지난 2년간의 학회지 "신경정신의학" 심사 평가보고

김찬형,김세주,김도관,김성곤,박원명,송동호,박용천,이영문,오강섭,정영철,이상열,김주한,이동영,이헌정,함병주,김율리,김문두,김정진,이강욱,천근아,김재진,홍진표,홍승철 大韓神經精神醫學會 2007 신경정신의학 Vol.46 No.6

8년간(1992~1999) 산업안전보건연구원에 의뢰된 직업병 심의 사례 분석

강성규,김규상,김양호,최정근,안연순,진영우,최병순,양정선,김은아,채창호,최용휴,김대성,박정선,정호근 대한산업의학회 2000 대한직업환경의학회지 Vol.12 No.2

Objectives : Pneumoconisis and noise-induced hearing loss (NIHL) have been reported as main occupational diseases by the Special Health Examination. The Industrial Accident Compensation Insurance has reported various work-related diseases, however, these two diseases occupied almost a half of compensated cases. Therefore, it was not well known about the status of occupational diseases other than pneumoconiosis, NIHL, and cardio-cerebrovascular accident (CVA). This study was conducted to analyze claimed cases as an occupational disease, that was requested to the Korea Industrial Safety and Health Agency (KOSHA). Methods : The local office of the Korea Labor Welfare Corporation (KLWC) has asked the KOSHA for confirmation of claimed cases as an occupational disease. We analyzed 379 cases requested from KLWC, the Ministry of Labor, employers, unions and occupational health agencies from 1992 to 1999. Results : Male was 80.7 % of the requested cases. Their mean age was 42 years old and 75.5 % of them were more than 35 years old. The requested cases were increased rapidly from 25 cases in 1992 to 108 cases in 1999 and the accept rate was 50.7 %. The majority of requested cases were respiratory diseases(22.4%), cancers(18.5%), Neuropsychiatric problems(14.5%), and musculoskeletal problems(13.5%). The accept rate was high in reproductive, respiratory, musculoskeletal and digestive disorders and low in neuropsychiatric, renal and otologic problems and occupational cancers. 73.6% of them were caused by chemical agents, especially 28.5 % were by organic solvents. 67% of them were clinically confirmed at university hospitals. A half of the cases were from KyongIn area, even the request came from the whole country. Conclusions : A claim was common in workers whose age was over 35 years old and exposure history was over 10 years. The respiratory diseases and neuropsychiatric disorders were still main problems in occupational health and occupational cancers was increasing even though its accept rate was not high yet.

Sulforaphane protects against acetaminophen-induced hepatotoxicity

Noh, Jung-Ran,Kim, Yong-Hoon,Hwang, Jung Hwan,Choi, Dong-Hee,Kim, Kyoung-Shim,Oh, Won-Keun,Lee, Chul-Ho Elsevier 2015 Food and chemical toxicology Vol.80 No.-

<P><B>Abstract</B></P> <P>Oxidative stress is closely associated with acetaminophen (APAP)-induced toxicity. Heme oxygenase-1 (HO-1), an antioxidant defense enzyme, has been shown to protect against oxidant-induced tissue injury. This study investigated whether sulforaphane (SFN), as a HO-1 inducer, plays a protective role against APAP hepatotoxicity <I>in vitro</I> and <I>in vivo</I>. Pretreatment of primary hepatocyte with SFN induced nuclear factor E2-factor related factor (Nrf2) target gene expression, especially HO-1 mRNA and protein expression, and suppressed APAP-induced glutathione (GSH) depletion and lipid peroxidation, which eventually leads to hepatocyte cell death. A comparable effect was observed in mice treated with APAP. Mice were treated with 300 mg/kg APAP 30 min after SFN (5 mg/kg) administration and were then sacrificed after 6 h. APAP alone caused severe liver injuries as characterized by increased plasma AST and ALT levels, GSH depletion, apoptosis, and 4-hydroxynonenal (4-HNE) formations. This APAP-induced liver damage was significantly attenuated by pretreatment with SFN. Furthermore, while hepatic reactive oxygen species (ROS) levels were increased by APAP exposure, pretreatment with SFN completely blocked ROS formation. These results suggest that SFN plays a protective role against APAP-mediated hepatotoxicity through antioxidant effects mediated by HO-1 induction. SFN has preventive action in oxidative stress-mediated liver injury.</P> <P><B>Highlights</B></P> <P> <UL> <LI> SFN pretreatment increases the cell viability against APAP-induced toxicity. </LI> <LI> SFN pretreatment protects depletion of cellular GSH after APAP treatment. </LI> <LI> SFN pretreatment enhances Nrf2 target gene expression, especially HO-1 after APAP treatment. </LI> <LI> SFN has protective effect against APAP overdose-induced liver injury <I>in vivo</I> model as well. </LI> </UL> </P>

Dimethylphthalate 와 1,4-butanediol간의 에스테르 교환반응에 관한 연구

김난화,박근호 國立 昌原大學校 産業技術硏究所 1999 産技硏論文集 Vol.13 No.-

Transesterification reaction between dimethylphthalate and 1,4-butandiol was kinetically investigated in the presense of various metal acetate catalysts at 140-180℃. The reaction rates measured by the amount of distilled methanol from the reaction vessel. The transesterification reaction was carried out under the first order conditions respect to the concentration of reactants, respectively. The overall reaction order was 2nd. The linear relationship was shown between apparent rate constant and reciprocal absolute temperature. By the Arrhenius plot the activation energy have been calculated as 6.29 kcal/mole under lead acetate catalyst and also apparent rate constant, k' was found to obey first kinetics with respect to the concentration of catalyst. The maximum reaction rate was appeared at the range of 1.4 to 1.6 of electronegativity of metal ions.

생체분해성 망막압정을 이용한 망막고정에 대한 실험적 연구

김용백,민병무,김창식,박근성,김승영,길숙종,조항진,이성복,노승무,송규상,강대영,조준식,양준묵,정경수,최선웅,이진호,김학용,인현빈 충남대학교 의과대학 지역사회의학연구소 1998 충남의대잡지 Vol.25 No.1

Biodegradable retinal fixation devices obtain mechnical fixation of the retina with desirable chorioretinal scarring and with the potential for local, sustained release of antimetabolites and steroids to inhibit proliferative vitreoretinopathy. We manufactured a biodegradable retinal tack with barb that was designed in order to prevent intrusion from implantation of retinal tacks. This study was carried to evaluate the efficacy for retinal fixation and the capability for sustained release of drugs with a newly designed biodegradable retinal tack Biodegradable retinal tacks were made of polymers of glycolic acids and were designed with barbs in a shape to prevent the disinsertion. Biodegradale retinal tacks are divided into 3 parts, a conical portion that is inserted into the sclera, a cylinder portion that remains in the vitreous, and a neck portion between the pin and the cylinder. The tapered conical end was manufactured to allow easy insertion through the retina and choroid into the sclera. A cylinder portion was manufactured with a tapered angle that fixes firmly into the orifice of 19 gauge spinal needle. A neck portion, 0.4 mm in diameter, was designed to prevent disinsertion from following implantation of retinal tack. The applicator was a 19 gauge spinal needle and its orifice was prepared to 15°angle to accept the tapered cylinder portion of the retinal tack. The retinal tacks, secured in the needles, were passed through the formed vitreous and inserted into the retina, choroid, and sclera and were released by pushing the internal needle, usually within 2-3mm of the medullary ray of the posterior rabbit retina A retinal tack was placed in each of 8 pigmented rabbit eyes. Slit-lamp biomicroscopy, indirect ophthalmoscopy and fundus photography were performed periodically from 1 day to 8 weeks after surgery. Eight eyes were enucleated and studied by light microscopy at 8 weeks. Biomicroscopic evaluation of the animals revealed edemas adjacent to the retinal surfaces immediately after insertion of the biodegradable retinal tacks in all the animals. These edemas disappeared after 1 week. The first noticeable change in the size of retinal tacks was shown after 2weeks. The size of the retinal tacks gradually got smaller, decreasing to about one-half at 4 weeks and about one-third at 8 weeks. All retinal tacks remained in inserted places without any movement for an 8 week period. On light microscopy, epiretinal proliferations were seen to extend into the vitreous cavity. Cellular capsules that lined the inner aspect of the scleral defect caused by tack insertion were found. However the adjacent retina had a normal cytologic appearance and architecture in all specimens. We manufactured a biodegradable retinal tack that is designed to prevent intrusion from implantation of retinal tacks. All biodegradable retinal tacks reduce in size with time, but no retinal tacks extruded from the inserted place. The newly designed biodegradable retinal tack can be used for retinal fixation and may be used as a vehicle for the introduction of pharmacologic agents to prevent the cellular events that promote proliferative vitreoretinopathy.

치과의원 경영실태에 관한 연구

김영남,정기호,권호근 대한구강보건학회 2003 大韓口腔保健學會誌 Vol.27 No.4

This study is to investigate financial performance at dental clinics from collecting objective data of income and cost. The data were collected from 149 dental clinics by stratified randomized sampling method. The results are as follows; 1. The total income is about 18,050 thousand won on a monthly average, composed of 7,300 thousand won from health insurance payment and 10,620 thousand won from out-of-pocket payment and 1,670 thousand won from uninsured patient or other insurance payment. 2. The total cost is 17,120 thousand won on a monthly average, composed of 9,720 thousand won in labor cost including director's cost, 3,000 thousand won in material cost, and 4,040 thousand won in management cost. The director's labor cost is estimated at 7,310 thousand won. 3. The average dental profit-income ratio is -2.5%. The ratio by region is -26.7% in Seoul, -2.2% in large cities, and 15.1% in small cities or counties or towns. Nowadays income of dental clinics is dependent of out-of-pocket payment, and most cost is composed of fixed cost same as labor and material cost. And the dental profit-income ratio is near by 0%. It means that the average directors in dental clinics make profits equal of labor cost estimated in this study. In the future, the study of comparison of financial performance before and after the opening of medical market will be needed. And we'll be able to use this study as baseline data.

유방에서 기원된 전이성 췌장암종 1예 : A case report

김윤신,이미숙,장원재,임성철,기근홍,전호종,서재홍 조선대학교 1994 The Medical Journal of Chosun University Vol.19 No.2

Pancreas is known for the unfavorable soil to the metastatic carcinoma, and pancreatic metastasis is achieved after systemic dissemination was developed. The primary tumors of metastatic pancreatic carcinoma are breast, lung, Iymphoma, malignant melanoma, leukemia, stomach. and colon. The breast carcinoma is the commonest tumor to metastasize to pancreas and both tumors are related to estrogen receptor for tumor growth. In the present case, tumor cells had small round nucleus and showed indian file infltrating pattern and lack of cohesion, which are seen in infiltrative breast carcinoma. The patient was underwent radical mastectomy due to infiltrative ductal carcinoma three years ago. And also the tumor cells showed nuclear reactivity to immunostaining for estrogen receptor In combination of the histopathologic. immunohistochemical, and her past history, we concluded that breast carcinoma was metastasized to pancreas, and we report a case of metastatic pancreatic carcinoma from breast with review of literatures.

경구용 Fluconazole 투여로 치유된 스포로트리쿰증 1예

김문범,오창근,장호선,권경술 대한의진균학회 1999 대한의진균학회지 Vol.4 No.2

We report a case of lymphocutaneous sporotrichosis in a 76-year-old female successfully treated with oral fluconazole. This case had showed almost complete clinical resolution by 200mg daily administration of oral fluconazole for 7 weeks and has got no relapse until 18 weeks after the completion of the treatment. We would emphasize good therapeutic effects of fluconazole such as more rapid therapeutic response than the previous reports and no observable side effects. [Kor J Med Mycol 4(2): 148-152]

난소적출 백서에서 estrogen투여가 실험적 치아이동에 미치는 영향

김오환,박병건,김정기,진근호 대한치과교정학회 1997 대한치과교정학회지 Vol.27 No.4

난소를 적출한 백서에서 실험적 치아이동 동안 치주와 치조골 조직의 반응에 대한 에스트로젠의 효과를 알아보기 위하여 체중 250gm 내외의 성숙한 백서 80마리를 난소척출한(ON)군과 난소적출하고 에스트로젠을 투여한 (OE)군, sham operation만 시행한(NN)군, sham operation을 시행하고 에스트로젠을 투여한 (NE)군으로 각각 분류하여 교정력을 가하였다. OE군과 ON군은 교정력을 가하기 3주전에 난소를 적출하여 에스트로젠 결핍성 골다공증을 유발시켰다. OE군과 NE군에서는 2일에 한번씩 에스트로젠을 50㎍/kg BW씩 복강내에 주사하였다. 치근의 압박측과 인장측의 Howship's lacuna와 파골세포수를 비교 분석하였고, 치아 이동량을 계측 분석하였으며 그 결과는 다음과 같다. 1. 교정력을 가하기 전 NN군에서 보다 ON군에서 치조골 부위에 더 많은 Howship's lacuna와 파골세포가 관찰되었다. 2. 교정력을 가한 후 1일에서 15일까지 압박측의 lacuna와 파골세포의 증가양상은 NN군에서 보다 ON군에서 더 컸으며, ON군의 lacuna수는 OE군보다 교정력을 가하는 전기간동안 높은 수치를 나타냈다. 3. 인장측의 파골세포수는 ON군에서 3일까지 급격히 증가하고 이후 감소하였으나, 전기간 동안 NN군에 비해 높은 수치를 나타냈다. 4. 치아이동 속도는 NN군, OE군, NE군에서 비슷하였고, ON군에서 7일에서 11사이에 다른 군에 비해 뚜렷한 증가를 보였다. 5. 교정력 제거 후 7일간 재발을 관찰한 결과 처음 12시간이 가장 큰 재발 이동량을 나타냈으며, 모든 군에서 유사한 양의 재발을 보였다. The purpose of this study was to evaluate the effect of estrogen on the periodontium and alveolar bone tissue response during experimental tooth movement in ovariectomized rats. Eighty female rats, 250gm in body weight, were classified into four groups; sham operated group(NN), ovariectomized before 3 weeks to begin the experiment, which resulted in estrogen-deficient osteoporosis. In OE group & NE group, estrogen was injected 50㎍/kg BW. every other days. The left maxillary 1st molar was moved mesially with 60g force. Each four rats were sacrificed after 1,3,5,15 days from application of orthodontic appliance and after additional 7days from removal of orthodontic appliance. Histological findings on mesial roots of upper 1st molar in pressure and tension side are observed. The results were summarized as follows; 1. In pressure side of alveolar bone, the number of osteoclasts and Howship's lacuna of ON group was significantly more than that of NN group from 1 day to 15 days(p<0.05). Especially the number of Howship's lacuna of ON group was significantly more than that of OE group during all experimental period(p<0.05) 2. In tension side of alveolar bone, the number of osteoclasts of ON group was significantly increased from 1 day to 3 days and decreased after 7 days. But the number of osteoclast of ON group was significantly more than that of NN group during all experimental period(p<0.05). Also the number of Howship's lacuna of all groups was abruptly increased at 1 day, but slowly decreased till experimental 15 days. And the number of Howship's lacuna of ON group was significantly more than that of NN group from O hr to 7 days(p<0.05) 3. The speed of tooth movement of OE group & NE group was similar to that of NN group(p>0.05). The amount of tooth movement of ON group between 7 days and 15 days was significantly greater than those of other groups(p>0.05). 4. The degree of relapse of ON group after 7 days from removal of orthodontic appliance was similar to those of other groups(p>0.05).

엘리트 체육정책에 따른 체육인의 의식조사

김현태,남태호,이근모 釜山大學校 附設 體育科學硏究所 1995 體育科學硏究所 論文集 Vol.11 No.-

The purpose of this was to determine effect of physical education policy of elite athletes on physical educator's attitudes in Pusan. For this study, subject were the elite athletes(senior high school and university students) and physical educators. The result of this was found as follows; 1. Unsatisfied attitudes were found in university students, physical educators, and senior high school students as order regarding the Ministry of Education, each sport federation of government body, school budget policies for promotion of elite athletes. 2. Regarding reduction of national competition policy, unsatisfied attitudes were found in senior high school students, university students, and physical educators as order. Also, the past elite athletes were agree reduction of national competition policy, but the non-past elite athletes were not. 3. Regarding athletes absent in the class, university students, physical educators, and senior high school students were disagreed with it as order. 4. Regarding the purpose of physical education and sport for all are different but both groups should promote for public health and social we lfare, senior high school students, university students, and physical educators were agreed with it as order. 5. Regarding the number of senior high school and university athletic teams were more decreasing than the number of semi-pro team and pro team, university students, physical educators, and senior high school students were mentioned that it is abnormal as order. 6. Regarding sport facilities for promoting athletic teams, university students, physical educators, and senior high school students were dissatisfied as order. The non-past elite athletes were more unsatisfied than the past elite athletes. 7. When some one dissatisfied facilities, significant difference was found that among groups. Physical educators preferred public facilities. University students preferred facilities near the school. And senior high school students preferred unsettled sport facilities. 8. Regarding ideal way of promoting elite athletes, there was significant difference between males and females. Both groups think that most ideal way of promoting elite athletes was department of cultural physical education support. 9. Regarding 40 points requirement of SAT for athletes, there was significant difference between groups of the elite and non-elite athletes. University students and physical educators preferred higher than 40 points. However, senior high school students preferred that 40 points requirement system is not good. The past elite athletes preferred breaking down 40 points of requirement, but the non-past elite athletes preferred higher scores than 40 points.