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AtFes1A is essential for highly efficient molecular chaperone function in Arabidopsis
Can Fu,Jingxia Zhang,Xiaxia Liu,Wenwen Yang,유홍빈,Jian Liu 한국식물학회 2015 Journal of Plant Biology Vol.58 No.6
AtFes1A is a co-chaperone of heat shock protein 70 (Hsp70), which is a key component of plant molecular chaperone systems. Plants without AtFes1A generally present defective thermotolerance. However, the underlying mechanism of this molecule has remained elusive. In the present study, we used thermolabile firefly luciferase as a molecular reporter to evaluate the efficiency of the plant molecular chaperone system. Renaturation of firefly luciferase in atfes1a mutants lagged far behind that of wild-type (WT) plants. In contrast, in vitro AtFes1A did not affect renaturation of firefly luciferase, whereas Hsp70 did significantly. We propose that AtFes1A is indirectly involved in plant molecular chaperone systems.
Investigation on the performance and flow characteristics of a liquid lead-bismuth pump
Yongchao Zhang,Can Kang,Yang Zhu,Hyoung Bum Kim 대한기계학회 2021 JOURNAL OF MECHANICAL SCIENCE AND TECHNOLOGY Vol.35 No.7
The liquid lead-bismuth pump is a core component of the main coolant circuit of the accelerator driven system. The pump performance has a significant effect on the safety and operational stability of the whole system. A liquid lead-bismuth pump was designed and the performance and flow characteristics of the pump were obtained numerically. Effects of transported medium on the performance of the pump and the forces acting on the hydraulic components were investigated. The results show that the operational performance of the pump is improved as the liquid medium of water is replaced with liquid lead-bismuth. The axial force acting on the impeller is dominated by the dynamic reverse force associated with flowing liquid lead-bismuth. Large-scale vortices formed at the bottom of the discharge chamber incur remarkable hydraulic loss. High risk of erosion exists at the outlet part of impeller blades and the inlet part of diffuser blades.
Event-triggered Control of Discrete-time Switched Linear Systems with An Arbitrary Sampling Period
Xiaozeng Xu,Yang Li,Can Liu,Hongbin Zhang 제어·로봇·시스템학회 2021 International Journal of Control, Automation, and Vol.19 No.1
In this paper, the event-triggered control problem for discrete-time switched linear systems with anarbitrary sampling period is considered. At each sampling instant, only the sampled information of system state andswitching signal is available to the controller. Particularly, the sampling period is arbitrary in this paper and frequentswitching is allowed to happen in an inter-event period. Based on that, by constructing a time- and mode-dependentquadratic piecewise Lyapunov function, a new globally exponentially stability (GES) result under modal dwell time(MDT) criteria is obtained. By the novel Lyapunov function and the state variable transformation technique, a statefeedback controller is designed for the switched linear system. At last, a numerical example is proposed to illustrateour approach.
Preparation and characterization of epoxidized microbial oil
Xinde Chen,Dan Yang,Lian Xiong,Bo Wang,Xuefang Chen,Can Wang,Hairong Zhang,Haijun Guo 한국화학공학회 2016 Korean Journal of Chemical Engineering Vol.33 No.3
The potential of microbial oil derived from yeasts through fermentation using crops biomass for the formation of plasticizers was investigated. Plasticizers were formed via epoxidation reaction. Five factors of the orthogonal experiment (reaction temperature, time, weight ratio of H2O2/MO, H2SO4/MO, and HCOOH/MO) have been used for optimization of parameters. To further enhance the iodine value of microbial oil and increase the epoxy value of the epoxide, an amount of soybean oil was added. The products were characterized by FTIR, 13C-NMR and 1H-NMR. Under the optimum condition, the epoxy value and the iodine value of epoxide product were 6.21% and 1.8 g I2/100 g with a yield of 91.86% at an oil conversion of 98.43%. This study successfully demonstrated the conversion of crops biomass into value-added chemicals using simple and conventional chemical reactions.
Xiao Song,Luo Yuanpei,Wu Jingchi,Zhang Can,Rao Yang,Wu Guangning,Deng Zhida,Sykulski Jan K. 대한전기학회 2021 Journal of Electrical Engineering & Technology Vol.16 No.3
High speed trains receive traction electrical energy from a high-voltage catenary via a pantograph catenary system (PCS). As the velocity of trains increases, the traditional PCSs face signifi cant challenges, such as strong aero resistance under highspeed conditions, severe electrochemical corrosion caused by poor contact between the pantograph strip and the catenary, harmful wear both on the pantograph strip and the contact wire produced by high-speed sliding friction between them, etc. The eff ectiveness and reliability of the PCS has a direct impact on the performance and safety of the HTS power supply. In order to alleviate some of these bottleneck eff ects related to the operation of the currently used PCSs, especially under high-speed conditions, this paper proposes a novel confi guration where rotatable pantograph rollers replace the currently used pantograph strips. As the sliding friction is now replaced by rotating friction, this has numerous benefi ts, such as less friction heat, better heat dispersion and improved catenary-tracking performance. Moreover, should the whole system be modularized, it could adapt to diff erent levels of traction power through adjusting the number of rollers.
Kang Chang,Yi Cheng,Jian-Bo Yang,Yujie Qiao,Rui Li,Can Zhang 한국물리학회 2019 THE JOURNAL OF THE KOREAN PHYSICAL SOCIETY Vol.74 No.6
This work aimed to study an algorithm for the unfolding spectrum acquired by using a water-pumping-injection multi-homocentric sphere neutron spectrometer. The readings of the water-pumping-injection multi-homocentric sphere neutron spectrometer under 32 different neutron sources, including $^{241}$Am-Be spontaneous, $^{238}$Pu Watt, and $^{232}$Th Maxwell fission, were obtained by using the FLUKA Monte Carlo code and were input as the neural network training values for constructing the method of back-propagation artificial neural network neutron spectrum unfolding (MBANSU). Two neutron readings that were Monte Carlo experimentally measured from $^{252}$Cf spontaneous and $^{245}$Cm Maxwell fission sources were used as the testing values for MBANSU. The calculated neutron energy spectrum was in good agreement with the ENDF energy spectrum, and the information entropy of the result spectrum approximated that of the ENDF spectrum. Results indicate that the established MBANSU algorithm has potential applications for unfolding spectra collected by using the water-pumping-injection multi-homocentric sphere neutron spectrometer.
Causal Relations between Exposome and Stroke: A Mendelian Randomization Study
Hong-Qi Li,Yi-Wei Feng,Yu-Xiang Yang,Xin-Yi Leng,Prof Can Zhang,Shi-Dong Chen,Kevin Kuo,Shu-Yi Huang,Xue-Qing Zhang,Yi Dong,Xiang Han,Xin Cheng,Mei Cui,Lan Tan,Qiang Dong,Jin-Tai Yu 대한뇌졸중학회 2022 Journal of stroke Vol.24 No.2
Background and Purpose To explore the causal relationships of elements of the exposome with ischemic stroke and its subtypes at the omics level and to provide evidence for stroke prevention. Methods We conducted a Mendelian randomization study between exposure and any ischemic stroke (AIS) and its subtypes (large-artery atherosclerotic disease [LAD], cardioembolic stroke [CE], and small vessel disease [SVD]). The exposure dataset was the UK Biobank involving 361,194 subjects, and the outcome dataset was the MEGASTROKE consortium including 52,000 participants. Results We found that higher blood pressure (BP) (systolic BP: odds ratio [OR], 1.02; 95% confidence interval [CI], 1.01 to 1.04; diastolic BP: OR, 1.03; 95% CI, 1.01 to 1.05; pulse pressure: OR, 1.03; 95% CI, 1.00 to 1.06), atrial fibrillation (OR, 1.18; 95% CI, 1.13 to 1.25), and diabetes (OR, 1.13; 95% CI, 1.07 to 1.18) were significantly associated with ischemic stroke. Importantly, higher education (OR, 0.69; 95% CI, 0.60 to 0.79) decreased the risk of ischemic stroke. Higher systolic BP (OR, 1.06; 95% CI, 1.02 to 1.10), pulse pressure (OR, 1.08; 95% CI, 1.02 to 1.14), diabetes (OR, 1.28; 95% CI, 1.13 to 1.45), and coronary artery disease (OR, 1.58; 95% CI, 1.25 to 2.00) could cause LAD. Atrial fibrillation could cause CE (OR, 1.90; 95% CI, 1.71 to 2.11). For SVD, higher systolic BP (OR, 1.04; 95% CI, 1.00 to 1.07), diastolic BP (OR, 1.06; 95% CI, 1.01 to 1.12), and diabetes (OR, 1.22; 95% CI, 1.10 to 1.36) were causal factors. Conclusions The study revealed elements of the exposome causally linked to ischemic stroke and its subtypes, including conventional causal risk factors and novel protective factors such as higher education.
Effect of humidity on mechanical properties of dissolving microneedles for transdermal drug delivery
Qi Lei Wang,Jia Wei Ren,Bo Zhi Chen,Xuan Jin,Can Yang Zhang,Xin Dong Guo 한국공업화학회 2018 Journal of Industrial and Engineering Chemistry Vol.59 No.-
Dissolving microneedles (DMNs) prepared from soluble polymers has been being widely investigated as a safe and effective transdermal delivery system for drug and vaccine. Limited by the materials, the air humidity would probably affect the mechanical property of DMNs, which is essential for the effective needle insertions and drug delivery. In this study, four kinds DMNs prepared by polyvinyl alcohol, sodium hyaluronate (HA), chitosan and gelatin are studied on the mechanical strength and insertion ability under varying humidity conditions. Based on these investigations, we hope to provide the effective time of DMNs to ensure a successful insertion and drug delivery.