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Yeun‑Ah Joo,Young‑Kyun Kim,윤태식,Kee‑Ahn Lee 대한금속·재료학회 2018 METALS AND MATERIALS International Vol.24 No.2
This study investigated the microstructure and high temperature oxidation property of Fe–Cr–B metal/ceramic compositemanufactured using powder injection molding process. Observations of initial microstructure showed a unique structurewhere α-Fe and (Cr, Fe)2B form a continuous three-dimensional network. High temperature oxidation tests were performedat 900, 1000 and 1100 °C, for 24 h, and the oxidation weight gain according to each temperature condition was 0.13, 0.84and 6.4 mg/cm2, respectively. The oxidation results according to time at 900 and 1000 °C conditions represented paraboliccurves, and at 1100 °C condition formed a rectilinear curve. Observation and phase analysis results of the oxides identifiedCr2O3and SiO2at 900 and 1000 °C. In addition to Cr2O3and SiO2,CrBO3and FeCr2O4formed due to phase decompositionof boride were identified at 1100 °C. Based on the findings above, this study suggested the high temperature oxidationmechanism of Fe–Cr–B metal/ceramic composite manufactured using powder injection molding, and the possibility of itsapplication as a high temperature component material was also discussed.
Poster Session : Small RNA and Gene Regulation ; ECgene: and alternative splicing database update
( Yeun Sook Lee ),( Young Hee Lee ),( Bum Jin Kim ),( Young Ah Shin ),( Seung Yoon Nam ),( Pora Kim ),( Nam Shin Kim ),( Won Hyong Chung ),( Jae Sang Kim ),( Sang Hyuk Lee ) 한국생화학분자생물학회 (구 한국생화학회) 2007 생화학분자생물학회 춘계학술발표논문집 Vol.2007 No.-
Park, Yeun-Soo,Noh, Hyung-Ah,Cho, Hyuck,Dumont, Ariane,Ptasinska, Sylwia,Bass, Andrew D.,Sanche, Leon 대한방사선방어학회 2008 방사선방어학회지 Vol.33 No.2
X선과 같은 고에너지 방사선에 의한 DNA 손상 중 간접적인 손상을 확인하기 위하여 탄탈륨(Ta) 박막위에 동결건조 과정으로 만들어진 pGEM-3Zf(-) plasmid DNA 단일층(monolayer)의 박막을 만든 다음, 에너지가 1.5 keV인 Al $K{\alpha}$ X선을 0분, 3분, 7분, 10분 동안 초고진공 상태에서 이 DNA 단일층에 조사하여 평균 흡수선량(mean absorbed dose)의 변화에 따른 DNA 손상을 관찰하였다. 또한 3 eV의 낮은 에너지 전자선을 조사하여 그 결과를 X선을 조사한 경우와 비교하였다. X선과 낮은 에너지 전자선으로 조사된 plasmid DNA를 전기영동(electrophoresis) 방법을 이용해 supercoiled DNA와 unsupercoiled DNA로 분리한 후 각각을 정량적으로 분석하였다. Supercoiled DNA는 X선과 3 eV 전자선의 조사에 따른 평균흡수선량이 증가함에 따라 선형적으로 감소했다. 그와 반대로 circular DNA와 crosslinked form 1 DNA는 평균흡수선량이 증가함에 따라 선형적으로 증가했다. 이것은 supercoiled DNA가 낮은 에너지 전자와 상호작용하여 외가닥 절단(single strand break)을 일으켰고 그 결과 unsupercoiled DNA로 변화되었음을 보여준다. 본 실험을 통해 X선과 같은 고에너지 방사선에 의한 DNA의 간접적 손상이 일어남을 관찰할 수 있었고, DNA의 이온화 에너지보다 작은 에너지($0{\sim}10\;eV$)를 갖는 전자에 의해서도 DNA 손상이 일어날 수 있음을 확인할 수 있었다. We observed DNA damages as a function of mean absorbed dose to identify the indirect effect of high-energy radiation such as x-ray. Monolayer films of lyophilized pGEM-3Zf(-) plasmid DNA deposited on tantalum foils were exposed to Al $K{\alpha}$ X-ray (1.5 keV) for 0, 3, 7 and 10 min, respectively, in a condition of ultrahigh vacuum state. We compared DNA damages by X-ray irradiation with those by 3 eV electron irradiation. X-ray photons produced low-energy electrons (mainly below 20 eV) from the tantalum foils and DNA damage was induced chiefly by these electrons. For electron beam irradiation, DNA damage was directly caused by 3 eV electrons. Irradiated DNA was analyzed by agarose gel electrophoresis and quantified by ImagaQuant program. The quantities of remained supercoiled DNA after irradiation were linearly decreased as a function of mean absorbed dose. On the other hand, the yields of nicked circular (single strand break, SSB) and interduplex crosslinked form 1 DNA were linearly increased as a function of mean absorbed dose. From this study, it was confirmed that DNA damage was also induced by low energy electrons ($0{\sim}10\;eV$) even below threshold energies for the ionization of DNA.
The successful clinical outcomes of pregnant women with advanced chronic kidney disease
( Ji Yeun Chang ),( Hanbeol Jang ),( Byung Ha Chung ),( Young Ah Youn ),( In Kyung Sung ),( Yong Soo Kim ),( Chul Woo Yang ) 대한신장학회 2016 Kidney Research and Clinical Practice Vol.35 No.2
Background: Successful pregnancy outcomes in patients with advanced chronic kidney disease (CKD) are increasingly common in Western countries. However, in Korea, the available literature addressing this clinical issue is scarce. Methods: We reviewed 5 successful parturitions [1 patient with Stage 5 CKD and 4 with maintenance hemodialysis (HD)] at Seoul St. Mary``s Hospital over 3 years and investigated changes in dialysis prescription, anemia management, and the incidence of maternal and neonatal complications. Results: There were no maternal or neonatal deaths in this cohort. The mean age at the time of conception and delivery was 35.8 ± 3.7 and 36.2 ± 3.5 years, respectively. Dialysis patients received more frequent and intensified HD during pregnancy, 20.0 ± 5.7 h/wk of HD over 5 visits with the ultrafiltration dose maintained between 1 and 2 kg per session. All patients received erythropoietin-stimulating agents and iron replacement therapy during pregnancy. The mean hematocrit was 33.1 ± 1.9% before pregnancy and was well maintained during gestation (33.9 ± 3.8% at the first trimester, 29.2 ± 4.2% at the second trimester, and 33.6 ± 8.7% at delivery). The mean gestation period was 32.7 ± 4.7 weeks, with 60% of patients experiencing premature delivery. The primary maternal complication was pre-eclampsia; 3 women developed pre-eclampsia and underwent emergency cesarean sections. Most neonatal complications were related to preterm birth. Conclusion: Dialysis-related care and general clinical management improved the clinical outcome of pregnancy for patients with advanced CKD.
1차원 수질 예측 모형의 검보정 자동화 시스템 개발 및 낙동강에서의 적용
손아롱 ( Ah Long Son ),한건연 ( Kun Yeun Han ),박경옥 ( Kyung Ok Park ),김병현 ( Byung Hyun Kim ) 한국환경영향평가학회 2011 환경영향평가 Vol.20 No.5
According to the total pollution load management system, exact prediction and analysis of water quality and discharge has been required in order to allocate the amount of pollution load to each local government. In this study, QUAL2E model was used for comparison with other water quality models and improve the inadequate to forecast future water quality. And Various calibration and verification methods were applied to deal with existing uncertainties of parameter during modeling water quality. For user convenience, A GUI(Graphical User Interface) system named QL2-XP model is developed by object-oriented language for the user convenience and practical usage. Suggested GUI system consist of hydraulic analysis, water quality analysis, optimized model calibration processes, and postprocessing the simulation results. Therefore this model will be effectively utilized to manage practical and efficient water quality.
흰쥐 신경교종세포에서 카드뮴 세포독성에 대한 키토산의 효과
백용아(Yong-Ah Baik),이정래(Jeoung-Rae Lee),김강득(Gang-Deuk Kim),김혜원(Hye-Won Kim),이한솔(Han-Sol Lee),허정무(Jung-Mu Hur),오재민(Jay-Min Oh),최민규(Min-Kyu Choi),정연태(Yeun-Tai Chung) 한국독성학회 2004 Toxicological Research Vol.20 No.1
Casapse-3 protease is known as a key role of apoptotic enzyme, and caspase-3 activity is a central event that occurs upstream of DNA fragmentation during apoptosis. This study demonstrates that chitosan pretreatment inhibits cadmium-induced apoptosis by attenuating the activity of caspase-3. We also analyzed the protective effect of chitosan on DNA fragmentation induced by cadmium. Cadmium toxicity was examined by DNA fragmentation and nuclear condensation with Hoechst stain. Caspase-3 activities were increased cadmium treated group for 3 hours compared with control. When chitosan (150 mg/ml) was pretreated at 30 min before cadmium treatment, cadmium cytotoxicity was suppressed in a dose-dependent manner evaluated by DNA fragmentation and caspase activity. From these results, it is suggest that the protective effect of chitosan pretreatment against cadmium-induced cytotoxicity is mediated through inhibition of caspase-3 protease activation and DNA fragmentation.