자동차 박판구조 접합 강도에 미치는 오일의 영향

문윤배,유재용 대구미래대학 2001 論文集 Vol.19 No.1

The improvements of the thin plate joint method are required because of the application of thin plate structures are diversified. The purpose of the investigation is to evaluate the applicability of the structural adhesive on the thin plate structures. This study is performed to evaluate how the jointing effects with oil are improved, compare with that of spot welding specimens after the tensile shear test under the various conditions of the specimen, which had the single lap joints by bonding and weldbonding for the structural jointing techniques.

전이금속촉매에 의한 환상중합고분자의 합성에 관한 연구

김윤희,문성배,김영인,정경규 부산대학교 1997 科學敎育硏究報 Vol.24 No.-

The cyclopolymerization of 4-ethyl-4-hydroxy-1,6-heptadiyne was carried out by transition metal catalysts such as MoCl_(5) or WCl_(6)-based catalysts. The catalytic activity of MoCl_(5) for this cyclopolymerization was greater than that of WCl_(6). The polymerization of 4-ethyl-4-hydroxy-1,6-heptadiyne by MoCl_(5) alone gives a quantitative yield of polymer. WCl_(6)-based catalyst system was not effective in this polymerization. The obtained polymer was generally insoluble in common organic solvents. The IR spectrum of poly (EHH) showed the stretching band of the carbon-carbon double bond at 1590-1650 cm^(-1) indicate a high conjugation. The thermal properties and oxidative stability of poly(EHH) were also studied. The electrical conductivity of the I2 doped poly(EHH) was 1.2 - 2.5 × 10^(-4) Scm^(-1). 본 연구에서는 4-위치에 에틸기와 히드록실기를 동시에 갖는 1,6-heptadiyne 유도체를 합성하여 이를 여러가지 전이 금속 촉매를 사용하여 합성하였다. MoCl_(5) - 단독 촉매를 사용할 경우 가장 높은 중합수율을 보였으며 WCl_(6)- 계 촉매의 경우 중합체가 얻어지지 않았다. 합성된 고분자는 여러 가지 분광 법으로 확인한 결과 주 사슬에 6각형 고리 구조를 가지면서 공액이중결합을 구조를 갖는 것으로 확인되었다. 중합된 고분자는 치환기의 효과로 여러 용매에 쉽게 용해되었으며 산화안정성도 높은 것으로 확인되었다. 합성된 고분자를 요오드로 도핑 시켜 전도도를 조사한 결과 1.2 - 2.5×10^(-4) Scm^(-1)를 갖는 것으로 확인되었다.

고등학교 공통 과학내 화학 영역을 중심으로 한 STS 내용 분석

김윤희,문성배 부산대학교 사범대학 과학교육연구소 1998 科學敎育硏究報 Vol.25 No.-

Science-technology-society(STS) has been concerned with a reform in science education as a new direction and goal for science education. STS was introduced in the Fifth curriculum an was more emphasized in the Sixth curriculum. In this study, The STS materials in the chemistry part of common science textbook were analyzed. In the chemistry part of common science textbooks, average 14% of the total page content was devoted to the STS materials. The STS materials were included 23.8% in the chapter of reactivity of materials, 14.17% in the control factors on reaction kinetics, 10.7% in exothermic reaction and endothermic reaction, 10% in elements with similar reactivity. The STS materials are analyzed by STS topics by Piel(1981). 34.6% of STS materials were the topics on effects of 'socialization of science', 31.8% on 'technological developments', 16% on 'environmental quality and utilization of natural resources', 13% on 'energy', 3.6% on 'human engineering', and there was no topics on 'space research and national defense', and 'population'. The topics of 'socialization of science' and technology developments were covered in all chapters. The topics of 'environmental quality and utilization of natural resources' and 'energy' were covered in 3 chapters. The activities of STS program in the common science textbook were mostly consists of example study, inquiry research, data analysis. However there was no role play and practical work.

6차 교육 과정에 따른 고등학교 공통 과학 (화학 부분) 교과서의 탐구 활동 분석

김윤희,정경규,문경근,문성배 부산대학교 사범대학 과학교육연구소 1998 科學敎育硏究報 Vol.25 No.-

In order to obtain the fundamental data for developing an ideal chemistry curriculum in the common science, four kind of common science textbooks were analyzed. Particularly, inquiry activities part was analyzed by the three dimension framework which consists of inquiry content dimension, inquiry process dimension and inquiry context dimension. The average volume of chemistry part in the common science text books was 13% (56 page). In the analysis of the inquiry content dimension of inquiry activities, the total number of themes in four kinds of textbook had similar inquiry activities. For the analysis of inquiry process dimension, 'interpreting data and formulating generalizations' category(39.1%) was most emphasized and the categories of 'observation and measuring'(30.8%), and 'building, testing and revising the theoretical model'(16.5%), 'seeing a problem and seeking ways to solve it'(13.5%) follow in order. As for the analysis of the inquiry context dimension, the scientific context was 82%, the individual context 1.8%, the social context 7.8% and the technical context 7.8%. It showed that the proportion of STS related contents in inquiry activities was 18%. For the purpose of common science text book in the 6th curriculum, it is expected to increase the proportion of the high level inquiry process and the proportion of STS related contents.

부산지역 시정악화의 원인 분석

김유근,문윤섭,배주현,곽진 한국환경과학회 1999 한국환경과학회지 Vol.8 No.6

After analyzing the correlation between air pollution and visibility, TSP and NO_2 is responsible for poor visibility in Pusan. After analyzing the correlation between meteorological factors and visibility, general pattern of humidity has clear negative correlation. The variation of wind speed has a positive correlation. In order to investigate the cause of poor visibility in Pusan area, the Andersen sampler and PM-2.5 are used to collect and analyze aerosol. This study was carried out to monitor the visibility using Forward scattering meter and to find out the characteristics and the cause of good visibility case and poor visibility case by measuring and analyzing a variety of parameters, such as particle size distributions, chemical compositions, and meteorological conditions in Pusan. According to the analysis of intensive sampling, NO_3^-, NH_4^+ ion concentration increased together with the mass concentration around 0.5∼2.5㎛ approximately during the case of poor visibility. NH_4NO_3, NH_4Cl, and NaCl were thought to be the major components of fine particles.

등방성-등방성 이종재료에 대한 균열 선단에서의 코스틱스 상에 관한 해석

유재용,문윤배 대구미래대학 2001 論文集 Vol.19 No.1

For the stress analysis in bi-materials, there have been used many theoretical and experimental methods. The experimental methods such as Morie, Photoelasticity, holography and caustics are primarily used by many researchers. In this paper, as the first step to develop the experimental method of caustics in bi-materials, the initial and caustic curve equations are established by introducing the existing stress component equations to the equation of the formation of Caustics and made the program for the generation of caustics in computer.

Comparison of the Pharmacological Effects of Roasted and Non-roasted Zizyphi Spinosi Semen: Differences in Chemical Constituents

홍학기, 이기남, 마유안, 김윤배, 남상윤, 송인섭, 문동철, 오기완 충북대학교 동물의학연구소 2008 Journal of Biomedical and Translational Research Vol.9 No.3

본문참고

간세포암환자에서 간동맥 화학 색전술 후 발생한 리피오돌에 의한 폐렴 1예

김소이,김유리,허현미,배서은,이명원,최윤정,김고흔,김태헌,유 권,문일환 이화여자대학교 의과대학 2009 EMJ (Ewha medical journal) Vol.32 No.2

Hepatocellular carcinoma(HCC)is one of common causes of cancer-related death in Korea where the majority of HCC patients were Hepaitc B virus(HBV)carriers and have cirrhosis. Transarterial chemoembolization(TACE)is commonly applied to the treatment of multinodular HCC in Korea and careful selection of candidate is important for the risk of various side effects. Besides common side effects as fever, nausea, abdominal pain and elevation of liver enzyme, TACE may predispose to hepatic failure, ischemic cholecystitis, pulmonary embolism, cerebral embolism and pneumonitis. In previous studies, some cases of pulmonary and cerebral embolism cases were reported but lipiodol pneumonitis after TACE was rarely reported. A 65-year-old woman with a multinodular HCC associated with HBV infection, was treated with TACE. Seven days after the procedure, nonspecific respiratory symptoms such as dyspnea and dry cough developed. Chest X-ray and chest computed tomography showed diffuse ground glass opacities in whole lung fields, suggestive of lipiodol pneumonitis. After several days of supportive care with steroid administration, radiologic abnormalities and subjective symptoms were much improved, considered that the disease was compatible with lipiodol pneumonitis.

Mutant p53-Notch1 Signaling Axis Is Involved in Curcumin-Induced Apoptosis of Breast Cancer Cells

Bae, Yun-Hee,Ryu, Jong Hyo,Park, Hyun-Joo,Kim, Kwang Rok,Wee, Hee-Jun,Lee, Ok-Hee,Jang, Hye-Ock,Bae, Moon-Kyoung,Kim, Kyu-Won,Bae, Soo-Kyung The Korean Society of Pharmacology 2013 The Korean Journal of Physiology & Pharmacology Vol.17 No.4

Notch1 has been reported to be highly expressed in triple-negative and other subtypes of breast cancer. Mutant p53 (R280K) is overexpressed in MDA-MB-231 triple-negative human breast cancer cells. The present study aimed to determine whether the mutant p53 can be a potent transcriptional activator of the Notch1 in MDA-MB-231 cells, and explore the role of this mutant p53-Notch1 axis in curcumin-induced apoptosis. We found that curcumin treatment resulted in an induction of apoptosis in MDA-MB-231 cells, together with downregulation of Notch1 and its downstream target, Hes1. This reduction in Notch1 expression was determined to be due to the decreased activity of endogenous mutant p53. We confirmed the suppressive effect of curcumin on Notch1 transcription by performing a Notch1 promoter-driven reporter assay and identified a putative p53-binding site in the Notch1 promoter by EMSA and chromatin immunoprecipitation analysis. Overexpression of mutant p53 increased Notch1 promoter activity, whereas knockdown of mutant p53 by small interfering RNA suppressed Notch1 expression, leading to the induction of cellular apoptosis. Moreover, curcumin-induced apoptosis was further enhanced by the knockdown of Notch1 or mutant p53, but it was decreased by the overexpression of active Notch1. Taken together, our results demonstrate, for the first time, that Notch1 is a transcriptional target of mutant p53 in breast cancer cells and suggest that the targeting of mutant p53 and/or Notch1 may be combined with a chemotherapeutic strategy to improve the response of breast cancer cells to curcumin.

Mutant p53-Notch1 Signaling Axis Is Involved in Curcumin-Induced Apoptosis of Breast Cancer Cells

Yun-Hee Bae,Jong Hyo Ryu,Hyun-Joo Park,Kwang Rok Kim,Hee-Jun Wee,Ok-Hee Lee,Hye-Ock Jang,Moon-Kyoung Bae,Kyu-Won Kim,Soo-Kyung Bae 대한생리학회-대한약리학회 2013 The Korean Journal of Physiology & Pharmacology Vol.17 No.4

Notch1 has been reported to be highly expressed in triple-negative and other subtypes of breast cancer. Mutant p53 (R280K) is overexpressed in MDA-MB-231 triple-negative human breast cancer cells. The present study aimed to determine whether the mutant p53 can be a potent transcriptional activator of the Notch1 in MDA-MB-231 cells, and explore the role of this mutant p53-Notch1 axis in curcumin-induced apoptosis. We found that curcumin treatment resulted in an induction of apoptosis in MDA-MB-231 cells, together with downregulation of Notch1 and its downstream target, Hes1. This reduction in Notch1 expression was determined to be due to the decreased activity of endogenous mutant p53. We confirmed the suppressive effect of curcumin on Notch1 transcription by performing a Notch1 promoter-driven reporter assay and identified a putative p53-binding site in the Notch1 promoter by EMSA and chromatin immunoprecipitation analysis. Overexpression of mutant p53 increased Notch1 promoter activity, whereas knockdown of mutant p53 by small interfering RNA suppressed Notch1 expression, leading to the induction of cellular apoptosis. Moreover, curcumin-induced apoptosis was further enhanced by the knockdown of Notch1 or mutant p53, but it was decreased by the overexpression of active Notch1. Taken together, our results demonstrate, for the first time, that Notch1 is a transcriptional target of mutant p53 in breast cancer cells and suggest that the targeting of mutant p53 and/or Notch1 may be combined with a chemotherapeutic strategy to improve the response of breast cancer cells to curcumin.