신통축어탕(身痛逐瘀湯)이 늑골골절 유발 Rat의 골유합에 미치는 영향

남대진 ( Dae-jin Nam ),오민석 ( Min-seok Oh ) 한방재활의학과학회 2020 한방재활의학과학회지 Vol.30 No.3

Objectives This study was designed to evaluate the bone regeneration effects of Sintongchukea-tang (SC) on rib fractured rats. Methods Rats were randomly divided into 5 groups (normal, control, positive control, SC low [SC-L] and SC high [SC-H]). All groups were subject to fractured rib except normal group. Normal group received no treatment at all. Control group was orally fed with phosphate buffered saline, and positive control group was medicated with tramadol (20 mg/kg). SC group was orally medicated with SC (50 mg/kg, 100 mg/kg) once a day for 14 days. The fracture healing process was observed by x-ray, micro CT and fracture tissue slide was observed by immunohistochemical staining. We analysed levels of transforming growth factor-β1, Ki67, alkaline phosphatase (ALP), runt-related transcription factor 2 (Runx2), receptor activator of nuclear factor kappa-β, tartrate resistant acid phosphatase (TRAP) and analysed levels of Osteocalcin in plasma. We measured levels of aspartate aminotransferase (AST), alanine aminotransferase (ALT), ALP, blood urea nitrogen (BUN) and creatinine in plasma, for hepatotoxicity and nephrotoxicity of SC. Results Though X-ray and micro-computed tomography, more callus formation was observed and bone union was progressing. Through Hematoxylin and Eosin, callus formation was increased compared to the control group. Runx2 level at SC-H was significantly increased and TRAP level at SC-L was significantly decreased compared with the control group. AST, ALT, ALP, BUN and creatinine were not statistically different from the control group. Conclusions As described above, SC promoted fracture healing by stimulating the bone regeneration factor. And SC shows no hepatotoxicity and nephrotoxicity. In conclusion, it seems that SC helps to promote fracture regeneration and it can be used clinically to patients with fracture. (J Korean Med Rehabil 2020;30(3):1-21)

쌍화탕의 국내 연구 및 치험례에 대한 고찰

남대진 ( Dae-jin Nam ),오민석 ( Min-seok Oh ) 대전대학교 한의학연구소 2019 혜화의학회지 Vol.28 No.2

Objectives : The aim of this review was to analyse the study tendency in papers related with Ssanghwa-tang which are published in Korea from 2000 to 2019. Methods : We searched the four electronic database (NSDL, RISS, Korean traditional knowledge portal, OASIS) and checked relevant Korean journals from 2000 to 2019. We classified the papers by publish date, speciality, study method, and field of study, and analysed the study tendency. Result : 1. papers were published annually on average. 2. After classifying papers by the speciality of journal, continuous study was followed not only in korean medicine, but also in many specialities like Dietetics, Pharmacology and Tourism management. 3. In study methods, in vivo was 46%, quantitative inspection was 21%, and in vitro was 19%. 4. After classifying papers by field of study, efficacy was 49%, qualitative analysis was 27%, toxicity was 14%, and safety was 5%. 5. In efficacy, it was effective in muscloskeletal disease, cardiovascular disease, prevention of neurologic disease, antioxidation, immunization disease and so on. Conclusions : These results suggest that Ssanghwa-tang can be used as cure medicine, not just as herbal tonic, but there are not sufficient evidence based papers, so there should be further studies in order to establish Ssanghwa-tang as a cure medicine.

요통으로 한방병원에 입원한 환자 601명에 대한 후향적 연구

남대진 ( Dae Jin Nam ),오민석 ( Min Seok Oh ) 한방재활의학과학회 2015 한방재활의학과학회지 Vol.25 No.2

Objectives The purpose of this study was to investigate the characteristics of inpatients who were admitted to Korean medicine hospital due to low back pain. Methods The current study was designed as a retrospective chart review to investigate descriptive characteristics of LBP patients. The clinical records of 601 patients who were hospitalized for treatment of LBP in Cheonan Korean Medicine Hospital, Daejeon University from 1st, January, 2013 to 31th, December, 2013 were analyzed. Results 1. Most frequently given diagnosis was sprain and strain of lumbar (45.93%). 2. Female outnumbered male patients in all disease groups except fracture of lumbar spine. 3. In distribution according to age, sprain and strain of lumbar, HNP of L-spine and lumbago with sciatica were most frequent at 30s, fracture of lumbar spine was most frequent at 50s and spinal stenosis was most frequent at 70s. 4. The most frequently motive for low back pain was traffic accident (35.4%) 5. Patients with no related medical history were 76.95% 6. 0~1week interval between onset and visit to Korean Medicine Hospital was most frequent in all disease groups. 7. 50.85% of patients went through treatment at medical institutions before the admitting to Korean Medicine Hospital. 8. The average admission days of female was higher than male``s. And age goes up, average duration of admission was longer. 9. In most (74.59%) of the patients, symptoms were more than improved. 10. Most frequently prescribed examination was X-ray (65.13%). 11. Most frequently prescribed herb medicine was whal-lak-tang (Huoluo-tang). Conclusions In most (74.59%) of the patients, symptoms were more than improved, especially in sprain and strain of lumbar and lumbago with sciatica. But Patients with a local hospital statistic is not be representative of the incidence of the population. In order to obtain more accurate statistics, it is necessary to compare analysis collect statistics from other medical hospitals. (J Korean Med Rehab 2015;25(2):135-153)

요통 치료의 빈용 경혈과 자가 운동 요법에 대한 체계적 문헌 고찰

남대진 ( Dae Jin Nam ),허건 ( Gun Huh ),이형은 ( Hyung Eun Lee ),최보미 ( Bo Mi Choi ),이정민 ( Jung Min Lee ),이은정 ( Eun Jung Lee ),오민석 ( Min Seok Oh ) 한방재활의학과학회 2013 한방재활의학과학회지 Vol.23 No.4

ObjectivesThe aim of this review is to figure out which acupoints are frequently used to treat low back pain and which exercises are effective to low back pain.MethodsWe searched the three electronic database (RISS, KISS, KTKP) and manually checked related Korean journals and reference lists up to June 2013. We investigated the frequency of acupoints for using treatment of low back pain. We Introduce exercise thera-pies we can do easily at home without professional skills for treatment low back pain.ResultsWe included 72 articles in this study. The most frequently adopted acupoints were BL25, BL23, BL24, GB30, BL40, BL26, BL60, GB34, BL52, BL57, GB39. The most frequently adopted meridian pathways were BL, GB, GV, ST. The most frequently adopt-ed disease causing low back pain were HIVD (Herniated intervertebral disc), Lumbar sprain, Spinal stenosis, Compression fracture, Cauda equina syndrome, Spondylolisthe-sis, Ankylosing spondylitis. There are many exercise therapies (Lumbar stabilizing ex-ercise, Resistance exercise, Bareunmom physical exercise, Mckenzie exercise, Williams exercise, Emblass exercise, Swiss ball exercise, Thera band exercise, Yoga) for treatment low back pain.ConclusionsThese results suggest that most frequently adopted acupoints were foot taeyang urinary bladder channel acupoints. Beacuse foot taeyang urinary bladder channel is passes through the waist, it will be effective for treatment of low back pain. Also exercise therapy is effective for enhance Muscular strength. In order to treatment of low back pain, Acupuncture treatment is also important, as well as exercise therapy. (J Korean Med Rehab 2013;23(4):59-71)

향기요법에 대한 국내연구 고찰

김현석 ( Hyun Suk Kim ),남대진 ( Dae Jin Nam ),허건 ( Gun Huh ),이정민 ( Jung Min Lee ),오민석 ( Min Seok Oh ) 대전대학교 한의학연구소 2014 혜화의학회지 Vol.23 No.1

Objective : The aim of this study is identify major trend and characteristics of studies on aromatherapy in Korea. Methods : We searched the three electronic database(RISS, NDSL, KTKP) and manually checked related Korean journals and reference lists 2000 up to June 2014. The studies were analyzed based on publication year, type of paper, intervention method, type of disease, type of aroma. Results : We included 79 articles in this study. 1. 5 papers were published annually on average. 2. After classifying papers by the speciality of thesis and journal, continuous study was followed not only nursing, but also in many specialities like alternative medicine, korean medicine. 3. Aroma therapy is effect of stress, anxiety, insomnia. 4. Many used interventions are inhalation. 5. The most commonly used in aromatherapy is lavender. Conclusions : These results suggest that Aromatherapy research is insufficient in korean medicine. But more research is needed to relieve stress, anxiety in the future.

교통사고 후 발생한 경항통 환자에 대한 황련해독탕약침과 분리정제봉약침의 치료 효과 비교연구: 무작위 배정

이옥진 ( Yu Chen Lee ),남대진 ( Dae Jin Nam ),허건 ( Gun Huh ),이재은 ( Jae Eun Lee ),김빛나라 ( Bin Na Ra Kim ),송은모 ( Eun Mo Song ),이은정 ( Eun Jung Lee ),이정민 ( Jung Min Lee ),오민석 ( Min Seok Oh ) 한방재활의학과학회 2014 한방재활의학과학회지 Vol.24 No.4

ObjectivesThe purpose of this study is to compare the effects of HWANGRY-UNHAEDOKTANG Pharmacopuncture and Essential Bee Venom pharmacopuncture on cervical pain caused by traffic accident.MethodsThe clincal study was conducted to traffic accident patients who had admitted to Dae-Jeon University Cheonan Oriental Hospital from May 17, 2014 to September 2, 2014. The patients were simple randomization and divided into two groups. In one group, patients were treated with the oriental medicine and HWANGRYUNHAEDOKTANGPharmacopuncture, While in the other group, patients were treated with the oriental medi-cine therapy and Essential Bee Venom pharmacopuncture therapy. visual analogue scale (VAS), pain threshold and neck disablity index (NDI) were used To estimate the efficacy of Pharmacopuncture treatment.Results1) HWANGRYUNHAEDOKTANG Pharmacopuncture Group showed significant decrease of VAS and NDI after 3rd times treatment than before treatment (p<0.001). Essential Bee Venom Pharmacopuncture showed significant decrease of VAS, NDI and improve ment of pain threshold after 3rd times treatment than before treatment (p<0.01, p<0.001). 2) There was no significant difference between HWANGRYUNHAEDOKTANGPharmacopuncture group and Essential Bee Venom Pharmacopuncture group in VAS, pain threshold and NDI. ConclusionsWe found out that HWANGRYUNHAEDOKTANG Pharmacopuncture and Essential Bee Venom Pharmacopuncture treatment are considered to be effective and useful in cervical pain caused by traffic accident. (J Korean Med Rehab 2014;24(4): 145-153)

요추부 염좌 환자에서 다용 경혈에 대한 침치료와 자가운동요법이 미치는 효과

이옥진 ( Yu Chen Li ),허건 ( Gun Huh ),남대진 ( Dae Jin Nam ),이은정 ( Eun Jung Lee ),오민석 ( Min Seok Oh ) 대전대학교 한의학연구소 2014 혜화의학회지 Vol.22 No.2

Objective : The purpose of this study was to investigate the effects of acupuncture treatment on frequently adopted acupuncture point and self exercise therapy for lumbar sprain patient Methods : For this study, a retrospective chart review was conducted. Data are derived from lumbar sprain patients who have received hospital treatment in Daejeon Univ. Cheon-Ahn Korean Hospital. All patients were treated with acupuncture treatment on high frequency acupuncture point (BL25, BL23, BL24, GB30, BL40, BL26, BL60, GB34), physical therapy and herbal medicine and self exercise therapy(Swiss ball exercise, Lumbar stabilization exercise.) We measured visual analogue scale(VAS), Oswestry disability index(ODI), Pain threshold twice(pre-treatment and post-treatment) on 1st day and 5 days later. Results : After being treated, lumbar sprain patients were meaningful improved in VAS, ODI, pain threshold The VAS score, ODI score were statistically decreased after treatment and the pain threshold was statistically increased after treatment. Conclusion : In this study, treatment on frequently adopted acupuncture point and self exercise therapy were effective on lumbar sprain patient.

12주간의 온천요법 전후 갱년기 환자의 혈압, 맥박, 체성분, 피부 변화에 관한 임상연구

김명규 ( Myoung Kyu Kim ),허건 ( Gun Huh ),남대진 ( Dae Jin Nam ),이재은 ( Jae Eun Lee ),김기홍 ( Ki Hong Kim ),이정민 ( Jung Min Lee ),오민석 ( Min Seok Oh ) 한방재활의학과학회 2015 한방재활의학과학회지 Vol.25 No.4

Objectives The aim of this clinical study was to find out the changes of vital sign, body composition, skin status before and after combined spa-exercise therapy in participants of middle-aged women. Methods In this study 24 participants of middle-aged women went through 12 weeks of combined spa-exercise therapy. Each week vital sign, body composition, skin status were measured before exercise, which consisted of warming-up, whole body exercise and final exercises bathing in spa (32~36oC). Results 1. The average of systolic blood pressure significantly decreased from 126.38± 19.33 mmHg to 120.46±11.18 mmHg after 11 weeks of spa-exercise therapy (p<0.05). 2. The average of moisture of skin significantly increased from 36.83±3.18 to 44.21±7.43 after 11 weeks of spa-exercise therapy (p<0.05). 3. The average of elasticity of skin significantly increased from 59.75±3.50 to 62.63±2.29 after 11 weeks of spa-exercise therapy (p<0.05). 4. The average of diastolic blood pressure, pulse, et cetera. didn``t significantly change after spa-exercise therapy. Conclusions The results showed that 12 weeks of spa-exercise therapy had significant effect on reducing systolic blood pressure, increasing moisture, elasticity of skin in participants of middle-aged women, which means spa-exercise therapy may be used as a treatment on high blood pressure and cutaneous diseases. Further studies are anticipated to find out other various effects of spa-exercise therapy. (J Korean Med Rehab 2015;25(4):123-137)

하위 요추부의 추간판 탈출증과 척추관 협착증에서 선택적 신경근 차단술과 미추 경막외 차단술의 치료 효과 비교

김태균(Tae Kyun Kim),박병하(Byung Ha Park),강성주(Sung Ju Kang),남대진(Dae Jin Nam) 대한정형외과학회 2022 대한정형외과학회지 Vol.57 No.5