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Return to Work in Multi-ethnic Breast Cancer Survivors - A Qualitative Inquiry
Tan, Foo Lan,Loh, Siew Yim,Su, TinTin,Veloo, V.W.,Ng, Lee Luan Asian Pacific Journal of Cancer Prevention 2012 Asian Pacific journal of cancer prevention Vol.13 No.11
Introduction: Return-to-work (RTW) can be a problematic occupational issue with detrimental impact on the quality of life of previously-employed breast cancer survivors. This study explored barriers and facilitators encountered during the RTW process in the area of cancer survivorship. Materials and Methods: Six focus groups were conducted using a semi-structured interview guide on 40 informants (employed multiethnic survivors). Survivors were stratified into three groups for successfully RTW, and another three groups of survivors who were unable to return to work. Each of the three groups was ethnically homogeneous. Thematic analysis using a constant comparative approach was aided by in vivo software. Results: Participants shared numerous barriers and facilitators which directly or interactively affect RTW. Key barriers were physical-psychological after-effects of treatment, fear of potential environment hazards, high physical job demand, intrusive negative thoughts and overprotective family. Key facilitators were social support, employer support, and regard for financial independence. Across ethnic groups, the main facilitators were financial-independence (for Chinese), and socialisation opportunity (for Malay). A key barrier was after-effects of treatment, expressed across all ethnic groups. Conclusions: Numerous barriers were identified in the non-RTW survivors. Health professionals and especially occupational therapists should be consulted to assist the increasing survivors by providing occupational rehabilitation to enhance RTW amongst employed survivors. Future research to identify prognostic factors can guide clinical efforts to restore cancer survivors to their desired level/type of occupational functioning for productivity and wellbeing.
Lan, Truong Thi Phuong,Huy, Nguyen Duc,Luong, Nguyen Ngoc,Quang, Hoang Tan,Tan, Trinh Huu,Thu, Le Thi Anh,Huy, Nguyen Xuan,Loc, Nguyen Hoang The Korean Society of Plant Biotechnology 2019 식물생명공학회지 Vol.46 No.3
The aim of this study is to evaluate the effect of yeast extract (YE) and salicylic acid (SA) on the expression of curcuminoid-biosynthesis genes (CzDCS and CURS1-3), and accumulation of curcumin in Curcuma zedoaria cell cultures. The results showed that, in cells treated with YE or SA, the expression levels of curcuminoid genes were 1.14- to 3.64-fold higher than the control (untreated cells), in which the YE exhibited a stronger effect in comparison with SA. Curcumin accumulation also tended to be similar to gene expression, curcumin contents in YE- or SA-treated cells were 1.61- to 2.53-fold higher than the control. The SA treatment at the fifth day of culture stimulated the curcumin accumulation and expression in all four genes compared to that at the beginning. While the YE treatments gave different results, the CzCURS1 and CzCURS3 genes were expressed strongly in cells that were treated at the beginning. However, the CzDCS and CzCURS2 genes showed the opposite expression pattern, they were activated strongly in the treatments at day five of the culture. However, the content of curcumin reached its maximum value on the fifth day of culture in all investigations.
Tan, Heng Kean,Moad, Ahmed Ismail Hassan,Tan, Mei Lan Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.16
The mammalian target of rapamycin (mTOR) kinase plays an important role in regulating cell growth and cell cycle progression in response to cellular signals. It is a key regulator of cell proliferation and many upstream activators and downstream effectors of mTOR are known to be deregulated in various types of cancers. Since the mTOR signalling pathway is commonly activated in human cancers, many researchers are actively developing inhibitors that target key components in the pathway and some of these drugs are already on the market. Numerous preclinical investigations have also suggested that some herbs and natural phytochemicals, such as curcumin, resveratrol, timosaponin III, gallic acid, diosgenin, pomegranate, epigallocatechin gallate (EGCC), genistein and 3,3'-diindolylmethane inhibit the mTOR pathway either directly or indirectly. Some of these natural compounds are also in the clinical trial stage. In this review, the potential anti-cancer and chemopreventive activities and the current status of clinical trials of these phytochemicals are discussed.
Oligo(aniline)-based Hole Transport Layer for Organic Solar Cells
Ngoc-Lan Phan Tan,김진석,김범준 한국고분자학회 2021 한국고분자학회 학술대회 연구논문 초록집 Vol.46 No.1
The contribution of interfacial layers to device performance and stability is considered important. The most widely used hole transport layer (HTL) for conventional organic solar cells (OSCs)–PEDOT:PSS has some shortcomings such as the acidity and the hygroscopicity which cause the limitation for long-term stability. In this study, we report the doping system of an aniline derivative (PTA) and an aryl sulfonic acid (NSO-2), which can be employed as HTL for OSCs. Devices fabricated from this HTL on PM6:Y6 active layers exhibited comparative power conversion efficiency (PCE) with control device of PEDOT:PSS (14.94% vs. 15.05%). Moreover, the devices with PTA:NSO-2 HTL also emphasizes its better moisture stability than PEDOT:PSS. Therefore, this initial result demonstrates the potential of aniline-based materials as HTL for OSCs as well as motivates the further optimization to achieve the higher photovoltaic performance.
Ngoc-Lan Phan Tan,김진석,이승진,김건우,김범준 한국고분자학회 2021 한국고분자학회 학술대회 연구논문 초록집 Vol.46 No.2
The selection of interfacial layers in organic solar cells (OSCs) is crucial for enhancing their power conversion efficiency (PCE) and stability. PEDOT:PSS is the most widely used hole transport layer (HTL); however, device stability is often severely degraded, owing to the strong acidity and hygroscopicity of PEDOT:PSS. Herein, we report a new efficient HTL system comprising an oligo(aniline) host (PBD) and a protonic acid dopant (PFBSA), and demonstrate its use in OSC devices. Desirable properties like high transmittance, excellent conductivity, and appropriate work function establish the suitability of the PBD:PFBSA film as an HTL. Thus, a PBD:PFBSA HTL is employed in the PM6:Y6-based OSC system to achieve a PCE of 15.24%. Importantly, the PBD:PFBSA HTL-based OSC exhibits significantly higher device stability than the PEDOT:PSS HTL. Our results highlight the successful design of an oligo(aniline)-based material and its practical application as an effective HTL for OSCs.
Beetroot as a Potential Functional Food for Cancer Chemoprevention, a Narrative Review
Mei Lan Tan,Shahrul Bariyah Sahul Hamid 대한암예방학회 2021 Journal of cancer prevention Vol.26 No.1
Patients with cancer are prone to several debilitating side effects including fatigue, insomnia, depression and cognitive disturbances. Beetroot (Beta vulgaris L.) as a health promoting functional food may be potentially beneficial in cancer. As a source of polyphenols, flavonoids, dietary nitrates and other useful nutrients, beetroot supplementation may provide a holistic means to prevent cancer and manage undesired effects associated with chemotherapy. The main aim of this narrative review is to discuss beetroot’s nutrient composition, current studies on its potential utility in chemoprevention and cancer-related fatigue or treatment-related side effects such as cardiotoxicity. This review aims to provide the current status of knowledge and to identify the related research gaps in this area. The flavonoids and polyphenolic components present in abundance in beetroot support its significant antioxidant and anti-inflammatory capacities. Most in vitro and in vivo studies have shown promising results; however, the molecular mechanisms underlying chemopreventive and chemoprotective effects of beetroot have not been completely elucidated. Although recent clinical trials have shown that beetroot supplementation improves human performance, translational studies on beetroot and its functional benefits in managing fatigue or other symptoms in patients with cancer are still lacking.