Chondroid tenosynovial giant cell tumor of the toe: A case report

손승명,이용문,신향미,Jae-Gul Chung,JongWon Chung,이옥준 충북대학교 동물의학연구소 2014 Journal of Biomedical and Translational Research Vol.15 No.1

Localized tenosynovial giant cell tumor (TGCT) usually occurs in the hand and foot regions. However, localized TGCT with extensive cartilaginous metaplasia is rare, es- pecially in the tendon sheath of the toe. Here, we report a case of localized TGCT with cartilaginous metaplasia in a 57-year-old man. The tumor presented as a lobular mass measuring 2.2 cm in its greatest dimension and arose in the flexor digitorum tendon sheath of the right 2nd toe. Clini- cally, the mass was palpable 1 year ago and brought pain during walking. Microscopically, the mass was composed of focal conventional TGCT and cartilaginous components. The conventional TGCT areas consisted of mononuclear cells, multinucleated giant cells, and hemosiderin deposition. The chondroid areas were extensive and comprised more than 90% of the whole tumor. In this case, the mononuclear cells in the conventional TGCT areas showed focal immu- nohistochemical staining for podoplanin and S100 protein as well as diffuse staining for CD68, which is consistent with the staining pattern of conventional TGCT. The mono- nuclear cells in the chondroid areas were focal positive for podoplanin and diffuse positive for S100 protein. Chondroid metaplasia in diffuse TGCT has been reported in 10 cases involving the temporomandibular, elbow, and hip joints. However, there has been no report of a localized form of chondroid TGCT involving an extra-articular region.

Localized Thymic Amyloidosis Presenting with Myasthenia Gravis: Case Report

손승명,이옥준,이용문,김시욱 대한의학회 2014 Journal of Korean medical science Vol.29 No.1

A mediastinal mass was incidentally found on chest radiography in a 46-yr-old woman who had had myasthenia gravis (MG) for 2 months. Computed tomography revealed a 4-cm in size, well-defined, and lobulating mass with nodular calcification that was located in the thymus. Microscopically, the mass consisted of diffuse amorphous eosinophilic materials. These deposits exhibited apple-green birefringence under polarized light microscopy after Congo red staining. Immunohistochemical analysis revealed that they were positive for both kappa and lambda light chains and negative for amyloid A. A diagnosis of localized primary thymic amyloidosis was finally made. After thymectomy, the symptoms of MG were controlled with reduced corticosteroid requirements. Localized thymic amyloidosis associated with MG has not been reported to date.

Evaluation of Urine Cytology in Urothelial Carcinoma Patients: A Comparison of CellprepPlus® Liquid-Based Cytology and Conventional Smear

손승명,구지혜,최송이,이호창,이용문,송형근,황혜경,한혜숙,윤석중,김원재,김은중,이옥준 대한병리학회 2012 Journal of Pathology and Translational Medicine Vol.46 No.1

Background: Urine cytology is an important test in the screening of urothlelial neoplasms. The conventional smear (CS) method of testing urine samples has a low sensitivity, approximately 50% result accuracy for detecting urothelial carcinomas, while liquid-based cytology (LBC) has much improved diagnostic accuracy, sensitivity, and specificity. The aim of this study was to compare the morphologic features and diagnostic efficacy of CellprepPlus® LBC with those of CS for urine cytology. Methods: A total of 713 cases of urine specimens collected from November 2009 to September 2010 were included. All specimens were divided equally for the preparation of CellprepPlus® LBC and CS for each case. Results: CellprepPlus® revealed more cellularity, a cleaner background and better cytomorphologic features, but it showed a less intact architectural pattern compared to that of CS. Of the 88 histologically confirmed cases, the diagnostic sensitivity for CellprepPlus® was 50% and higher than the 37.5% for CS. The specificity of both preparations was 100%. Conclusions: The CellprepPlus® showed an improved quality of slides and provided better diagnostic accuracy, thus CellprepPlus® could be a first-line screening tool in urinary tract cytology.

위 경부 상피 이형성에서 이행한 미만형 선암종의 면역 조직학적 고찰

손승명, 이용문, 성노현 충북대학교 의과대학 충북대학교 의학연구소 2014 忠北醫大學術誌 Vol.24 No.1

연구 목적: Lauren은 위 선암종의 조직학적 유형을 장형과 미만형으로 나누었다. 장형 선암종의 전구 질환은 장형 이형성으로서 장형 이형성의 생물학적 성상은 잘 밝혀져 있는 반면에 미만형 선암종의 전 구 질환에 대하여는 명확하게 밝혀지지는 않았다. Ghandur Mnaymneh 등이 미만형 선암종의 전구 질환으로서 경부 상피 이형성를 보고하였으나, 후속 연구는 적어서 그들의 보고를 뒷받침하지 못하고 있다. 경부 상피 이형성에서 미만형 선암종으로 이행하는 위 조직에서 경부 상피 이형성의 특징과 미만 형 선암종과의 관계를 면역 조직학적으로 고찰하였다. 재료 및 방법: 경부 상피 이형성에서 미만형 선암종으로 이행하는 위 조직 병리 표본 3예를 광학 현미 경으로 관찰하고 paraffin 포매 조직을 이용하여 각각 위 소와 상피, 소장 상피, 대장 상피의 표지자 와 종양 억제 단백인 p53 그리고 상피 세포 사이의 유착 분자인 E-cadherin에 대한 항체를 이용한 면역 염색을 하여 주변 점막 상피, 이형성과 선암종 세포의 관계, 그리고 종양의 성상을 살폈다. 결과: 경부 상피 이형성은 위 선와의 경부를 중심으로 비정형성 경부 세포가 위 선와의 상부와 하부로 단층 증식하는 특징적인 모습을 보였다. 병변의 중심부에서는 경부 세포의 비정형성이 증가하였고 종양 세포가 작은 덩어리 또는 낱개의 종양 세포로서 주변 점막 기질에 침윤하여 미만형 선암종을 형성하였 다. 주변 점막에서는 비화생성 만성 위염의 소견을 보였으며 경부 세포의 증식으로 선와의 경부가 길어 져서 점막이 다소 비후된 소견을 보였다. 면역 조직학적으로 주변 점막과 경부 상피 이형성 그리고 미 만형 선암종은 장형 화생의 증거는 없었다. p53은 이형성과 미만형 선암종 모두에서 발현하지 않았다. E-cadherin 발현은 이형성 상피 세포가 주변 점막 상피 세포보다 감소하였으며, 미만형 선암종 세포 에서는 현저하게 감소하였다. 결론: p53 단백의 이상 발현이 대부분의 위 선암종에서는 중요한 발암기전인 것에 반하여, 경부 상피 이형성에서 발생하는 미만형 선암종은 CDH1 유전자의 하향 조절이 중요한 발암기전임을 뒷받침하였 다. 경부 상피 이형성은 일반적으로 병변이 매우 작아서 육안으로 그리고 현미경으로도 발견이 쉽지 않 으므로, 미만형 이형성을 발견하여 미만형 선암종을 예방하는 것은 어렵다. 미만형 이형성의 인접 점막 에서는 공통적으로 Helicobacter 감염에 의한 만성 위염이 나타났으며, 경부 세포의 증식으로 인하여 경부가 길어져서 점막은 다소 두터워지고, 전정부 점막의 결정성 비후 또는 체부의 점막 주름의 비후로 서 관찰되었다. 이러한 소견이 나타나는 경우에는 환자를 밀착 추적함으로써 미만형 선암종을 예방 또 는 조기 치료할 수 있다.

위의 경부세포 이형성 (1예 보고)

성노현, 구지혜, 손승명, 최송이 충북대학교 의과대학 충북대학교 의학연구소 2011 忠北醫大學術誌 Vol.21 No.1

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안와거짓종양 양상으로 발현한 특발다중심Castleman병

한상훈,손승명,이성현 대한신경과학회 2020 대한신경과학회지 Vol.38 No.4

Comparison of HER2 status in primary gastric adenocarcinomas and corresponding malignant ascites

김홍식,손승명,한혜숙 대한내과학회 2017 대한내과학회 추계학술대회 Vol.2017 No.1

Histologic Changes in Non–Small Cell Lung Cancer under Various Treatments: A Comparison of Histology and Mutation Status in Serial Samples

우창곡,손승명,이호창,한혜숙,이기형,김도훈,김응국,이옥준 대한암학회 2022 Cancer Research and Treatment Vol.54 No.3

PurposeHistologic change is a resistant mechanism in lung cancer. The most common histological change is the switch from adenocarcinoma (AdenoCa) to small cell carcinoma (SCC) against to tyrosine kinase inhibitors (TKI). However, it is not clear whether other treatment modalities are involved in the histologic changes.Materials and MethodsWe investigated histological changes in eight cases, after various treatments, and compared the molecular profiles between primary tumors and changed tumors using exome sequencing where tissue was available.ResultsThree cases of AdenoCa that were changed into SCC retained the initial mutations after TKI and/or surgical treatment. After treatment with TKI and immunotherapy, an <i>EGFR</i> (epidermal growth factor receptor)-mutant AdenoCa changed to squamous cell carcinoma (SqCa). SqCa in a patient treated with surgery was changed into combined AdenoCa and SqCa. These two cases showed the same genetic variations between the two distinct non–small cell carcinomas (NSCC). Three patients experienced two histologic changes, which the changed tumors returned to its original subtype or changed to a combined tumor after treatments. Four cases showed combined histology in the first or second change.ConclusionThe histology of NSCC can be changed to a single pattern or combined subtypes after various treatment modalities, and the phenotypic changes seem not fixed. Therefore, additional morphologic changes may occur regardless of their genetic status and types of treatments. To refine the new treatment strategy, consecutive repeated biopsies in progressive disease or recurrent tumor are necessary.

원발성 위암으로 오인된, 동시에 진단된 소엽성 유방암의위 전이

신영덕,손승명,송영진,박성수,최영진 한국유방암학회 2017 Journal of Breast Disease Vol.5 No.1

Gastric metastasis from invasive lobular breast carcinoma is rare. Mostly gastrointestinal metastasis presents as one among multiple metastases, several years after primary diagnosis of breast carcinoma. Herein, we report a synchronously diagnosed gastric metastasis from invasive lobular carcinoma, mimicking primary gastric linitis plastica with pyloric obstruction. We reviewed clinical and pathological findings of gastric carcinoma metastatic from the breast. In particular, we focused on immunohistochemical studies of selected antibodies, including those for estrogen receptors, gross cystic disease fluid protein-15, and caudal-type homeobox transcription factor 2, for accurate differential diagnosis. Clinical suspicion, repeat endoscopic biopsy, and detailed histological analysis including immunohistochemistry are necessary for diagnosis of gastric carcinoma metastatic from the breast.

Characteristics of Renal Cell Carcinoma Harboring TPM3-ALK Fusion

우창곡,윤석중,손승명,임영현,이옥준 연세대학교의과대학 2020 Yonsei medical journal Vol.61 No.3

The World Health Organization 2016 edition assigned anaplastic lymphoma kinase (ALK) rearrangement-associated renal cellcarcinoma (ALK-RCC) as an emerging renal tumor entity. Identifying ALK-RCC is important because ALK inhibitors have beenshown to be effective in treatment. Here, we report the case of a 14-year-old young man with ALK-RCC. Computed tomographyrevealed a well-demarcated 5.3-cm enhancing mass at the upper pole of the left kidney. There was no further history or symptomsof the sickle-cell trait. The patient underwent left radical nephrectomy. Pathologically, the mass was diagnosed as an unclassifiedRCC. Targeted next-generation sequencing identified a TPM3-ALK fusion gene. The present report and literature review demonstratethat TPM3-ALK RCC may be associated with distinct clinicopathological features. Microscopically, the tumors showed diffusegrowth and tubulocystic changes with inflammatory cell infiltration. Tumor cells were dis-cohesive and epithelioid with abundanteosinophilic cytoplasm and cytoplasmic vacuoles. If morphological features and TFE3 expression are present in adolescentand young patients, molecular tests for ALK translocation should be performed. This awareness is critically important, because ALKrearrangement confers sensitivity to ALK inhibitors.