국내 상급종합병원과 종합병원 간호사의 정맥주입간호실무지침의 확산정도

은영(Young Eun),구미옥(Mee Ok Gu),조용애(Young Ae Cho),정재심(Jae Shim Jeong),권정순(Jeong Soon Kwon),유정숙(Cheong Suk Yoo5),정영선(Young Sun Jeong),정인숙(In Sook Jung),김경숙(Kyeong Sug Kim),이선희(Seon Heui Lee),서현주(Hyun Ju S 한국근거기반간호학회 2015 근거와 간호 Vol.3 No.1

Purpose: This study was conducted to investigate the extent of diffusion of Intravenous infusion nursing practice guideline among nurses in advanced general hospitals and general hospitals in Korea. Methods: The subjects were 234 nurses who practice the intravenous infusion in 24 advanced general hospitals and general hospitals. Data were collected between October 5 and November 2, 2015 by mail (return rates: 97.5 %). Data were analyzed using descriptive statistics, t-test, and ANOVA with SPSS/ WIN 21. Results: The average guideline diffusion score and levels of diffusion was 3.39±0.58 (level of “use sometimes”). 44 recommendations (46%) were in level of “use always” and 50 recommendations (53%) were in “use sometimes”. Extent of diffusion were significantly different according to present status (F=2.81, p=.040) and education (F=4.35, p=.014). The facilitating factors to use the guideline were education by department of nursing service, convenient composition of guideline and barrier factors were “no time to use the guideline”, “don’t know the guideline” and “there is no guideline at ward”. Conclusion: Extent of diffusion of Intravenous infusion nursing practice guideline among nurses was moderate level. The strategies for promoting the implementation of guideline in clinical practice is needed. Further study of outcome evaluation of guideline implementation will be needed.

발달장애학생을 위한 웹기반 의사소통능력신장 프로그램의 개발과 적용 사례

김동현,유영환,김좌중,천경철,이청용,김봉수 국립특수교육원 2005 연구보고서 Vol.- No.10

발달장애학생의 의사소통능력은 단순한 언어문제 이상의 의미를 지닌다. 의사소통능력은 모든 학습의 기초가 되고 결국 인간의 삶의 질을 좌우하게 하는 중요한 요소가 되고 있기 때문에 의사소통능력에 문제가 많은 발달장애학생에게 있어서 의사소통능력 신장은 매우 중요하다. 발달장애학생의 언어 및 의사소통능력의 결함은 사회적 결함과 인지적 결함에 상호 관련성이 있어 다른 사람으로부터의 의사소통을 이해하는 능력과 자신의 생각을 표현하는 능력이 제한되어 다른 사람과의 상호관계를 맺는데 어려움이 많았다. 따라서 발달장애학생의 언어지도는 생활 장면에서 교수하는 것이 가장 바람직하다고 하겠다. 그러나 지금까지 주로 활용된 전통적인 언어지도 방법은 어휘를 증가시키고, 발화의 길이를 널리는 데는 효과가 있었지만, 학습된 내용을 생활 장면에서의 일반화에는 문제점이 있는 것으로 지적되고 있다. 발달장애학생의 언어지도 방법은 일상생활 속에서 학습 내용을 선정하고 이를 실생활 장면 혹은 이와 유사한 환경에서 효과적으로 지도할 수 있는 적절한 교수 방법이 필요하다. 그래서 발달장애학생의 의사소통능력 신장을 위한 환경중심 언어지도 방법을 활용한 웹(Web)기반 언어지도 프로그램을 개발하였다. 웹(Web)기반 언어지도 프로그램은 제7차 특수학교 기본교육과정과 국립특수교육원에서 발간한 ‘발달장애학생의 언어교육 프로그램(1998)’ 분석을 통하여 개인 · 가정생활, 학교 · 사회생활, 경제 · 여가생활 등의 6개 영역으로 구분하여 각 영역별 학습주제를 선정하였으며, 학습주제에 대한 학습의 진행 형태는 학습목표, 낱말학습, 상황학습, 평가로 진행할 수 있도록 하였으나, 학습자의 현재 수행 능력을 고려하여 능력에 따른 진행의 절차를 학습자가 선택할 수 있게 하였다. 본 프로그램을 적용해본 결과 다음과 같은 교육적인 효과를 얻을 수 있었다. 첫째, 웹을 활용한 가상체험을 통하여 적극적이고 흥미 있는 참여를 유도하며, 학습자 중심의 주도적인 학습과 안내자, 촉진자로서의 교사의 역할을 통해 발달장애학생의 의사소통 능력을 신장시킬 수 있었다. 둘째, 교실에서 이루어지는 지금까지의 수업방식을 탈피하여 학습자가 언제, 어디서나, 누구든지 학습할 수 있는 열린 학습체제의 교육환경을 조성할 수 있었다. 셋째, 문자정보, 그래픽, 애니메이션, 사진, 음성, 비디오 등 다양한 형태의 정보가 상호대화 형식으로 활용되며, 수준별 반복학습을 실시함으로써 교수-학습 방법의 개선뿐만 아니라 양질의 수업을 진행하는데 도움을 줄 수 있었다. 본 프로그램을 활용한 언어지도가 발달장애학생의 의사소통능력 신장을 위한 최선의 방법이라고 말할 수는 없으며, 언어지도의 한 가지 방법이라고 말할 수 있다. 따라서 본 프로그램의 활용한 언어지도는 학교에서 교사가 학생의 능력과 흥미를 고려하여 지도한다면 발달장애 학생의 의사소통능력 신장에 많은 도움이 될 것이다. The developmental disability of the metal handicapped children means more than simple linguistic problem. The developmental disability is the base of all the learning and important factor which decides the happiness of the human being finally, so the extension of mutual understanding ability is so important, in the case of the metal handicapped children who have a problem of the mutual understanding ability. In the case of the metal handicapped children, the defects of the mutual understanding and linguistic ability are related with the social defect and the defect of recognition, and the ability of understanding about mutual relations with other people and self-expression ability are limited. So they have many problems in mutual relations with other people. Therefore, the linguistic instruction of the metal handicapped children is recommended to be done in the living. But, the traditional linguistic instruction which's used mainly as yet, is effective in increase of a vocabulary and the length of a locutionary act, but it has a problem in the popularization of the learning in the real life. The method of the linguistic instruction for the metal handicapped children, should be selected as contents in the real life, and the right learning method which can be done under the real life or the similar environment with it, is needed. Because of the above realities, the linguistic teaching web-based program is developed, using the linguistic instruction which is focused on the environment, for the extension of the mutual understanding ability of the metal handicapped children. In the linguistic teaching web-based program, it is divided with 6 field (personal · home life, school · social life, economical · leisure life) and the educational subject classified by each field is selected, by the analysis of 'The linguistic educational program for the children who have developmental disability' published by the 7th basic education course of special school and the national special education organization. Besides, the progress form of learning about the educational subject is directed by educational goal, word learning, situation learning and valuation, but a learner can choose a procedure followed by ability, regarding to his accomplishment ability. As the result of the application of this program, the educational effects that we could get are the following : 1. We could lead a positive and interesting participation by virtual experience through WEB, and the communication ability of the metal handicapped children was extended by a role of a teacher, as a guide and promoter and a leading learning focused on a learner. 2. The teaching method which is done in school now, is dismissed and we could form the educational environment of the learning system that a learner could learn, without distinction of time, a place and a person. 3. The various form of information, like text, graphic, animation, photo, sound, video and so on, is applied as a form of communication. Therefore, the program was useful in not only the improvement of the teaching-learning method, but also the proceeding of the effective lesson. The linguistic teaching which use this program, can not be the best method of the extension of the mutual understanding ability and it's just one method of linguistic teaching. if the linguistic teaching which use this program is conducted, regarding to a ability and a interest of a student, it will be so useful in the extension of the mutual understanding ability, for the children who have developmental disability.

圓光醫大 附屬 第2病院 神經精神科 患者에 對한 統計的 考察(Ⅱ)

박민철,장광철,김상원,김한주,유미경,김훈,유용진,김현정,박남진,오상우,이귀행,노승호,백영석 圓光大學校 醫科大學 神經精神科學敎室 1992 圓光精神醫學 Vol.8 No.1

본 연구는 1986년 7월 11일부터 1991년 7월 10일까지 원광의대 부속 제2병원 신경정신과에서 의래 및 입원치료를 받았던 6,072명의 환자를 대상으로 병원 역학조사를 실시하고 그 결과를 1차조사 (박민철 등1986)와 비교했다. 1.전체 환자 중 남자가 54.4%로 여자보다 많았고, 이리와 이리 인접지역이 84.0%로 대부분의 지역을 나타났다. 의료보장상태는 보험환자가 57.1%, 의료보호환자21.8%, 일반환자 21.1%였으며 연령별로는 20대 24.6%, 30대 22.8%로 20대 30대가 절반정도를 차지했다. 2.외래환자에서는 신경중성장애가 46.0%로 가장 많고 정동장애, 경련성장애 순이며, 입원환자에서는 정신분열증이 30.5%로 가장 많고 기질성정신장애, 정동장애의 순이었다. 3.남자는 신경증성쟝애(23.4%), 정신분열증, 기질성정신장애 순이고 여자는 신경증성장애(39.9%), 정동장애, 정신분열증의 순이었다. 남자가 여자보다 많은 진단은 알코올정신장애(94.6%), 기질성정신장애, 소아정신장애 순이고, 여자가 남자보다 많은 진단은 정동장애(64.5%), 신경증성장애였다. 4.진단별 연령분포에서 신경증성장에는 30대(25.3%), 20대, 40대 순이고, 정신분열증은 20대(40.5%), 30대, 40대 순이며, 정동장애는 20대, 30대, 50대 순이나 비교적 비슷한 융이었다. 5.진단별 발병연령에서 신경증성장에는 20대, 30대가 절반이고,정신분열증은 20대(51.3%), 10대, 30대 순이며 정동장애는 20대(30.7%), 30대, 50대 순이었다. 진단별 평균 발병연령은 신경증성장애 32.7세, 정동장애 36.1세, 정신분열증 23.6세였다. 6.진단별 이병기간은 2년이상이 신경증성장에 28.3%, 정신분열증 68.5% 정동장애 43.9%인데 전체적으로 41.0%였다. 진단별 평균 이병기간은 정신분열증 73.2개월, 정동장애 45.5개월, 신경증성장애 29.5개월이었다. We examined epidemiologic study of 6,072 patients who visited Wonkwang Neuropsychiatric hospital since July 11 of 1986 until July 10 of 1991 and compared this results with previous study(Park et al 1986). The study revealed as follows:1. Of total patients males visited this hosptial more than females as 57.1%, Most of them(84.0%) resided Iri and neighbouring Iri. In the point of insurance, insured patients, medicaid patients and uninsured patients were 57.1%, 21.8% and 21.1% respectively. On the distribution of age, the twenties, the thirties were 24.6%, 22.8% respectively and twenties and thirties were about half of total patients. 2. Of outpatients neurotic disorder was the most as 46.0%, secondly mood disorder and thirdly convulsive disorder, but of inpatients schizophrenia was the most as 30.5%, secondly organic mental disorder and thirdly mood disorder. 3. Of males neurotic disorder was the most as 23.4%, secondly schizophrenia, and thirdly organic mental disorder, but of females neurotic disorder was the most as 39.9%, secondly mood disorder and thirdly schizophrenia. alcoholic mental disorder(94.6%), organic mental disorder, child mental disorder were mostly found in males,but mood disorder(64.5%) and neurotic disorder were mostly found in females. 4. On the distribution of age neurotic disorder was found the most in the thirties(25.3%), next in the twenties and in the forties, and schizophrenia was found the most in the twenties(40.5%), next in the thirties and in the forties, but mood disorder was found the most in the twenties, next in the thirties and in the forties but revealed similar rates relatively. 5. On the distribution of age of onset neurotic disorder developed nearly half during the twrnties and the thirties, schizophrenia developed mostly during the twenties (51.3%), secondly the teens and thirdly the thirties, but mood disorder developed firstly the twenties(30.7%), secondly the thirties and thirdly the fifties. on the average age of onset of illness neurotic disorder, mood disorder and schizophrenia were 32.7 years, 36.1 years and 23.6 years respectively. 6. On the duration of illness more than two years was 28.3% in neurotic disorder, 68.5% in schizophrenia and 3.9% in mood disorder and on the average duration of illness schizophrenia, mood disorder and neurotic disorder were 73.2 months, 45.5 months and 29.5 months respectively.

그래프 임베딩 기반의 이더리움 피싱 스캠 탐지 연구

정유영 ( Yoo-young Cheong ),김경태 ( Gyoung-tae Kim ),임동혁 ( Dong-hyuk Im ) 한국정보처리학회 2022 한국정보처리학회 학술대회논문집 Vol.29 No.2

최근 블록체인 기술이 부상하면서 이를 이용한 암호화폐가 범죄의 대상이 되고 있다. 특히 피싱 스캠은 이더리움 사이버 범죄의 과반수 이상을 차지하며 주요 보안 위협원으로 여겨지고 있다. 따라서 효과적인 피싱 스캠 탐지 방법이 시급하다. 그러나 전체 노드에서 라벨링된 피싱 주소의 부족으로 인한 데이터 불균형으로 인하여 지도학습에 충분한 데이터 제공이 어려운 상황이다. 이를 해결하기 위해 본 논문에서는 이더리움 트랜잭션 네트워크를 고려한 효율적인 네트워크 임베딩 기법인 trans2vec 과 준지도 학습 모델 tri-training 을 함께 사용하여 라벨링된 데이터뿐만 아니라 라벨링되지 않은 데이터도 최대한 활용하는 피싱 스캠 탐지 방법을 제안한다.

Association of Uncoupling Protein-1 Haplotypes with Body Fat Area

Kim, Young-Joo,Cheong, My-Young,Cha, Min-Ho,Choi, Sun-Mi,Kim, Jong-Yeol,Kim, Kil-Soo,Shin, Seung-Uoo,Park, Young-Kyu,Kim, Hyun-Ju,Suh, Soong-Hyuck,Yoon, Yoo-Sik Korean Society for Bioinformatics and Systems Biol 2009 Interdisciplinary Bio Central (IBC) Vol.1 No.4

Obesity is a major cause of morbidity and mortality and is associated with risks for type 2 diabetes mellitus, heart disease, metabolic syndrome, hypertension, stroke, and certain forms of cancer. The glutamate decarboxylase 2 (GAD2), insulin-induced gene 2 (INSIG2), ectonucleotide pyrophosphatase/phosphodiesterase 1 (ENPP1), melanocortin 4 receptor (MC4R), fresh touring origination (FTO), and uncoupling protein-1 (UCP-1) genes have been investigated for their association with obesity. Since the A-3826G SNP in the UCP-1 gene was first shown to be the key genetic determinant of obesity and body fat accumulation, many studies have been performed in various populations to measure the association of the G allele of this SNP with obesity phenotypes. The association of the A-3826G SNP with obesity has been controversial, however, suggesting that one SNP does not sufficiently explain the effects of genomic variation on body fat accumulation. In this study, 9 SNPs were newly identified in the 5'-flanking region of the UCP-1 gene by direct sequencing of genomic DNA from 21 Korean subjects, and 6 haplotypes were obtained by SNP genotyping and haplotype reconstruction. According to our haplotype analysis, ht2 of the G allele of A-3826G, was significantly associated with overall fat measures after age and body weight were adjusted. Ht6 of the A allele of A-3826G, was significantly linked to reduced fat accumulation. These results provide an explanation for the controversies that have been reported in many obesity association studies and suggest that haplotype associations between polymorphic loci and neighbor loci that harbor functional sequence variants can be exploited to identify disease-predisposing alleles.

제어 흐름 그래프 기반 스마트 컨트랙트 취약성 탐지 연구

정유영 ( Yoo-young Cheong ),최라연 ( La Yeon Choi ),임동혁 ( Dong-hyuk Im ) 한국정보처리학회 2023 한국정보처리학회 학술대회논문집 Vol.30 No.2

스마트 컨트랙트는 블록체인 상에서 실행되는 프로그램으로 복잡한 비즈니스 논리를 처리할 수 있다. 그러나 블록체인의 무결성과 조건에 따라 실행되는 특성을 이용한 악의적 사용으로 인하여 블록체인 보안에서 시급한 문제가 되고있다. 따라서 스마트 컨트랙트 취약성 탐지문제는 최근 많은 연구가 이루어지고 있다. 그러나 기존 연구의 대부분이 단일 유형의 취약성 여부에 대한 탐지에만 초점이 맞춰져 있어 여러 유형의 취약성에 대한 동시 식별이 어렵다. 이 문제를 해결하고자 본 연구에서는 스마트 컨트랙트 소스코드 제어 흐름 그래프를 기반으로 그래프의 forward edge와 backward edge를 고려한 신경망으로 그래프 구조를 학습한 후 그래프 multi-label classification을 진행하여 다중 취약성을 탐지할 수 있는 모델을 제안한다.

국내 상급종합병원과 종합병원에서의 정맥주입간호실무지침에 대한 태도와 확산정도

은영(Young Eun),구미옥(Mee Ok Gu),조용애(Young Ae Cho),김신미(Shin Mi Kim),정재심(Jae Shim Jeong),권정순(Jeong Soon Kwon),유정숙(Cheong Suk Yoo),정영선(Young Sun Jeong),정인숙(In Sook Jung),김경숙(Kyeong Sug Kim)이선희(Seon Heui Lee 한국근거기반간호학회 2014 근거와 간호 Vol.2 No.1

Purpose: This study was conducted to investigate the level of attitudes to and diffusion of Intravenous infusion nursing practice guideline in advanced general hospitals and general hospitals in Korea. Methods: The subjects were 41 nurses who were in charge of guideline diffusion in 41 advanced general hospitals and general hospitals. Data were collected between September 25 and November 2, 2014 by mail (return rates: 68.3 %). Data were analyzed using descriptive statistics, t-test, and ANOVA with SPSS/WIN 18.0. Results: The average attitude score of guideline among nurses in charge of guideline diffusion were 3.98±0.38 (range 1~5). The average guideline diffusion score and levels of diffusion was 2.26±1.39 (level of “persuasion of nursing knowledge”) for staff nurses, 3.05±0.86 (level of “use sometimes”) for nurses in charge of guideline diffusion, 2.87±0.78 (level of “use sometimes”) for nurse directors. 41.4 % of nursing divisions in 41 hospitals reviewed the intravenous infusion nursing practice guideline, educated the guideline to nurses, and implemented the guideline in clinical practice for guideline diffusion. Conclusion: Study findings indicate that nurses in charge of intravenous infusion nursing practice guideline in hospitals had positive attitude for guideline. The levels of guideline diffusion in hospitals was “persuasion of nursing knowledge” to “use sometimes”. Therefore, the strategies for promoting the diffusion and implementation of guideline in clinical practice in the level of nursing division is needed. Further study of outcome evaluation of guideline implementation will be needed.

Identification of Calmodulin Isoform-specific Binding Peptides from a Phage-displayed Random 22-mer Peptide Library

Choi, Ji-Young,Lee, Sang-Hyoung,Park, Chan-Young,Heo, Won-Do,Kim, Jong-Cheol,Kim, Min-Chul,Chung, Woo-Sik,Moon, Byeong-Cheol,Cheong, Yong-Hwa,Kim, Cha-Young,Yoo, Jae-Hyuk,Koo, Ja-Choon,Ok, Hyun-Mi,Chi Plant molecular biology and biotechnology research 2002 Plant molecular biology and biotechnology research Vol.2002 No.-

Plants express numerous calmodulin (CaM) isoforms that exhibit differential activation or inhibition of CaM-dependent enzymes in vitro; however, their specificities toward target enzyme/protein binding are uncertain. A random peptide library displaying a 22-mer peptide on a bacteriophage surface was constructed to screen peptides that specifically bind to plant CaM isoforms(soybean calmodulin(ScaM)-1 and SCaM-4 were used in this study)in a Ca^(2+)-dependent manner. The deduced amino acid sequence analyses of the respective 80 phage clones that were independently isolated via affinity panning revealed that SCaM isoforms require distinct amino acid sequences for optimal binding. SCaM-1-binding peptides conform to a 1-5-10 ((FILVW)XXX(FILV)XXXX(FILVW)) motif(where X denotes any amino acid), whereas SCaM-4-binding peptide sequences conform to a 1-8-14 ((FILVW)XXXXXX(FAILVW)XXXXX(FILVW) motif. Theses motifs are classified based on the positions of conserved hydrophobic residues. To examine their binding properties further, two representative peptides from each of the SCaM isofrom-binding sequences were synthesized and analyzed via gel mobility shift assays, Trp fluorescent spectra analyses, and phosphodiesterase competitive inhibition experiments. The results of these studies suggest that SCaM isoforms possess different binding sequences for optimal target interaction, which therefore may provide a molecular basis for CaM isoform-specific function in plants. Furthermore, the isolated peptide sequences may serve not only as useful CaM-binding sequence references but also as potential reagents for studying CaM isoform-specific function in vivo.

쾌속조형기법을 이용한 생분해성 스텐트용 메쉬필름의 약물방출거동 효과

정신영(Sin Young Cheong),김양은(Yang Eun Kim),고영주(Young Joo Koh),신왕수(Wang Soo Shin),이준희(Jun Hee Lee),김완두(Wan Doo Kim),유영은(Young Eun Yoo),박수아(Su A Park) 한국고분자학회 2014 폴리머 Vol.38 No.1

약물방출 고분자 코팅 스텐트는 수술후 재협착을 획기적으로 줄였지만, 약물방출이 균일한 구조체를 제작하는 것이 어렵고 체내에 구조체를 영구적으로 남겨야 하는 부담을 여전히 가지고 있다. 이를 해결하는 방안으로 생분해성 고분자로 스텐트를 제작하는 방법들이 활발하게 연구되고 있다. 본 연구에서는 조형가공기술(solid freeformfabrication, SFF)의 하나인 쾌속조형기법(rapid prototyping technique)의 3차원 플로팅(3D plotting) 기술을 이용하여파크리탁셀(PTX) 약물을 함유한 폴리카프로락톤(PCL) 3차원 구조체를 제작하였고, 생분해성 PCL 고분자로부터PTX의 방출거동과 스텐트 제작 가능성을 고찰하였다. 약물을 포함한 구조체의 표면특성을 SEM으로 확인한 결과굴곡이 자연스럽고 매끄러운 표면을 가지고 있었다. FTIR을 통해서 약물이 성공적으로 구조체에 포함되었음을 확인하였고, NMR과 HPLC를 통해서 PCL 구조체 중의 PCL함량과 PTX의 서서히 방출됨을 확인되었다. 또한 세포실험을 통해 구조체에서 방출된 약물이 생물학적으로 활성을 유지하고 있으며, 반복제작된 구조체에서도 균일한 활성의 약물이 방출됨을 확인하였다. 이와 같은 쾌속조형기법을 이용하여 약물을 포함하는 구조체를 제작하고 분석함으로써, 생분해성 고분자 스텐트로서의 적용가능성을 제시하였다. Biodegradable drug-eluting stent has dual functions of supporting the lumen and treating internal tumor preventingthe restenosis by releasing drug. In this study, the polycaprolactone (PCL) based three dimensional (3D) meshloaded with paclitaxel (PTX) was presented by rapid prototyping (RP) technique of solid freeform fabrication (SFF) forbiodegradable drug-eluting stent application. PCL has many advantageous properties such as good biocompatibility, goodmechanical properties, and good drug permeability. PTX is widely used in the cancer treatment by inhibiting tumor cellproliferation. Analytical methods of HPLC and NMR were used for simultaneous quantification of PTX. Scanning electronmicroscopy (SEM) was performed to observe the architecture and morphologies of 3D mesh. The cytotoxicity assayresults indicated released PTX`s biological activity. This study provided that PCL based 3D mesh loaded with PTX byRP technique has great potential for biodegradable drug-eluting stent application.

상수처리 : 팔당상수원내 내분비계장애물질의 모니터링 및 오존,UV,오존/UV공정에 의한 제거 효율연구

정연정 ( Youn Cheong Cheong ),오병수 ( Byung Soo Oh ),김경숙 ( Kyoung Suk Kim ),주설 ( Seul Ju ),오영진 ( Young Jin Oh ),유영숙 ( Young Sook Yoo ),강준원 ( Joon Wun Kang ) 한국물환경학회 ( 구 한국수질보전학회 ) 2004 공동 추계학술발표회 Vol.2004 No.-