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      • SCOPUSKCI등재

        Etomidate 와 Midazolam 이 가토 복부대동맥과 폐동맥에 미치는 영향

        서정국,유희구,염종훈 대한마취과학회 1994 Korean Journal of Anesthesiology Vol.27 No.7

        Etomidate and midazolam are newly developed and used in clinical trials. Etmoidate, a carboxylated imidazole derivative, decreases systemic vascular resistance and increases the pulmonary artery pressure in vivo. Midazolam, a water soluble derivative of benzodiazepine, decreases pulmonary artery pressure and is useful for pulmonary hypertensive patients. This study was designed to investigate the direet effects of etomidate and midazolam on vascular tension of the rabbit abdominal aorta and the pulmonary artery in vitro. In the vascular preparations with or without endothelium, changes in tension were measured following cumulative administration of etomidate (10^(-6)M, 10^(-5) M, 5×10^(-4) M) and midazolam (10^(-6)M, 10^(-5)M, 10^(-4)M). Vascular effects of these drugs were also studied in the preparations pretreated with indomethacin, nitro(w)-L-arginine methyl ester (L-NAME) and methylene blue. The results wer as follows; 1) Etomidate and midazolam induced vasorelaxation and the degree of relaxation depended on he concentration. 2) After denudation of the endothelium, vasorelaxant effect of etomidate and midazolam was efficiently decreased in abdominal aorta but not in pulmonary artery. 3) Indomethacin reduced vasorelaxing effect of etomidate efficiently, but didn't affect vasorelaxing effect of midazolam. 4) Following pretreatment of vascular preparations respectively with L-NAME and methylene blue, the relaxing responses to etomidate (10^(-5) and 5×10^(-5) M) of both abdominal aorta and pulmonary artery were depressed. Also, depressed was the relaxing response of abdominal aorta to midazolam (10^(-5) M). The results of present study suggest that etomidate and midazolam possess vasorelaxing effects in both rabbit aMominal aorta and pulmonary artery. The vascular effect of etomidate is mediated via the nitric oxide pathway and also in part, by PGI2, whereas part of the vascular effect of midazolam is associated with the nitric oxide pathway.

      • SCOPUSKCI등재
      • 後縱靭帶 骨化로 인한 頸椎 脊髓症에서 椎弓 成形術의 治療 結果 : 퇴행성 경추 척수증과의 비교연구

        서정국,김진환 인제대학교 백병원 2002 仁濟醫學 Vol.23 No.3

        Objective : Retrospective study to evaluate the characteristics and operative results of cervical myelopathy due to ossification of posterior longitudinal ligament (OPLL) and to prove the effectiveness of laminoplasty. Materials and Methods : Among 49 laminoplasty, OPLL was found in 8 patients and other cases were degenerative cervical myelopathy. The symptoms and signs, MRI, JOA score and Hirabayashi recovery rate of the patients were evaluated. Results : The age ranged from 34 to 76, mean 48.5yrs. and 7 patients were male and 1 female. In OPLL group, the mean age of the patient was relatively younger and male was predominent. The trauma history related clinical symptom was more in OPLL group. On MRI, mean cord compression was 56%, ranged from 40 to 70%. High cord signal change was observed in 4 cases. Mean preoperative JOA score in OPLL was 11.6 compared to 11.1 in degenerative cases and mean postoperative JOA score was 13.9 compared to 13.4. Average Hirabayashi recovery rate was 42.5% and 43.6%. Subjective symptoms improved in all cases. Conclusion : OPLL group has relatively early onset and male dominant, short symptom duration. OPLL group has low Hirabayashi recovery rate especially in patients who had high signal change in T2 weighted MRI image. Laminoplasty was effective procedure in cervical myelopathy due to OPLL by indirect decompression with few complication.

      • 경추 척수증에서 불충분한 전방 감압술후 추궁판 성형술 5례 보고

        서정국,김정훈 인제대학교 백병원 2002 仁濟醫學 Vol.23 No.2

        Objective: We have analyzed the clinical and radiological outcomes in 5 patients who showed no improvement after anterior decompression so that underwent laminoplasty. Materials and Methods: We studied retrospectively 5 patients who underwent laminoplasty after anterior decompression between January 1998 and April 1999. The mean age was 55.4 years (46 to 60). The mean duration from anterior decompression to laminoplasty was 39 months (12 to 90). We evaluated clinical symptoms and signs. Plain radiogram and MRI were taken before and after surgery. In evaluating the clinical results, the evaluation system established by the Japanese Orthopedic Association (JOA score) and Hirabayashi recovery rate was employed. Results: Postoperative radiograms showed an incresasement of body to canal ratios(average 0.79 pre-op, to 1.15 post-op.) and the mean JOA score increased from 11.8 preoperatively to 14.4 at the final follow-up with a mean recovery rate of 48%. Conclusion: It is better to do anterior decompression in patients who have one or two segments involved. Otherwise, patients who involve more than 3 segments can be managed using laminoplasty. Laminoplasty for patients who underwent incomplete ant, decompression may be useful method.

      • KCI등재

        극돌기간 관절형성증 환자에서 저에너지 손상에 의해 발생한 흉요추부의 삼주 골절 - 증례 보고 -

        서정국,박인근,이준구 대한척추외과학회 2019 대한척추외과학회지 Vol.26 No.4

        Study Design: Case report. Objectives: We report a case of 3-column fracture caused by low-energy trauma in a patient with Baastrup disease who complained of acute radiating pain and motor weakness in the lower limbs after 3 weeks of conservative treatment. Subsequently, posterior fusion surgery was performed. Summary of Literature Review: Baastrup disease is characterized by enlargement and close approximation of adjacent spinous processes, and it mostly affects the L4-5 level of the spine. In patients with Baastrup disease affecting multiple levels of the lumbar spine, low-energy trauma can cause an unstable 3-column fracture with neurological compromise. Early recognition and surgical treatment prior to the emergence of a neurological deficit are required. Materials and Methods: An 84-year-old woman presented with back pain after falling down backward and colliding with the edge of a shelf at ground level. Considering the patient’s general condition and age, she was initially treated with close observation and placement of a spinal brace with serial radiographic follow-up. Results: Computed tomography found 3-column fracture at the T11 level, which is quite rare in cases of minor trauma. At a 3-week follow-up, she complained of gradual lower extremity weakness, and her general lower extremity motor function decreased to grade 1–2. The patient underwent posterior fusion 2 levels above and below the affected vertebral body (T9-10-12-L1). Surgery was uneventful and the patient’s motor function recovered. Conclusions: In patients with Baastrup disease affecting multiple levels of the lumbar spine, based on our experience, low-energy trauma can cause an unstable 3-column fracture with neurological compromise. We highly recommend scrutiny of the interspinous space in elderly patients, especially those with a spinal fracture caused by low-energy trauma. Key words: Baastrup’s disease, Kissing spine, Three-column fracture, Posterior fusion 연구 계획: 증례 보고목적: 본 증례 보고는 Baastrup’s disease를 가진 환자에서 저에너지 손상으로 발생한 삼주골절의 3주간의 보존적 치료 후 하지 방사통과 근력 감소로 후방 고정술을 시행한 증례에 대한 보고이다. 선행 연구문헌의 요약: Baastrup’s disease는 주로 제 4, 5요추를 침범하는 가시돌기의 거대화와 가시돌기 간격의 협착을 특징으로 하는 질환이다. 이Baastrup’s disease 가 요추의 여러 층을 침범하는 경우, 저에너지 손상에 의해서도 불안정한 삼주골절이 발생 할 수 있다. 신경학적 결손이 발생하기 전이 질병의 조기 발견과 적절한 수술적 처치가 필요할 것으로 생각된다. 대상 및 방법: 84세 여성 환자로 뒤로 넘어지며 선반 모서리에 등을 부딪힌 후 발생한 요통을 주소로 내원하였다. 특별한 과거력은 없었으며, 환자의 연령과 전신 상태를 고려하여 척추 보호대를 착용하며 방사선 촬영을 추시 하였다. 결과: 촬영한 CT 영상에서 저에너지 손상에서 드문 삼주골절이 제 11흉추에서 발견되었다. 보존적 치료를 시행한 지 3주 후 환자는 점진적인 하지 근력의 감소를 호소하였고, 골절 부위의 위, 아래 각각 2레벨(제 9,10,12흉추 및 제 1요추) 을 고정하는 후방 고정술을 시행하였다. 수술은 특별한 일 없이 마쳤으며 근력은 회복되었다. 결론: 저자들의 경험에 비추어 보았을 때, 척추의 여러층을 침범한 Baastrup’s disease는 저에너지 손상에도 신경손상이 동반된 불안정한 삼주골절이 발생 할 수 있다. 고령 환자에 있어서 저에너지 손상으로 발생한 척추 골절이 있을 시 가시돌기 간격에 대한 철저한 평가가 필요할 것으로 생각된다. 약칭 제목: 극돌기간 관절형성증 환자의 삼주 골절

      • KCI등재

        인터넷 보안 시뮬레이션을 위한 공격 모델링

        서정국,최경희,정기현,박승규,심재홍,Seo, Jung-Kuk,Choi, Kyung-Hee,Jung, Gi-Hyun,Park, Seung-Kyu,Sim, Jae-Hong 한국정보처리학회 2004 정보처리학회논문지 C : 정보통신,정보보안 Vol.11 No.2

        최근 인터넷 사용이 폭발적으로 증가함에 따라 인터넷은 다양한 공격에 노출되었다. 이러한 인터넷 공격을 시뮬레이션 하기 위해서는 공격을 효과적으로 모델링 할 수 있어야 한다. 그러나 기존의 인터넷 공격 모델링 기법들은 공격을 단순히 특징에 파라 분류하거나 종류를 나누는 네 중점을 두고 있으며, 인터넷 보안 시뮬레이션을 위한 공격 시나리오를 표현하는데 있어서는 적합하지 않았다. 본 논문에서는 기존의 트리기반 공격 모델링 기법을 보완하여 인터넷 보안 시뮬레이션의 공격 모델링 기법으로 활용할 수 있게 개선하였다. 개선된 공격 모델링 기법은 복잡한 시나리오의 표현 불가, 공격 실행 순서의 모호함, 시스템 상태 정보의 결여 풍과 같은 기존 트리 기반 모델링 기법의 문제점들을 해결하였다. 또한 기존 모델링 기법으로는 기술할 수 없었던 동시간 공격 표현, 정밀한 공격 시작 및 수행기간 지정 등이 가능하도록 하였다. As the use of the Internet has explosively increased, it is likely for the Internet to be exposed to various attacks. Modeling the Internet attacks is essential to simulate the attacks. However, the existing studies on attack modeling have mainly focused on classifying and categorizing the attacks and consequently they are not suitable to representing attack scenarios in the Internet security simulation. In this paper, we introduce the existing methods of attack modeling, and propose an adapted attack modeling to properly express the properties for the Internet security simulator. The adapted attack modeling suggests a solution to the problems of the existing attack tree modelings, such as difficulty of composing complex scenarios ambiguity of attack sequence, lack of system state information. And it can represent simultaneous, precise time-dependent attack, and attack period, which are nearly impossible to be represented in many other existing methods.

      • 슬관절 고정술에 대한 임상적 고찰

        서정국,안치성 인제대학교 1997 仁濟醫學 Vol.18 No.4

        슬관절 고정술은 최근에는 정형외과 영일에 있어 비교적 드문 수술이다. 그러나 심한 변형의 교정과 안정성을 얻고 염증성 질환에 있어 병의 진행을 종식시키기 위해 비교적 젊은 연령층이나 중노동을 필요로 하는 환자에 있어 아직도 시행되고 있다. 본 연구는 1989년 1월에서 1994년 12월까지 만 6년에 걸쳐 외상성 관절염과 화농성 관절염 및 결핵성 관절염이 있는 환자 12예를 대상으로 슬관절 고정술을 치험하였기에 보고하는 바이다. In the past, arthrodesis was a widely used procedure especially for patients with tuberculosis or poliomyelitis but recently, with the development of replacement arthroplasty, the incidence of arthrodesis has been decreased. However, for those in the young age group, people employed in hard labor and patients with acute inflammatory disease, this operations can be still used. From January 1989 to December 1994, 12 cases of arthrodesis of the knee joint were carried out. The results were as follows ; 1.The methods of arthrodesis used were Charnley compression arthrodesis in 9 cases, external fixator compression arthrodesis in 2 cases, and cross pinning in 1 case. 2.Bone union was achieved in all 11 cases of compression arthrodesis at an average of 20.9 weeks and 1 case of non-compression arthrodesis at an 26 weeks. 3.Among the 12 cases, there were 3 complications; one supracondylar fracture of femur, one pin tract infection and one skin necrosis. 4.Bone union was achieved in all cases, and compression arthrodesis showed faster bone union at an average 5 weeks earlier than noncompression arthrodesis. In conclusion, the arthrodesis can be utilized as one of treatment methods in some cases of knee problems.

      • 요추 전방 전위증 부위에 발생된 척수 종양 1례

        서정국,장석환 白中央醫療院 2005 仁濟醫學 Vol.26 No.1

        Intradural extramedullary tumors grow slowly and can have various clinical manifestations depending on their location in the spine. They often mimic other spinal disorders thus delaying the diagnosis. These tumors are usually histologically benign and can be resected with complete extirpation and have excellent prognosis. We report a case of intradural extramedullary schwannoma which was initially diagnosed as spondylolisthesis of the lumbar spine with review of pertinent literature.

      • KCI등재

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