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‘잘 모르겠음’ 답지와 추측에 대한 차별점수화가 차별기능검사와 피험자 응답 적합도에 미치는 영향
시기자,이유미,성태제 이화여자대학교 교육과학연구소 2007 교육과학연구 Vol.38 No.3
선택형 검사는 피험자가 추측에 의하여 응답할 수 있는 단점을 지니고 있으며, 추측에 의한 응답은 피험자 능력추정의 오차를 증가시킬 뿐 아니라 검사의 양호도에도 영향을 미친다. 이 연구에서는 추측에 의한 응답을 줄이기 위해 ‘잘 모르겠음’이라는 답지를 포함하는 것과 오답과 ‘잘 모르겠음’이라는 응답에 대해 차별적으로 점수를 적용하는 방안이 검사의 측정학적 특성에 어떠한 영향을 미치는지 차별기능검사와 피험자응답 적합도 측면에서 살펴보고자 하였다. 이를 위해 아무런 처치도 가하지 않은 집단과 ‘잘 모르겠음’이라는 답지를 포함한집단, 추측한 응답에 대해 차별점수를 적용한다고 공지한 집단으로 구분하여 검사를시행하였다. 추측에 대한 차별점수화의 영향을 알아보기 위하여 오답과 ‘잘 모르겠음’답지에 대한 차별점수화를 공지한 집단의 경우 자료처리에 있어서는 차별점수를 적용하는 조건과 적용하지 않는 조건으로 구분하였다. 분석결과, 4가지 조건 중 ‘잘 모르겠음’이라는 답지를 포함하고 있는 조건에서 피험자 응답 적합도가 보다 양호한 것으로나타났으며, 동일한 내용을 측정하는 검사라 할지라도 추측에 의한 응답을 고려하지않는 검사 유형과 비교할 때 ‘잘 모르겠음’이라는 답지를 포함하거나 ‘잘 모르겠음’이라는 답지를 포함하면서 추측에 대한 차별점수화를 예고할 경우 검사가 달리 기능하는것으로 분석되었다. The primary purpose of this study is to investigate the effects of ‘don't know’response option and differential scoring for ‘don't know’ response on DTF andperson fit, and to detect the methods to reduce the effect of guessing inmultiple-choice test. Three forms of each test unit were prepared. The group 1 took forms containingitems with five responses and the group 2 took forms which had an additionalresponse of I don't know, while the group 3 took forms with ‘don't know’ responseoption and information of weight on the choice of ‘don't know’ option. The group3 data is processed to study the effect on weight by two methods to weight of‘1/number of alternative’ for ‘don't know’ response and not to. Person fit shows good result in the case of addition of a ‘don't know’ option. Also, even though tests are constructed by the same items, there are the effectsof ‘don't know’ response option and the information of differential scoring for‘don't know’ response and tests differently function.
김보영,박용규,박형서,노상필,정승현,이유선,이정우,이재환,최시완,정진옥,성인환 충남대학교 의과대학 의학연구소 2003 충남의대잡지 Vol.30 No.1
Atherosclerosis is now viewed as an inflammatory disease of the vascular system. Expression of several chemokines, including monocyte chemoattractant protein(MCP)-1, MCP-4, RANTES(regulated on activation normal T-cell expressed and secreted), and interleukin-8(IL-8) are increased in human atherosclerotic plaques compared with normal vessels. They are involved in the pathogenesis of atherosclerosis and plaque rupture by activating and directing leukocytes into the atherosclerotic lesions. However, some are involved in homeostatic functions such as normal leukocyte traffic and growth regulation. SDF-la is a multi-functional cytokine that is involved in myelogenesis, hematopoiesis, angiogenesis and injured gastric mucosal regeneration in the gastric ulcer patient. SDF-la is recently shown to be highly expressed in atherosclerotic plaques and a potent platelet agonist. At least in high concentrations, SDF-la may mediate antiinflammatory and matrix stabilizing effects in unstable angina. Many studies are going on to know the function of SDF-la in coronary artery diseases. I investigated the difference of the plasma level of SDF-la between control group and coronary artery disease group. Total 75 subjects were enrolled. The diagnosis of coronary artery disease was confirmed in all patients by coronary angiography. Control subjects in this study were confirmed normal by coronary angiography. Clinical profile and risk factors were also reviewed. Control subjects in this study were 27 (M=10, F=17). Plasma for the study was collected before the angiography and centrifuged. SDF-la analysis was performed by ELISA. Plasma level of SDF-la is significantly increased in patients with stable angina(n=20) and unstable angina group(n=28) compared with healthy control group(n=27). the risk factors do not influence the plasma level of SDF-la in coronary artery diseases. In this study, plasma level of SDF-la is increased in patients with stable angina and unstable angina groups compared with healthy control group(P<0.05). the risk factors do not influence the plasma level of SDF-la in coronary artery diseases.
차나무와 동백나무 꽃잎 혼합 추출물이 HT29 세포주의 성장 억제 및 세포자살에 미치는 효과
Si Young Lee,Myoung Gun Choung,Hannah Lee,Eun Ji Go,Chang Yeon Yu,Jung Dae Lim 한국약용작물학회 2017 한국약용작물학술대회 발표집 Vol.2017 No.05
Backgrounds : The action mechanisms of several chemopreventive agents derived from herbal medicine and edible plants have become attractive issues in cancer research. Tea is the most widely consumed beverage worldwide. It have been demonstrated that the active principles of tea sources such as flower extract Camellia sinensis (CSF) and Camellia japonica (CJF)were attributed to their tea polyphenols. We focused on investigating CSF, CJF, mixtures of CSF and CJF has been proven to suppress colonic tumorigenesis. Methods and Results : In this study, human colorectal carcinoma HT-29 cells were treated with CSF, CJF, mixture of CSF and CJF to examine the anti-proliferative and pro-apoptotic effects of mixture of CSF and CJF (3 : 1), as well as the molecular mechanism underlying these effects. Cell viability assay, nuclear staining, DNA fragmentation, caspase assay, cytochrome c release, were utilized to dissect the signaling pathways. In mixture of CSF and CJF (3 : 1), CSF appeared most anticancer effect by both MTT assays and the cleavage analysis of apoptosis-related molecules and PARP. Interestingly, we found that CJF make it possible to express the apotosis inducing by CSF in a short time and apoptosis effect of CSF maintained sustainable. Conclusion : In summary, our results from this study suggest that in HT-29 human colon cancer cells (i) CSF treatment causes damage to mitochondria, and (ii) CJF contributed CSF induced apoptotic cell death mediates cytochrome C release, (ⅲ) mixture of CSF and CJF (3 : 1) the potential to function as a chemopreventive agent against colon cancer.
Lee, Si-Young,Chu, Sang-Mi,Lee, Si-Myung,Kim, Hyo-Jin,Cho, Hyun-Suk,Yu, Chang-Yeon,Kim, Jae-Kwang The Korean Society for Applied Biological Chemistr 2010 Applied Biological Chemistry (Appl Biol Chem) Vol.53 No.2
A simple and sensitive method for determining indole-3-carbinol (I3C) and indole-3-acetonitrile (I3A) from Brassica vegetable was developed using high-performance liquid chromatography with fluorescence detection. The indolic glucosinolate as well as I3C and I3A concentrations were found to be significantly higher in Brassica rapa L. ssp. pekinensis than in B. juncea var. integrifolia.
Lee, Yu-Si,Jo, Seo-Hee,Cho, Sun-Duk,Kim, Gun-Hee,Kim, Yong-Mu,Lee, Dong-Ho,Park, Sun-Hee,Bae, Dong-Ho,Chung, Myung-Sub,Bahk, Gyung-Jin,Ha, Sang-Do The Korean Society for Applied Biological Chemistr 2009 Applied Biological Chemistry (Appl Biol Chem) Vol.52 No.3
We established optimum washing and sanitizing conditions for fresh-cut lettuce using sodium hypochlorite to reduce microbial hazards. Reduction of microbial hazards, including total aerobic bacteria, Escherichoa coli, and Staphylococcus aureus at different sodium hypochlorite concentrations (0-500 ppm), immersion times (0-20 min), temperatures (0-30$^{\circ}C$), and washing times (0-4 min) was evaluated. The optimum washing and sanitizing conditions using sodium hypochlorite for lettuce were determined as immersion at more than 50 ppm for 1 min at 20$^{\circ}C$ and washing twice for 30 sec after dipping. Application of these optimum conditions will improve safety and added value of lettuce as a fresh-cut-food without detrimental effects on sensory characteristics.