돈황 막고굴에 나타난 다보탑의 변천

조정식,김버들,조해현,김보람,Cho, Jeong-Sik,Kim, Bue-Dyel,Jo, Jae-Hyun,Kim, Bo-Ram 한국건축역사학회 2013 건축역사연구 Vol.22 No.5

This study aims to investigate the architectural characteristics of the Da-bo stupa by examining the correlation among architectural languages and by studying the features of its architectural components and transitional changes shown in Da-bo stupa line drawings in Dunhuang Mogao Grottes. The results are as follows. 1st, the Da-bo stupa of Dunhuang faithfully follows the sutra of lotus, and although the form changes, the fundamental essence of Bo-tap-yong-chul and two seated Buddhas provided by the Gyun-bo-tap-pum in the sutra of lotus is consistent. 2nd, the pagoda body can be periodically divided into parasol, stupa, and royal palace types. The parasol type has an incomplete tower body, which makes distinguishing each of its architectural components difficult. The stupa type appeared between the early (AD 618-712) and middle (AD 766-835) Tang dynasty. It combines the form of Indian stupa type and East Asian wood structural architecture. The royal palace type, which appeared between the peak period of the Tang (713-765) and Sung Dynasties, shows the standardized pattern of the Da-bo stupa described as two seated Buddhas and Bo-tap-yong-chul. 3rd, the use of a stylobate does not appear in the early construction of Da-bo stupa, only in the later period, in the form of high pillars. Forms include many Su-mi-jwah and three-way stairways and Dab-do, but as time passes, the forms are simplified to the form of high pillars. 4th, the purpose of early Da-bo stupa was to provide space for Da-bo-yu-rae of Gyun-bo-tap-pum; hence, it did not have sangryoon(the top part). However, after it was influenced by general pagodas, sangryoon was established. Toward the Tang Dynasty, sangryoon has come to emphasize the forms of boryoon(nine wheels) or dome. However, this form is eventually simplified to only retain bo-joo(the orb).

성인에서 장기간 Furosemide오용과 연관된 신수질 석회화

김윤구,이윤하,이규백,장세호,김대중,오하영,김보현,김미경,조윤숙 대한신장학회 1996 대한신장학회잡지 Vol.15 No.4

유제놀에 의한 즉시형 알레르기 반응의 억제

김상현,신태용,김형룡,이영미,이은희,신보경,김윤철,안년형,김형민 우석대학교 의약품개발연구소 1996 藥學硏究誌 Vol.1 No.-

The current study evaluates the capacity of eugenol to regulate immediate allergic reaction by control of histamine release. Administrations of eugenol (1 M/kg. i.p.) at 60 min before and 5.10 min after the compound 48/80 treatment (8 mg/kg.i.p.) were shown the mortality rates as 0.44.4. and 77.8%. respectively. A 60 min before administered group revealed a singificant inhibition of serum his-tamine release compared with those of 5 and 10 min after the compound 48/80 injection. Eugenol (6-48mM) was also showed a dose-dependent activity on the compound 48/80-induced histamine release from the highly purified population of Alcian Blue-positive peritoneal mast cells. These results indicate that in vitro treatment with exogenous eugenol inhibited the active response of mast cell populations and modulated its characteristics.

Distribution and mitochondrial DNA tracing of the invasive Argentine ants (Linepithema humile) in South Korea

Park Sang‐Hyun,Ha Young‐Ho,Kim Dong Eon,Kim Chang‐Jun,Choi Moon Bo 한국곤충학회 2021 Entomological Research Vol.51 No.3

Argentine ants (Linepithema humile) are one of the world’s most invasive species and were first reported in South Korea, near Busan Port in 2019. The distribution of their initial spread was investigated here from April to July 2020. In the invasion area, numerous nests and individuals were identified, indicating that they had settled and successfully invaded the habitat. To track the invasion of the Argentine ants we conducted haplotype analysis using COI, COII, and Cytb sequences of their mitochondrial DNA. The invasive ants had the same mitochondrial haplotype (H3) as Argentine ants from America (Chile, Ecuador, Bermuda) and East Asia (Japan). When comparing the import trade volumes at Busan port with the Argentine ant haplotypes from other countries, it was determined that the invasive ants may have originated from the United States or Japan. Numerous ecological and economic impacts due to their invasion and spread in other countries has previously been reported. Therefore, prompt control measures for the Argentine ants found at Busan port, at this relatively early stage of settlement, is required.

항정신병약물을 처음으로 사용하는 초발 정신증 환자에서 나타나는 체중 및 대사성 지표의 변화 : 후향적 연구

김우진,심주철,공보금,강제욱,문정준,김정은,김민걸,박민경,김성진,김현정,정도운 대한생물치료정신의학회 2011 생물치료정신의학 Vol.17 No.2

Objectives:This study was to identify weight & metabolic changes in first-episode psychotic patients with antipsychotics use and investigate the differences of weight & metabolic changes between first-episode psychotic patients and controls with antipsychotics use. Method:In this retrospective study, twenty eight first-episode psychotic patients and twenty eight controls with schizophrenia, schizoaffective or bipolar disorder defined by DSM-IV criteria were included. Information about demographic and clinical characteristics of the subjects was gathered from the medical records. Also body weight, sBP, dBP, fasting glucose, lipid profile and WBC count were evaluated before and after antipsychotics use. Rogistic regression was conducted to assess factors associated with weight gain. Results:First-episode psychotic patients showed more weight and BMI changes than controls after antipsychotics use, and these changes continue over 12 months. On the other hand, there were no significant factors associated with weight gain. Conclusion:The results of present study suggest that antispychotics is one of the major causes inducing weight gain of psychotic patients and antipsychotics-induced weight gain is more vulnerable to drug-naive first-episode psychotic patients.

녹동균 세포외막 단백질 백신 CFC-1-101의 안정성 및 면역원성 검토 : 임상 제 Ⅰ/Ⅱa상 시험

장인진,김익상,유경상,임동석,김형기,신상구,장우현,박완제,이나경,정상보,안동호,조양제,안보영,이윤하,김영지,남성우,김현수 대한감염학회 1998 감염 Vol.30 No.3

목적 : 제일제당에서는 녹농균의 세포외막 단밸질을 유효성분으로 하는 백신인 CFC-101을 개발하였으며, 동물시험에서 이 백신의 안전성과 유효성을 입증하였다. 본 연구에서는 이 녹농균 백신의 인체에 대한 안전성과 면역원성을 평가하는 동시에 인체 접종시의 최적 투여 용량을 결정하기 위하여 제 I/Ⅱa상 임상시험을 수행하였다. 방법 : 건강한 성인 남자를 피험자로 선별하여 각 용량군에 백신투여자 6명, 위약투여자 2명을 배정하였다. 백신 투여군은 0.25mg, 0.5mg 또는 1.0mg 용량의 녹농균 백신을 7일 간격으로 3회에 걸쳐 근육주사 하였으며, 위약 투여군에게는 세포외막 단백질을 제외한 동일한 성분을 투여하였다. 백신접종 후 국소적 또는 전신적인 반응의 발생여부를 관찰하고, 혈액시료를 체취하여 백신의 역가와 유효성을 검정하였다. 결과 : 녹농균 백신 CFC-101은 모든 접종자에서 양호한 내약성을 보였다. 또한 0.5mg 과 1.0mg 백신 투여군에서는 100%의 항체양전율을 나타내었다. 생성된 항체는 녹농균 세포외막단백질에 특이성을 보였고, 녹농균 감염에 대해 방어효능이 있었다. 결론 : 이와같은 결과로부터 이 녹농균 백신은 인체에 안전하게 투여할 수 있으며, 높은 항체 생성능으로 감염방어 효능을 보이고 0.5mg과 1.0mg이 최적용량인 것으로 판단되었다. Background : We developed a Pseudomonas aeruginosa outer membrane protein(OMP) vaccine CFC-101, and the prophylactic efficacy of which has been demonstrated in animal models. In order to evaluate the safety and immunogenicity of the P. aeruginosa vaccine, we carried out a phase I/Ⅱa clinical trial in healthy male volunteers. Methods : Groups of eight volunteers, including two placebo subjects, were vaccinated intramuscularly with three doses of 0.25, 0.5 or 1.0 mg of the vaccine at one week intervals. Sings of systemic and local reactions observed after vaccination were recorded for each vaccinee for 5 days. Physical examinations were performed on days 0, 1, 7, 8, 14, 15, 21, and 42, and clinical laboratory tests were done on days 0, 3, and 21. Blood samples for assay of serum antibody levels were obtained up to 42 days after the first vaccination. Results : The vaccine was generally well tolerated by all vaccinees, showing no significant side effects. In the three dosage groups, all vaccinees, except one receiving the 0.25 mg dose, showed significant elevation in serum IgG antibody titers against the vaccine proteins, indicating 100% seroconversion in 0.5 and 1.0 mg groups. The human antibodies induced by the vaccine were specific for P. aeruginosa OMPs, as confirmed by western blot analysis and immunoprecipitation assays. The capacity of the human antisera to enhance opsonophagocytic killing activity by polymorphonuclear leukocytes and to confer protection against P. aeruginosa infections indicates that the antibodies elicited by the vaccine have protective efficacy. Conclusion : We conclude that the P. aeruginosa OMP vaccine is safe and effective for human use and its optimal dose to be 0.5 or 1.0 mg.

S-580 : Vitamin D and carotid subclinical atherosclerosis in SLE

( Chang Bum Bae ),( Ju Yang Jung ),( Bo Ram Go ),( Hyun Ah Kim ),( Chang Hee Suh ) 대한내과학회 2013 대한내과학회 추계학술대회 Vol.2013 No.1

Vitamin D and carotid subclinical atherosclerosis in SLE Chang-Bum Bae, Ju-Yang Jung, Bo-ram Go, Hyun-Ah Kim, Chang-Hee Suh Department of Rheumatology, Ajou University School of Medicine, Suwon, Korea Introduction Atherosclerosis develops earlier in systemic lupus erythematosus (SLE) and is the important cause of mortality. It has been suggested that vitamin D deficiency contributed cardiovascular disease and immune dysregulation in SLE. Methods One-hundred two female patients with SLE and 52 normal controls (NC) were recruited. The carotid artery intima-media thickness (cIMT) and plague were assessed by B-mode ultrasound at the carotid artery level. Vitamin 25(OH)D3 levels were checked by immunoradiometric assay using the Bio-Line 25(OH)D3-Ria CT kit (Bio-Line S.A., Belgium). Disease activity markers were checked at the time of enrollment. Results The cIMT of SLE is 0.41±0.08mm, which is higher than NC (0.37±0.11 mm, p=0.012). Also, carotid artery plague index (PI) of SLE is higher than NC (0.68±1.39 vs 0.26±0.87, p=0.026). The cIMT was correlated with age (r=0.442, p<0.001), body mass index (r=0.246, p=0.013), waist-hip ratio (r=0.245, p=0.013), SLE disease activity index (r=0.239, p=0.016), taking aspirin (r=0.244, p=0.013), and the carotid artery PI was correlated with renal involvement (r=0.224, p=0.023) in patients with SLE. Vitamin 25(OH)D3 was not showed correlation with cIMT and carotid artery PI. Also, it was not correlated with disease activity markers. Conclusion In patients with SLE, the risk of cardiovascular disease measured by cIMT and carotid artery plaque was higher than NC, which may be derived from systemic inflammation. However, vitamin D levels were not showed significant correlations with carotid subclinical atherosclerosis. It may be not suitable to assess vitamin D as marker of disease activity or subclinical atherosclerosis.

노인의 여가활동과 삶의 질에 관한 탐색적 연구

김보현,안영선 동국대학교 사회과학연구원 2008 사회과학연구 Vol.15 No.1

본 연구는 노인의 여가활동과 삶의 만족도에 관한 탐색적 연구이다. 일반적으로 노인들의 여가는 공식적인 사회적 역할보다는 비공식적 사회참가가 많은 것이 그 특징이다. 연구결과에 의하면, 여가활동을 통한 여가만족이 노년기의 삶의 질과 관련성이 높은 것으로 나타났다. 여가만족에 영향을 미치는 요인으로 사회적응력이 여가참가수준과 여가만족 긍정적으로 기여하며, 그리고 타인과의 밀접한 관계가 의미 있는 여가활동 참여가 성공적인 노화의 중요한 요소이다. This article is an exploratory study on the relationship between spare time activity and quality of life of the elderly. In general, the leisure of the elderlies are informal social participation. As a result of the research, there are strong relationship between leisure satisfaction and quality of life on the elderly. And leisure satisfaction is related to leisure participation which connected with others.

전자출판물 납본제도 도입방안 : 외국사례의 비교연구

김보현,선명순 동국대학교 사회과학연구원 2007 사회과학연구 Vol.14 No.1

본 연구는 전자출판물 납본제도 도입방안에 관하여 외국의 사례를 한국과 비교․분석하고 한국의 온라인 전자출판물 납본제도 도입에 따른 문제점과 도입방향을 고찰하였다. 한국의 온라인 전자출판물 납본제도 도입방안으로 첫째, 한국의 특성에 맞는 온라인 전자출판물 납본법령과 체제마련 및 납본주체와 피납본기관의 명확한 규정 확립 그리고 납본대상 자료의 범주규정 등 온라인 전자출판물 납본제도의 법적 근거마련이 요구된다. 둘째, 온라인 전자출판물은 한정적인 수집이 곤란하므로 자료선정기준 및 자료선정위원회 등의 구성이 필요하다. The purpose of this thesis is to inquire the introduction to the electronic specimen copy presentation system in Korea through the comparison with some foreign country cases. And also we consider the policy options for the introduction to the electronic specimen copy presentation system. As the results of the research, we suggest following alternatives. Firstly, we should prepare the legalistic basis for the presentation laws. Secondly, we also should organize the selection committee which choose the appropriate electronic specimen copy presentation.

Trimethylolpropane triacrylate의 합성

김동국,박보현 漢陽大學校 工學技術硏究所 2001 工學技術論文集 Vol.10 No.-

환경오염을 야기시키지 않으므로 소비가 급격히 증가되고 있는 U.V. 경화형 도료의 원료로 사용되고 있는 아크릴계 다량체인 trimethylolpropane triacrylate를 다양한 반응조건에서 합성하고 분리하여 최적의 합성조건을 선정하였다. Trimethylolpropane triacrylate의 합성에서 trimethylolpropane : acrylic acid를 1 : 4로 하고 반응용매로 ethylbengene을, 촉매로 황산을, 중함 금지제로 2,6-di-tert-butyl-4-methylphenol과 Cu-powder 또는 zinc-sulfate를 함께 사용하는 반응 조건이 최적조건이었다. Trimethylolpropane triacrylate that is used for the composition of environmental-friendly UV curable coating materials wase synthesized in order to investigate the optimized reaction condition, The opitmal reaction condition was as follows : ratio of trimethlolpropane / acrylic acid : 1 / 4, solvent : ethylbenzene, catalyst : sulfuric acid, inhibitors : 2,6-di-tert-butyl-4-methylphenol / zinc-sulfate / Cu-powder.