BOX-Wilson 실험계획법에 의한 인산알루미늄의 최적합성조건에 관한 연구

신화우,강태욱,안세민 원광대학교 식품약품안전성연구소 1992 食品藥品安全性硏究 Vol.5 No.-

Aluminum phosphate is used as an antacid in pharmacy as the gel or dried gel, must meet specified neutralization rate and acid consuming capacity criteria. This nonadsorbable antacid has been used in place of aluminum hydroxide gel where loss of phosphate may be a problem to the patient. Since aluminum phosphate gel is regenerated in the intestine, endogenous phosphate is spared. The acid-consuming ability of aluminum phosphate is based on the release of phosphate anion : AlPO_4 ?? Al^3+ + PO^3-, PO^3-_4 + H_3O^+ ?? HPO^2-_4 + H_2O, HPO^2-_4 + H_3O^- ?? H_2PO_4 + H_2O. Aluminum phosphate gel was synthesized by reacting aluminum chloride as a soluble aluminum salt to sodium phosphate in this study ; AlCl_3 + NaPO_4 → AlPO_4↓ + 3NaCl. The optimum synthesis conditions based on the yield of product were investigated by applying Box-Wilson experimental design. It was found that optimal synthesis conditions were as follows ; Reaction temperature;90∼98℃, Concentration of two reactants;15.3∼15.5%, Concentration ratio of two reactants, [Na_3PO_4]/[AlCl_3];1.48∼1.49, reaction time;10minutes, drying temperature of product;60∼70℃.

Box-Wilson 計劃法에 依한 炭酸마그네슘의 製造條件에 關한 硏究 : (1報) 黃酸마그네슘으로 부터 製造 (Ⅰ) Preparation from Magnesium Sulfate

申和雨 圓光大學校 1980 論文集 Vol.14 No.2

Medicinal magnesium Carbonate is a basic hydrated magnesium carbonate or a neutral hydrated magnesium carbonate of very indefinite composition. It has been known that the composition of magnesium carbonate is greatly affected by the concentration, temperature, and mole-ratio of reactant solutions, and also by the temperature at which the precipitate is dried and the temperature of washing water. The purpose of this study is to determine the optimum preparation condition of medicinal magnesium carbonate. A randomized complete block design suggested by G. E. P. Box and K. B. wilson was applied for this purpose. Medicinal magnesium carbonate was prepared by reacting magnesium sulfate and sodium carbonate solutions in this study. The optimum preparation condition of magnesium carbonate obtained from this study is as follows; 1) reacting temperature range is 57-67˚C, 2) Concentration range of reactant solutions is 13-17%, 3) mole-ratio (MgSO₄/Na₂Co₃) is 1.0-1.3, 4) drying temperature range is 84-100˚C, 5) temperature range of washing water is 36.5-41.5˚C.

Box-Wilson 計劃法에 依한 炭酸마그네슘의 製造條件에 關한 硏究 : (2) Preparation from Magnesium Chloride

申和雨 圓光大學校 1982 論文集 Vol.16 No.2

In the previous paper, it has been reported that preparation from magnesium sulfate. It has been known that the composition or particle size of magnesium carbonate is greatly affected by the concentration. temperature. and mole-ratio of reactant solutions as well as the temperature at which the precipitate is dried and the temperature of washing water. The purpose of this study is to determine the optimum preparation condition of medicinal Magnesium Carbonate. A rabdomized complete block design suggested by G. E.P. Box and K. B. Wilson was applied for this purpose. Medicinal magneslum carbonate was prepared by reacting magnesium chloride and sodium carbonate solutions in this study. The optimum preparation condition of magnesium carbonate obtained from this study is as follows; 1) The reacting temperature range is 50~63℃ 2) The concentration range of reactant solutions is 16.5~50%, 3) The optimum mole-ratio(MgCI₂/Na₂CO₃)is 0.6~1.38, 4) The drying temperature range is 75~100℃, 5) The temperature range of washing water is 28~32℃.

珪酸마그네슘의 合成條件에 關한 硏究

전우정,신화우,최광식,안세민,이광표,장영수 원광대학교 식품약품안전성연구소 1993 食品藥品安全性硏究 Vol.6 No.-

Magesium twisilicate is mainly uaed as a nonsytemic antacid andabsrbent. Magnesium trisilicate when teeated with anacid sxuh as diluted hydrochloric acid in gastric juice decomposes to form Magnesium chloride and colloidal Silicates. 2MgO·3SiO_2 + 4Hcl - 2MgCl_2 + H_4Si_3O_8 (or 3SiO_2 + 2H_2O) Colloidal mixture The resultng colloidal silicates can protect ahe ulcer frdm further acid and peptic attack and possibly adsorb the pepsin. It is well known that yield of Magnesium trisilcate produced is greatly affected by the Synthesis condition such as the reactant concentration, reaction temperature and moleatio of reactant solutions as well as by the emperature at which the precipitate is dried and the temperature of washing water, etc. The purpose of this study is to investigate the optimum synthesis conditions of Magnesium trisilicate. A randomized complete block design suggested by G.E.P. Bdx and K.B. Wagnesium sulfate solution with Sodium silicate solution in this study. It was found that optimal synthesis conditidns were: Reaction temperature range : 57-90 ℃. Concentration range of reactants (Sodium silicate and Magnesium sulfate) : 19.1-29% molar ratio of the reactants. [Sodium silicate]/[Magnesium sulfate]: 1.47-1.80. temperature range of washing water: 45-48℃ and drying temperature range: 65-82℃ The antacidic activity of five Magnesium trisilicate samples which shows the maximum antacidic efficacy was tested by pharmacopeia acid consuming capacity test. The five Magnesium trisilicate samples were samples were identified by chemical analysis.

Box-Wilson 계획법에 의한 沈降炭酸칼슘의 製造條件에 關한 硏究

김영윤,신화우,최광식,안세민,이광표,장영수 원광대학교 식품약품안전성연구소 1993 食品藥品安全性硏究 Vol.6 No.-

Medicinal Precipitated Clacium Carbonate is prepared by the interaction of Calcium Chloride and Ammonium Carbonate Solutions in this study. It has been known that the particle size of Precipitated Calcium Carbonate is greatly affected by the concentration, temperature, and moli-ratio of reactant solutions as well as the temperature at which the precipitate is dried and the temperature of washing water. The purpose of this study is to determine the optimum preparation Condition of medicinal Precipitated Calcium Carbonate. A randomized complete block design wuggested by G.E.P. Box and K.B.Wilson was for this purpose. The optimum preparation condition of light and fine precipitated Calcium Carbonate obtained from this study is as follows : 1) The reacting temperature range is 25∼45℃ 2) The concentration range of reactant solutions is 10∼30% 3) The optimum mole-ratio (CaCl/(NH) CO) is 1.0∼2.0. 4) The drying temperature range is 60∼80℃. 5) Temperature range of washing water is 25∼60℃.

Hydrotalcite의 製造條件에 關한 硏究

안세민,신화우,최광식,이광표,장영수 원광대학교 식품약품안전성연구소 1993 食品藥品安全性硏究 Vol.6 No.-

Hydrotalcite is mainly used as a antacid and adsorbent. It is Well Known that the yield of hydrotalcite produced is greatly affected by the preparation conbition such as the reactant concetration, reaction temperature, reaction time, mole ratio of reactants and grying tepeeature, etc. the purpose of this study is to investigate the optimum preparation condition of hydrotalcite. Arandomived complete block design suggested by G.E.P.Box and K.B. Wilson was appliedfor this purpose. Hydrotalcite was prepared by reacting sodium carbonate. Magnesium oxide and Aluminum sulfate solutions in this study. The optimum preparation condition of hydrotalcite obtained from this study is as follows: 1) The reaction temperature range is 48-63℃ 2) The concentration of reactant solutions is about 20% 3) The optimum mole-ratio (MgO/Al. sulfate) is 7.35-8.1. 4) The reacting time tatge is 10-11 min.. 5) The drying temperature range is 78-82℃ The outcome of D.S.C. indicated a desolvation of hydrotalcite occured at about 98℃ The dehydration of the compound ceased at about 250℃, and the decarboxylation ceased at about 446℃ The physical and chemical properties of hydrotalcite as medicine were studied by use of chemical analysis, bulk volume test and acid consuming capacity measurements.

苦汁으로 부터 炭酸마그네슘과 酸化마그네슘의 最適合成條件에 關한 硏究

鄭東燻,辛宗根,申和雨 圓光大學校 1989 論文集 Vol.23 No.2

고즙과 탄산나트륨을 원료로 1)반응액의 온도, 2)반응액의 농도, 3)혼합비율(〔Bittern〕/〔Na₂CO₃〕), 4)작용시간 및 5)건조온도를 합성요인으로 하여 Box-Wilson 실험계획법에 의해 탄산마그네슘의 최적합성조건을 추구하고 그 중 우수제품에 대해 D.S.C.를 측정하여 이를 기준으로 하소시켜 산화마그네슘을 제조하여 용적시험, 제산도시험 및 광학현미경사진을 관찰한 결과 1. 탄산마그네슘의 최적합성조건의 범위는 ①반응액의 온도범위는 50∼70℃ ②반응액의 농도범위는 고즙은 37.3∼38.1%, 탄산나트륨은 9.9∼10.3%, ③혼합비율(〔Bittern〕/〔Na₂CO₃〕)의 범위는 1.485∼1.503, ④작용시간의 범위는 10∼12분, ⑤건조온도의 범위는 73∼83℃이다. 2. 시료탄산마그네슘의 D.S.C.측정결과 75℃정도에서 결정수의 이탈로 보이는 흡열Peak를 나타냈고, 290℃정도에서 구조수의 이탈로 생각되는 흡열Peak를 나타냈으며, 408℃정도에서 탄산깨스의 이탈로 생각되는 흡열Peak를 나타냈다. 3. 탄산마그네슘의 하소온도는 500∼600℃가 적당하겠으며, 용적시험결과는 모두 경질품이었고, 시판품보다 모두 용적시험치가 큰 결과를 나타냈다. 4. 제산도시험의 결과는 시판품의 제산능보다 모두 크며 광학현미경사진에 의한 관찰을 하였다. Optimal Synthesis Condition of Magnesium Carbonate were investigated from the viewpoint of bulkiness according to a randomized complete block design proposed by G.E.P. Box and K.B. Wilson. Bittern and Sodium Carbonate were utilized as reactants in order to prepare Magnesium Carbonate. It was found that optimum temperature range of reactant solutions was 50∼70℃ and the optimum concentration range of the reactant solutions was 37.3∼38.1%(Bittern), 9.9∼10.3%(Sodium Carbonate), on the viewpoint of bulkiness. The optimum mole ratio of Bittern to Sodium Carbonate was in the range of 1.485∼1.503and the optimum reacting time range was 10∼12minutes. The optimum drying temperature range was 73∼83℃. Magnesium Oxide comes two types of granules when prepared by calcination of Magnesium Carbonate. The outcome of D.S.C. indicated a desolvation of Magnesium Carbonate occurred at about 75℃. The dehydration of the compound ceased at about 290℃ and the decarboxylation ceased at about 408℃. The physical and chemical properties of Magnesium Oxide as medicine were studied by use of Volume Test, Optical microscopic photographs and Acid Consuming Capacity measurments.

萬頃江流域에 있어서 井水中의 弗素含量에 관한 硏究

金完泰,安榮根,申和雨,張賢淑 원광대학교 식품약품안전성연구소 1987 食品藥品安全性硏究 Vol.1 No.-

This study is the survey about Fluorine contents in the well water of area of Mankyung River side and water of Mankyung River. The result of this survey is as followings: The water of well in this area contained 0.5∼1.3ppm and it's average value was about 0.8 ppm. The water from Mankyung River contained 0.8∼0.9ppm and it's average value is 0.87ppm. By the regionally sectional survey the well water of the area of Mankyung River side, the well water of Chun-Ju, Iri, Samye, and Kusan contained 0.5∼0.8ppm, but the well water of Baikku area contained 0.6∼1.3ppm. Especially in Baikku area 63% of well contained 0.6∼1.0ppm and 38% of well contained 1.1∼1.3ppm. From the above results one can conclude that the 38% of well water of the Baikku area is troubled one.

동종 조혈모세포이식 후 발생한 치명적 홍역 폐렴 1예

백창렬,이동건,최정현,정현화,조유경,박훈준,이승훈,박윤희,이교영,민우성,김춘추,신완식 대한감염학회 2001 감염 Vol.33 No.4

As a result of the enlarging pool of unvaccinated children and young adults, there has been an increase in measles in our countries. In these situation, it has been reported that measles associated pneumoinia is easily complicated with fatal respiratory failure, espycially in immunocompromised patients. Herein we report the case of lethal measles pneumonia after allogenic hematopoietic stem cell transplantation in adults proven by autopsy. Recently, one case of measles was encountered in 39-year-old female patients after allogenic bone marrow transplanted case (chronic myelogenous leukemia), who progressed into interstitial pneumonia pattern, despite treatment including antibiotics, immunoglobulin. The patient died of giant cell pneumonia compatible with that of measles which was comfirmed in the section of necropsy lung specimen. (Korean J Infect Dis 33:301∼309, 2001)

Effect of Electrolytes on Rheological Properties of Young-Il Bentonite Suspension

Shin, Wha-Woo,Lee, Kwang-Pyo The Pharmaceutical Society of Korea 1985 Archives of Pharmacal Research Vol.8 No.2

Dependence of the flow behavior of aqueous suspension of Young-Il bentonite on the concentration and the type of electrolytes was studied. Viscosity measurements were made was Rion Viscotester, using No. 3 rotor at 62.5 R. P. M. at 25.deg.C. As electrolyte concentration increased, the apparent viscosity was observed to increase. Changes in viscosity were in general agreement with predicted results based on the Hofmeister sequence and the Schulze-Hardy rule. The observed electrolyte effect on the apparent viscosity was discussed in terms of the Verwey-Overbeek theory.