertilized women(20~44 years old) as 87.8% and 79.5% respectively and that of malignant ovarian tumors showed in women over 45 years old as 50.8%. 5. The mean live births in patients of nonneoplastic ovarian cyst, benign ovarian tumors and malignant ovarian tumors were 1.7, 1.7 and 2.4 respetivley. 6. Menstrual pattern was regular in over 50%, and Menstrual amount was in normal range in 61.4% of nonneoplastic ovarian cyst, 53.6% of benign ovarian tumors and 38.1% of malignant ovarian tumors. 7. In benign ovarian tumors, abdominal pain and discomfort was present in 53.0 %, asymptomatic in 35.6%, lumbago in 27.8% and abdominal palpable mass in 27.1%. In malignant ovarian tumors, abdominal pain and discomfort was present in 63.3%, acdominal palpable mass in 49.2%, asymtomatic in 31.3% and lumbago in 29.7%. Weight loss was present in 0.4% of benign ovarian tumors and 9.4% of malignant ovarian tumors. 8. The mean size of tumors was 7.2cm in nonneoplastic ovarian cyst, 9.1cm in benign ovarian tumors and 11.9cm in malignant ovarian tumors. 9. Bilatrality of ovarian tumors was 13.9% in nonneoplastic ovarian cyst, 22.2% in benign ovarian tumors, 37.5% in malignant ovarian tumors, especially 40.4% in endometrial cyst, 47.6% in adenocarcinoma, 54.3% in serous cystadenocarcinoma and 75.0% in Krukenberg tumor.

포상기태 제거후 혈중 B-hCG값의 감소양상과 예후인자들

이태순(TS Lee),송기창(KC Song),김창이(CY Kim),배석년(SN Bae),정재근(JK Jung),김대훈(DH Kim),김승조(SJ Kim) 대한산부인과학회 1989 Obstetrics & Gynecology Science Vol.32 No.10

가톨릭의과대학 부설 융모성질환 연구소에 등록된 포상기태 환자 275예를 대상으로 혈중 B-hCG 경쾌기간에 따라 포상기태의 예후에 영향을 미치는 것으로 생각되는 인자들을 비교 분석하여 다음과 같은 결론은 얻었다. 1. 연령의 증가에 따라 혈중 B-hCG 경쾌기간은 증가하는 경향을 보였으나 통계적으로 유의는 없었다. 2. 기왕분만 횟수가 증가할수록 혈중 B-hCG 경쾌기간은 유의하게 길어졌다. 3. 부분 포상기태에서는 혈정 B-hCG 경쾌기간이 짧은 반면에 재발성 포상기태에서는 혈중 B-hCG 경쾌기간이 길었다. 4. 임신주수에 비하여 자궁의 크기가 클수록 혈중 B-hCG 경쾌기간은 길었다. 5. 포상기태 제거전 뇨중 hCG값이 높을수록 혈중 B-hCG 경쾌기간은 길었다. 6. 혈중 B-hCG 경쾌기간이 긴 경우에 존속성 융모성 빈도가 높았다. 이상의 결론으로 보아 혈중 B-hCG 경쾌기간이 길어질수록 예후가 나빴으며 고위험군에 대한 조기 화학요법 치료가 필요하다고 생각된다. 1. There appeared to be a tendency of increase is regressin period according to age, but not statistically significantly 2. Regression period became prolonged with increased number of parity 3. There was an incarese in regression period in complete mole group and a sincindence increase in regression period in recurrent mole group when compared with that of partial mole group . 4. In relation of uterine size to gestatinal months there was significantly increase in regression period in large for dates group when compared with that of normal and small for dates group 5. There was significantly increase in regression period in the higher initial hCG titer group than the lower group 6. frequency of persistnat gestational trophoblastic tumor was higher with those who showed prologed B-hCG regression period.

임신중 기형종의 복강내 파열 1례

이충훈(CH Lee),김태응(TE Kim),김진우(JW Kim),배석년(SN Bae),김창이(CY Kim) 대한산부인과학회 1984 Obstetrics & Gynecology Science Vol.27 No.10

저자들은 비교적 희귀한, 임신중에 동반된 기형종 파열 1례를 경험하였기 문헌고찰과 함께 보고하는 바이다. A case of intraperitoneal rupture of benign cystic teratoma during pregnancy is one of the most unusual and tragic accident in obstetrics. Little has been done to improve the diagnosis of this condition, which presents high risk to the mother. Authors present a case of it, with a brief review of literatures available.

한국형 자궁경부 촬영진 ( New Cervicography ) , 세포검사 그리고 HPV-DNA 검사를 이용한 새로운 자궁경부암 검진 모델 ( Model ) 개발

김승조(SJ Kim),박찬규(CK Park),이효표(HP Lee),남궁성은(SE Namkoong),강순범(SB Kang),서호석(HS Saw),이재관(JK Lee),김수녕(SN Kim),김재원(JW Kim),배석년(SN Bae),김찬주(CJ Kim),이근호(KH Lee),이선영(SY Lee),김인호(IH Kim),이찬(C Lee),이정노(JN Lee) 대한산부인과학회 2001 Obstetrics & Gynecology Science Vol.44 No.5

N/A Objective : The false negative rate of conventional cytology is reported to range from 18 to 45%. It is necessary to develop more effective screening strategies that would ideally be more accurate than conventional cytology. This study is designed to investigate the potential of conventional cytology, cervicography, HPV-DNA testing and their combinations as primary screening techniques for cervical neoplasia. The purpose of this project is to develop the models and guidelines for screening tools of cervical cancer of the uterus by evaluating sensitivity, specificity and cost-effectiveness of all the screening methods. Study design : We conducted a screening of random sample of women who visited the department of OB-Gyn. of five different major university hospitals such as Catholic University Hospital, Korea University Hospital, Seoul National University Hospital, Yeonsei University Hospital and Pochon CHA University Bundang CHA Hospital, from May 1, 1996 to April 30, 1999. In a cohort women with an age range of 20 to 70 who underwent routine cytologic screening at Catholic University, Hospital Bundang CHA General Hospital and local clinics from April 1, 1996 to Decomber 31, 2000. cervicography (n=417,125) and testing for HPV-DNA (n=1,347) by the hybrid capture assay were studied for the ability of the cervical cancer screeuing. A new cervicography system with Kim's classification which was developed by Prof. Kim Seung Jo as an adjunctive method for the cervical cancer screening was applied in this cohort study. And then, accuracy, effectivencess, cost-effectiveness of the single or combined screening method were analysed. Result : Sensitivity and specificity of Pap smear were ranged from 55.6% to 83.1% and 72.8% to 88.3% respectively. The combination of Pap smear and cervicography had sensitivity from 89.7% to 98.6%, specificity from 68.2% to 93.2%. With combination of Pap smear, HPV DNA test and cervicography, sensitivity became also highest accuracy among all screening methods from 92.8% to 98.8%. Considering medical charges for diagnosis and social cost occurred by false positive and false negative results, the most cost-effective diagnostic modality was thought to be the combination of Pap smear and cervicography(91,433 won). In patients who were diagnosed as LSIL, colposcopic examination confirmed progression to high grade intraepithelial lesion(HSIL) in 10.7% patients, persistence of LSIL in 55% patients during the 3 year follow-up period. Accuracy of the screening for cervical cancer and CIN can significantly be improved by cytology with new cervicography rather than cytology alone. We concluded that cervicography can be important adjunctive tests for cervical cytology, improving the effectiveness of cervical screening by allowing a more sensitive detection of cervical neoplasia.

자궁경부암에서 Glutathione-S-Transferase와 P-glycoprotein의 발현에 대한 연구

배석년,김도강,김수평,김용욱,장병우,변태섭 대한산부인과학회 1998 Obstetrics & Gynecology Science Vol.41 No.1

Expression of glutathione-S-transferase-π and multidrug resistance gene was examined immunohistochemically in relation to the response to neoadjuvant chemotherapy with cisplatin and etoposide in 23 patients with primary squamous cell carcinoma of uterine cervix(Stage ⅠB2 and ⅡA). Glutathione- S-transferase-π was detected in 19 patients(82.6%). Eleven patients(47.8%) showed positive staining for both proteins. After radical hysterectomy, 11 patients showed pathological response from no residual malignancy to microinvasive cancer. Six of 12(50.0%) tumors showing positive glutathione-S-transferase-π staining were drug resistant(no change or progressive disease), whereas six of 11(54.5%) tumors showing negative gutathione-S-transferase-π staining were drug resistant. This difference in the response rates of the two groups was not significant(p > 0.05). Ten of 19(52.6%) tumors showing positive multidrug resistance staining were diug resistant(no change or progressive disease), whereas 2 of 4(50.0%) tumors showing negative multidrug resistance staining were drug resistant. This difference in the response rates of the two groups was not significant(p > 0.05). Five of 11(45.5%) tumors showing positive staining for both gene were drug resistant, Whereas two of 4 (50%) showing negative staining for both gene were drug resistant. This difference in the response rates of the two groups was not significant(p > 0.05). These data suggest that glutathione S-transferase-π and multidrug resistance gene were not useful predictive markers of drug resistance composed of cisplatin and etoposide in squamous cell carcinoma of uterine cervix.