뇌졸중 환자의 우울증에 영향을 미치는 요인

김대용,정주호 고신대학교 의과대학 2009 고신대학교 의과대학 학술지 Vol.24 No.2

Background: The diseases are getting increasingly chronic as the fast development of medical and scientific technical advances prolong the human life span. Among many chronic diseases, the apoplexy leads to partial paralysis, speech disorder, perception disorder and paresthesia and motor disturbance. It also causes mental disorder to patients. This research was aimed to check the level of stress perceived by apoplexy patients according to the socioeconomic factors and disease characteristics. Method: Applying the Beck's depression measurement, we surveyed the depression level of 150 inpatients and outpatients who have been currently taken care of by the departments of neurology, neurosurgery and rehabilitation at a university hospital and two general hospitals in Busan. Results: According to this survey, 84 out of 150 patients are estimated to be depressed, accounting 56% of the total samples. The depression level related to the socioeconomic factors is higher in patients who are older, separated from spouse and who have low education level and financial dependence on offsprings. The depression level related to the neurological manifestations is higher in patients who have multiple strokes, long term illness, bilateral paralysis, and other neurological sequelae (particularly gait disturbance). Conclusion: The result suggest that poststroke patients are highly likely to suffer from depression by various socioeconomic factors and neurological manifestations. Therefore, it can be concluded that poststroke patients need not only medical treatments and rehabilitation procedures but also more proactive mental remedies and social supports considering patient's backgrounds and characteristics.

이담자 효모의 세포간 성응집의 특성과 표면단백질의 관련성

정영기,이태호,최용락,강원대 동의대학교 기초과학연구소 1996 基礎科學硏究論文集 Vol.6 No.1

When mating type A and a cells of heterobasidiomycetous yeast Rhodosporidium toruloides were mix-cultured, both of the mating type cells have shown strong agglutination. But this agglutination was not detactable when the A and a cell were cultured separately. From reagglutination made just after the result of disassembling the agglutination by sonication, we knew that the agglutination was sexual-agglutination, not simple physical cell agglutination. The sexual agglutination was progressed actively on logarithmic phase and, in addition, progressed faster on mating type a cell treated with rhodotorucine A. These sexual agglutination have been inhibited by several protease such as trypsin, pronase, chymotrpysin and thermolysin and inhibited by 5 mM DTT as well.

호염세균으로부터 추출한 카로테노이드 색소의 안정성

정영기,최병대 동의대학교 기초과학연구소 2000 基礎科學硏究論文集 Vol.10 No.1

A carotenoid pigment, which was a determinant for food quality, was extracted from a marine halophilic bacteria. The stability of the pigment extract was investigated for a food additive. The optimum temperature for stability was 20℃. The pigment degradation was significantly affected by solvent polarity, however, stable in salvent methanol and ethanol. The pigment degradation was highly sensitive to light and UV exposure.

Multiple Spinal Intradural Schwannomas Combined with Sequestered Lumbar Disc Herniation

김대용,김진욱,정주호,조재훈 고신대학교 의과대학 2008 고신대학교 의과대학 학술지 Vol.23 No.2

In this report, we describe a case of multiple intradural schwannomas in the spine combined with a upward sequestered disc herniation at L4-L5. It is often difficult to differentiate this tumor from lumbar disc herniation, especially a sequestered hernia. Gadolinium-enhanced MR images were a useful preoperative examination modality for differentiating these lesions from other diseases. Microscopically, the intradural tumors were successfully removed. The dura maters of the L2 and S1 were opened microsurgically, allowing the nerve fibers involved in the tumor to be identified. The involved fibers were cut around the tumor, and the lesion was resected while the intact nerve fibers were preserved. An upward sequestered lumbar disc herniation at L4-L5 was also successfully removed. Based on histological examination of the resected specimen, the tumors were diagnosed as schwannomas. Microsurgery allowed the tumors to be removed with minimal impairment from cutting of nerve fibers in the each nerve root.

혈액투석 환자에게서 발생한 재생불량성 빈혈 1예

정지용,윤나라,강대웅,오종찬,장재현,선길홍,박경희,정종훈,김현리 朝鮮大學校 附設 醫學硏究所 2005 The Medical Journal of Chosun University Vol.30 No.1

Aplastic anemia is a disease characterized by pancytopenia in the peripheral blood and hypocellular bone marrow with the fatty infiltration. The causes of the acquired aplastic anemia were usually related to drugs and immune-related diseases. A 34-years old man was admitted due to general weakness. He has been going hemodialysis for 2 years because of end stage renal disease (ESRD) due to chronic glomerulonephritis. At admission, laboratory tests showed hemoglobin 6.2 g/dL, hematocrit 18.0 %, WBC 5,710mm (neutrophil 71.8%, lymphocyte 19.1%, monocyte 5.9%), reticulocyte 1.9%, platelet 93,000/mm, Fe 12.8 ug/dL, TIBC 204 ug/dL, ferritin 941.47 ng /ml, haptoglobin 0.72 g/L, vitamin B12 508.17 pmol/L, folate 24 ng/mL, total protein 6.54 g/dL, albumin 3.76 g/dL, Alk. pohsphatase 79 IU/L, AST 30.0 IU/L, ALT 39.7 IU/L, total bilirubin 0.57 mg/dl, BUN 79.4 mg/dl and creatinine 10.18 mg/dl. Peripheral blood smear showed the normocytic normochromic anemia with anisocytosis. Anemia was diagnosed but it was irresponsive to the recombinant human erythropoietin (EPO) and blood transfusion. In the bone marrow aspiration smear were there the hypoplastic myeloid and erythroid precursors. The bone marrow biopsy section showed the hypoplasia of all components (10-20%) and the fatty infiltration. We have experienced one case of the idiopathic aplastic anemia in a patient going through hemodialysis and we just report it with documentary records. 저자들은 혈액 투석 중인 환자에서 약물, 면역계 이상등의 원인을 발견할 수 없었음에도 재생 불량성 빈혈이 발생한 1예를 경험하여 문헌 고찰과 함께 보고하는 바이다.

一柱門의 建築形式에 關한 硏究

정대열,이재환,이용대,예명해 대구대학교 과학기술연구소 2001 科學技術硏究 Vol.8 No.2

The purpose of this study is to discover the architectural type of 「Il-joo-moon」 It deals with 「Il-joo-moon」 that has been built before 1910 in Gyoung-sang province. This study analyzes type of member, jointing method, frame structure method by dividing 「Il-joo-moon」 into four parts such as roof, bracket system, frame structure, podium. The results of this analysis are as follows 1) Roof: The 「Pal-ssac」 style of roof and the 「Matt-bae」 style of roof are dominant and double caves mainly appears. 2) Bracket system: The arrangement of bracket system can be divided into one-line-arrangement and two-line-arrangement. As far as 「Chul-mock-soo」 concerned, 3 or 4 「Chul-mock-soo」 is predominent. 「Tong-jae-gong」 has been used to connect front and back bracket system for some 「Il joo-moon」. When it comes 「jae-gong」, 「Sue-soe」 style, 「Yon-bong」 style and 「Yon-hwa」 style are mainly seen. 3) Frame structure: There are 5 forms in classifying frame structure depending on the jointing method of main-column, diagonal member, sub-column etc. and weight transmission method. 4) Podim: Natural foundation stone is majority. It is judged that 「Il-joo-moon」 has no podium or natural ones, however, it has recently been converted into artificially processed podium in many cases.

Bi-계 고온초전도 선재의 Jc 향상에 관한 연구(Ⅰ)

정대영,오영우,한일용 慶南大學校 附設 工業技術硏究所 1992 硏究論文集 Vol.10 No.-

Ag가 피복된 Bi-계 고온 초전도 선재의 임계전류밀도(Jc)향상을 위하여 분말 충진법과 아울러 압연과 소결의 혼합공정의 반복법을 사용하였다. 선재에서 높은 Jc를 얻기 위한 요인으로는 높은 고온상(Bi-2223상)분율, 방향화된 미세조직, 입계에선의 강한 결합, 미립의 비 초전도상의 균일한 분포등이다. 압연을 통하여 유된 입자의 방향적 배열화에 의하여 weak-link는 상당히 제거될 수 있었다. 본 연구에서 얻어진 가장 높은 Jc는 77K와 OT에서 6,350 A/cm²의 값이었다. In order to improve the critical current density(Jc)by obtaining well grain-aligned morphology, Ag-sheathed Bi(Pb)-Sr-Ca-Cu-O superconducting tapes were prepared using the powder-in-tube method and a repeatition of the combined process of rolling and sintering. Key factors for obtaining high Jc in the tapes are known to be high content of hegh-Tc phase(Bi-2223 phase), well grain-aligned morphology, good bonding at grain boundaries and uniform dispersion of nonsuperconducting particles. The weak-links could be considerably eliminated by directional grain-alignment induced by rolling. The highest Jc obtained in the present study was 6,350 A/cm²at 77K and OT.

이담자균 효모의 성분화 과정중 인지질의 작용과 배지조성의 제한이 성분화에 미치는 영향

정영기,강원대,남수완 동의대학교 기초과학연구소 1997 基礎科學硏究論文集 Vol.7 No.1

The action of phospholipid on the rhodotorucine A(Rh.A) acceptance by heterobasidiomyceteous yeast Rhodospori-dium toruloides mating type a cells and the effect of medium composition during sexual differentiation were investigated. Activation of trigger peptidase(TPase) was very sensitive to the originated phospholipid from R. toruloides and was more sensitive to phospholipid liposome made up of phospholipid. Phospholipid present on the membrane of mating type a cells consists of phospatidylglycerol(PG), phosphatidylethanolamine(PE), phospatidylcholine(PC), phospatidylinositol(PI), and phosphatidylserine(PS) of 12.9, suprisingly 45.4, 11.0, and 13.9%, respectively. As the result of using C-1 and N-1 mediums which limited C and N sources capable of inhibiting the synthesis of phospholipid. it resulted inhibiting sexual differentiation and production of Rh.A from mating type A cells.

플라즈마 표면복합처리한 구상흑연주철의 열피로 특성

정봉용,주대헌,박주승,김명호 대한금속재료학회 2003 대한금속·재료학회지 Vol.41 No.9

This paper reports an investigation of the characteristics of plasma duplex treated ductile cast irons during thermal fatigue tests on a thermal cycling rig. The thermal fatigue cracking behaviors and microstructure of untreated and plasma surface treated ductile cast irons have been investigated. Both ferrite and pearlite matrix ductile cast irons were evaluated. During the tests, 60 mm long cylinders with 20 mm diameter were subjected to 1,000 high frequency induction heating and water cooling cycles, lasting 7 and 5 sec, respectively. The thermal fatigue damage was evaluated by analyzing different crack dimensions and distribution by light microscopy. The results showed that the plasma surface treatment increased thermal fatigue cracking resistance. When thermal fatigue cracking occurs, the cracks always initiate at the surface of the specimen. The major path of crack propagation is generally along the ferrite grain boundaries. The hardened layer had an effect on the thermal fatigue property. In addition, the ductile cast iron with an pearlite matrix has a better resistance to thermal fatigue than that of ferrite matrix.

정신분열병 및 정신분열형 장애에 대한 올란자핀의 효과와 안전성

안용민,강대엽,권준수,김창윤,김철응,반건호,신영민,이기철,이동우,이중서,조현상,채정호,김용식 大韓神經精神醫學會 2001 신경정신의학 Vol.40 No.4

연구목적 : 본 다기관 공동임상연구는 국내 환자를 대상으로 새로운 항정신병약물인 올라자핀의 치료 효과와 안전성을 확인하고자 시행되었다. 방 법 : 1999년 7월부터 2000년 3월까지 국내 10개 병원에 방문한 정신분열병 및 정신분열형 장애 105명을 대상으로 비대조 개방 임상연구를 시행하였다. 중등도 이상의 정신병 증상을 지니거나, 부작용으로 약물교체가 필요한 경우 또는 기분장애 증상의 치료가 필요한 환자를 대상으로 하였다. 2∼7일간의 약물 배설기간 후에 1일 10mg의 올란자핀을 투여하였고, 이후로 3∼7일 간격으로 용량을 조절하여 총 8주간 투여하였다. 치료 효과는 PANSS(Positive and Negative Syndrome Scale), BPRS(Brief Psychiatric Rating Scale), CGI(Clinical Global Impression-Severity), MADRS(Montgomery-Asberg Depression Rating Scale), HAM-A(Hamilton Rating Scale for Anxiety)로 판정하였다. 안전성 평가는 자발적인 이상반응 보고, 활력징후와 혈액 검사 및 SAS(Simpson-Angus Scale), BARS(Barnes Akathisia Rating Scale), AIMS(Abnormal Involuntary Movement Scale)척도를 이용하였다. 결 과 : 105명중에서 85.7%인 90명이 8주간의 치료를 완료하였다. 평균 최빈 용량은 일일 16.1(±4.7)mg이었고, 종료시점에서의 BPRS전체 점수가 기저 상태에 비해 40%이상 감소된 반응군은 69.5%이었다. PANSS의 양성 증후군과 일반정신병리 뿐만 아니라 음성 증후군 소척도에서도 유의한 감소를 보였으며, 이 감소들은 치료 초기부터 나타나서 8주간 지속되었다. 43.8%의 피험자가 중등도 이상의 우울증상을 같이 지니고 있었으며, 올란자핀에 의해 MADRS와 HAM-A가 유의하게 감소하였다. 치료 기간 동안에 활력징후에는 뚜렷한 변화가 없었으나 체중은 8주간 지속적으로 증가하였다. SAS와 AIMS는 감소하였으며, 정좌불능증을 제외한 나머지 추체외로 증상의 발생비율도 낮았다. 임상적인 증상이나 징후를 동반하지 않는 ALT/SGPT의 상승을 보였지만 프로락틴을 포함하는 대부분의 혈액 검사상 뚜렷한 이상 변화는 없었다. 결 론 ; 비록 본 임상연구가 비대조 개방 임상연구로서 많은 제한점을 가지고 있지만, 올란자핀이 기존 약물에 내약성을 보이거나 기분증상을 동반하는 정신병에 치료 효과가 있었다. 그리고 기존 항정신병약물 치료시에 문제가 되었던 추체외로 증상과 고프르로락틴 혈증을 포함하는 대부분의 부작용면에서 안전성을 보여 주었다. Objective : This multicenter clinical trial was carried out to investigate the efficacy and the safety of olanzpine for the treatment of Korean patients. Mothod : 105 patients with schizophrenia and schizophreniform disorder, visited at 10 mental or university hospitals, had received an open and non-comparative treatment with olanzapine for 8 weeks. Patients had psychotic or depressive symptoms with the severity above moderate degree or intolerable side effects to previous antipsychotics. After a wash-out period of 2-7 days, 10mg olanzapine was prescribed initially to all the patients, and then the dosage could be adjusted within the range of 5-20mg/day of olanzapine by 3-7 days. Results : 90(85.7%) of 105 patients completed the 8-weeks trial and the mean modal dose of olanzapine was 16.1(±4.7%)mg/day. At the end of the trial, 73 patients(69.5%) were classified as responder, which was defined as 40% or more improvement in BPRS(Brief Psychiatric Rating Scale) score comparing to baseline. There was a significant reduction in the scores of PANSS(Positive and Negative Syndrome Scale)and subscales including negative symptom scores and CGI. Also weekly analysis showed that the reductions in scores were kept on for the whole period of the trial. 43.8% of all the patients had depressive symptoms at the baseline and total scores of MADRS(Montgomery-Asberg Depression Rating Scale) and HAM-A(Hamilton Rating Scale for Anxiety) were also reduced after the trials. Vital signs revealed no clinically significant changes but continuous weight gain was observed during the treatment with olanzapine. The scores of SAS(Simpson-Angus Scale) and AIMS(Abnormal Involuntary Movement Scale) for assessing the EPS(extrapyramidal symptoms)and tardive dyskinesia respectively were significantly decreased and only a few patients reported EPS as adverse events. Although mild and clinically non-significant of ALT/SGPT was observed, most laboratory parameters including plasma prolactin level showed to significant changes during the trial. Conclusions : Although this trial had many limitations because it was a non-comparative and open study, olanzapine showed high efficacy on the positive, negative and depressive symptoms in schizophrenia and schizophreniform disorder.In addition to that, olanzapine showed a substantially favorable safety profile, such as low incidence of EPS and hyperprolactinemia.