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植物의 生物活性物質探索 : 고사리의 發癌物質 The Carcinogen of Bracken Fern
이영란,윤주영,박춘임,안정애,임의섭,김미현,조혜경,이정아 이화여자대학교약학회 1992 梨花藥學硏究 Vol.- No.31
Naturally occurring carcinogens of plant origin were briefly reviewed. The historical background of the studies on the bracken carcinogen and the cattle bracken poisoning and some attempts at the characterization of the active principle(s) were described. finally, ptaquiloside, an unstable glycoside of an illudane-type norsesquiterpene, was characterized as the active principle. On the basis of the chemical and biological nature of ptaquiloside, a bilogical assay method using a modified Ames' test and a chemical assay using thin-layer chromatographydensitometry were devised. By using these methods, several processed or untreated samples of the fern collected in different places, and in different seasons, were assayed for their ptaquiloside contents to show under what conditions the decompositon of ptaquiloside took place, the epidemiological meanings and whether or not they were safe as food. Wide occurrence of ptaquiloside-like compounds in the ferns of the Pteridaceae family was also revealed by the same methods and four new analogous compounds were isolated and characterized. These analogs and illudins S and M, sesquiterpenes of illudane-type from Basidiomycetes, were shown to have mutagenecity in the modified Ames' test and in chromosome abberation in CHL cells of ptaquiloside and were to be the carcinogens of the same type as ptaquiloside.
A Case of Acquired Brown Syndrome after Surgical Repair of a Medial Orbital Wall Fracture
Il Hun Seo,Jay Won Rhim,Young Woo Suh,Yoon Ae A. Cho 대한안과학회 2010 Korean Journal of Ophthalmology Vol.24 No.1
A case of acquired Brown syndrome caused by surgical repair of medial orbital wall fracture is reported in the present paper. A 23-year-old man presented at the hospital with right periorbital trauma. Although the patient did not complain of any diplopia, the imaging study revealed a blow-out fracture of the medial orbital wall. Surgical repair with a calvarial bone autograft was performed at the department of plastic surgery. The patient was referred to the ophthalmologic department due to diplopia that newly developed after surgery. The prism cover test at distant fixation showed hypotropia of the right eye, which was 4 prism diopters (PD) in primary gaze, 20 PD in left gaze, while orthophoric in right gaze. Eye movement of the right eye was markedly limited on elevation in adduction with normal elevation in abduction with intorsion in the right eye present. Forced duction test of the right eye showed restricted elevation in adduction. Computerized tomography scan of the orbits showed the right superior oblique muscle was entrapped between the autografted bone fragment and posterior margin of the fracture. When repairing medial orbital wall fracture that causes Brown syndrome, surgeons should always be careful of entrapment of the superior oblique muscle if the implant is inserted without identifying the superior and posterior margin of the orbital fracture site.
제2형 당뇨병 입원 환자에서 혈당변동성 지표인 Average Daily Risk Range와 관련된 인자
박신애 ( Shin Ae Park ),고승현 ( Seung Hyun Ko ),이승환 ( Seung Hwan Lee ),조재형 ( Jae Hyung Cho ),문성대 ( Sung Dae Moon ),장상아 ( Sang A Jang ),송기호 ( Ki Ho Song ),손현식 ( Hyun Shik Son ),윤건호 ( Kun Ho Yoon ),차봉연 ( Bon 대한당뇨병학회 2009 Diabetes and Metabolism Journal Vol.33 No.1
Original Article : Analysis of the Effects of Medial Rectus Muscle Resection for Recurrent Exotropia
( Young Woo Suh ),( Il Hun Seo ),( Yoon Ae A. Cho ),( Seung Hyun Kim ) 대한안과학회 2011 Korean Journal of Ophthalmology Vol.25 No.5
Purpose: The purpose of this paper is to investigate how much correction is obtained per millimeter of medial rectus (MR) resection for recurrent exotropia after bilateral lateral rectus (BLR) recession, and to determine the difference in the effects between unilateral and bilateral resection, and the influence of previous lateral rectus (LR) recession on the effects of MR resection. Methods: A total of 59 patients who had undergone MR resection after BLR recession were included in this study. The unilateral group consisted of 38 patients and bilateral group, 21 patients. Thirty patients in the unilateral group were divided into two groups: patients who had undergone previous LR recession of 7 mm or greater (21 patients) and less than 7 mm (9 patients). Main outcome measures were average deviation corrected per millimeter of MR resection at 1 month postoperative. Results: The average effect of MR resection was 4.2 prism diopters (PD, 2.0 to 6.7 PD)/mm. The average effect in the unilateral group was 4.2 PD/mm and 4.1 PD/mm in the bilateral group. There was no significant difference between groups (p = 0.60). The average effect in the recession 7 mm or greater group was 4.0 PD/mm, and the average effect in the recession less than 7 mm group was 4.2 PD/mm (p = 0.698). Conclusions: The effect of MR resection per millimeter was variable. The laterality and previous amount of LR recession did not influence the effect of MR resection. These variable outcomes dictate that caution be exercised when MR resection is performed for recurrent exotropia.
신정은,정성애,유민아,최영주,조지윤,김수현,유권,문일환 梨花女子大學校 醫科大學 醫科學硏究所 2002 EMJ (Ewha medical journal) Vol.25 No.1
목적 : 50세 이상에서 대장암 선별 검사를 위한 대장 내시경의 유용성은 이미 알려져 있으나, 50세 미만을 대상으로 한 연구는 부족한 실정으로, 50세 미만의 대장 용종 환자의 임상적 특성과 용종의 특성을 파악함으로써 대장 내시경 시행 여부에 대한 지침으로 삼고자 연구를 시행하였다. 방법 : 2001년 1월부터 2001년 8월까지 이화여자 대학교 목동병원에서 대장 내시경을 시행받은 50세 미만의 환자를 대상으로 하여 이들 중 가족성 용종증으로 진단된 경우를 제외한 대장 용종 환자 94명의 임상적 양상을 조사 분석하였다. 위치 및 크기는 가장 큰 용종을 기준으로 하였으며, 진행성 용종은 크기가 1㎝ 이상, 융모성 선종 혹은 고도의 이형성증이 포함된 경우로 정의하였다. 결과 : 연령별 분포는 40대가 65예(69.1%)로 가장 많았고, 30대가 25예(26.6%), 20대가 3예(3.2%), 10대가 1예(1.1%)였고, 남녀비는 2.03 : 1이었다. 검사를 시행한 원인 증상은 복통이 28예(29.8%)로 가장 많았고, 직장 항문 출혈 17예(18.1%), 무증상 검진 12예(12.7%), 설사 11예(11.7%), 변비 9예(9.6%)의 순이었다(Table 3). 대장 용종의 위치는 직장이 36예(38.3%), s 상결장 24예(25.5%)로 직장 및 s 상결장에 절반 이상이 분포되어 있었다. 크기는 0.5㎝ 미만인 경우가 60예(63.8%)로 가장 많았고, 0.5㎝이상 1㎝미만은 20예(21.3%), 1㎝ 이상인 경우가 14예(14.9%)였다. 전체 용종의 수는 156병소였고, 선종이 86예(55.1%), 염증성 용종이 60예(38.5%), 과형성성 용종이 10예(6.4%)였다. 선종 중 진행성 선종을 보인 경우는 17예(20.0%)였고, 이들 중 3예에서는 부분적인 점막암 소견을 보였다. 복통 혹은 직장 항문 출혈의 증상이 있거나 다발성 용종을 가지는 경우 혹은 대장암의 가족력이 있는 경우 진행성 선종의 빈도가 높은 것으로 나타났다(p<0.05)(Table 6). 결론 : 50세 미만의 대장 용종에서 복통과 직장항문 출혈이 가장 흔한 증상이며, 복통 혹은 직장 항문 출혈의 증상이 있거나 다발성 용종인 경우 및 대장암의 가족력이 있는 경우에 진행성 선종의 위험이 증가함을 알 수 있었다. 젊은 연령층의 대장 내시경의 적절한 적응증의 확립을 위해서는 경제성을 고려한 다기관 공동 연구가 필요할 것으로 생각된다. Objectives : The aim of this study was to evaluate the clinicopathologic characteristics of the colorectal polyps in people under 50 years old. Methods : From January to August 2001, the colonoscopic finding and pathologic reports of 527 patients under 50 years old who underwent colonoscopy were reviewed retrospectively. The advanced polyp was defined as an adenoma more than 10㎜ in diameter or with the histology of villous or high grade dysplasia. Results : Total 94 colonic polyps(17.8%) were analyzed. On age distribution, 65 cases(69.1%) were in forth decade, 25 cases(26.6%) in third decade. Abdominal pain(29.8%) was the most common cause of taking the colonoscopic examination followed by rectal bleeding(18.1%), asymptomatic screening(12.7%). Rectosigmoid area was the most common site of polyps in 63.8%. On the pathologic review, adenoma was found 55.1%, inflammatory polyp 38.5% and hyperplastic polyp 6.4%. Advanced adenomas were 17.9%(17/156) and adenomas with focal carcinomatous changes were 1.9%(3/156). Patients who had symptoms of abdominal pain or rectal bleeding, multiple polyps or familial history of colorectal cancer had a higher prevalence of advanced adenoma than that of non-advanced adenoma(p<0.05). Conclusion : This study showed that major symptoms of patients with advanced polyps under 50 years old were abdominal pain and rectal bleeding. The symptoms, multiplicity of polyp and family history were important indicator of advanced polyps. Further study was needed for reasonable indication and cost effectiveness for colonoscopic examination in young age people.