http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
- 中文 을 입력하시려면 zhongwen을 입력하시고 space를누르시면됩니다.
- 北京 을 입력하시려면 beijing을 입력하시고 space를 누르시면 됩니다.
RISS 인기검색어
- 검색키워드
- 저자 : Bo Zhi Chen (검색결과 40 건)
- 무료
- 기관 내 무료
- 유료
-
Zhi-qiang Li,Dan Gui,Zhi-hua Sun,Jun-bo Zhang,Wen-zhi Zhang,Hui Zhang,Fei Guo,Chuangfu Chen 대한수의학회 2015 Journal of Veterinary Science Vol.16 No.4
Brucellosis is a zoonotic disease that causes animal and human diseases. Vaccination is a major measure for prevention of brucellosis, but it is currently not possible to distinguish vaccinated animals from those that have been naturally infected. Therefore, in this study, we constructed the Brucella (B.) abortus 2380 wbkA mutant (2308DwbkA) and evaluated its virulence. The survival of 2308DwbkA was attenuated in murine macrophage (RAW 264.7) and BALB/c mice, and it induced high protective immunity in mice. The wbkA mutant elicited an anti-Brucella-specific immunoglobulin G response and induced the secretion of gamma interferon. Antibodies to 2308DwbkA could be detected in sera from mice, implying the potential for use of this protein as a diagnostic antigen. The WbkA antigen would allow serological differentiation between infected and vaccinated animals. These results suggest that 2308DwbkA is a potential attenuated vaccine against 16M. This vaccine will be further evaluated in sheep.
-
-
A damage localization method based on the singular value decomposition (SVD) for plates
Zhi-Bo Yang,Jin-Tao Yu,Shao-Hua Tian,Xue-Feng Chen,Guan-Ji Xu 국제구조공학회 2018 Smart Structures and Systems, An International Jou Vol.22 No.5
Boundary effect and the noise robustness are the two crucial aspects which affect the effectiveness of the damage localization based on the mode shape measurements. To overcome the boundary effect problem and enhance the noise robustness in damage detection, a simple damage localization method is proposed based on the Singular Value Decomposition (SVD) for the mode shape of composite plates. In the proposed method, the boundary effect problem is addressed by the decomposition and reconstruction of mode shape, and the noise robustness in enhanced by the noise filtering during the decomposition and reconstruction process. Numerical validations are performed on plate-like structures for various damage and boundary scenarios. Validations show that the proposed method is accurate and effective in the damage detection for the two-dimensional structures.
-
Vibration control of a stay cable with a rotary electromagnetic inertial mass damper
Zhi Hao Wang,Yan Wei Xu,Hui Gao,Zheng Qing Chen,Kai Xu,Shun Bo Zhao 국제구조공학회 2019 Smart Structures and Systems, An International Jou Vol.23 No.6
Passive control may not provide enough damping for a stay cable since the control devices are often restricted to a low location level. In order to enhance control performance of conventional passive dampers, a new type of damper integrated with a rotary electromagnetic damper providing variable damping force and a flywheel serving as an inertial mass, called the rotary electromagnetic inertial mass damper (REIMD), is presented for suppressing the cable vibrations in this paper. The mechanical model of the REIMD is theoretically derived according to generation mechanisms of the damping force and the inertial force, and further validated by performance tests. General dynamic characteristics of an idealized taut cable with a REIMD installed close to the cable end are theoretically investigated, and parametric analysis are then conducted to investigate the effects of inertial mass and damping coefficient on vibration control performance. Finally, vibration control tests on a scaled cable model with a REIMD are performed to further verify mitigation performance through the first two modal additional damping ratios of the cable. Both the theoretical and experimental results show that control performance of the cable with the REIMD are much better than those of conventional passive viscous dampers, which mainly attributes to the increment of the damper displacement due to the inertial mass induced negative stiffness effects of the REIMD. Moreover, it is concluded that both inertial mass and damping coefficient of an optimum REIMD will decrease with the increase of the mode order of the cable, and oversize inertial mass may lead to negative effect on the control performance.
-
In Vitro and in Vivo Antitumor Evaluation of Berbamine for Lung Cancer Treatment
Hou, Zhi-Bo,Lu, Kai-Jin,Wu, Xiao-Li,Chen, Cong,Huang, Xin-En,Yin, Hai-Tao Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.4
Purpose: Lung cancer, one of the most frequently diagnosed cancers in the world, is characterized by relatively high morbidity and mortality. Berbamine (BER) has been initially reported to exert anti-proliferative effects against a series of cancers. Methods: In this study the in vitro cytotoxicity of BER was measured by MTT assay. In vivo anti-cancer efficacy of BER was assessed in A549 xenografts. Results: Cytotoxicity tests showed dose-dependent cell growth inhibition effects of BER against A549 cells. Moreover, BER significantly reduced the growth of lung cancer in a dose-dependent manner in nude mice with prolonged survival time. Conclusion: Therefore, BER might be in herbal medicine for cancer therapy and further efforts are needed to explore therapeutic strategies.
-
A damage localization method based on the singular value decomposition (SVD) for plates
Yang, Zhi-Bo,Yu, Jin-Tao,Tian, Shao-Hua,Chen, Xue-Feng,Xu, Guan-Ji Techno-Press 2018 Smart Structures and Systems, An International Jou Vol.22 No.5
Boundary effect and the noise robustness are the two crucial aspects which affect the effectiveness of the damage localization based on the mode shape measurements. To overcome the boundary effect problem and enhance the noise robustness in damage detection, a simple damage localization method is proposed based on the Singular Value Decomposition (SVD) for the mode shape of composite plates. In the proposed method, the boundary effect problem is addressed by the decomposition and reconstruction of mode shape, and the noise robustness in enhanced by the noise filtering during the decomposition and reconstruction process. Numerical validations are performed on plate-like structures for various damage and boundary scenarios. Validations show that the proposed method is accurate and effective in the damage detection for the two-dimensional structures.
-
Gang Chen,Qiang Chen,Bo Wang,Zhi-ming Du 대한금속·재료학회 2015 METALS AND MATERIALS International Vol.21 No.5
Al-Zn-Mg-Cu alloys are the strongest aluminum alloys which have been widely used for aerospace applications. They are usually machined from the wrought state usually with a high waste percentage. To reduce waste, it is important to thixoform these alloys in near net shape. In this work, the thixoformability of a commercial high performance Al-Zn-Mg-Cu alloy 7075 was studied. A novel multistep reheating regime was developed in recrystallization and partial melting (RAP) route to obtain spheroidal semi-solid microstructures. The as-extruded 7075 alloy was fully recrystallized for a short holding time using the multistep reheating regime. Semi-solid microstructures with fine and spherical solid grains with a grain size of 40-50 μm embedded in liquid matrix were obtained. The advantage of the multistep reheating regimes over those conventional routes was also discussed. Some wheel-shaped components were thixoformed from the as-received 7075 alloy. The ultimate tensile strength, yield strength and elongation to fracture of the thixoformed component based on multistep reheating regime, are 510 MPa, 446 MPa and 17.5% respectively. These values are superior to those of the products manufactured with the conventional RAP route. As the results indicated, thixoforming could be conducted based on commercial extruded Al-Zn-Mg-Cu alloys, which has important practical significance.
-
Zhang Chen,Su Yongbo,Mei Bo,Yang Feng,Zhang Jialin,Yun Huanqing,Liu Bo,Sun Yi,Zhang Haiming,Jin Zhi,Zhong Yinghui 한국물리학회 2023 Current Applied Physics Vol.48 No.-
InP-based hetero-junction bipolar transistors (HBTs) are attractive for various millimeter-wave and terahertz electronics due to their ultrahigh frequency performance. Therefore, the study of their irradiation reliability is extremely urgent. In this work, 2 MeV proton irradiation experiment has been carried out on self-fabricated N+Np+ InP/InGaAs hetero-junction. The degradation mechanisms have systematically been studied after exposure to protons of 5 × 1013 H+/cm2. The voltage range of recombination current at low forward bias has been largely expanded from 0-0.2 V to 0–0.6 V. Furthermore, the interface states properties have been characterized by utilizing the frequency-dependent conductance technique, the interface states density (Dit) has increased from approximately 9.02 × 1012 cm-2 eV-1–1.99 × 1013 cm-2 eV-1 to 9.51 × 1012 cm-2 eV-1–2.00 × 1013 cm-2 eV-1 after irradiation. The study would be great significance for understanding the evolution of proton irradiation on relative devices.
-
Isoprenaline Induces Periostin Expression in Gastric Cancer
Lin Chen,Guo-Xiao Liu,Hong-Qing Xi,Xiao-Yan Sun,Zhi-Jun Geng,Shao-Wei Yang,Yan-Jie Lu,Bo Wei 연세대학교의과대학 2016 Yonsei medical journal Vol.57 No.3
Purpose: Periostin mediates critical steps in gastric cancer and is involved in various signaling pathways. However, the roles of periostin in promoting gastric cancer metastasis are not clear. The aim of this study was to investigate the relevance between periostinexpression and gastric cancer progression and the role of stress-related hormones in the regulation of cancer development and progression. Materials and Methods: Normal, cancerous and metastatic gastric tissues were collected from patients diagnosed with advanced gastric cancer. The in vivo expression of periostin was evaluated by in situ hybridization and immunofluorescent staining. Meanwhile,human gastric adenocarcinoma cell lines MKN-45 and BGC-803 were used to detect the in vitro expression of periostin by using quantitative real-time polymerase chain reaction (PCR) and western blotting. Results: Periostin is expressed in the stroma of the primary gastric tumors and metastases, but not in normal gastric tissue. In addition,we observed that periostin is located mainly in pericryptal fibroblasts, but not in the tumor cells, and strongly correlated to the expression of α-smooth muscle actin (SMA). Furthermore, the distribution patterns of periostin were broader as the clinical staging of tumors progressed. We also identified a role of stress-related signaling in promoting cancer development and progression,and found that isoprenaline upregulated expression levels of periostin in gastric cancer cells. Conclusion: These findings suggest that the distribution pattern of periostin was broader as the clinical staging of the tumor progressedand found that isoprenaline upregulated expression levels of periostin in gastric cancer cells.
-
Wavelet-based automatic identification method of axle distribution information
Ning-Bo Wang,Wei-Xin Ren,Zhi-Wei Chen 국제구조공학회 2017 Structural Engineering and Mechanics, An Int'l Jou Vol.63 No.6
Accurately extracting the axle distribution information of a passing vehicle from bridge dynamic responses experiences a key and challenging step in non-pavement bridge weigh-in-motion (BWIM). In this article, the wavelet transformation is adopted and the wavelet coefficient curve is used as a substitute for dynamic response. The driving frequency is introduced and expanded to multi-axle vehicle, and the wavelet coefficient curve on specific scale corresponding to the driving frequency is confirmed to contain obvious axle information. On this basis, an automatic method for axle distribution information identification is proposed. The specific wavelet scale can be obtained through iterative computing, and the false peaks due to bridge vibration can be eliminated through cross-correlation analysis of the wavelet coefficients of two measure points. The integrand function that corresponds to the maximum value of the cross-correlation function is used to identify the peaks caused by axles. A numerical application of the proposed axle information identification method is carried out. Numerical results demonstrate that this method acquires precise axle information from the responses of an axle-insensitive structure (e.g., girder) and decreases the requirement of sensitivity structure of BWIM. Finally, an experimental study on a full-scale simply supported bridge is also conducted to verify the effectiveness of this method.
연관 검색어 추천
이 검색어로 많이 본 자료
활용도 높은 자료
