사례분석을 통한 기술형 입찰 활성화 모색

박상욱,김동인,신교성,홍단기,백경민,Park, Sang-Uk,Kim, Dong-In,Sin, Gyo-Seong,Hong, Dan-Gi,Baek, Gyeong-Min 한국도로학회 2017 한국도로학회지 Vol.19 No.3

위치기반(LBS) 홍수정보 생산 및 제공 플랫폼 개발 - 홍수대응골든타임확보연구단_3세부-

박상욱,김성준,노재경,이기하,고덕구,임성만,원영진,강성대,변성준,Park, Sang-Uk,Kim, Seong-Jun,No, Jae-Gyeong,Lee, Gi-Ha,Go, Deok-Gu,Im, Seong-Man,Won, Yeong-Jin,Gang, Seong-Dae,Byeon, Seong-Jun 한국수자원학회 2018 물과 미래(한국수자원학회지) Vol.51 No.6

지능형 CCTV 기반 동적 범죄예측 기술 동향

박상욱,오선호,박수완,임경수,최범석,박소희,김상원,한승완,한종욱,김건우,Park, Sangwook,Oh, Seon Ho,Park, Su Wan,Lim, Kyung Soo,Choi, Bum Suk,Park, So Hee,Ghyme, Sang Won,Han, Seung Wan,Han, Jong-Wook,Kim, Geonwoo 한국전자통신연구원 2020 전자통신동향분석 Vol.35 No.2

Predicting where and when a crime may occur in an area of interest is one of many strategies of predictive policing. Multidimensional analysis, including CCTV, can overcome the limitations of hotspot prediction, especially of violent crimes. In order to identify the precursors of a crime, it is necessary to analyze dynamic data such as attributes and activities of people, social information, environmental information, traffic flows, and weather. These parameters can be recognized by CCTV. In addition, it provides accurate analysis of the circumstances of a crime in a dynamic situation, calculates the risk, and predicts the probability of a crime occurring in the near future. Additionally, it provides ways to gather historical criminal datasets, including sensitive personal information.

Glutamate-Induced Serotonin Depletion in Fetal Rat Brainstem Cultures

박상욱,위명복,송동근,김용식,김영희,Park, Sang-Wook,Wie, Myung-Bok,Song, Dong-Keun,Kim, Yong-Sik,Kim, Yung-Hi The Korean Society of Pharmacology 1993 대한약리학잡지 Vol.29 No.2

흰쥐태 뇌간의 세포를 배양하여 glutamate에 6시간까지 노출시 glutamate의 농도 및 노출 시간에 의존적으로 세포내 5-HT 및 5-HIAA의 함량이 감소하였고, 배양액으로 LDH의 유출이 증가하였다. Tetrodotoxin은 glutamate의 작용을 차단하지 못하였다. NMDA 수용체 통로 봉쇄제인 MK-801에 의해 glutamate의 작용이 효과적으로 차단되었고, non-NMDA 길항제인 CNQX는 효과가 없었으므로, serotonin 신경세포에 대한 glutamate의 작용은 NMDA 수용체의 자극에 의한 것으로 사료된다. Exposure of dissociated cultures from fetal rat brainstem to glutamate for upto 6 h decreased cellular contents of 5-hydroxytryptamine and 5-hydroxyindoleacetic acid in a concentration- and time-dependent manner. In addition, glutamate induced lactate dehydrogenase leakage. Tetrodotoxin did not block the effects induced by glutamate. MK-801 $(1{\mu}M)$, an N-methyl-D-aspartate (NMDA) channel blocker, but not 6-cyano-2,3-dihydroxy-7-nitro-quinoxazoline $(CNQX;\;3{\mu}M)$, a non-NMDA receptor antagonist, blocked glutamate-induced effects, indicating that these glutamate-induced responses are mediated through NMDA receptors.

인간 폐섬유아세포에서 TGF-β 자극에 의한 VEGF 분비

박상욱,신주화,심재원,김덕수,정혜림,박문수,심정연,Park, Sang-Uk,Shin, Joo-Hwa,Shim, Jae-Won,Kim, Deok-Soo,Jung, Hye-Lim,Park, Moon-Soo,Shim, Jung-Yeon 대한소아청소년과학회 2008 Clinical and Experimental Pediatrics (CEP) Vol.51 No.8

목 적 : 폐섬유아세포는 예전에는 기도의 구조적 세포로만 알려져 왔으나, 최근에는 천식에서 기관지 운동의 톤을 조절할 뿐만 아니라 기도의 면역조절과 기도 개형에서 중요한 역할을 하는 것으로 밝혀지고 있다. VEGF는 혈관 내피세포에서 강력한 작용을 하는 다기능적 사이토카인으로서, 상피내 세포의 세포분열을 유도하고, 상피세포의 투과도를 증가시키며, 상피세포의 이동을 향상시키는 역할을 하는 것으로 알려져 있다. TARC는 Th2 세포의 선택적 이동을 유도하는 케모카인으로 알려져 있다. 본 연구에서는 PDGF와 TGF-${\beta}$로 자극시킨 인간 폐섬유아세포에서 VEGF와 TARC가 생성되는지와 dexamethasone이 폐섬유아세포에서 VEGF의 분비를 억제하는지를 알아보고자 하였다. 또한 폐섬유아세포와 기관지 평활근 세포와 함께 배양했을 때 VEGF 생성에 미치는 효과를 단독배양 시와 비교하였다. 방 법 : 폐섬유아세포와 인간 기관지 평활근세포를 각각 혹은 함께 배양한 뒤 48시간동안 무혈청 배지에서 성장을 정지시킨 후 TGF-${\beta}$ (10 ng/mL)와 PDGF (20 ng/mL)로 자극하였다. 자극 후의 세포 증식 반응과 배양액 상층액의 VEGF, TARC 농도를 측정하여 dexamethasone ($10^{-6}M$)으로 전처치 후 자극한 것과 비교하였다. 결 과 : PDGF와 TGF-${\beta}$로 자극하였을 경우 폐섬유아세포에서 VEGF 분비가 의미있게 증가하였고, 특히 PDGF와 TGF-${\beta}$로 함께 자극하였을 경우 더욱 의미있는 상승을 보였다. Dexamethasone은 폐섬유아세포의 VEGF 분비를 PDGF로 자극한 경우와 PDGF, TGF-${\beta}$ 같이 자극한 경우 모두에서 억제하였다. 인간 기관지 평활근 세포와 폐섬유아세포를 혼합 배양했을 때 VEGF 분비에는 상승적인 효과가 없었다. Dexamethasone은 폐섬유아세포 증식을 억제시키지 않았다. 폐섬유아세포를 PDGF와 TGF-${\beta}$로 자극했을 때 TARC는 분비되지 않았다. 결 론 : 폐섬유아세포는 VEGF 분비를 통해 기도 개형에 관여하며, 기관지 평활근 세포와 함께 배양해도 VEGF 분비에 상승 효과는 없다. Dexamethasone은 VEGF 분비를 억제하였으나 폐섬유아세포의 증식을 억제하지는 못하였다. Purpose : The human lung fibroblast may act as an immunomodulatory cell by providing pro-inflammatory cytokines and chemokines, which are important in airway remodeling. Vascular endothelial growth factor (VEGF) induces mucosal edema and angiogenesis. Thymus and activation regulated chemokine (TARC) induces selective migration of T helper 2 cells. We investigated whether human lung fibroblasts produced VEGF and TARC, and the effects were augmented with the co-culture of fibroblasts and human bronchial smooth muscle cells (HBSMC), and whether dexamethasone can inhibit the proliferation and the release of VEGF in lung fibroblasts. Methods : Human lung fibroblasts were cultured with and without HBSMC, growth-arrested in serum-deprived medium, and pretreated with dexamethasone for 16 hours. After 24-hour stimulation with platelet derived growth factor-BB (PDGF-BB) and/or transforming growth factor-${\beta}$ (TGF-${\beta}$), culture supernatant was harvested for assays of VEGF and TARC. Cell proliferation was assayed using BrdU cell proliferation ELISA kit. Results : 1) The release of VEGF was significantly increased after stimulation with TGF-${\beta}$, and its release was augmented when co-stimulated with PDGF and TGF-${\beta}$. 2) VEGF release induced by PDGF or TGF-${\beta}$ was inhibited by dexamethasone. 3) There was no synergistic effect on the release of VEGF when human lung fibroblasts were co-cultured with HBSMC. 4) Dexamethasone did not suppress human lung fibroblasts proliferations. 5) Neither TGF-${\beta}$ nor PDGF induced TARC release from lung fibroblasts. Conclusion : Human lung fibroblasts may modulate airway remodeling by release of VEGF, but they have no synergistic effects when co-cultured with HBSMC. Dexamethasone suppresses VEGF release, not proliferation of lung fibroblast.

고고도 장기체공무인기 주익 Spar 비선형 구조 해석

박상욱,신정우,이무형,김태욱,Park, Sang-Wook,Shin, Jeong-Woo,Lee, Mu-Hyoung,Kim, Tae-Uk 한국항공운항학회 2015 한국항공운항학회지 Vol.23 No.1

In order to increase endurance flight efficiency of long endurance electric powered UAV, main wing of UAV should have high aspect ratio and low structural weight. Since a spar which consists of thin and slender structure for weight reduction can cause catastrophic failure during the flight, it is important to develop verification method of structural integrity of the spar with the light weight design. In this paper, process of structural analysis using non-linear finite element method was introduced for the verification of structural integrity of the spar. The static strength test of the spar was conducted to identify structural characteristic under the static load. Then, the experimental result of the spar was compared to the analytical result from the non-linear finite element analysis. It was found that the developed process of structural analysis could predict well the non-linear structural behavior of the spar under ultimate load.

Chemical absorption of carbon dioxide into phenyl glycidyl ether solution containing THA-CP-MS41 catalyst

박상욱,최영선,오광중,Min-Chul Kim 한국화학공학회 2010 Korean Journal of Chemical Engineering Vol.27 No.6

Carbon dioxide was absorbed into the phenyl glycidyl ether (PGE) solution within a range of 0-2.0 kmol/m3 in a stirred batch tank with a planar gas-liquid interface at 333-363 K and 101.3 kPa. Trihexylamine-immobilized on chloropropyl-functionalized MCM-41 (THA-CP-MS41) was used as a mesoporous catalyst, dispersed in organic liquid for the reaction between carbon dioxide and PGE. The measured absorption rates were analyzed to obtain the reaction kinetics of the consecutive chemical reactions which consisted of two steps using the mass transfer mechanism based on film theory. The overall reaction kinetics, analyzed with the pseudo-first-order reaction constant in the consecutive reaction model, was equivalent to the consecutive reaction kinetics. Effects of polar solvent, such as N, Ndimethylacetamide,N-methyl-2-pyrrolidinone, and dimethyl sulfoxide, on the reaction rate constants were observed using the solubility parameter of the solvent.

화학방법에 의한 액 - 액 계면 면적

박상욱,문진복,신정호,박대원,김종현 ( Sang Wook Park,Jin Bok Moon,Jeung Ho Shin,Dae Won Park,Jong Hyeon Kim ) 한국공업화학회 1993 공업화학 Vol.4 No.1

교반기를 사용하여 n-butyl acetate의 알카리 가수분해반응의 액-액 불균일계에서 n-butyl acetate의 총괄물질전달속도를 측정하여 실험변수와의 관계를 고찰하고, 화학반응을 수반한 물질전달기구를 경막설에 적용하여 용질에 대한 확산방정식의 근사해로부터 구한 n-butyl acetate의 반응촉진계수의 이론값과 측정값을 비교하여 물질전달계수를 구하였다. 이로부터 분산용액의 액적 면적을 산출할 수 있었다. The rates of overall mass transfer of n-butyl acetate in the alkaline hydrolysis of n-butyl acetate were measured by using a mechanically agitated vessel in order to get the relationship between the mass transfer rates and experimental variables. The interfacial area between liquid-liquid heterogeneous phases could be obtained by comparing the theoretical values of reaction enhancement factor from an approximated solution of a diffusion equation based on the film theory with the experimental data.

Chemical Reaction of Carbon Dioxide with AMP in w/o Emulsion Membrane

박상욱,최병식,김성수,이재욱,Park Sang-Wook,Choi Byoung-Sik,Kim Seong-Soo,Lee Jae-Wook The Membrane Society of Korea 2004 멤브레인 Vol.14 No.4

본 연구에서는 준 회분식 교반조를 사용하여 polybutene (PB)와 polyisobutylene (PIB)고분자를 용해한 벤젠 용액을 연속상, 물을 불연속상으로 구성한 w/o 에멀션액막에 $CO_2$을 흡수시켜 흡수속도를 측정하였다. 점탄성을 나타내는 Deborah 수를 사용하여 점탄성 비뉴튼액체에서 구한 부피물질전달계수 ($k_La$)를 고찰하고, 수용액에 첨가한 2-amino-2-methyl-1-propanol(AMP)와 $CO_2$의 반응 메카니즘을 해석하였다. Carbon dioxide was absorbed into water-in-oil (w/o) emulsion composed of aqueous 2-amino-2-methyl-1-propanol (AMP) droplets as a dispersed phase and benzene solutions of polybutene and polyisobutylene as a continuous phase in a flat-stirred vessel to investigate the effect of non-Newtonian rheological behavior on the rate of chemical absorption of $CO_2$, where the reaction between $CO_2$ and AMP in the aqueous phase was assumed to be a pseudo-first-order reaction. It was expressed that PIB with elastic property made the rate of chemical absorption of $CO_2$ accelerated by comparison of mass transfer coefficient of $CO_2$ in the non-Newtonian liquid with that in the Newtonian liquid.

산삼 약침이 정상 중년여성의 맥파요인에 미치는 영향

박상욱,김이순,황원덕,김경철,Park, Sang-Wook,Kim, Yi-Soon,Hwang, Won-Deok,Kim, Gyeong-Cheol 대한약침학회 2011 Journal of pharmacopuncture Vol.14 No.1

Objectives: The aim of this experiment is to know about Effect of pulse-wave factors in Middle Aged Women by Mountain Cultivated Ginseng Pharmacopuncture. Methods: First 20 Middle Aged women are diagnosed by pulse diagnosis, and then Mountain Cultivated Ginseng Pharmacopuncture(1 injection 20cc) were injected. 30 minutes later, pulse diagnosis again performed. As a result, method of one-group pretest-posttes design were used for evaluation. Results: T(Total pulse cycle) time statistically significant increased on both left and right chon, kwan, cheok. T4 time statistically significant increased on both left and right chon, kwan, cheok. T4-T1/T indexs except left cheokmaek, Right cheokmaek observation area decreased significantly in four sites. Wm(indicating high pressure retention time) indexs increased significantly in the five sites were observed except right chon maek. Conclusions: Effect of pulse-wave factors in Middle Aged Women by Mountain Cultivated Ginseng Pharmacopuncture increased T, T4, Wm and decreased T4-T1/T indexs. The results of this experiment, Mountain Cultivated Ginseng Pharmacopuncture induced to increase the Pulse-wave's stability and strength.