(R)과 (S)형의 N-(4-{3-[1-(4-tert-Butylpheny)ethyl] thioureidomethyl}-phenyl)-methanesulfonamide 의 합성 및 바닐로이드 수용체 길항효과

장미정,유정현,정정화,김희두 숙명여자대학교 약학연구소 2003 약학논문집-숙명여자대학교 Vol.19 No.-

(R) & (S)-form of N-(4-{3-[l-(4-tert-Butylphenyl)ethyl]thioureidomethyl} phenyl)methanesulfonamide was designed, synthesized and evaluated as a vanilloid receptor antagonist.

염증이 있는 충수돌기의 초음파 진단 : 자가 위치선정법의 정확도 Accuracy of Self-localization Technique

장현정,임효근,김승훈,이민희,윤지영,김경아,임재훈,정연권 대한초음파의학회 1998 ULTRASONOGRAPHY Vol.17 No.4

Analysis about TV advertisement Expression by the Post-structuralism

Jang,Ho Hyun,Pyo,Hee Chan (사)한국디지털디자인협의회 2006 (사)한국디지털디자인협의회 conference Vol.2006 No.2

서울시에서 산발적으로 분리된 Salmonella enterica Serotype Typhi 임상분리균주들의 분자역학적 분석

이희무,김철현,손장욱,김민자,박미선,이복권 대한감염학회 2000 감염 Vol.32 No.5

인간 면역부전 바이러스(HIV) 감염자 사이에서의 1기 및 2기 매독의 유행

장희창,조재현,박완범,이기덕,이창섭,김홍빈,오명돈,최강원 대한감염학회 2004 감염과 화학요법 Vol.36 No.6

목적 : 국내 HIV 감염자 사이에서 발생한 매독의 유행을 보고하고, 그 역학적 특성을 규명하고자 하였다. 재료 및 방법 : 1999년 7월부터 2003년 9월까지 서울대학교 병원에서 추적 관찰을 받아온 HIV 감염자를 대상으로 하여 1기 및 2기 매독의 발생을 조사하였다. 발생률을 정확히 구하기 위해 추적 관찰을 받은 모든 HIV 감염자의 인년을 6개월 간격으로 구하였다. 결과 : 51개월 동안, 465명의 HIV 감염자가 서울대학교 병원에서 추적 관찰을 받았다. 이중 38명이 1기 및 2기 매독으로 진단되었다. 1기 및 2기 매독의 발생률은 이기간 동안 100인년 당 4.1명이었다. 1999년 7월부터 2001년 12월 사이에는 발생자가 없었으나, 이후 발생률은 꾸준히 증가하여 2003년 9월에는 100인년 당 18.8명이 되었다. 1기 및 2기 매독의 발생률은 동성애자 및 양성애자에서 이성애자에서보다 4.3배 높았고, HAART로 치료를 받지 않은 환자에서 HAART로 치료를 받고 있던 환자에서 보다 10.9배 높았다. 결론 : 2002년부터 국내 HIV 감염자 사이에서 1기 및 2기 매독이 유행하기 시작하였고, 이러한 유행은 동성애자와 양성애자 및 HAART로 치료를 받고 있지 않던 사람 사이에서 발생하였다. Background : This study was performed to characterize the epidemiologic and clinical features of outbreak of syphilis among HIV sero-positive patients in Korea. Materials and Methods : A retrospective case review of patients diagnosed with primary and secondary syphilis from July 1999 to September 2003 was carried out at Seoul National University Hospital in Korea. To estimate the incidence, person-years (PYs) of all HIV sero-positive patients, who visited the hospital in the same period, were calculated every 6 months. Results : In a 51 month period, 465 HIV-positive patients were followed up at Seoul National University Hospital. 38 cases of primary and secondary syphilis were diagnosed. The incidence of primary and secondary syphilis was 4.1 per 100 PYs during the study period. There was no case from July 1999 to December 2001, and then the incidence rose until September 2003 from 5.5 per 100 PYs in 1999 to 18.8 per 100 PYs in 2003. The rate of primary and secondary syphilis was 4.3 times higher among homosexual and bisexual men than heterosexual men (95% CI 1.87 to 11.17), and 10.9 times higher among patients who did not receive HAART than patients who were receiving HAART (95% CI 5.47 to 21.79). Conclusion : The outbreak of primary and secondary syphilis among HIV-positive patients started in 2002 and has been escalating, especially among homosexual/bisexual men and in patients who did not receive HAART.

항암요법을 받은 폐암환자의 삶의 질

장군자,박점희,류은경,김현미 慶北大學校 醫科大學 1996 慶北醫大誌 Vol.37 No.3

목적 : 항암요법을 받은 폐암환자의 삶의 질 정도를 파악하여 효과적인 암환자 간호를 하기 위한 기초자료를 제공하기 위해 본 연구를 시도하였다. 대상 및 방법 : 1995년 10월 1일부터 1996년 3월 31일까지 대구시내 소재 1개 대학교 병원에 입원하여 폐암을 진단받은 후 항암요법을 받은 환자 97명을 대상으로 하여 구조화된 질문지를 이용하여 자료를 수집하였으며, 자료의 분석은 SAS program을 이용하여 실수, 백분율, 최소값, 최대값, 평균, 표준편차, t-test 및 ANOVA, 단계적 중회귀분석을 하였고, 도구의 신뢰도는 Cronbach's α값을 구하였다. 결과 : 항암요법을 받은 폐암환자의 삶의 질 평균은 4.67이었고, 영역별로는 신체적 영역 3.90, 정신적 영역 4.23, 사회경제적 영역 5.65였다. 인구학적 특성에 따른 삶의 질은 연령과 교육수준에서, 질환특성에 따른 삶의 질은 신체적 활동정도에서 유의한 차이가 있었고, 항암제 종류와 항암치료횟수에 따른 삶의 질은 유의한 차이가 없었다. 결론 : 항암요법을 받은 폐암환자의 삶의 질 정도는 4.67로 다른 암진단을 받은 환자들에 비해 낮은 편으로 폐암에 대한 간호학적인 지식의 축적과 효과적인 간호중재에 대한 계속적인 연구, 항암요법이 폐암환자의 삶의 질에 미치는 영향에 대해서 더 많은 연구가 필요하다고 생각된다. This study was designed to investigate the quality of life in lung cancer patients with chemotherapy. Ninety seven patients with chemotherapy were sampled from one university hospital located in Taegu. The data were analyzed by percentage, mean, t-test. ANOVA. and stepwise multiple regression analysis, using the SAS program. The results were as follows; The mean score of quality of life was 4.67/10. The mean score of psychological dimension was 4.23/10. The mean score of socio-economic dimension was 5.65/10. The general characteristics related to quality of life were age. education level. A cancer characteristics related to quality of life was performance state. There was no statistically significant difference between chemoagents, chemotherapy frequency and quality of life.

상추(Lactuca sativa L.)의 ACAT 억제 Diterpenoid, Phytol : 식용 식물자원으로부터 활성물질의 탐색 Development of Biologically Active Compound from Edible Plant Sources

장태오,방면호,송명종,홍윤희,김지영,정대균,배동근,권병목,김영국,이현선,김인호,백남인 한국농화학회 2003 Applied Biological Chemistry (Appl Biol Chem) Vol.46 No.1

간접접착술식에서 접착제의 종류에 따른 전단결합강도와 파절 양상

장문주,이대희,김현덕,전영미,김정기 大韓齒科器材學會 2001 대한치과재료학회지 Vol.28 No.4

The purpose of this study was to compare the shear bond strength and failure type of various adhesives in indirect bonding technique. Five types of orthodontic bonding adhesives - ES(Excel sealant), EP(Excel paste), EA(sealant and past), T(Transbond XT sealant), L(Light bond sealant) - were used in this study. Metal bars(70×7×7㎜) were milled and sand-blasted with 50㎛ alumina and then coated with resin. resin blocks(3×4×5㎜) were made and bonded to the resin-coated metal bars with various adhesives. Shear bond strengths were measured by an universal testing machine. The film thickness, interface region. Self-curing resin, EX(Excel sealant) showed the greatest shear bond strength(22.82±3.05 ㎫) and self-curing resin, EP(Excel paste) showed the lowest shear bond strength(13.91±2.70 ㎫). The shear bond strength of self-curing resin, EA(sealant and past : 20.94±0.92 ㎫) was similar to those of light-curing resins, T(Transbond XT sealant : 20.90±2.34 ㎫), L(Light bond sealant : 18.12±1.63 ㎫) group. Most of the failure occurred between the resin coated metal bars and sealant regardless of the adhesives.

부산시 소재 각급 학교에 대한 대기오염도의 비교분석

이현희,정장표,장영환,이무강 慶星大學校 環境問題硏究所 2002 環境硏報 Vol.12 No.1

According to the conclusion of this study, air pollution concentration of Youngdo-gu belong to Seobu educational institution was in the lowest density.(SO_2 : 0.002 ppm, PM-10 : 32 ㎍/㎥, No_2 : 0.016 ppm) and Dongnae-gu belong to Dongnae educational institution was in the highest.(SO_2 : 0.002 ppm, PM-10 : 88㎍/㎥, No_2 : 0.047 ppm) Air pollution level by classification of each educational institution about elementary schools, middle schools, high schools in Busan appeared that the pollution level about all air pollutants appeared high in Dongnae, Dongbu, Bukbu, Haeundae, Nambu, Seobu in due order. Air pollution level by classification of each Gu about elementary schools, middle schools, high schools in Busan appeared that the pollution level of Geumjeong-gu was very high (SO_2 : 0.002 ppm, No_2 : 0.047 ppm, PM-10 : 89 ㎍/㎥) and level of pollution around high school in Busan was the highest. To improve air quality getting worse day by day, steady and systematic control of observing the air quality standards should be continued. The more effective and active method of air quality improvement should be considered.

NSIP와 BOOP의 고해상전산화단층촬영 소견과 비교

백상현,박재성,차장규,홍현숙,김대호,박성진,조준희,이혜경,최진수 순천향의학연구소 2003 Journal of Soonchunhyang Medical Science Vol.9 No.2

Purpose: BOOP and NSIP also share similar clinical features such as subacute flu-like illness, the finding of bronchoalveolar lavage, the result of pulmonary function test and more favourable outcome than usual interstitial pneumonia(UIP). The author try to compare the HRCT findings of NSIP with BOOP by pattern and distribution of diseases. Materials and Methods: HRCT findings of histopathologically proven NSIP(Group Ⅰ; 6, Group Ⅱ; 7, Group Ⅲ; 2) in 15 patients(5 male, 10 female, age range, 39-69 years; mean age, 53 years), BOOP in 15 patients(6 male, 9 female, age range, 26-76 years; mean age, 52 years) were reviewed retrospectively. Results: The common pattern of the two diseases was admixed consolidation, ground glass attenuation & reticular densities with/without architectural distortion(NSIP; 53.3%, BOOP; 46.7%). The main component of the pattern wan predominantly consolidation(NSIP; 46.7%, BOOP; 73.3%) and ground glass attenuation(NSIP; 40.0%, BOOP;20.0%). Architectural distotion was more provinent finding with NSIP(mild ; 3, moderate ; 4, severe; 2) compared with BOOP(mild; 7, moderate; 2, severe; 0). The predominant overall distribution was lower lung, peribronchovascular & peripheral lung field in both of the two entities(NSIP;73.3%, BOOP; 73.3%). Peribronchovascular involvement was more common with NSIP(100%) than BOOP(80%), whereas peripheral involvement was more common with BOOP(93.3%) than NSIP(80%). Conclusion: The HRCT findings of NSIP and BOOP were similar in pattern and distribution. But NIP manifested more frequently ground-glass attenuation, whereas BOOP showed more frequently consolidation. Architectural distortion was more severe with NSIP than BOOP. NSIP invoved more frequently peribronchovascular space and BOOP were more common in peripheral lung field.