간세포암과 감별이 어려웠던 악성중피종 치험 1예

김선문,허원석,채경훈,강윤세,정재훈,김연수,박기오,문희석,이엄석,김석현,성재규,이병석,이헌영,신경숙,조준식,송인상,강대영 충남대학교 의학연구소 2003 충남의대잡지 Vol.30 No.2

Malignant peritoneal mesothelioma is a rare neoplasm that arises from the mesothelium of a serosal cavity and is a rapidly fatal disease with a median survival of 4 to 12 months for untreated cases. Recently, we experienced a case with malignant peritoneal mesothelioma who was suspected hepatocelluar carcioma by abdominal CT scan and was confirmed by biopsy including immunohistochemical stain(calretinin) after surgery. We performed tumor excisions and wedge resection of the liver(segment Ⅷ)and inserted Tencoff catheter in abdominal cavity at 25th day of post-operation. We treated with intraperitoneal paclitaxel(25mg/m^(2)/day for 5 days) six courses monthly. She was well tolerable and is still living without any evidence of recurrence for 14th month of post-operation.

국가예방접종전산등록체계 개발을 위한 민간의료 기관 하부구조 및 환경 조사연구

이무식,김은영,이건세,이석구,홍지영,김건엽,김대경,신의철,이연경,기몽서,나백주,김영택 한국모자보건학회 2003 한국모자보건학회지 Vol.7 No.2

자궁내 태아사망의 임상적 고찰

이권해,이정재,조현철,이석민,이임순,이해혁,김권대,이순곤,남계현 순천향의학연구소 1999 Journal of Soonchunhyang Medical Science Vol.5 No.2

Objective: This study was designed to evaluate diagnosis and complication, prognosis during clinical study of cases of intrauterine fetal death. Methods and materials: This is a clinical study of 56 cases of the intrauterine fetal death among 8064 deliveries at Seoul Sunchunhyang university hospital during 5 years from January, 1994 to December, 1998. Results: The incidence was 0.7%. The age distribution of mothers was 18 - 44 years and was highest in the 25 - 29 years range(46.4%). The parity was the most highest in the nulliparous group(51.8%). The most common gestational weeks was 20 - 28 weeks gestational period(46.4%), and most common presentation was cephalic(73.5%). The most common weights of the intrauterine fetal death was from 5,00gm to 1,000g(48.2%). The mode of the most common delivery was the induction of delivery(57.2%). The etiologic factors were: unknown(42.9%), preeclampsia(17.9%), chorioamnionitis(14.3%), congenital anomaly(12.5%), abruptio placenta(7.1%), cord complication(3.6%), placenta previa, death of one for twin. There were 2 cases of maternal complication(DIC, Uterine atony). Conclusion : Intrauterine fetal death should be diagnosised early and treated properly to reduce risk of the maternal complication.

교통사고 후 발생한 경항통 환자에 대한 황련해독탕약침과 분리정제봉약침의 치료 효과 비교연구: 무작위 배정

이옥진 ( Yu Chen Lee ),남대진 ( Dae Jin Nam ),허건 ( Gun Huh ),이재은 ( Jae Eun Lee ),김빛나라 ( Bin Na Ra Kim ),송은모 ( Eun Mo Song ),이은정 ( Eun Jung Lee ),이정민 ( Jung Min Lee ),오민석 ( Min Seok Oh ) 한방재활의학과학회 2014 한방재활의학과학회지 Vol.24 No.4

ObjectivesThe purpose of this study is to compare the effects of HWANGRY-UNHAEDOKTANG Pharmacopuncture and Essential Bee Venom pharmacopuncture on cervical pain caused by traffic accident.MethodsThe clincal study was conducted to traffic accident patients who had admitted to Dae-Jeon University Cheonan Oriental Hospital from May 17, 2014 to September 2, 2014. The patients were simple randomization and divided into two groups. In one group, patients were treated with the oriental medicine and HWANGRYUNHAEDOKTANGPharmacopuncture, While in the other group, patients were treated with the oriental medi-cine therapy and Essential Bee Venom pharmacopuncture therapy. visual analogue scale (VAS), pain threshold and neck disablity index (NDI) were used To estimate the efficacy of Pharmacopuncture treatment.Results1) HWANGRYUNHAEDOKTANG Pharmacopuncture Group showed significant decrease of VAS and NDI after 3rd times treatment than before treatment (p<0.001). Essential Bee Venom Pharmacopuncture showed significant decrease of VAS, NDI and improve ment of pain threshold after 3rd times treatment than before treatment (p<0.01, p<0.001). 2) There was no significant difference between HWANGRYUNHAEDOKTANGPharmacopuncture group and Essential Bee Venom Pharmacopuncture group in VAS, pain threshold and NDI. ConclusionsWe found out that HWANGRYUNHAEDOKTANG Pharmacopuncture and Essential Bee Venom Pharmacopuncture treatment are considered to be effective and useful in cervical pain caused by traffic accident. (J Korean Med Rehab 2014;24(4): 145-153)

김대건 (안드레아) 신부 얼굴복원

한승호(Seung-Ho Han),박대균(Dae-Kyoon Park),이우영(U-Young Lee),고기석(Ki-Seok Kohl),김희진(Hee-Jin Kim),허경석(Kyung-Seok Hu),남용석(Yong-Seok Nam) 대한체질인류학회 2001 대한체질인류학회지 Vol.14 No.3

본 작업은 서울대교구 명동성당에서 가툴릭의대에 우리나라 최초의 신부인 김대건 신부의 얼굴복원작 업을 의뢰해 1999년 9월부터 약15개월에 걸쳐 북원작업을 한 것으로 1971년 가툴릭의대 해부학교실에서 조사한 김대건 신부 머리뼈의 직접제측치와 사진 자료를 창조하여 제작하였다 작업의 과정은 머리뼈 계측값이 가장 비슷한 머리뼈를 찾아 복제를 하고 계측치에 맞게 수정한 후, 해부학 실습용 시체에서 직접계측하거나 초음파를 이용하여 간접계측을 한 한국인 얼굴의 표준두께를 적용하여 영굴을 복원하였다. 아울러 한국인에서 조사 한 머리뼈와 얼굴 각 부위의 연관관계자료를 토대로 유토를 이용한 복원작업을 시행하였으며 최종 결과물은 청동을 소재로 흉상을 만들었다. 이와 같은 작업은 법의학분야에서 신원미확인 머리뼈가 발견되었을 때 얼굴복원을 통해 신원을 확인하는 법 의인류학적 연구의 하나로, 한국인의 자료를 토대로 작업한 최초의 영굴복원이며 앞으로 신원확인을 위해 얼굴 을 복원하는 작업에 도움이 될 것으로 생각한다.

장애인 입소시설과 특수학교의 구강건강관리 실태에 대한 조사 연구

이광희,김대업,하순영,박종석 대한소아치과학회 2000 大韓小兒齒科學會誌 Vol.27 No.2

전국의 123개 장애인 입소시설과 102개 특수학교를 대상으로 구강건강관리 실태를 파악하여 장애인의 구강건강관리 계획을 수립하는 데 사용할 수 있는 근거를 마련하고자 하였다. 설문지 조사법으로 연구하였다. 정기구강검진은 특수학교에서 연2회 실시하고 있었으나, 장애인 입소시설에서는 56.8%에서 시행하였다. 우식 예방 프로그램은 장애인 입소시설의 69.1%, 특수학교의 86.3%에서 시행하였으며 프로그램의 종류는 입소시설에서 규칙적 칫솔질이 58.1%, 특수학교에서 예방교육이 65.7%로 가장 많았다. 불소를 이용한 우식예방은 입소시설과 특수학교에서 각각 8.6%, 11.8%에서 시행하고 있었으며, 열구전색은 각각 6.8%, 6.9%에서 시행하였다. 치과치료를 시행하고 있는 입소시설과 특수학교에서는 각각 84.2%, 39.2%이었고, 입소시설에서 치료를 받기 위해 이용하는 곳은 치과의원(60.2%), 보건소(16.8%), 자원봉사자(15.3%), 대학병원(1.0%) 등이었다. 치료를 위해 치과의원에 방문하여 치료를 거부당한 경험이 있는 응답자는 17.7%이었다. 주요어 : 장애인, 입소시설, 특수학교, 정기구강검진, 우식예방, 치과치료. The purpose of study was to investigate the oral health care status in institutions and special schools for the disabled in Korea. Nurses in 123 institutions and nurse-teachers in 102 special schools were asked to fill questionnaires regarding periodic oral examination. preventive dental programs, and dental treatment. The results of this study were as follow. 1.56.8% of institutions implemented regular oral examinations and all of special schools did it twice a year. 2.Preventive programs for dental caries were done in 69.1% of the institutions and 86.3% of the special schools. Programs included regular toothbrushing and dental health education. 3.Dental treatment was done in 84.2% of the institutions and 39.2% of the special schools. Institutions utilized private dental clinics(60.2%), public health centers(16.8%), volunteers(15.3%), and dental hospitals. 4.17.7% of the institutions experienced the refusal to treat the disabled by private dental clinics.

살모사 교상 후에 발생한 뇌간 경색

권석범,이병철,배재천,황성희,김대훈 대한신경과학회 1998 대한신경과학회지 Vol.16 No.4

수중식물과 침전물에 의한 용존산소 변화량 결정 : 하천모델 이용법;a Stream Model Approach

이용석,최은주,박민대,박석순 江原大學校 附設 環境硏究所 1993 環境硏究 Vol.10 No.-

하천모델을 이용하여 한강 지류인 탄천에서 수초와 침전물에 의한 용존산소 변화량을 측정하였다. 수질자료에 따르면 탄천은 상류의 부영양화 지역 (Eutrophic Zone)과 하류의 강부수성 지역 (Polysaprobic Zone)으로 구분되며 상류는 수초의 광합성과 호흡이, 하류는 침전물 산소요구량이 수중 용존산소 농도 결정에 주 역할을 하고 있다. 하천조사는 1990년5월과 10월 2회에 걸쳐 2일간 연속적으로 실시되었다. 조사 결과 상류의 경우 수초 광합성과 호흡에 의한 매우 큰 용존산소 일주변화가 관찰되었다. 그러나 하류의 경우 침전물 산소요구량이 크고 수초 성장이 없기 때문에 일주변화가 거의 나타나지 않는 매우 낮은 농도가 측정되었다. 1차 조사시 상류에서 수중식물의 광합성량과 호흡양은 각각 55~100g 0₂/m²/day, 30~70g 0₂/m²/day으로 측정되었으며, 2차 조사시 각각 40~80g 0₂/m²/day, 25~55g 0₂/m²/day으로 측정되었다. 하류에서는 침전물 산소요구량이 1차 및 2차 조사시 동일하게 4~100g 0₂/m²/day로 측정되었다. The dissolved oxygen changes caused by aquatic plants and sediments were comput-ed in the Tancheon, a tributary of the HanRiver, by utilizing a stream model. According to the collected water quality conditions, the Tancheon was classified into two distinc-tive zones which were eutrophic zone in upstream area and polysaprobic zone in downstream area. The dissolved oxygen levels of the stream were determined mainly by the photosynthesis and respiration of the macrophytes in upstream area and by the sediment oxygen demand in downstream. Field data were obtained from two synoptic stream surveys performed during May and October, 1990 for two consecutive days The high diurnal dissolved oxygen variation was observed in upstream area due to an excessive growth of aquatic plants. In downstream area, however, little diurnal varia-tion with low dissolved oxygen level was observed, which would be attributed to high sediment oxygen demand and no discernible aquatic plant growth. In upstream area, the dissolved oxygen changes caused by the photosynthesis and respiration were ranged from 55g 100g 0₂/m²/day from 30 to 70 g 0₂/m²/day, respectively, during the first survey. The changes were ranged from 40 to 80g 0₂/m²/day for the photosynthesis and from 25 to 55g 0₂/m²/day for the respiration during the second survey, In downstream area, the sediment oxygen demands were measured from 4 to 100g o₂/m²/day during both surveys.

洪水追跡法에 의한 河道變移豫測(Ⅰ) (理論)

李大澈,이종석,朴昌圭 大田産業大學校 1996 한밭대학교 논문집 Vol.13 No.1

This study is in order to evaluate for the topographic variation by the flood routing method in alluvial channel of the erodibility. Basic equations in natural open channel induced from the control volume for the governing equation with continuity and momentum in water and sediment and the solution for these equations worked out by the finite difference method in numerical analysis. Predictions of the topographic variation leading out from as change direction and rate the various in channel width, changes in bed profiles and radius of curvature. And also, bank erodibility factor induced by the correction coefficient with conditions of bank organization and material properties, and the values used in zero to one from non-erodibility bank to non-cohesive bank, respectively.

Cyanobacterium Synechocystis PCC6803 내에서 Bacillus thuringiensis subsp. morrisoni PG-14 cryIVD 유전자의 발현

이대원,박현우,진병래,정영호,박영목,강석권 한국미생물생명공학회 ( 구 한국산업미생물학회 ) 1996 한국미생물·생명공학회지 Vol.24 No.2

미생물 살충제로 사용되고 있는 B. thuringiensis를 모기유충방제에 적용하기 위한 시도는 B. thuringiensis가 수서생태계에서 부유하지 못하고 가라앉으며, 생활환을 이루지 못한다는 문제점으로 인해 적용에 어려움이 있다. 따라서 본 연구는 모기유충에 강한 독성을 갖는 B. thuringiensis subsp. morrisoni PG-14의 cryIVD 유전자를 모기유충의 먹이인 cyanobactrium에 도입하기 위하여 발현벡터 pCYASK 5-1을 제작하고, cyanobacterium Synechocystis PCC6803에 형질전환시켜, 세포내에서 cryIVD 유전자의 발현과 뇌염모기에 대한 독성을 조사하였다. 그 결과 형질전환체 내에서 cryIVD 발현은 immunoblot 분석을 통해 B. thuringiensis subsp. morrisoni PG-14에서 발현된 단백질과 같은 분자량으로 발현되는 것을 확인하였으며, 모기유충에 대한 형질전환체의 독성은 1.40×10^6 cells/ml 농도에서 약 80%의 치사율을 나타내었다. Bacillus thuringiensis subsp. morrisoni PG-14 is a gram-positive soil bacterium producing mosquitocidal parasporal inclusions composed of several crystal proteins. Among these crystal protein genes, cryIVD gene is one of major component which has 72 kDa in size. However, these parasporal inclusions sink quickly from the surface of water where mosquito larval feeding occurred. To develope mosquitocidal cyanobacterium, therefore, we constructed the expression vector, pCYASK 5-1 harboring cryIVD gene. The expression vector, pCYASk5-1 was transformed into the cyanobacterium Synechocystis PCC6803 reported as a natural mosquito larval food source and the transformants were selected with kanamycin. Expression of cryIVD gene in transformant was characterized by SDS-polyacrylamide gel electrophoresis (PAGE) and immunoblot analysis. The mosquitocidal activity of a transformant was determined electrophoresis (PAGE) and immunoblot analysis. The mosquitocidal activity of a transformant was determined with Culex tritaeniorhynchus. The results showed that the transformed cyanobacterium is toxic to mosquito larvae and will be expected as a potential agent that is used for mosquito control.