경항통으로 한방병원에 입원치료한 환자 459명에 대한 후향적 연구

허건 ( Gun Huh ),오민석 ( Min Seok Oh ) 한방재활의학과학회 2015 한방재활의학과학회지 Vol.25 No.2

Objectives The purpose of this study was to investigate the characteristics of inpatients who were admitted to Korean medicine hospital due to neck pain. Methods Four hundred fifty nine neck pain patients who were admitted to Cheonan Korean Medicine Hospital, Dae-jeon University from 1st, January, 2013 to 31th, December, 2013 were retrospectively reviewed according to medical charts. Results In this study, people in their 30s, females, within 0~2 weeks after onset, motivated by traffic accident, diagnosed with neck sprain, with no medical history related to neck pain, underwent outpatient treatment at medical institutions, took the highest percentage from each category of patients who admitted to Korean Medicine Hospital due to neck pain. In most (78.77%) of the patients, symptoms were more than improved. Conclusions Neck pain inpatients in Korean medicine hospital, it is difficult to find tendency. This study suggests the characteristics of neck pain inpatients who were hospitalized in Koean medicine hospital. (J Korean Med Rehab 2015;25(2):119-134)

황렬해독탕에 대한 국내의 연구 동향 분석

허건 ( Gun Huh ),오민석 ( Min-seok Oh ) 대전대학교 한의학연구소 2019 한의학연구소 논문집 Vol.28 No.2

Objectives : Hwangryunhaedok-tang. a traditional Korean herbal medicine, has been widely used for the treatment. This study is purposed to analyze the research trend of Hwangryunhaedok-tang in Korea for developing further research plan. Methods : A search of Korean research database( OASIS, RISS, Korean traditional knowledge portal, NDSL) was conducted to find studies for Hwangryunhaedok-tang. We analyzed studies by publish date, speciality, study method, and field of study. Result : 1. 2.65 papers were published annually on average. 2. After analyzing for the speciality of the journal, most of the papers were published in Traditional Korean Medicine. 3. After analyzing for the study method, in vivo was 33.96%, in vitro was 32.08% and quantitative inspection was 13.21% 4. After analyzing for the subject of the studies, beneficial effect was 81.13%, quantitative and qualitative analysis was 13.21%, toxicity was 3.77% 5. Papers on beneficial effect were classified by the type of diseases. Hwangryunhaedok-tang was most used in skin disease. Conclusions : Hwangryunhaedok-tang is effective in various category of diseases. This study will be useful to future researchers and clinicians to conduct a study on Hwangryunhaedok-tang

Guilain-Barre Syndrome 환자에 대한 한방치료 1례

허건 ( Gun Huh ),이옥진 ( Yu Chen Lee ),이정민 ( Jung Min Lee ),오민석 ( Min Seok Oh ) 대전대학교 한의학연구소 2014 한의학연구소 논문집 Vol.23 No.1

Objective : This is clinical about the Wei syndrome(위證)-patient diagnosed as Guillian-Barre Syndrome(GBS). GBS, What is called acute inflammatory plolyneuritis, is a disorder in which the body``s immune system attacks parts of peripheral nerve system. It is characterized by the rapid onset of weakness, paralysis of the legs, arms, breathing muscles and face. But the analysis of CSF and electical tests on nerve and muscle function can be performed to confirm the diagnosis. Most cases occur shortly after a viral infection. Methods & Result : This is the clinical report about the one patient diagnosed as Guillain-Barre Syndrome. The patient, 46-year-old men had weakness in both legs and arms after divertculitis. His weakness and general condition improved after oriental medical treatment and acupuncture. As a result, symptoms were improved remarkably. Conclusion : We report that we had good effects of oriental medical treatment on Guillain-Barre Syndrome.

골절 유발 Rat에 대한 혈부축어탕(血府逐瘀湯)의 전임상 연구

허건 ( Gun Huh ),오민석 ( Min-seok Oh ) 한방재활의학과학회 2020 한방재활의학과학회지 Vol.30 No.3

Objectives The purpose of this study is to evaluate the healing effect of Hyeolbuchugeo-tang (HC) in rats with rib fracture. Methods Rats were randomly divided into 5 groups (naive, control, positive control, HC-L and HC-H). All groups except naive group were subjected to bone fracture of rib. Naive group received no treatment at all. Control group was fed with phosphate buffered saline. Positive control group was orally medicated with tramadol. Experimental group was orally medicated with HC extract (50 mg/kg for low concentration [HC-L], 100 mg/kg for high concentration [HC-H]). X-ray and micro-computed tomography (micro-CT) were conducted to assess the effect of HC. We analysed the level of 2) transforming growth factor-β1 (TGF-β1), Ki67, alkaline phosphatase (ALP), receptor activator of nuclear factor kappa-β, runt-related transcription factor 2 (Runx2) and tartrate resistant acid phosphatase (TRAP) on 7 and 14 days after fracture. ALP, alanine aminotransferase, aspartate aminotransferase, blood urea nitrogen, creatinine was measured for safety assessment. Results X-ray and micro-CT, showed HC enhance bone repair process. Callus formation was increased in experimental group at 7 days after fracture, but decreased at 14 days after fracture. 7 days after fracture, the level of TGF-β1 in experimental group was decreased. The level of Ki67, Runx2 in HC-H, TRAP in HC-L was increased. 14 days after fracture, the level of Ki67 in HC-L and HC-H was decreased. The level of ALP, Runx2, BUN in HC-L, TRAP in HC-L and HC-H was increased. Conclusions Taken together the results, HC promoted healing of bone fracture. In conclusion, HC has a potential to promote healing of bone fracture. (J Korean Med Rehabil 2020;30(3):23-44)

Bacillus subtilis Y3-7 배양액의 α-glucosidase 활성 억제 효과

명길선(Kil-Sun Myoung),허건(Gun Heo),윤석영(Suck-Yong Yoon),심재중(Jae-Jung Shim),이정희(Jung-Hee Lee),임광세(Kwang-Sei Lim),허철성(Chul-Sung Huh) 한국식품과학회 2008 한국식품과학회지 Vol.40 No.5

본 연구에서는 전통 발효 식품에서 분리한 B. subtilis Y3-7 균주의 배양액이 α-glucosidase의 활성에 미치는 영향을 살펴보았다. B. subtilis Y3-7 균주를 TSB 배지에 30시간 이상 배양한 배양액은 1.62 ㎎/mL의 농도로 yeast α-glucosidase의 활성을 50%까지 저해할 수 있었다. 또한 효소학적 분석을 통해 이것이 배양액 내 물질이 효소의 기질과 경쟁적으로 작용하여 억제효과가 나타남을 확인하였다. B. subtilis Y3-7 균주의 배양액은 yeast 뿐만 아니라 실험동물의 장내 α-glucosidase의 활성에도 영향을 미쳐 당부하에 따른 급격한 혈당상승을 억제할 수 있었다. 이와 같은 결과로 보아 대량배양이 가능한 B. subtilis Y3-7을 통해 탄수화물 흡수에 중요한 역할을 하는 α-glucosidase 활성억제 물질을 얻음으로써 항당뇨 물질의 안정적인 생산이 기대되는 바이다. Culture broth of Bacillus subtilis Y3-7 in tryptic soy broth (TSB) isolated from Korean traditional fermented food was evaluated for the inhibition of α-glucosidase. The results of in vitro studies using the yeast α-glucosidase demonstrated that the culture broth exerted inhibitory effects on α-glucosidase with IC?? value of 1.62 ㎎/mL, and functioned as a competitive inhibitor. Furthermore, the culture broth of B. subtilis Y3-7 significantly improved glucose tolerance in normal and streptozotocin-induced diabetic mice. The blood glucose levels in the mice receiving sucrose supplementation in the culture broth (1 g/㎏, 2 g/㎏) were measured at 48.7%, which corresponded to 22.2% of the levels measured in the control mice. These results indicated that the culture broth of B. subtilis Y3-7 in TSB might be considered as a useful compound for the preparation of functional foods for diabetic patients.

요통 치료의 빈용 경혈과 자가 운동 요법에 대한 체계적 문헌 고찰

남대진 ( Dae Jin Nam ),허건 ( Gun Huh ),이형은 ( Hyung Eun Lee ),최보미 ( Bo Mi Choi ),이정민 ( Jung Min Lee ),이은정 ( Eun Jung Lee ),오민석 ( Min Seok Oh ) 한방재활의학과학회 2013 한방재활의학과학회지 Vol.23 No.4

ObjectivesThe aim of this review is to figure out which acupoints are frequently used to treat low back pain and which exercises are effective to low back pain.MethodsWe searched the three electronic database (RISS, KISS, KTKP) and manually checked related Korean journals and reference lists up to June 2013. We investigated the frequency of acupoints for using treatment of low back pain. We Introduce exercise thera-pies we can do easily at home without professional skills for treatment low back pain.ResultsWe included 72 articles in this study. The most frequently adopted acupoints were BL25, BL23, BL24, GB30, BL40, BL26, BL60, GB34, BL52, BL57, GB39. The most frequently adopted meridian pathways were BL, GB, GV, ST. The most frequently adopt-ed disease causing low back pain were HIVD (Herniated intervertebral disc), Lumbar sprain, Spinal stenosis, Compression fracture, Cauda equina syndrome, Spondylolisthe-sis, Ankylosing spondylitis. There are many exercise therapies (Lumbar stabilizing ex-ercise, Resistance exercise, Bareunmom physical exercise, Mckenzie exercise, Williams exercise, Emblass exercise, Swiss ball exercise, Thera band exercise, Yoga) for treatment low back pain.ConclusionsThese results suggest that most frequently adopted acupoints were foot taeyang urinary bladder channel acupoints. Beacuse foot taeyang urinary bladder channel is passes through the waist, it will be effective for treatment of low back pain. Also exercise therapy is effective for enhance Muscular strength. In order to treatment of low back pain, Acupuncture treatment is also important, as well as exercise therapy. (J Korean Med Rehab 2013;23(4):59-71)

12주간의 온천요법 전후 갱년기 환자의 혈압, 맥박, 체성분, 피부 변화에 관한 임상연구

김명규 ( Myoung Kyu Kim ),허건 ( Gun Huh ),남대진 ( Dae Jin Nam ),이재은 ( Jae Eun Lee ),김기홍 ( Ki Hong Kim ),이정민 ( Jung Min Lee ),오민석 ( Min Seok Oh ) 한방재활의학과학회 2015 한방재활의학과학회지 Vol.25 No.4

Objectives The aim of this clinical study was to find out the changes of vital sign, body composition, skin status before and after combined spa-exercise therapy in participants of middle-aged women. Methods In this study 24 participants of middle-aged women went through 12 weeks of combined spa-exercise therapy. Each week vital sign, body composition, skin status were measured before exercise, which consisted of warming-up, whole body exercise and final exercises bathing in spa (32~36oC). Results 1. The average of systolic blood pressure significantly decreased from 126.38± 19.33 mmHg to 120.46±11.18 mmHg after 11 weeks of spa-exercise therapy (p<0.05). 2. The average of moisture of skin significantly increased from 36.83±3.18 to 44.21±7.43 after 11 weeks of spa-exercise therapy (p<0.05). 3. The average of elasticity of skin significantly increased from 59.75±3.50 to 62.63±2.29 after 11 weeks of spa-exercise therapy (p<0.05). 4. The average of diastolic blood pressure, pulse, et cetera. didn``t significantly change after spa-exercise therapy. Conclusions The results showed that 12 weeks of spa-exercise therapy had significant effect on reducing systolic blood pressure, increasing moisture, elasticity of skin in participants of middle-aged women, which means spa-exercise therapy may be used as a treatment on high blood pressure and cutaneous diseases. Further studies are anticipated to find out other various effects of spa-exercise therapy. (J Korean Med Rehab 2015;25(4):123-137)

요추부 염좌 환자에서 다용 경혈에 대한 침치료와 자가운동요법이 미치는 효과

이옥진 ( Yu Chen Li ),허건 ( Gun Huh ),남대진 ( Dae Jin Nam ),이은정 ( Eun Jung Lee ),오민석 ( Min Seok Oh ) 대전대학교 한의학연구소 2014 혜화의학회지 Vol.22 No.2

Objective : The purpose of this study was to investigate the effects of acupuncture treatment on frequently adopted acupuncture point and self exercise therapy for lumbar sprain patient Methods : For this study, a retrospective chart review was conducted. Data are derived from lumbar sprain patients who have received hospital treatment in Daejeon Univ. Cheon-Ahn Korean Hospital. All patients were treated with acupuncture treatment on high frequency acupuncture point (BL25, BL23, BL24, GB30, BL40, BL26, BL60, GB34), physical therapy and herbal medicine and self exercise therapy(Swiss ball exercise, Lumbar stabilization exercise.) We measured visual analogue scale(VAS), Oswestry disability index(ODI), Pain threshold twice(pre-treatment and post-treatment) on 1st day and 5 days later. Results : After being treated, lumbar sprain patients were meaningful improved in VAS, ODI, pain threshold The VAS score, ODI score were statistically decreased after treatment and the pain threshold was statistically increased after treatment. Conclusion : In this study, treatment on frequently adopted acupuncture point and self exercise therapy were effective on lumbar sprain patient.

향기요법에 대한 국내연구 고찰

김현석 ( Hyun Suk Kim ),남대진 ( Dae Jin Nam ),허건 ( Gun Huh ),이정민 ( Jung Min Lee ),오민석 ( Min Seok Oh ) 대전대학교 한의학연구소 2014 혜화의학회지 Vol.23 No.1

Objective : The aim of this study is identify major trend and characteristics of studies on aromatherapy in Korea. Methods : We searched the three electronic database(RISS, NDSL, KTKP) and manually checked related Korean journals and reference lists 2000 up to June 2014. The studies were analyzed based on publication year, type of paper, intervention method, type of disease, type of aroma. Results : We included 79 articles in this study. 1. 5 papers were published annually on average. 2. After classifying papers by the speciality of thesis and journal, continuous study was followed not only nursing, but also in many specialities like alternative medicine, korean medicine. 3. Aroma therapy is effect of stress, anxiety, insomnia. 4. Many used interventions are inhalation. 5. The most commonly used in aromatherapy is lavender. Conclusions : These results suggest that Aromatherapy research is insufficient in korean medicine. But more research is needed to relieve stress, anxiety in the future.

교통사고 후 발생한 경항통 환자에 대한 황련해독탕약침과 분리정제봉약침의 치료 효과 비교연구: 무작위 배정

이옥진 ( Yu Chen Lee ),남대진 ( Dae Jin Nam ),허건 ( Gun Huh ),이재은 ( Jae Eun Lee ),김빛나라 ( Bin Na Ra Kim ),송은모 ( Eun Mo Song ),이은정 ( Eun Jung Lee ),이정민 ( Jung Min Lee ),오민석 ( Min Seok Oh ) 한방재활의학과학회 2014 한방재활의학과학회지 Vol.24 No.4

ObjectivesThe purpose of this study is to compare the effects of HWANGRY-UNHAEDOKTANG Pharmacopuncture and Essential Bee Venom pharmacopuncture on cervical pain caused by traffic accident.MethodsThe clincal study was conducted to traffic accident patients who had admitted to Dae-Jeon University Cheonan Oriental Hospital from May 17, 2014 to September 2, 2014. The patients were simple randomization and divided into two groups. In one group, patients were treated with the oriental medicine and HWANGRYUNHAEDOKTANGPharmacopuncture, While in the other group, patients were treated with the oriental medi-cine therapy and Essential Bee Venom pharmacopuncture therapy. visual analogue scale (VAS), pain threshold and neck disablity index (NDI) were used To estimate the efficacy of Pharmacopuncture treatment.Results1) HWANGRYUNHAEDOKTANG Pharmacopuncture Group showed significant decrease of VAS and NDI after 3rd times treatment than before treatment (p<0.001). Essential Bee Venom Pharmacopuncture showed significant decrease of VAS, NDI and improve ment of pain threshold after 3rd times treatment than before treatment (p<0.01, p<0.001). 2) There was no significant difference between HWANGRYUNHAEDOKTANGPharmacopuncture group and Essential Bee Venom Pharmacopuncture group in VAS, pain threshold and NDI. ConclusionsWe found out that HWANGRYUNHAEDOKTANG Pharmacopuncture and Essential Bee Venom Pharmacopuncture treatment are considered to be effective and useful in cervical pain caused by traffic accident. (J Korean Med Rehab 2014;24(4): 145-153)