한국인 Fragile X 환자들의 Lactic Dehydrogenase에 관한 연구

김종봉,윤인숙,김강영 대구효성가톨릭 대학교 1997 연구논문집 Vol.54 No.2

This study was conducted to determine physiological characteristics of Korean unclassified mental retardees. The results were as follows. Fragile X chromosomes were identified in three patients, and the frequencies of fragile X chromosomes were 4∼15%. In fragile X syndrome patients and unclassified mental retardees, the serum LDH activity was 147.66±24.58(IU/L), 171.22±53.08(IU/L) respectively. The results revealed lower level of the serum LDH activity in fragile X syndrome patients and unclassified mental retardees than in Down' syndrome patients and control group.

적십자간호사업의 역사적 고찰

양원영,강윤숙,이옥철,조인재 적십자간호전문대학 2000 적십자간호전문대학논문집 Vol.22 No.-

염색체 위치 특이적 삽입과 안정적인 유전자 발현을 유도하는 플라스미드 백터의 제작

문영준,강윤성,최지혜,손진숙,민나영,이광호 中央大學校 基礎科學硏究所 2002 基礎科學硏究所 論文集 Vol.16 No.-

Insertion of reporter constructs into the mammalian genome leads to variable gene expression due to position effects at the site of integration. This random integration has limited the gene therapy of human genetic disorders by its undesirable effects. We report here the newly constructed plasmid vector(pIRES-neo-YJ) based on the concepts of homologous recombination and position-independent promoter enhancing of beta-globin matrix attachment region(Glb-MAR). chromosome 7 centromere-specific alpha satellite(alphoid) DNA sequence was cloned into pIRES-neo-YJ for homologous recombination of the cloned gene with the centromeric region of chromosome 7, which is genetically silent. Beta Glb-MAR sequence that allows high levels of transcription independent of the chromosomal site of integration was also inserted into pIRES-neo-YJ to ensure the stable and higher expression of the cloned genes. We expect that pIRES-neo-YJ would provide a valuable tool to eliminate random integration of cloned genes into the undesirable chromosomal region and their short-lived expression which often encounters during the construction of transgenic animals and human gene therapy.

임상 증상이 심하지 않은 심낭 삼출 환자의 장기 추적 결과

배장호,김기식,강미숙,남명희,김미정,김민수,김기영,님창욱,김윤년,김권배,정시전,김여희 대한순환기학회 1999 Korean Circulation Journal Vol.29 No.7

韓國 看護大學 敎育課程에 對한 硏究

文姬子,金潤喜,趙潔子,趙美映,姜賢淑 慶熙大學校 1982 論文集 Vol.11 No.-

The changes of social issues and nursing concepts require the expansion of nursing needs and nursing role, therefore it is keenly demanded the necessity of the research for new curriculum development in nursing. So to make a contribution to the development of nursing education in Korea, we made a comparative study of nursing curriculum of each universities which have baccalaureate program and put them into operation at present; they are 10 Korean universities, 5 American universities and 4 Japanese Universities. Thus by researching the differences among them. We acquired the conclusions as followings. The purpose of Nursing education In case of Korean parts, the contents of those aims must be explained more clearly and more in detail than another results of research. There also has to be made the statements upon the scientific researching methodology in scholarly respect, or the self-development in individual respect, or the lasting endeavour for studies in professional respect. We must put an emphasis upon the statement and education of the direct nursing provider, or the primary health care manager at hospital and community, who is one of the important aims of modern nursing education. The substance of nursing curriculum. 1) Total credits for completion and the comparison of curriculums, classified by the field. The scope of total credits of each nation, according to Colleges ranges; Korea: 140-163, U.S.A.: 121-187, Japan: 13-158 Compared with those of U.S.A. and Japan, the average credits of Korea is higher. Classified by the field, the credits alloted to major courses are 73.3% and liberal courses, only 26%, which shows that it does not satisfy the current educational trend that emphasizes the liberal course. 2) The comparison of curriculums, classified by a school year. In case of Korea, the total credits are evenly assigned to all grades, but the freshman taken the concentration of liberal courses (81.2%). Among the major courses are preponderant the Nursing Supportive subjects in the sophomore and the nursing major ones in the junior and senior. 3) Curriculums classified by the subject. (1) As compared with those of Japan and U.S.A. Korean students are less free in chosing subjects their own way all over the curriculums. It is, therefore, required that the range of the optionals be widened for the open and flexible education. (2) We can find all of three nations (Korea, Japan, U.S.A.) neglect the sphere of the behavioral sciences among the fundamental nursing subjects. In the field of social sciences, among Korea, Japan, and U.S.A., top ranks Japan that tends of the interested in social well-being. In Korea only two universities have this subjects. (3) Nursing major subjects. Defficulties in comparing them lie in the gulfs of the title of subjects, and the structural differences of the formation of curriculums among nations. In case of Korea, although there are a few differences of the number of credit of subjects among colleges, she has uniform aspects for U.S.A., which says that there are no characteristics and self-control each colleges has in Korea. We can notice that the subjects each Korean university shares are also doubled with those of the national examination for nursing qualification. Japan differs from Korea in that subjects are more differentiated and students are provided with more chances to make a choice through the system of subjects and the texture of a curriculum are similar to those of Korea. In case of Korea, therefore, the unification of fundamental subjects (especially in the medical field) and clinical practices is required. (4) The course for teaching profession is taken as either the required or optional just in Korea (80%) and Japan (75%). The number of subjects and total credits of teaching courses is different according to the colleges of Korea and Japan. As for the contents of subjects Korea deals with theory and Japan, the practical thing with which students can adjust themselves to the spot of society. As a result of that, in case of Korea, demanded are the entire review and research upon the purpose of establishing a curriculum, its relation to the total credits and the choice of substance of subjects etc. 4) The patterns of organization in curriculum development. Most of the patterns of organization, classified by clinic subject pivot upon disease and subjests are not mutually unified in case of Korea and Japan. Though the patterns of organization of subjects if formally unified, that of curriculums is not substantially or wholy synthesized, while in case of U.S.A. the unification of the patterns of organization entire curriculum as well as the mutual unification of subjects is attained and each college runs a characteristic curriculum, since the application of nursing theory and the model of a curriculum are different according to college. The prevention of disease, the promoting health and the disease system is patterned, centering around the healthy and their families. Therefore, in case of Korea, it is urgent to unify the curriculum of nursing education for the efficiency of the future oriented nursing education, and it is also imminent to develop the new pattern of a nursing curriculum suited for our own social demand and situation. And we need the continuous studies and search for the method of application in order to development the new curriculum. The comparison of a curriculum with the purpose of nursing education. The substances of subjects are not consistently in accord with the aims of nursing education each college states in Korea, Japan and U.S.A. Especially in case of Korea, the most statements upon the purpose of education are in the social dimension, but the most subjects have the academic dimension. In Korea it is stringent to examine and study the choice of the contents of education in terms of learning, profession, individual and society.

간세포암과 감별이 어려웠던 악성중피종 치험 1예

김선문,허원석,채경훈,강윤세,정재훈,김연수,박기오,문희석,이엄석,김석현,성재규,이병석,이헌영,신경숙,조준식,송인상,강대영 충남대학교 의학연구소 2003 충남의대잡지 Vol.30 No.2

Malignant peritoneal mesothelioma is a rare neoplasm that arises from the mesothelium of a serosal cavity and is a rapidly fatal disease with a median survival of 4 to 12 months for untreated cases. Recently, we experienced a case with malignant peritoneal mesothelioma who was suspected hepatocelluar carcioma by abdominal CT scan and was confirmed by biopsy including immunohistochemical stain(calretinin) after surgery. We performed tumor excisions and wedge resection of the liver(segment Ⅷ)and inserted Tencoff catheter in abdominal cavity at 25th day of post-operation. We treated with intraperitoneal paclitaxel(25mg/m^(2)/day for 5 days) six courses monthly. She was well tolerable and is still living without any evidence of recurrence for 14th month of post-operation.

뇨(尿)중 3-Methylhistidine 함량의 측정과 이용

정수현,서형주,김윤숙,이효구,강덕호 한국식품영양학회 1996 韓國食品營養學會誌 Vol.9 No.2

기존의 방법을 일부 수정하여 뇨중 3-methylhistidine을 분석하였다. 뇨중 3-methylhistidine을 fluorescamine 유도체화하여 HPLC에 주입하고 C_18 column과 10 mM acetonitrile/sodium phosphate buffer(pH 7.5)로 분리·용출시켜 형광검출기로 측정하였다. 3-methylhistidine의 체류시간은 7분 이내이었으며, histidine과의 분리상태도 서로 간섭함이 없이 양호하였다. 뇨에 3-methylhistidine을 첨가하고 이를 분석하였을 때의 회수율은 93∼106%로 높은 수준이었다. 체육학과 남학생중 웨이트 트레이닝 단련자와 비단련자를 대상으로 조사한 단기간의 웨이트 트레이닝에 따른 뇨중 3-methylhistidine 함량의 변화는 두 집단 모두 웨이트 트레이닝후의 3-methylhistidine 분비량이 유의하게 증가하였다. A modified method is given for the precolumn derivatization and subsequent high-pressure liquid chromatographic seperation of 3-methylhistidine from urine. The elution contained isocratic solution with acetonirile and 10 mM sodium phosphate(pH 7.5) requires less than 7 min. The recoveries of 3-methylhistidine from urine control were 93% to 106%. 3-Methylhistidine determinations were performed on urine samples from volunteers who were both male trained and non-trained physical undergraduates. As the result, urinary 3-methylhistidine content of volunteers increased significantly after weight training.

노인의 영적 간호요구

최미혜,김경희,김귀옥,김기숙,김수강,김정신,김춘숙,노흥진,박지연,성혜연,오명선,이선희,이원옥,이윤영,이현수,장명재,차혜경,채정선,홍상희 중앙대학교 의과대학 간호학과 간호과학연구소 2001 중앙간호논문집 Vol.5 No.1

This study was designed to exam the aged's needs for spiritual nursing care. The purpose was to serve as a basis for the development of spiritual nursing practice. The major findings are as follows : 1. The degree of needs for spiritual nursing care as area was that needs of love and relationship mean 22.0, needs of meaning and object mean 28.2, needs of forgiving mean 13.5. Total needs for spiritual nursing care mean 63.7, which was on the upper middle level. The needs of meaning and object was rated highest. 2. Among the general characteristics of the subjects, needs of love and relatiohship wasn't significanlty different. 3. Among the general characteristics of the subjects, needs of meaning and object was significantly different according to two factors : age(F=7.260, p=0.001), religion(F=5.275, p=0.001). Higher needs of meaning and object was possessed by the older than the younger, by the one who have religion than the other. 4. Among the general characteristics of the subjects, four factors made a significantly difference to needs of forgiving : sex(t=-2.851, p=0.006), age(F=8.201, p=0.001), religion(F=6.928, p=0.000), disease(t=2.327, p=0.024). Higher needs of forgiving was possessed by man than woman, by the older than the younger, by the one who have religion than the other, by the one who have disease than the other.

위내시경검사로 진단된 원발성 유전분증 1 예

김영수,김현태,유재형,윤준현,강응택,김종숙,설무종,장세경,박용욱 대한내과학회 1987 대한내과학회지 Vol.32 No.2

A case of AL type primary amyloidosis is reported. Diagnosis was made by gastrofiberscopic mucosal biopsy and confirmed by polarizing, electron microscopy, serum protein electrophoresis and immune elecfrophoresis. We discussed this case of primary amyloidosis with review of literature.

에페리손에 의한 즉시형 과민반응 증례 보고

강동윤 ( Dong Yoon Kang ),이진 ( Jin Lee ),손경희 ( Kyoung-hee Sohn ),강성윤 ( Sung Yoon Kang ),조윤숙 ( Yoon Sook Cho ),강혜련 ( Hye-ryun Kang ) 대한천식알레르기학회(구 대한알레르기학회) 2017 Allergy Asthma & Respiratory Disease Vol.5 No.4

Eperisone is a widely used muscle relaxant and believed to be relatively free of adverse drug reactions. However, a rare case of fatal anaphylaxis has been reported in the literature. Poor awareness due to its rarity and combined administration with other drugs are the major hurdles in diagnosing eperisone-induced anaphylaxis. We experienced 3 cases of immediate hypersensitivity reaction occurring after eperisone administration. Case 1, a 63-year-old female, was admitted via the Emergency Department with urticaria, generalized erythroderma, sore throat, chest discomfort, and dyspnea within 1 hour after administration of common cold remedy. Case 2, a 58-year-old male, visited our allergy clinic to detect culprit drugs. He experienced itching, urticaria, hypotension for several hours after administration of the pills for back pain in the last 3 years. Case 3, a 58-year-old male developed urticaria and dyspnea after administration of medication for a headache. He also experienced urticaria and facial edema after administration of the common cold remedy. Among the medications, eperisone hydrochloride was proven as the culprit drug and others were excluded through oral provocation tests. We advised them to avoid eperisone and issued drug safety card. Clinicians should be aware that eperisone hydrochloride is a potential culprit agent of fatal anaphylaxis. (Allergy Asthma Respir Dis 2017;5:228-231)