가토에서 Vecuronium bromide 의 용량에 따른 근육이완 효과

김동원,이동호,민경호,전세웅,유희구,김경헌,승익상,김교상,서정국 대한마취과학회 1987 Korean Journal of Anesthesiology Vol.20 No.6

The introduction of muscle relaxants was an epoch making event in the development of clinical anesthesia and their use has hecame essential to anesthesia practice. Vecuronium, one of the newest muscle relaxants, many advantages; it is .apid acting, non-accumulating, has minimals side reactions and is promptly antagonized by anticholinesterases. However, its pharmacological effect, like other conventional muscle relaxants depends upon the dose and is influenced br many factors including body temperature, blood flow, interaction with other drugs, antibiotics, diuretics and so forth, To obtain a dose·response relationship which is important for clinical use, the effect of the vecuronium in various doses on the neuromuscular block in rabbits was investigated. The results were as follows. 1) In the vecuronium 0.025 mg/kg group, maximal twitch depression was varied between 75 to 92% with a mean value of 84,9%. The spontaneous recovery index was 141.0 seconds (2.35 min). 2) In the vecuranium 7.75 mg/kg group, thmean maximum twitch depression and spontaneous recovery index were 98.4% and 218.6 seconds (3.64 min.) respectively. 3) In the vecuronium 7.1 mg/kg group, maximum twitch depression was 100% and the spontaneous recovery index was markedly prolonged to 627.8 seconds (10.35 min).

위치 기반 서비스에서 미래 위치 검색을 위한 이동 객체 색인

서동민,복경수,유재수 충북대학교 컴퓨터정보통신 연구소 2004 컴퓨터정보통신연구 Vol.12 No.1

최근 위치 기반 기술에 대한 활용이 증가하면서 이동 객체를 효율적으로 관리하기 위한 색인 구조의 필요성이 증가하고 있다. 하지만, 기존에 제안된 색인 구조들은 이동 객체의 계속되는 위치 이동으로 빈번한 색인의 변경과 성능 저하 문제를 가진다. 본 논문에서는 미래 위치 검색 및 갱신 비용을 최소화하기 위한 새로운 시공간 색인 구조를 제안한다. 제안하는 색인 구조는 갱신 비용을 최소화하기 위해 이동 객체의 현재 위치를 직접 접근하기 위한 보조 색인 구조와 공간 분할 기반의 KDB-트리를 결합한 색인 구조이다. 제안하는 색인 구조에서는 이동 객체의 미래 위치 검색 및 갱신 비용을 줄이기 위해 KDB-트리의 중간 노드에 시간에 대한 파라미터를 유지한다. 또한 제안하는 색인 구조에서는 공간활용도 및 검색 효율을 극대화하기 위한 새로운 갱신 및 분할 기법을 제안한다. 제안하는 색인 구조의 우수성을 입증하기 위해 다양한 실험을 통해 성능 평가를 수행한다. Recently, with the rapid development of location-based techniques, index structures to efficiently manage moving objects have been required. Existing index structure frequently need updates because moving objects change continuatively its position. That caused entire performance loss of index structure. In this paper, we propose a new spatio-temporal index structure that supports a future position retrieval and minimizes a update cost. The proposed index structure combines an assistant index structure that directly accesses current positions of moving objects with KDB-tree that is a space partitioning access method. The internal node in our proposed index structure keeps time parameters in order to support the future position retrieval and to minimize a update cost. Moreover, we propose new update and split methods to maximize the space utilization and the search performance. We perform various experiments to show that our proposed index structure outperforms the existing index structure.

인체동작분석시 Wavelet변환을 이용한 영상자료의 보간 및 분석

김기형,김민기,유경석,김희영 한국운동역학회 1997 한국운동역학회지 Vol.7 No.1

Inputting data of human motion analysis means signal processing of changes in linear time dependent spatial coordinates of anatomical landmarks. Commercial CCD camera appears to be sampling 30 fps imposing limitation for human motion analysis which needs at least 60 fps. For the interpolation 60 fps fast algorithm of inverse wavelet transformation (IWT) was utilized producing 60 fps out of normal 30 fps. The original data from free fall and cycling motion of lower extremity were used to test the applicabiility of wavelet interpolation to human motion analysis. The test results showed linear relationship between two data sets. In the test of free fall, data curves of two sets, theoretical 30 frame data and 60 frame data after inverse wavelet transformation, appeared to be almost identical. Regression analysis of free fall test showed R^2 = 0.99 meaning Y = IWT. In the test with cycling motion of lower extremity % cycle of maximum flexion and extension at the joints was compared between two data sets showing same result, as in free fall test.

Effects of Regular Exercise and L-Arginine Intake on Abdominal Fat, GH/IGF-1 Axis, and Circulating Inflammatory Markers in the High Fat Diet-Induced Obese Aged Rat

Sok Park(박석),Ki Woon Sung(성기운),Jin Lee(이진),Cheon Ho Lee(이천호),Young Jun Lee(이영준),Young June Yoo(유영준),Kyoung Shil Park(박경실),Byung Jin Min(민병진),Yong Sub Shin(신용업),Jung Suk Kim(김정석),Hun Jung(정훈) 한국생명과학회 2012 생명과학회지 Vol.22 No.4

본 연구는 비만과 노화가 동시에 유발된 흰쥐에서 12주간의 트레드밀 운동과 L-arginine의 투여가 복부지방량, GH, IGF-Ⅰ, somatostatin, fibrinogen, PAI-1에 미치는 영향을 관찰하고 이를 개선하는데 더욱 효과적인 방법을 제시하는데 그 목적이 있다. 이를 위해 단독 처치 군과 복합 처치 군으로 나누어 실험하여 그 효과를 비교, 분석한 결과 다음과 같은 결론을 얻었다. 1. 복부지방량은 통제집단에 비해 모든 집단에서 유의하게 감소하였다(p<0.01). 2. AG+EX, AG+LA+EX집단에서 통제집단에 비해 GH의 혈중 농도가 유의하게 높게 나타났다(p<0.1). 3. AG+EX, AG+LA+EX집단에서 통제집단에 비해 IGF-Ⅰ의 혈중 농도가 유의하게 증가하였다(p<0.01). The purpose of this study was to investigate the effect of exercise and/or L-arginine on abdominal fat, IGF-1 on GH/IGF-1 axis, fibrinogen, and PAI-1 in aged and obese rats. Male Sprague-Dawley rats were treated with a D-galactose aging inducing agent (50 mg/kg) given intraperitoneally for 12 weeks. Thirty-two male Sprague-Dawley rats were treated and divided into four groups: aging-high fat diet group (AG+HF), AG+HF with L-arginine intake group (AG+LA), AG+HF with exercise group (AG+EX), and AG+EX with L-arginine intake group (AG+LA+EX). The experimental rats underwent treadmill training (60 min/day, 6 days/week at 0% gradient) for 12 weeks. L-arginine was given orally (150 mg/kg/day) for 12 weeks. After the experiment, blood was collected from the left ventricle and abdominal fat was extracted. The results showed that GH was significantly increased in AG+EX and AG+AL+EX. IGF-1 was significantly increased in both the AG+AL+EX and AG+EX group (p<0.05), while fibrinogen and PAI-1 were not significantly different among the groups. Abdominal fat was significantly decreased in the AG+LA, AG+EX, and AG+LA+EX groups (p<0.05) compared with the AG+HF group. In conclusion, this study suggests that exercise alone or L-arginine alone or a combination not only increases the GH and IGF-1 concentration, but also decreases the abdominal fat mass.

다양한 냉ㆍ해동 방법에 따른 양파의 이화학적 특성 및 영양성분 변화

정유경(You-Kyoung Jung),장민영(Min-Young Jang),황인국(In-Guk Hwang),유선미(Seon-Mi Yoo),민상기(Sang-Gi Min),조연지(Yeon-Ji Jo),천지연(Ji-Yeon Chun),최미정(Mi-Jung Choi) 한국식품영양과학회 2015 한국식품영양과학회지 Vol.44 No.10

다양한 방법으로 냉·해동된 양파의 이화학적 및 영양학적 특성을 관찰하였다. 냉동은 자연대류냉동(0.5°C/min), 강제 송풍냉동(3.9°C/min), 극저온냉동(14.9°C/min) 순으로 급격히 빠르게 냉동되며 상변이 구간이 매우 단축되었다. 냉・해동에 따른 pH와 수분 함량의 변화는 유의적인 차이를 보였으나 그 영향은 미미한 것으로 사료된다. 냉・해동 처리가 양파의 황색도에 가장 영향을 많이 미치고 다음으로 명도변화에 영향을 주었으며, 급속냉동을 한 경우 양파의 명도를 전반적으로 어둡게 하는 경향을 보였다. 특히 황색도는 냉동 방법에 의한 변화가 더 두드러짐을 알 수 있다. 해동 감량은 모든 냉동방법에서 초음파해동과 유수해동 처리구가 유의적으로 낮은 경향을 보였고 이에 따라 강도도 높게 나타나는 경향을 보였다. 보수력은 극저온냉동을 하였을 때 유수 및 초음파 해동 시 보수력이 유의적으로 높은 값을 보이며 효과적임을 알 수 있었다. 현미경을 통한 조직 관찰의 결과 강제 송풍냉동과 극저온냉동 시 얼음결정이 작게 생성됨을 관찰하였다. 영양학적 품질 변화를 관찰한 결과 비타민 C는 생시료에 비해 데치기 후 시료 및 냉·해동 후 시료의 함량이 감소함을 보였으며, 강제송풍냉동 및 초음파해동에서 높은 값을 나타내었다. 유리당 및 유기산의 함량은 데침 처리 후 감소하였으며, 초음파해동 시 가장 손실이 적었다. 전반적인 결과로 볼 때 강제송풍냉동이 효과적인 것으로 사료되며 초음파해동이 효과적인 것으로 사료된다. This study evaluated the combination effect of various freezing and thawing techniques on the quality and nutritional aspects of onions. Onions were frozen by natural air convection freezing (NCF), air blast freezing (ABF), and liquid nitrogen freezing (LNF). Onions were frozen for 76 min by NCF, 9 min by ABF, and 9 min by LNF. The freezing treatment was stopped when the core temperature reached -12°C for NCF and ABF, and -120°C for LNF. Frozen samples were thawed through natural air convection thawing, running water thawing, sonication thawing (ST), or microwave thawing. The quality and nutritional aspects of frozen-thawed onions were evaluated by measuring thawing loss, pH, texture, water content, color, and SEM image. ST was found to cause the least loss in onion sample among the tested thawing methods, whereas the freezing methods did not cause any significant loss. In our experiment, thawing is found to be a more critical technique when compared to that of freezing. There were no clear quantifications or trends of pH and water content among different freezing and thawing techniques. The highest total color difference (ΔE) was observed in the NCF sample. For morphological observation, ABF gave the smallest ice crystal size, as well as minimum cell collapse. Loss of vitamin C, free sugar, and organic acid content was lower in the ABF and ST sample, when compared to other trials. In our study, we found that combination of ABF and ST could preserve the quality and nutritional aspects of frozen-thawed onions better than other methods.

Oral tissue response to soft tissue expanders prior to bone augmentation: in vitro analysis and histological study in dogs

Yoo, Jung Min,Amara, Heithem Ben,Kim, Min Kyoung,Song, Ju Dong,Koo, Ki-Tae Korean Academy of Periodontology 2018 Journal of Periodontal & Implant Science Vol.48 No.3

Purpose: To determine whether the swelling and mechanical properties of osmotic self-inflating expanders allow or not the induction of intraoral soft tissue expansion in dogs. Methods: Three different volumes (0.15, 0.25, and 0.42 mL; referred to respectively as the S, M, and L groups) of soft tissue expanders (STEs) consisting of a hydrogel core coated with a silicone-perforated membrane were investigated in vitro to assess their swelling behavior (volume swelling ratio) and mechanical properties (tensile strength, tensile strain). For in vivo investigations, the STEs were subperiosteally inserted for 4 weeks in dogs (n=5). Soft tissue expansion was clinically monitored. Histological analyses included the examination of alveolar bone underneath the expanders and thickness measurements of the surrounding fibrous capsule. Results: The volume swelling ratio of all STEs did not exceed 5.2. In tensile mode, the highest mean strain was registered for the L group ($98.03{\pm}0.3g/cm$), whereas the lowest mean value was obtained in the S group ($81.3{\pm}0.1g/cm$), which was a statistically significant difference (P<0.05). In addition, the S and L groups were significantly different in terms of tensile strength ($1.5{\pm}0.1g/cm$ for the S group and $2.2{\pm}0.1g/cm$ for the L group, P<0.05). Clinical monitoring showed successful dilatation of the soft tissues without signs of inflammation up to 28 days. The STEs remained volumetrically stable, with a mean diameter in vivo of 6.98 mm, close to the in vitro post-expansion findings (6.69 mm). Significant histological effects included highly vascularized collagen-rich fibrous encapsulation of the STEs, with a mean thickness of $0.67{\pm}0.12mm$. The bone reaction consisted of resorption underneath the STEs, while apposition was observed at their edges. Conclusions: The swelling and mechanical properties of the STEs enabled clinically successful soft tissue expansion. A tissue reaction consisting of fibrous capsule formation and bone loss were the main histological events.

Design and Implementation of a Chatbot System for Smart Stores

Min-Soo Kim,I-Na Kim,Jung-kwon Cho,Kyu-nam Lee,Min-young Kim,Do-Jin Choi,Jongtae Lim,Gyeong-Min Kim,Kyoung-Soo Bok,Jae-Soo Yoo 한국콘텐츠학회 2017 한국콘텐츠학회 ICCC 논문집 Vol.2017 No.12

A Probabilistic Assessment of Human Health Risk from Arsenic-Contaminated Rice Grown Near The Mining Areas of Korea

Min-Kyoung Paik,Won-Il Kim,Ji-Hyock Yoo,Jin-Kyoung Kim,Geon-Jae Im,Moo-Ki Hong 한국식품위생안전성학회 2010 한국식품위생안전성학회지 Vol.25 No.2

Chronic exposure to Arsenic (As) causes significant human health effects including various cancers. Total As concentrations from 300 polished rice samples cultivated near the mining areas in Korea were analyzed to estimate a probabilistic assessment of human health risk from As-contaminated rice. The mean of total As concentrations in rice was 0.09 mg/kg and lognormal distribution model was set for total As concentrations. Human health risk for As in rice was estimated using gender-specific rice consumption data and average daily dose (ADD). While cancer risk (CR) and hazard quotient (HQ) were calculated using oral cancer slope factor (OCSF) and Reference dose (RfD) suggested by the U.S. EPA. Mean of CR posed by total As was 2.16 (for male) and 1.83 (for female) per 10,000. The HQ for general population from rice cultivated near the mining areas in Korea was below 1 as the 50th percentile of general population. However, less than 10% of general population consuming rice cultivated near the mining areas would exceed 1.0. This result is similar with those from each gender-specific group.

Evaluation of Group Genetic Counseling Sessions via a Metaverse-based Application

Yoo Boeun,Kim Arang,Moon Hye Sung,So Min-Kyung,Jeong Tae-Dong,Lee Kyoung Eun,Moon Byung-In,Huh Jungwon 대한진단검사의학회 2024 Annals of Laboratory Medicine Vol.44 No.1

Background: Group genetic counseling has been implemented to meet growing demand. A metaverse platform, in which a society is built and activities are carried out in the virtual world, has not yet been implemented in group genetic counseling. We investigated whether a metaverse platform could be an alternative service-delivery model for group genetic counseling. Methods: Participants (N=131) were divided into three groups: patient (N=45), family (N= 43), and interested (N=43) groups. Participants entered the metaverse through a link sent to their mobile phones and attended a 20-min group genetic counseling session reviewing hereditary breast cancer, followed by a 10-min question-and-answer period. Results: The overall median score of post-educational knowledge (9.0, range 8.0–10.0) significantly increased compared to that of pre-educational knowledge (6.0, range 3.0–8.0) (P<0.001). There was no significant difference in the pre- and post-educational knowledge scores among the three groups (P>0.05). Most participants (95%) responded that their understanding of hereditary breast cancer had increased after the group genetic counseling session and that their satisfaction was high. The main advantage noted with metaverse was no limit of space and location while attending the session (97%), and the main disadvantage was a possibility of missing content due to an unstable internet connection (67%). Conclusions: The metaverse platform would be acceptable as an alternative group genetic counseling service. More studies are needed to investigate how, for whom, and in what circumstances metaverse can be effectively utilized.

중앙 집중형 망에서 인공면역체계 기반의 적응적 망 이상 상태 탐지 모델 설계

유경민(Kyoung-Min Yoo),양원혁(Won-Hyuk Yang),이상열(Sang-Yeol Lee),정혜련(Hye-Ryun Jeong),소원호(Won-ho So),김영천(Young-Chon Kim) 한국통신학회 2009 韓國通信學會論文誌 Vol.34 No.3

기존의 망 이상 상태 탐지 시스템들은 주로 정상 상태의 시스템 사용률 등과 같은 통계 값으로 결정된 임계값을 기반으로 탐지하기 때문에 이상 상태임에도 불구하고 정상 상태와 비슷한 시스템 통계 값을 가지면 탐지하지 못하는 문제점이 있다. 이러한 단점들을 해결하기 위하여 본 논문에서는 인간면역체계의 학습, 적응, 기억 능력등의 특성을 이용하는 인공면역체계 기반의 적응적 망 이상 상태 탐지 모델을 제안한다. 이를 위하여 인간면역 시스템의 수지상 세포 (Dendritic Cell)와 T 세포 사이의 상호 작용을 이용한 탐지 모델을 설계하고 각 구성 요소 및 기능을 정의한다. 중앙 집중 제어 노드는 각 라우터 노드로부터 전달받은 정보를 분석하여 대응 방법을 해당 라우터들에게 전달한다. 또한 라우터 노드는 학습을 통해 얻어진 데이터를 기반으로 이상 상태를 탐지할 뿐만 아니라 중앙 집중 제어 노드로부터 전달받은 정보를 이용하여 이상 상태를 처리한다. 최종적으로 제안된 이상 상태 탐지 모델의 타당성을 검증하기 위하여 구성 모듈을 설계하고 flooding 공격에 대한 시뮬레이션을 수행한다. The traditional network anomaly detection systems execute the threshold-based detection without considering d ynamic network environments, which causes false positive and limits an effective resource utilization. To overco me the drawbacks, we present the adaptive network anomaly detection model based on artificial immune system (AIS) in centralized network. AIS is inspired from human immune system that has learning, adaptation and mem ory. In our proposed model, the interaction between dendritic cell and T-cell of human immune system is adopte d. We design the main components, such as central node and router node, and define functions of them. The ce ntral node analyzes the anomaly information received from the related router nodes, decides response policy and sends the policy to corresponding nodes. The router node consists of detector module and responder module. The detector module perceives the anomaly depending on learning data and the responder module settles the anomaly according to the policy received from central node. Finally we evaluate the possibility of the proposed detection model through simulation.