비병원성 야생효모, Apiotrichum sacrabaeorum WP49-1로부터 β-Glucosidase 생산

신유리, 장지은, 이종수 배재대학교 자연과학연구소 2016 自然科學論文集 Vol.32 No.1

콩에 함유되어 있는 식물성 여성 호르몬인 estrogen의 흡수를 증가시키기 위해 높은 활성의 β-glucosidase를 생산하는 비병원성 야생 효모의 선별과 β-glucosidase의 생산 조건을 조사하였다. 38종의 비병원성 야생효모 중 Apiotrichum scarabaeorum WP49-1의 무세포 추출물이 6.5 unit의 가장 높은 β-glucosidase 활성을 보였고 Zygosaccharomyces rouxii O-5-7도 5.9 Unit의 높은 활성을 보였다. 최종적으로 β-glucosidase 생성 효모 균주로 Apiotrichum scarabaeorum WP49-1 균주를 선별하였다. β-Glucosidase는 Apiotrichum scarabaeorum WP49-1을 yeast extract-peptone-dextrose 배지에 접종하여 30℃에서 72시간 배양했을 때 최대로 생성되었다. 선발 균주는 구형으로 출아에 의한 영양증식을 하였고 포자를 형성하지 않았다. 또한 비타민이 함유되어 있지 않은 배지에서도 생육하였고 5% 에탄올에 대하여 내성을 보였다

완전탈구된 치아의 지연 재석

한유리,최형준,이제호,최병재 大韓小兒齒科學會 2002 大韓小兒齒科學會誌 Vol.29 No.4

완전탈구된 치아의 치료법은 재식술을 들 수 있는데, 이는 치조와에서 이탈된 치아를 가능한 빠른 시간 내에 재식립하는 술식이다. 일반적으로 재식술의 성공여부는 치수와 치주인대 손상의 정도, 치아상실 시부터 치조와 내로 재식될 때까지의 경과시간, 탈구된 치아의 보관 상태, 치근의 발육 정도 등에 좌우된다. 그 중 치아상실 시부터 재식까지의 경과시간이 특히 중요한데, 일반적으로 30분 이내에 재식을 시행한 경우에는 90%이상의 성공률을 보인 반면 30분에서 90분 사이에서는 43%, 90분 이상 경과 시에는 7%의 성공률을 보인다고 알려져 있다. 본 증례는 완전탈구 후 오랜 시간이 지연되어 재식을 시행하였으나 치근유착을 통해 비교적 양호한 임상적 결과를 얻었다. 이러한 치료로 결국은 치아의 손실이 일어날지라도, 이것은 환자 및 보호자의 사고에 따른 충격을 감소시켜주고, 자체로 공간 유지장치로서의 기능을 할 수 있으며, 발치에 따른 치조골의 흡수를 늦추는 한편, 적극적인 보철치료를 위한 시간을 벌어줄 수 있을 것으로 사료된다. Replantation may be treatment choice for a completely avulsed tooth caused by traumatic injury. The outcome of replantation depends on the following factors: minimal damage to pulp and periodontal membrane the length of time the avulsed tooth was out of the mouth, how the tooth was stored the level of root formation, etc. The time from the act of avulsion of the tooth to the actual replantation is especially important. Generally, when replanted within 30 minutes, more than 90% of cases succeed but when the time is between 30 to 90minutes 43% and greater than 90 minutes 7%. This is a case of a replanted tooth with relatively good prognois by ankylosis though there was a great time lapse since the tooth was avulsed. Though such treatment lead to loss of the tooth in case of children or adolescents this treatment is meaningful because it may earn time until any definitive therapy functionally stimulate the alveolar bone to retain its hight for a better prognosis for future treatment and act as space maintainer

주부의 인터넷 쇼핑의 유용성 인지가 활용도에 미치는 영향

박미석,이유리 숙명여자대학교 2000 生活科學硏究誌 Vol.15 No.-

This study analyzes the trend of the awareness of usefulness and usage frequency of Internet shopping and closely examines the influential factors of the trend. In addition, in this study the usage rate of Internet shopping are divided into that of search and purchase, so that the relationships of variables are easily derived through a process matrix. After all, the purpose of this methodology was to provide informatized housewives and household with fundamental data by finding a way to increase the awareness of usefulness and usage frequency of Internet shopping. The major findings are follows: (1) Those who are college-educated, married and employed, positive about information household, Internet-educated, highly capable of the Internet, and comfortable with an issue of an effluence of personal data showed high awareness of usefulness of Internet shopping. (2) Those who are young, college graduate or above, and employed showed the high usage rate of search. Those who are age 20 to 30, college graduate or above, employed, and at the early stage of family life style showed the high usage rate of purchase. In addition, those who are positive about information household, high in the tendency of innovation and the awareness of time constraints, exposed to the Internet education, high in the Internet capability, and low in a burden of the Internet bills and the effulence of personal data showed the high usage rate of search and purchase. (3) An awareness of time constraints and a concern for the effulence of personal data directly influence the usage rate of purchase and indirectly influence the usage awareness of internet shopping. And an attitude toward information household' and Internet capability directly influence the usage rate of search and purchase and indirectly influence the usage awareness of internet shopping. Therefore, according to the result of process matrix, an awareness of usefulness of Internet shopping, an attitude of information household, Internet capability are the variables that influence the usage rate of Internet shopping.

랫드에서 법제유황과 비법제유황의 독성비교

김근수, 정유리, 이남진, 홍성희, 유종훈, 정재황, 강종구 충북대학교 동물의학연구소 2006 Journal of Biomedical and Translational Research Vol.7 No.2

본문참고

동아시아 국가의 가족정책 비교연구 : 한국·일본·중국·싱가포르·홍콩을 중심으로

양옥경,이유리 梨花女子大學校 社會科學大學 社會科學硏究所 2005 사회과학연구논총 Vol.14 No.-

동아시아 국가들에서 가족은 급격한 사회변화를 겪어왔다. 정치·경제·문화 등 다양한 사회구조와 상호작용함과 동시에 사회발전과 정책변화에도 막대한 영향을 미치는 핵심적인 요인으로서 작용해왔으며 복지생산의 기본적 단위로서의 위상도 지니고 있다. 그럼에도 동아시아 가족관련 연구에 대한 체계적인 비교연구는 부재했었고, 가족정책 전반에 대한 기초적인 사실조차 제대로 소개되지 않은 것이 현실이었다. 이 논문은 향후 본격적인 동아시아 가족정책 비교연구를 위한 출발점으로서, 한국·일본·중국·싱가포르·홍콩 의 가족구조 및 가족가치관에 대한 최근 동향과 변화추이를 개괄적으로 조망하고 그러한 변화에 대응하는 가족정책을 체계적으로 비교분석하고자 하였다. 여기에는 한국, 일본, 중국, 싱가포르, 홍콩정부가 발간한 공식통계자료와 각국 가족관련 연구 자료가 활용되었다. 연구의 결과, 첫째, 급속한 산업화와 근대화의 영향에 대한 가족 구조, 여성의 지위 등의 변화추이와 방향은 동아시아 국가들에서 매우 유사한 형태로 나타나고 있었다. 둘째, 동아시아 국가 모두 가족관련 가치관은 개방적으로 변화하고 있지만, 보수적·가족주의적 성향도 존재하고 있어 아직까지 서구적인 핵가족의 모습으로 변화하였다고는 볼 수 없음을 확인할 수 있었다. 셋째, 동아시아 국가에는 직접적이고 명백한 가족정책이 존재하지는 않지만, 사회보장 체계 안에서 소득지원, 자녀양육지원, 노인부양지원의 형태로 가족을 둘러싼 변화에 대응하고 가족기능을 유지하기 위한 정책들을 펼쳐나가고 있었다. In many East Asian countries, family experiences a rapid social change and plays a fundamental role of welfare production as a key factor that interacts with politics, economy, and culture while it affects social developments and political changes. Nonetheless, an absence of the systematic comparative study and an insufficiency of introducing basic actualities of the family policy have been made in our reality. This study will provide a starting point for the study of East Asian family policy. It will take a general view of the recent tendency and the transition of Korean, Japanese, Chinese, Singaporean and Hongkongite family Structure and Family Value. The result of this study are sum-up as follows. First, the changing pattern and the direction of the family structure, woman's status on the rapid industralization and modernization is appearing as a similar pattern among the East Asian countries. Second, in the East Asian countries, changing of the family value becomes openly; however, the continuities of some traditional attitudes and values on the family have been found in all the East Asia, because conservative familism still exist and East Asian family is hard to identified as Westernized nuclear family. Third, direct and obvious family policy does not exist among the East Asian countries, but family policy to confront family changes and maintain family functions as a form of income supplementation, child care assistance, elderly care assistance has been practiced in the socal welfare system.

인체 췌장암세포주(Capan-1)의 증식에 미치는 amiloride의 억제효과

임대관,김신,김유리,노지훈,이지현,김지연,박무인,정근옥,박건영,구자영 고신대학교 의학부 2004 高神大學校 醫學部 論文集 Vol.19 No.1

Background/Aims Cytoplasmic alkalinization induced by activation of the Na+/H+anti porter which is stimulated upon the addition of growth-promoting agents, such as insulin, epidermal growth factor, phorbol ester, plays an essential role in the initiation on cell proliferation. In the present study the effects of amiloride, a specific and reversible inhibitor of Na+/H+antiporter, on the growth of human pancreatic carcinoma cell line, Capan-1 cells was examined and the effects of 5-fluorouracil (5-FU) were also studied. Cell cycle analysis was done to examine the mechanisms for the inhibitory effects of amiloride. Materials/Methods The growth of Capan-1 cells were examined by counting cell number on two and four days treatment with 1 μM, 5 μM, 10 μM, 20 μM, 40 μM, 80 μM, 160 μM amiloride, and 0.1 ㎍/㎖, 0.3 ㎍/㎖ 5-FU, after plating Capan-1 cells into 35-mm2 plastic dishes at d density of 10x104 cells/dish. The reversibility of the effects of amiloride was examined on two day to eight days treatment with 20 μM amiloride after seeding 2×104 cells/dish. Cell cycle analysis was done on the sells after four days treatment with 20 μM amiloride. Results Amiloride significantly inhibited the growth of Capan-1 cells in a dose-dependent fashion (p<0.05). The inhibitary effect of amiloride on the growth of Capan -1 cells was firstly shown at the concentration of 5 μM, which is not so higher than the concentration of 0.1-0.2 μM attainable by administration of usual dose of amiloride (5-10㎎). Forty-eight percent inhibition of growth was found at an amiloride concentration of 20μM after 4 days treatment, and ninety-three percent inhibition of growth was found at an amiloride concentration of 160μM after 4 days treatment. The inhibitory effect of amiloride on growth of Capan-1 cells was reversible since removal of amiloride by a media change after 48 hours treatment lead to significantly more growth than amiloride treated group (p<0.05). The reversibility of growth inhibition suggests that amiloride in not a non-specific cytotoxin for Capan-1 cells. Amiloride combined with 5-FU significantly inhibited the growth of Capan-1 cells in a dose-dependent fashion compared to an amiloride or a 5-FU alone (p<0.05). After four days treatment with 20 μM amiloride, the faction of cells in G0-G1 phase, S phase and G2-M phase was 47.3%, 35.8%, 16.9% respectively in the amiloride group (20 μM), and 44.3%, 37.1%, 18.6% in the control group. showing no significant differences between the two groups. Conclusions Amiloride significantly inhibited the growth of Capan-1 cells in a dose-dependent fashion, which was reversible. The reversibility of growth inhibition suggests that amiloride is not a non-specific cytotoxin for Capan-1 cells. The concentration of 5 μM, which is not so higher than the concentration of 0.1-0.2 μM attainable by administration of usual dose of amiloride (5-10㎎), which suggests amiloride or its analogues may be used alone or in conjunction with 5-FU for the treatment of pancreatic carcinoma. Further study is needed to clarify the effects of more potent analogues of amiloride on the growth of human pancreatic carcinoma cells.

A study on the Structural Equation Modeling of Interpersonal problem, Stress coping strategy, Mental health of University students at risk of Smartphone addiction

Yu-ri Lee,Jeong-Sook Park 한국융합학회 2019 한국융합학회논문지 Vol.10 No.2

본 연구의 목적은 구조방정식모형을 활용하여 스마트폰중독 위험군 대학생의 대인관계문제, 스트레스대처방식, 정신건강의 관계를 분석하는 것이다. 연구 결과, 대인관계문제는 정신건강의 심각성을 악화시키는 직접적 영향력을 미치는 것으로 나타났다. 스트레스대처전략은 대인관계문제와 정신건강 사이의 영향관계에서 부분 매개효과를 갖는 것으로 나타 났고, 소극적 대처는 위험요인, 적극적 대처는 보호요인으로 분석되었다. 이러한 결과를 바탕으로 스마트폰중독 위험군 대 학생의 정신건강 증진을 위한 다양한 실천적·정책적 개입전략을 제시하였다. This study aimed to analyze the relationship between interpersonal problem, stress coping strategies and mental health for university students at risk of smartphone addiction using a structural equation modeling. Key results of the analysis were as follows. The interpersonal problem increased the severity of mental health. Stress coping strategies had partial mediating effects in the relationship between interpersonal problem and mental health. Passive coping strategy was risk factor and Active coping strategy was protective factor. Based on these results, various interventions for improving mental health for university students at risk of smartphone addiction were suggested.

Is the adefovir plus entecavir combination therapy superior than adefovir plus lamivudine in patients with antiviral resistant chronic hepatitis B?

( Yu Ri Cho ),( Dong Hyeon Lee ),( Jeong Hoon Lee ),( Su Jong Yu ),( Jung Hwan Yoon ),( Hyo Suk Lee ),( Yoon Jun Kim ) 대한내과학회 2011 대한내과학회 추계학술대회 Vol.2011 No.1

Background: Antiviral resistance is a major challenge for the treatments that are currently available for hepatitis B virus. However, the efficacy of adefovir (ADV) and entecavir (ETV) combination therapy in patients who developed antiviral resistance was not fully evaluated. In this study, we aimed to evaluate the efficacy of ADV and ETV combination therapy as compared to the efficacy of LAM and ADV in patients with antiviral resistant chronic hepatitis B (CHB). Methods: Antiviral resistance was defined as follows: persistently detectable HBV DNA after 36 weeks after LAM or ADV therapy ; virological breakthrough with previous LAM or ADV therapy ; or documented LAM or ADV-resistant mutations. We assessed 90 patients with antiviral resistant CHB. Of these, 27 patients were treated with a combination of ADV+ETV and 63 patients were treated with a combination of LAM+ADV. The virological and biochemical parameters were compared between the two groups at 3, 6, 9 and 12 months, respectively. Results: Treatment with a combination of ADV+ETV resulted significant difference in virological response compared to that in the LAM+ADV group through 12 months (p=0.001). At 12 months, the HBV DNA declined more in the ADV+ETV group than that in the LAM+ADV group (-4.52±1.956 vs. -2.65±1.723 log10IU/ml; p=0.001). The rate of a virological non-response, which is defined as <1 log10IU/ml reduction in HBV DNA concentration at 3 months was significantly greater in the LAM+ADV group than that in the ADV+ETV group (26.78% vs. 7.40%, p=0.022). Also, the rate of a virological complete response at 12 months was greater in the ADV+ETV group than that in the LAM+ADV group (73.68% vs. 31.48%, p=0.005). In the multivariate analysis, parameters related to a virological response at Month 12 were the baseline HBV DNA level [OR, 0.403 ; p=0.004] and virological non-response at Month 3 [OR, 0.102 ; p=0.028]. Conclusion: In patients with antiviral resistant CHB, the response to ADV+ETV was significantly superior compared to that of the LAM+ADV group for suppressing HBV DNA through 12 months. The result indicates that ADV+ETV should be used in the patients antiviral resistant CHB, especially in the area where tenofovir is not available.

A case of secondary anetoderma after rapidly involuting congenital hemangioma

( Yu Jin Han ),( Hyunjoon Chang ),( Suyeun Kim ),( Minah Cho ),( Se Hoon Lee ),( Yu Ri Woo ),( Hei Sung Kim ),( Jeong Deuk Lee ),( Sang Hyun Cho ) 대한피부과학회 2022 대한피부과학회 학술발표대회집 Vol.73 No.2

Predicting US and Chinese consumers` purchase intention of Korean textiles and apparel related cultural products

Yu Ri Lee,So Young Kim,Yun Jin Cho 한국복식학회 2010 International journal of costume and fashion Vol.10 No.2

This study aims to examine if a consumer`s evaluations of and purchase intentions towards textiles and apparel-related cultural products are influenced by their culture, as indicated by their nationalities. Additionally, several psychological variables, such as novelty-seeking tendency, world-mindedness, and familiarity with Northeast Asian culture were included in the analyses to compare the relative importance of cultural influences with the importance of individual characteristics. To conduct a quantitative analysis, we collected data from 400 female consumers in two countries: 200 from the USA and 200 from China. Key findings showed that, nationality and novelty-seeking were found to have a strong influence on purchase intention when product evaluation variables were not included. Evaluation of appearance and Northeast Asian design emerged highly significant predictors of purchase intention for Korean cultural products, regardless of the product type. Cross cultural comparative research on cultural product evaluations is extremely rare. This study focused on groups of consumers residing in the US and China and asked them to evaluate a series of textiles and apparel-related cultural products produced in Korea.