Mossbauer 분광법에 의한 Fe₂SiO₄의 연구

이성호,김웅태,채광표,정덕조 建國大學校基礎科學硏究所 1988 理學論集 Vol.13 No.-

Fe₂SiO₄에 관한 X-선 회절실험과 Mossbauer 분광실험을 하였다. X-선 회절실험 결과 본 시료는 olivine group에 속하는 fayalite로서 orthorhombic 구조(??)임을 알 수 있었다. Mossbauer 분광실험은 60K-834K의 온도구간에서 행하여 졌으며, Mossbaure 스펙트럼을 분석한 결과 철은 high spin 2+ 상태임을 알 수 있었고, X-선 회절실험 결과와는 다르게 철이 산소 이온들과 함께 일그러진 octahedron을 형성하고 있음을 알 수 있었다. The Fe₂SiO₄ has been studied by means of X-ray diffractometry and Mossbauer spectroscopy. The analysis of X-ray diffraction pattern shows that Fe₂SiO₄is fayalite of orthorhombic structure(??). The Mossbauer spectra which have been taken between 60K and 834K show that the valence state of iron is ferrous and high spin state and that the iron ions occupy sites of distorted octahedron whereas the X-ray analysis shows it is at a site of regular one.

골절단을 이용한 급속 치아이동 후 치수 및 치주조직 변화

강경화,김은철,이선경,임채웅,마쓰다 기꾸,태기출,김상철 대한치과교정학회 2004 대한치과교정학회지 Vol.34 No.2

본 연구는 골절단을 이용한 치아-치조골 분절의 급속 치아이동 후 치수, 치주인대 및 치조골의 변화를 유성견에서 평가하고자 하였다. 하악 제4소구치의 근심, 원심, 치근단 부위에서 피질골을 절단하여 치아-골 분절을 형성하고 하악 제3소구치를 발거하면서 협측, 설측 부위의 피질골을 삭제하였다. 1주 휴지기 부여에 따라 휴지기군과 비휴지기군으로 나누어 치아의존형 견인장치로 6일 동안 견인하고 강화기를 거친 후 0주, 1주, 2주, 4주, 6주, 8주에 희생시켜 치수, 치주인대 및 치조골의 조직 변화를 임상적, 방사선적, 조직학적 및 면역화학적으로 평가하여 다음과 같은 결과를 얻었다. 1. 치아이동 양과 강화기 동안의 조직 치유 양상에서 휴지기 유무에 따른 차이는 없었다. 2. 견인측에서 골형성은 강화기 8주까지 계속되었는데 강화기 1-2주에 가장 활발하였으며 6-8주간의 변화는 적었다. 3. 비휴지기군의 강화기 1주에서 치조골 흡수 및 파골세포 출현, 염증세포 침윤이 가장 많았으며, 특징적으로 파상아세포가 압박측의 치주인대와 치수 내에 나타났다. 4. TGF-β는 치조골의 골기질 및 골모세포, 파골세포, 치수 내 파상아세포에서 강양성 발현을 보인 반면 치수, 백악모세포, 무세포성 백악질에서 경미한 양성 발현을 나타내는 부위 특이성이 있었다. 5. TGF-β는 견인측 치주인대의 치조골에 인접한 혈관 및 치주인대세포, 골모세포에서 강화기 초기 1-2주에 주로 발현되었으며 6주 이후에는 발현이 크게 감소하였다. The movement of tooth-bone segments by osteotomy can simultaneously shift tooth and surrounding alveolar bone in a relatively short period. The purpose of this study was to evaluate the tissue changes in pulp, periodontal ligament, and alveolar bone in rapid tooth bone movement with osteotomy. The mandibular 3rd premolar of a dog was extracted and cortical bones of the buccal and lingual area were eliminated, and then cortical bones around the mesial and distal area of root, and below the root apex of the mandibular 4th premolar were osteotomized. After a one week latency period, a tooth-borne distraction device was activated for 6 days. And pulp, periodontal ligament and alveolar bone were evaluated clinically, radiologically, histologically and immunohistochemically at 0, 1, 2, 4, 6, 8 weeks of the consolidation period and conclusions were reached as follows. 1. Latency period didn't affect total amount of tooth movement and healing process of tissue during consolidation period. 2. Bone formation continued through 8 weeks of consolidation in distracted side, with a high peak at 1-2 weeks, and the lowest at 6-8 weeks of consolidation. 3. At 1 week of consolidation, alveolar bone resorption, osteoclast appearance and inflammatory cell infiltration were the most active, and dentinoclasts characteristically appeared on the pulp and pressure side of the periodontal ligament. 4. The expression of TGF-β was area-specific, as it was strong-positive at bone matrix, osteoblast, osteoclast of alveolar bone, and dentinoclast inside pulp, but weak in pulp, cementoblast and acellular cementum. 5. The expression of TGF-β was generally observed at the initial 1-2 weeks of consolidation at vessels, periodontal ligament cells, and osteoblast near alveolar bone on the distraction side of the periodontal ligament, and was significantly decreased after 6 weeks of consolidation.

다동온실의 복합환경 제어시스템을 위한 소프트웨어 개발

이대원,김채웅 성균관대학교 생명공학연구소 1999 生命工學硏究 Vol.5 No.1

A hybrid environmental control system was designed and built in the multi-greenhouses. After the hardware system was developed, the software was designed and constructed for this project. A software was adequate for reading data from many sensors and operating side windows, top windows, curtains and fans in the two greenhouses. Separate programs for control of the hardware, written Visual basic, Turbo-C and Assembler computer language, were developed to make the hybrid environmental control system operate. The program was a menu driven program within Windows environment. The initial menu was easily implemented by pressing a keypad key(KPK) on the keyboard or a mouse. Continued manipulation of the KPK or a mouse enable the user to reach easily any of the sub modes in the many modes. This software proved to be a reliable program for the hybrid environmental control system in the two greenhouse.

Dietary uptake, biodistribution, and depuration of microplastics in the freshwater diving beetle <i>Cybister japonicus</i>: Effects on predacious behavior

Kim, Shin Woong,Kim, Dokyung,Chae, Yooeun,An, Youn-Joo Elsevier 2018 Environmental pollution Vol.242 No.1

<P><B>Abstract</B></P> <P>Microplastics (MPs) have adverse effects on aquatic organisms in marine environments; however, there is a lack of information on freshwater environments. This study investigated the dietary uptake, and biodistribution and depuration of MPs in the freshwater diving beetle <I>Cybister japonicus</I> (Coleoptera: Dytiscidae) after consumption of zebrafish (<I>Danio rerio</I>) exposed to MPs. The transfer of MPs in diving beetles after consumption of zebrafish was assessed to determine whether the presence of MPs affected diving beetle behavior and predation. We found that diving beetles that consumed MP-exposed fish had a significantly lower ingestion rate than the control. In addition, the trophic transfer rate of MPs was 13–18%. However, MPs were found only in the crop and proventriculus of the beetles, and all particles were depurated within 48 h, likely via regurgitation. As diving beetle is a top predator in freshwater ecosystems and could facilitate transfer from aquatic to terrestrial ecosystems via predation, its behavior towards indigestible MPs in its digestive organs (i.e., filtering and vomiting) could represent a meaningful phenomenon as a potential vector for MP transport. This is the first report of the trophic transfer of MPs from fish to dytiscid species, which helps clarify the effects and mechanisms of MPs in freshwater systems.</P> <P><B>Highlights</B></P> <P> <UL> <LI> Microplastic (MP) transfer was assessed between freshwater fish and beetles. </LI> <LI> MPs can be transferred from fish to predacious diving beetles. </LI> <LI> Dietary uptake of MPs affects the ingestion rate of diving beetles. </LI> <LI> Diving beetles can recognize MPs as indigestible food items. </LI> <LI> Diving beetles may transfer MPs from freshwater to terrestrial ecosystems. </LI> </UL> </P> <P><B>Graphical abstract</B></P> <P>[DISPLAY OMISSION]</P>

Poster Session : Expression of a human phenylethanolamine-N-metyltransferase(hPNMT) and design of hPNMT inhibitors using in silico screening and NMR spectroscopy

( Woong Hee Kim ),( Dong Il Kang ),( Jee Young Lee ),( Ji Young Yang ),( Eugene Park ),( Young Kee Chae ),( Yang Mee Kim ) 한국생화학분자생물학회 (구 한국생화학회) 2007 생화학분자생물학회 춘계학술발표논문집 Vol.2007 No.-

Fabrication and characterization of CGS / CIGS tandem solar cells by low temperature process

Chae-Woong KIM,Hye Jin KIM,Gwangwe YOO,Hyung-Jun KIM,Chaehwan JEONG 한국진공학회 2016 한국진공학회 학술발표회초록집 Vol.2016 No.8

Intracellular cleavage of osteopontin by caspase-8 modulates hypoxia/reoxygenation cell death through p53.

Kim, Hyo-Jin,Lee, Ho-June,Jun, Joon-Il,Oh, Yumin,Choi, Seon-Guk,Kim, Hyunjoo,Chung, Chul-Woong,Kim, In-Ki,Park, Il-Sun,Chae, Han-Jung,Kim, Hyung-Ryong,Jung, Yong-Keun National Academy of Sciences 2009 PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF Vol.106 No.36

<P>Osteopontin (OPN) is highly expressed in cancer patients and plays important roles in many stages of tumor progression, such as anti-apoptosis, proliferation, and metastasis. From functional screening of human cDNA library, we isolated OPN as a caspase-8 substrate that regulates cell death during hypoxia/reoxygenation (Hyp/RO). In vitro cleavage assays demonstrate that OPN is cleaved at Asp-135 and Asp-157 by caspase-8. Cellular cleavage of OPN is observed in apoptotic cells exposed to Hyp/RO among various apoptotic stimuli and its cleavage is blocked by zVAD or IETD caspase inhibitor. Further, over-expression of OPN, the form with secretion signal, inhibits Hyp/RO-induced cell death. Caspase cleavage-defective OPN mutant (OPN D135A/D157A) is more efficient to suppress Hyp/RO-induced cell death than wild-type OPN. OPN D135A/D157A sustains AKT activity to increase cell viability through inhibition of caspase-9 during Hyp/RO. In addition, OPN is highly induced in some tumor cells during Hyp/RO, such as HeLa and Huh-7 cells, which is associated with their resistance to Hyp/RO by sustaining AKT activity. Notably, OPN C-terminal cleavage fragment produced by caspase-8 is detected in the nucleus. Plasmid-encoded expression of OPN C-terminal cleavage fragment increases p53 protein level and induces apoptosis of wild-type mouse embryonic fibroblast cells, but not p53(-/-) mouse embryonic fibroblast cells. These observations suggest that the protective function of OPN during Hyp/RO is inactivated via the proteolytic cleavage by caspase-8 and its cleavage product subsequently induces cell death via p53, postulating caspase-8 as a negative regulator of tumorigenic activity of OPN.</P>

Intravesical bacillus Calmette–Guérin-induced myopathy presenting as rhabdomyolysis: a case report

Chae Hun Lee,Byeong Joo Choi,Jung Hun Kim,Tae Woong Yang,Gi Jeong Kim,Ha Young Shin,Se Hoon Kim,Seung Woo Kim 영남대학교 의과대학 2023 Yeungnam University Journal of Medicine Vol.40 No.4

Intravesical bacillus Calmette–Guérin (BCG) instillation is an adjuvant treatment for non–muscle-invasive urinary bladder cancer. Although most complications associated with BCG immunotherapy are mild and self-limiting, rare albeit serious complications have been reported. Only a few cases of BCG-related rhabdomyolysis have been reported. In this study, we present the case of a 72-year-old woman who developed severe weakness and hyperCKemia following intravesical BCG instillation. A muscle biopsy was performed, and a diagnosis of drug-induced myopathy was made.

Synthesis of Large-Area Graphene Layers on Poly-Nickel Substrate by Chemical Vapor Deposition: Wrinkle Formation

Chae, Seung Jin,Gü,neş,, Fethullah,Kim, Ki Kang,Kim, Eun Sung,Han, Gang Hee,Kim, Soo Min,Shin, Hyeon-Jin,Yoon, Seon-Mi,Choi, Jae-Young,Park, Min Ho,Yang, Cheol Woong,Pribat, Didier,Lee, Young WILEY-VCH Verlag 2009 Advanced Materials Vol.21 No.22

<B>Graphic Abstract</B> <P>Large-area, few-layer graphene is grown on a poly-nickel substrate using optimized CVD conditions. High temperature, short growth time, and an optimal gas mixing ratio (C<SUB>2</SUB>H<SUB>2</SUB>/H<SUB>2</SUB> = 2/45) are found to be necessary to synthesize highly crystalline few-layer grapheme, which may find applications in electronic devices. The wrinkles that are observed under all growth conditions are proposed to be formed by two processes. <img src='wiley_img/09359648-2009-21-22-ADMA200803016-content.gif' alt='wiley_img/09359648-2009-21-22-ADMA200803016-content'> </P>

2형 당뇨 환자에 있어서 C형 간염의 유병률에 관한 연구

김구영,서광섭,유광렬,임병욱,채선애,강남훈,김창훈,권영우,김희수,류성태,이정환,박성우,오웅식,김정한 중앙대학교 의과대학 의과학연구소 2003 中央醫大誌 Vol.28 No.1

Background: We have doubt about the truth that Type 2 DM is associated with chronic hepatitis C infection. The aim of our study was to prove a close relationship between chronic HCV infection and type 2 DM in korean patients. Methods: We reviewed the out-patient's medical records of 466 patients with type 2 DM who visit the Sung-ae hospital from March 2000 to August 2001. Diabetic patients were analyzed for the following variables: age, sex, waist circumference, weight, waist/hip ratio, using of self monitoring of blood glucose, method of therapy, duration of disease, experience of previous transfusion, major surgical procedure, accompanied disease, liver function tests (LFT), HbA1 c. We ruled out patients with liver cirrhosis. Results: Hepatitis C virus infection was observed more frequently in patient with Type 2 DM. Of 466 Type 2 DM patients, 13 patients were infected with Hepatitis C virus (2.79%). Compared with mean prevalence of Korean population (1.3~1.6%), it's value is very high. the other hand, 21 patients were infected with Hepatitis B virus (4.5%). Such results are similar to mean prevalence of the general public (4~5%). Conclusions: Prevalence of hepatitis C was closely associated in korean patients with type 2 DM. And an increased prevalence is independent of cirrhosis.